Sensory perception changes induced by transcranial magnetic stimulation over the primary somatosensory cortex in Parkinson's disease.
Identifieur interne : 003280 ( Ncbi/Merge ); précédent : 003279; suivant : 003281Sensory perception changes induced by transcranial magnetic stimulation over the primary somatosensory cortex in Parkinson's disease.
Auteurs : Francisco J. Palomar [Espagne] ; Francisco Díaz-Corrales ; Fatima Carrillo ; Miguel Fernández-Del-Olmo ; Giacomo Koch ; Pablo MirSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.
English descriptors
- KwdEn :
- Adult, Afferent Pathways, Aged, Dopamine Agents (pharmacology), Dopamine Agents (therapeutic use), Electromyography, Female, Fingers (innervation), Humans, Male, Middle Aged, Parkinson Disease (pathology), Parkinson Disease (therapy), Sensory Thresholds (physiology), Somatosensory Cortex (physiology), Statistics, Nonparametric, Touch, Touch Perception (physiology), Transcranial Magnetic Stimulation.
- MESH :
- chemical , pharmacology : Dopamine Agents.
- chemical , therapeutic use : Dopamine Agents.
- innervation : Fingers.
- pathology : Parkinson Disease.
- physiology : Sensory Thresholds, Somatosensory Cortex, Touch Perception.
- therapy : Parkinson Disease.
- Adult, Afferent Pathways, Aged, Electromyography, Female, Humans, Male, Middle Aged, Statistics, Nonparametric, Touch, Transcranial Magnetic Stimulation.
Abstract
Sensory symptoms are common nonmotor manifestations of Parkinson's disease. It has been hypothesized that abnormal central processing of sensory signals occurs in Parkinson's disease and is related to dopaminergic treatment. The objective of this study was to investigate the alterations in sensory perception induced by transcranial magnetic stimulation of the primary somatosensory cortex in patients with Parkinson's disease and the modulatory effects of dopaminergic treatment. Fourteen patients with Parkinson's disease with and without dopaminergic treatment and 13 control subjects were included. Twenty milliseconds after peripheral electrical tactile stimuli in the contralateral thumb, paired-pulse transcranial magnetic stimulation over the right primary somatosensory cortex was delivered. We evaluated the perception of peripheral electrical tactile stimuli at 2 conditioning stimulus intensities, set at 70% and 90% of the right resting motor threshold, using different interstimulus intervals. At 70% of the resting motor threshold, paired-pulse transcranial magnetic stimulation over the right primary somatosensory cortex induced an increase in positive responses at short interstimulus intervals (1-7 ms) in controls but not in patients with dopaminergic treatment. At 90% of the resting motor threshold, controls and patients showed similar transcranial magnetic stimulation effects. Changes in peripheral electrical tactile stimuli perception after paired-pulse transcranial magnetic stimulation over the primary somatosensory cortex are altered in patients with Parkinson's disease with dopaminergic treatment compared with controls. These findings suggest that primary somatosensory cortex excitability could be involved in changes in somatosensory integration in Parkinson's disease with dopaminergic treatment.
