Mortality from Parkinson's disease: a population-based prospective study (NEDICES).
Identifieur interne : 003376 ( Ncbi/Merge ); précédent : 003375; suivant : 003377Mortality from Parkinson's disease: a population-based prospective study (NEDICES).
Auteurs : Ignacio J. Posada [Espagne] ; Julián Benito-Le N ; Elan D. Louis ; Rocío Trincado ; Alberto Villarejo ; María José Medrano ; Félix Bermejo-ParejaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.
Descripteurs français
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : Spain.
- mortality : Cardiovascular Diseases, Lung Diseases, Neoplasms, Parkinson Disease.
- Aged, Aged, 80 and over, Cause of Death, Comorbidity, Data Collection, Female, Humans, Male, Proportional Hazards Models, Prospective Studies, Risk Factors.
Abstract
Most studies of mortality in Parkinson's disease have been clinical studies, yielding results that are not representative of the general population. We assessed the risk of mortality from Parkinson's disease in the Neurological Disorders in Central Spain (NEDICES) study, a prospective population-based study in which Parkinson's disease patients who were not ascertained through medical practitioners were also included. The cohort consisted of 5262 elderly subjects (mean baseline age, 73.0 years), including 81 with Parkinson's disease at baseline (1994-1995). Thirteen-year mortality was assessed. Two thousand seven hundred and one of 5262 subjects (51.3%) died over a median follow-up of 12.0 years (range, 0.04-14.8 years), including 66 of 81 subjects (81.5%) with Parkinson's disease at baseline and 2635 of 5181 subjects (50.8%) without Parkinson's disease at baseline. In an unadjusted Cox model, the hazard ratio of mortality was increased in subjects with Parkinson's disease (hazard ratio, 2.29; 95% confidence interval, 1.80-2.93; P < .001) versus subjects without Parkinson's disease (reference group). In a Cox model that adjusted for a variety of demographic factors and comorbidities, the risk of mortality remained elevated in subjects with Parkinson's disease (hazard ratio, 1.75; 95% CI, 1.32-2.31, P < .001). In additional Cox models, Parkinson's disease patients with dementia had particularly high risks of mortality (adjusted hazard ratio, 2.62; 95% CI, 1.40-4.90; P < .001). In this prospective population-based study, Parkinson's disease was an independent predictor of mortality in the elderly. Parkinson's disease patients with dementia had particularly high risks of mortality.
DOI: 10.1002/mds.23921
PubMed: 21915906
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mortality from Parkinson's disease: a population-based prospective study (NEDICES).</title><author><name sortKey="Posada, Ignacio J" sort="Posada, Ignacio J" uniqKey="Posada I" first="Ignacio J" last="Posada">Ignacio J. Posada</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Hospital 12 de Octubre, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Benito Le N, Julian" sort="Benito Le N, Julian" uniqKey="Benito Le N J" first="Julián" last="Benito-Le N">Julián Benito-Le N</name></author><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D" last="Louis">Elan D. Louis</name></author><author><name sortKey="Trincado, Rocio" sort="Trincado, Rocio" uniqKey="Trincado R" first="Rocío" last="Trincado">Rocío Trincado</name></author><author><name sortKey="Villarejo, Alberto" sort="Villarejo, Alberto" uniqKey="Villarejo A" first="Alberto" last="Villarejo">Alberto Villarejo</name></author><author><name sortKey="Medrano, Maria Jose" sort="Medrano, Maria Jose" uniqKey="Medrano M" first="María José" last="Medrano">María José Medrano</name></author><author><name sortKey="Bermejo Pareja, Felix" sort="Bermejo Pareja, Felix" uniqKey="Bermejo Pareja F" first="Félix" last="Bermejo-Pareja">Félix Bermejo-Pareja</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1002/mds.23921</idno><idno type="RBID">pubmed:21915906</idno><idno type="pmid">21915906</idno><idno type="wicri:Area/PubMed/Corpus">001054</idno><idno type="wicri:Area/PubMed/Curation">001054</idno><idno type="wicri:Area/PubMed/Checkpoint">001226</idno><idno type="wicri:Area/Ncbi/Merge">003376</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Mortality from Parkinson's disease: a population-based prospective study (NEDICES).