DOI: 10.1002/mds.23779
PubMed: 21638325
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Palomar</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville</wicri:regionArea><wicri:noRegion>Seville</wicri:noRegion></affiliation></author><author><name sortKey="Diaz Corrales, Francisco" sort="Diaz Corrales, Francisco" uniqKey="Diaz Corrales F" first="Francisco" last="Díaz-Corrales">Francisco Díaz-Corrales</name></author><author><name sortKey="Carrillo, Fatima" sort="Carrillo, Fatima" uniqKey="Carrillo F" first="Fatima" last="Carrillo">Fatima Carrillo</name></author><author><name sortKey="Fernandez Del Olmo, Miguel" sort="Fernandez Del Olmo, Miguel" uniqKey="Fernandez Del Olmo M" first="Miguel" last="Fernández-Del-Olmo">Miguel Fernández-Del-Olmo</name></author><author><name sortKey="Koch, Giacomo" sort="Koch, Giacomo" uniqKey="Koch G" first="Giacomo" last="Koch">Giacomo Koch</name></author><author><name sortKey="Mir, Pablo" sort="Mir, Pablo" uniqKey="Mir P" first="Pablo" last="Mir">Pablo Mir</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1002/mds.23779</idno><idno type="RBID">pubmed:21638325</idno><idno type="pmid">21638325</idno><idno type="wicri:Area/PubMed/Corpus">001148</idno><idno type="wicri:Area/PubMed/Curation">001148</idno><idno type="wicri:Area/PubMed/Checkpoint">001103</idno><idno type="wicri:Area/Ncbi/Merge">003280</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Sensory perception changes induced by transcranial magnetic stimulation over the primary somatosensory cortex in Parkinson's disease.</title><author><name sortKey="Palomar, Francisco J" sort="Palomar, Francisco J" uniqKey="Palomar F" first="Francisco J" last="Palomar">Francisco J. Palomar</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville</wicri:regionArea><wicri:noRegion>Seville</wicri:noRegion></affiliation></author><author><name sortKey="Diaz Corrales, Francisco" sort="Diaz Corrales, Francisco" uniqKey="Diaz Corrales F" first="Francisco" last="Díaz-Corrales">Francisco Díaz-Corrales</name></author><author><name sortKey="Carrillo, Fatima" sort="Carrillo, Fatima" uniqKey="Carrillo F" first="Fatima" last="Carrillo">Fatima Carrillo</name></author><author><name sortKey="Fernandez Del Olmo, Miguel" sort="Fernandez Del Olmo, Miguel" uniqKey="Fernandez Del Olmo M" first="Miguel" last="Fernández-Del-Olmo">Miguel Fernández-Del-Olmo</name></author><author><name sortKey="Koch, Giacomo" sort="Koch, Giacomo" uniqKey="Koch G" first="Giacomo" last="Koch">Giacomo Koch</name></author><author><name sortKey="Mir, Pablo" sort="Mir, Pablo" uniqKey="Mir P" first="Pablo" last="Mir">Pablo Mir</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Afferent Pathways</term><term>Aged</term><term>Dopamine Agents (pharmacology)</term><term>Dopamine Agents (therapeutic use)</term><term>Electromyography</term><term>Female</term><term>Fingers (innervation)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (therapy)</term><term>Sensory Thresholds (physiology)</term><term>Somatosensory Cortex (physiology)</term><term>Statistics, Nonparametric</term><term>Touch</term><term>Touch Perception (physiology)</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dopamine Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agents</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Fingers</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Sensory Thresholds</term><term>Somatosensory Cortex</term><term>Touch Perception</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Afferent Pathways</term><term>Aged</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Statistics, Nonparametric</term><term>Touch</term><term>Transcranial Magnetic Stimulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sensory symptoms are common nonmotor manifestations of Parkinson's disease. It has been hypothesized that abnormal central processing of sensory signals occurs in Parkinson's disease and is related to dopaminergic treatment. The objective of this study was to investigate the alterations in sensory perception induced by transcranial magnetic stimulation of the primary somatosensory cortex in patients with Parkinson's disease and the modulatory effects of dopaminergic treatment. Fourteen patients with Parkinson's disease with and without dopaminergic treatment and 13 control subjects were included. Twenty milliseconds after peripheral electrical tactile stimuli in the contralateral thumb, paired-pulse transcranial magnetic stimulation over the right primary somatosensory cortex was delivered. We evaluated the perception of peripheral electrical tactile stimuli at 2 conditioning stimulus intensities, set at 70% and 90% of the right resting motor threshold, using different interstimulus intervals. At 70% of the resting motor threshold, paired-pulse transcranial magnetic stimulation over the right primary somatosensory cortex induced an increase in positive responses at short interstimulus intervals (1-7 ms) in controls but not in patients with dopaminergic treatment. At 90% of the resting motor threshold, controls and patients showed similar transcranial magnetic stimulation effects. Changes in peripheral electrical tactile stimuli perception after paired-pulse transcranial magnetic stimulation over the primary somatosensory cortex are altered in patients with Parkinson's disease with dopaminergic treatment compared with controls. These findings suggest that primary somatosensory cortex excitability could be involved in changes in somatosensory integration in Parkinson's disease with dopaminergic treatment.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21638325</PMID><DateCreated><Year>2011</Year><Month>09</Month><Day>20</Day></DateCreated><DateCompleted><Year>2012</Year><Month>01</Month><Day>27</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>11</Issue><PubDate><Year>2011</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Sensory perception changes induced by transcranial magnetic stimulation over the primary somatosensory cortex in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>2058-64</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23779</ELocationID><Abstract><AbstractText>Sensory symptoms are common nonmotor manifestations of Parkinson's disease. It has been hypothesized that abnormal central processing of sensory signals occurs in Parkinson's disease and is related to dopaminergic treatment. The objective of this study was to investigate the alterations in sensory perception induced by transcranial magnetic stimulation of the primary somatosensory cortex in patients with Parkinson's disease and the modulatory effects of dopaminergic treatment. Fourteen patients with Parkinson's disease with and without dopaminergic treatment and 13 control subjects were included. Twenty milliseconds after peripheral electrical tactile stimuli in the contralateral thumb, paired-pulse transcranial magnetic stimulation over the right primary somatosensory cortex was delivered. We evaluated the perception of peripheral electrical tactile stimuli at 2 conditioning stimulus intensities, set at 70% and 90% of the right resting motor threshold, using different interstimulus intervals. At 70% of the resting motor threshold, paired-pulse transcranial magnetic stimulation over the right primary somatosensory cortex induced an increase in positive responses at short interstimulus intervals (1-7 ms) in controls but not in patients with dopaminergic treatment. At 90% of the resting motor threshold, controls and patients showed similar transcranial magnetic stimulation effects. Changes in peripheral electrical tactile stimuli perception after paired-pulse transcranial magnetic stimulation over the primary somatosensory cortex are altered in patients with Parkinson's disease with dopaminergic treatment compared with controls. These findings suggest that primary somatosensory cortex excitability could be involved in changes in somatosensory integration in Parkinson's disease with dopaminergic treatment.</AbstractText><CopyrightInformation>Copyright © 2011 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Palomar</LastName><ForeName>Francisco J</ForeName><Initials>FJ</Initials><AffiliationInfo><Affiliation>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Díaz-Corrales</LastName><ForeName>Francisco</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Carrillo</LastName><ForeName>Fatima</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Fernández-del-Olmo</LastName><ForeName>Miguel</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Koch</LastName><ForeName>Giacomo</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Mir</LastName><ForeName>Pablo</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>06</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015259">Dopamine Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000344">Afferent Pathways</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015259">Dopamine Agents</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000494">pharmacology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004576">Electromyography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005385">Fingers</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000294">innervation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012684">Sensory Thresholds</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013003">Somatosensory Cortex</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018709">Statistics, Nonparametric</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014110">Touch</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D055698">Touch Perception</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D050781">Transcranial Magnetic Stimulation</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2009</Year><Month>3</Month><Day>3</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2011</Year><Month>3</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>4</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2011</Year><Month>6</Month><Day>2</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>6</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>6</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>1</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.23779</ArticleId><ArticleId IdType="pubmed">21638325</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country></list><tree><noCountry><name sortKey="Carrillo, Fatima" sort="Carrillo, Fatima" uniqKey="Carrillo F" first="Fatima" last="Carrillo">Fatima Carrillo</name><name sortKey="Diaz Corrales, Francisco" sort="Diaz Corrales, Francisco" uniqKey="Diaz Corrales F" first="Francisco" last="Díaz-Corrales">Francisco Díaz-Corrales</name><name sortKey="Fernandez Del Olmo, Miguel" sort="Fernandez Del Olmo, Miguel" uniqKey="Fernandez Del Olmo M" first="Miguel" last="Fernández-Del-Olmo">Miguel Fernández-Del-Olmo</name><name sortKey="Koch, Giacomo" sort="Koch, Giacomo" uniqKey="Koch G" first="Giacomo" last="Koch">Giacomo Koch</name><name sortKey="Mir, Pablo" sort="Mir, Pablo" uniqKey="Mir P" first="Pablo" last="Mir">Pablo Mir</name></noCountry><country name="Espagne"><noRegion><name sortKey="Palomar, Francisco J" sort="Palomar, Francisco J" uniqKey="Palomar F" first="Francisco J" last="Palomar">Francisco J. 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