</title><author><name sortKey="Posada, Ignacio J" sort="Posada, Ignacio J" uniqKey="Posada I" first="Ignacio J" last="Posada">Ignacio J. Posada</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Hospital 12 de Octubre, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Benito Le N, Julian" sort="Benito Le N, Julian" uniqKey="Benito Le N J" first="Julián" last="Benito-Le N">Julián Benito-Le N</name></author><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D" last="Louis">Elan D. Louis</name></author><author><name sortKey="Trincado, Rocio" sort="Trincado, Rocio" uniqKey="Trincado R" first="Rocío" last="Trincado">Rocío Trincado</name></author><author><name sortKey="Villarejo, Alberto" sort="Villarejo, Alberto" uniqKey="Villarejo A" first="Alberto" last="Villarejo">Alberto Villarejo</name></author><author><name sortKey="Medrano, Maria Jose" sort="Medrano, Maria Jose" uniqKey="Medrano M" first="María José" last="Medrano">María José Medrano</name></author><author><name sortKey="Bermejo Pareja, Felix" sort="Bermejo Pareja, Felix" uniqKey="Bermejo Pareja F" first="Félix" last="Bermejo-Pareja">Félix Bermejo-Pareja</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cardiovascular Diseases (mortality)</term><term>Cause of Death</term><term>Comorbidity</term><term>Data Collection</term><term>Female</term><term>Humans</term><term>Lung Diseases (mortality)</term><term>Male</term><term>Neoplasms (mortality)</term><term>Parkinson Disease (mortality)</term><term>Proportional Hazards Models</term><term>Prospective Studies</term><term>Risk Factors</term><term>Spain (epidemiology)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Cardiovascular Diseases</term><term>Lung Diseases</term><term>Neoplasms</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cause of Death</term><term>Comorbidity</term><term>Data Collection</term><term>Female</term><term>Humans</term><term>Male</term><term>Proportional Hazards Models</term><term>Prospective Studies</term><term>Risk Factors</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Most studies of mortality in Parkinson's disease have been clinical studies, yielding results that are not representative of the general population. We assessed the risk of mortality from Parkinson's disease in the Neurological Disorders in Central Spain (NEDICES) study, a prospective population-based study in which Parkinson's disease patients who were not ascertained through medical practitioners were also included. The cohort consisted of 5262 elderly subjects (mean baseline age, 73.0 years), including 81 with Parkinson's disease at baseline (1994-1995). Thirteen-year mortality was assessed. Two thousand seven hundred and one of 5262 subjects (51.3%) died over a median follow-up of 12.0 years (range, 0.04-14.8 years), including 66 of 81 subjects (81.5%) with Parkinson's disease at baseline and 2635 of 5181 subjects (50.8%) without Parkinson's disease at baseline. In an unadjusted Cox model, the hazard ratio of mortality was increased in subjects with Parkinson's disease (hazard ratio, 2.29; 95% confidence interval, 1.80-2.93; P < .001) versus subjects without Parkinson's disease (reference group). In a Cox model that adjusted for a variety of demographic factors and comorbidities, the risk of mortality remained elevated in subjects with Parkinson's disease (hazard ratio, 1.75; 95% CI, 1.32-2.31, P < .001). In additional Cox models, Parkinson's disease patients with dementia had particularly high risks of mortality (adjusted hazard ratio, 2.62; 95% CI, 1.40-4.90; P < .001). In this prospective population-based study, Parkinson's disease was an independent predictor of mortality in the elderly. Parkinson's disease patients with dementia had particularly high risks of mortality.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21915906</PMID><DateCreated><Year>2011</Year><Month>12</Month><Day>15</Day></DateCreated><DateCompleted><Year>2012</Year><Month>02</Month><Day>28</Day></DateCompleted><DateRevised><Year>2012</Year><Month>08</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>14</Issue><PubDate><Year>2011</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Mortality from Parkinson's disease: a population-based prospective study (NEDICES).</ArticleTitle><Pagination><MedlinePgn>2522-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23921</ELocationID><Abstract><AbstractText>Most studies of mortality in Parkinson's disease have been clinical studies, yielding results that are not representative of the general population. We assessed the risk of mortality from Parkinson's disease in the Neurological Disorders in Central Spain (NEDICES) study, a prospective population-based study in which Parkinson's disease patients who were not ascertained through medical practitioners were also included. The cohort consisted of 5262 elderly subjects (mean baseline age, 73.0 years), including 81 with Parkinson's disease at baseline (1994-1995). Thirteen-year mortality was assessed. Two thousand seven hundred and one of 5262 subjects (51.3%) died over a median follow-up of 12.0 years (range, 0.04-14.8 years), including 66 of 81 subjects (81.5%) with Parkinson's disease at baseline and 2635 of 5181 subjects (50.8%) without Parkinson's disease at baseline. In an unadjusted Cox model, the hazard ratio of mortality was increased in subjects with Parkinson's disease (hazard ratio, 2.29; 95% confidence interval, 1.80-2.93; P < .001) versus subjects without Parkinson's disease (reference group). In a Cox model that adjusted for a variety of demographic factors and comorbidities, the risk of mortality remained elevated in subjects with Parkinson's disease (hazard ratio, 1.75; 95% CI, 1.32-2.31, P < .001). In additional Cox models, Parkinson's disease patients with dementia had particularly high risks of mortality (adjusted hazard ratio, 2.62; 95% CI, 1.40-4.90; P < .001). In this prospective population-based study, Parkinson's disease was an independent predictor of mortality in the elderly. Parkinson's disease patients with dementia had particularly high risks of mortality.</AbstractText><CopyrightInformation>Copyright © 2011 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Posada</LastName><ForeName>Ignacio J</ForeName><Initials>IJ</Initials><AffiliationInfo><Affiliation>Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benito-León</LastName><ForeName>Julián</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Louis</LastName><ForeName>Elan D</ForeName><Initials>ED</Initials></Author><Author ValidYN="Y"><LastName>Trincado</LastName><ForeName>Rocío</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Villarejo</LastName><ForeName>Alberto</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Medrano</LastName><ForeName>María José</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Bermejo-Pareja</LastName><ForeName>Félix</ForeName><Initials>F</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 NS039422</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS042859</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>09</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Mov Disord. 2012 Jun;27(7):926; author reply 927</RefSource><PMID Version="1">22555983</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002318">Cardiovascular Diseases</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000401">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002423">Cause of Death</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015897">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D003625">Data Collection</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008171">Lung Diseases</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000401">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009369">Neoplasms</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000401">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000401">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016016">Proportional Hazards Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011446">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012307">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic" UI="D013030">Spain</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>4</Month><Day>5</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2011</Year><Month>7</Month><Day>5</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>7</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2011</Year><Month>9</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>9</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>9</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>3</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.23921</ArticleId><ArticleId IdType="pubmed">21915906</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><noCountry><name sortKey="Benito Le N, Julian" sort="Benito Le N, Julian" uniqKey="Benito Le N J" first="Julián" last="Benito-Le N">Julián Benito-Le N</name><name sortKey="Bermejo Pareja, Felix" sort="Bermejo Pareja, Felix" uniqKey="Bermejo Pareja F" first="Félix" last="Bermejo-Pareja">Félix Bermejo-Pareja</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D" last="Louis">Elan D. Louis</name><name sortKey="Medrano, Maria Jose" sort="Medrano, Maria Jose" uniqKey="Medrano M" first="María José" last="Medrano">María José Medrano</name><name sortKey="Trincado, Rocio" sort="Trincado, Rocio" uniqKey="Trincado R" first="Rocío" last="Trincado">Rocío Trincado</name><name sortKey="Villarejo, Alberto" sort="Villarejo, Alberto" uniqKey="Villarejo A" first="Alberto" last="Villarejo">Alberto Villarejo</name></noCountry><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Posada, Ignacio J" sort="Posada, Ignacio J" uniqKey="Posada I" first="Ignacio J" last="Posada">Ignacio J. Posada</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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