Mood and Cognition in Leucine-rich Repeat Kinase 2 G2019S Parkinson’s Disease
Identifieur interne : 003229 ( Ncbi/Merge ); précédent : 003228; suivant : 003230Mood and Cognition in Leucine-rich Repeat Kinase 2 G2019S Parkinson’s Disease
Auteurs : Vicki Shanker [États-Unis] ; Mark Groves [États-Unis] ; Gary Heiman [États-Unis] ; Christina Palmese [États-Unis] ; Rachel Saunders-Pullman [États-Unis] ; Laurie Ozelius [États-Unis] ; Deborah Raymond [États-Unis] ; Susan Bressman [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2011.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Cognition Disorders (etiology), Cognition Disorders (genetics), Female, Genetic Predisposition to Disease (genetics), Glycine (genetics), Humans, Jews (genetics), Male, Middle Aged, Mood Disorders (etiology), Mood Disorders (genetics), Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (genetics), Protein-Serine-Threonine Kinases (genetics), Psychiatric Status Rating Scales, Serine (genetics).
- MESH :
- chemical , genetics : Glycine, Protein-Serine-Threonine Kinases, Serine.
- complications : Parkinson Disease.
- etiology : Cognition Disorders, Mood Disorders.
- genetics : Cognition Disorders, Genetic Predisposition to Disease, Jews, Mood Disorders, Parkinson Disease.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales.
Abstract
The behavioral and cognitive features of the leucine-rich repeat kinase G2019S mutation in Parkinson’s disease in the Ashkenazi Jewish population are not well described; therefore we sought to more systematically characterize these features using a semi-structured psychiatric interview and neuropsychological testing.
Twenty-one Ashkenazi Jewish patients having the leucine-rich repeat kinase G2019S mutation were compared with age, sex and gender matched Ashkenazi Jewish Parkinson’s disease patients without mutations.
While overall rates of affective disorders were not greater in mutation carriers, the carriers exhibited a six-fold increased risk of pre-morbid affective disorders (OR 6.0, p=0.10) as determined by the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders–IV. Of interest, we identified two leucine-rich repeat kinase carriers with bipolar disorder; no mutation negative subjects had this diagnosis. Performance on the Hopkins Verbal Learning Test- Revised, Judgment of Line Orientation, and Frontal Assessment Battery was consistent with previous reports and did not differ between groups.
Study findings suggest a possible association between pre-morbid mood disorders and leucine-rich repeat kinase Parkinson’s disease warranting further evaluation.
Url:
DOI: 10.1002/mds.23746
PubMed: 21611978
PubMed Central: 3972755
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USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Groves, Mark" sort="Groves, Mark" uniqKey="Groves M" first="Mark" last="Groves">Mark Groves</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Heiman, Gary" sort="Heiman, Gary" uniqKey="Heiman G" first="Gary" last="Heiman">Gary Heiman</name><affiliation wicri:level="4"><nlm:aff id="A2">Rutgers University, Piscataway, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rutgers University, Piscataway</wicri:regionArea><orgName type="university">Université Rutgers</orgName><placeName><settlement type="city">New Brunswick (New Jersey))</settlement><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Palmese, Christina" sort="Palmese, Christina" uniqKey="Palmese C" first="Christina" last="Palmese">Christina Palmese</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Saunders Pullman, Rachel" sort="Saunders Pullman, Rachel" uniqKey="Saunders Pullman R" first="Rachel" last="Saunders-Pullman">Rachel Saunders-Pullman</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Ozelius, Laurie" sort="Ozelius, Laurie" uniqKey="Ozelius L" first="Laurie" last="Ozelius">Laurie Ozelius</name><affiliation wicri:level="2"><nlm:aff id="A3">Mount Sinai Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mount Sinai Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Raymond, Deborah" sort="Raymond, Deborah" uniqKey="Raymond D" first="Deborah" last="Raymond">Deborah Raymond</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (genetics)</term><term>Female</term><term>Genetic Predisposition to Disease (genetics)</term><term>Glycine (genetics)</term><term>Humans</term><term>Jews (genetics)</term><term>Male</term><term>Middle Aged</term><term>Mood Disorders (etiology)</term><term>Mood Disorders (genetics)</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (genetics)</term><term>Protein-Serine-Threonine Kinases (genetics)</term><term>Psychiatric Status Rating Scales</term><term>Serine (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glycine</term><term>Protein-Serine-Threonine Kinases</term><term>Serine</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Mood Disorders</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cognition Disorders</term><term>Genetic Predisposition to Disease</term><term>Jews</term><term>Mood Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Psychiatric Status Rating Scales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>INTRODUCTION</title><p id="P1">The behavioral and cognitive features of the leucine-rich repeat kinase G2019S mutation in Parkinson’s disease in the Ashkenazi Jewish population are not well described; therefore we sought to more systematically characterize these features using a semi-structured psychiatric interview and neuropsychological testing.</p></sec><sec id="S2"><title>METHODS</title><p id="P2">Twenty-one Ashkenazi Jewish patients having the leucine-rich repeat kinase G2019S mutation were compared with age, sex and gender matched Ashkenazi Jewish Parkinson’s disease patients without mutations.</p></sec><sec id="S3"><title>RESULTS</title><p id="P3">While overall rates of affective disorders were not greater in mutation carriers, the carriers exhibited a six-fold increased risk of pre-morbid affective disorders (OR 6.0, p=0.10) as determined by the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders–IV. Of interest, we identified two leucine-rich repeat kinase carriers with bipolar disorder; no mutation negative subjects had this diagnosis. Performance on the Hopkins Verbal Learning Test- Revised, Judgment of Line Orientation, and Frontal Assessment Battery was consistent with previous reports and did not differ between groups.</p></sec><sec id="S4"><title>DISCUSSION</title><p id="P4">Study findings suggest a possible association between pre-morbid mood disorders and leucine-rich repeat kinase Parkinson’s disease warranting further evaluation.</p></sec></div></front></TEI><double pmid="21611978"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mood and Cognition in Leucine-rich Repeat Kinase 2 G2019S Parkinson’s Disease</title><author><name sortKey="Shanker, Vicki" sort="Shanker, Vicki" uniqKey="Shanker V" first="Vicki" last="Shanker">Vicki Shanker</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Groves, Mark" sort="Groves, Mark" uniqKey="Groves M" first="Mark" last="Groves">Mark Groves</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Heiman, Gary" sort="Heiman, Gary" uniqKey="Heiman G" first="Gary" last="Heiman">Gary Heiman</name><affiliation wicri:level="4"><nlm:aff id="A2">Rutgers University, Piscataway, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rutgers University, Piscataway</wicri:regionArea><orgName type="university">Université Rutgers</orgName><placeName><settlement type="city">New Brunswick (New Jersey))</settlement><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Palmese, Christina" sort="Palmese, Christina" uniqKey="Palmese C" first="Christina" last="Palmese">Christina Palmese</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Saunders Pullman, Rachel" sort="Saunders Pullman, Rachel" uniqKey="Saunders Pullman R" first="Rachel" last="Saunders-Pullman">Rachel Saunders-Pullman</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Ozelius, Laurie" sort="Ozelius, Laurie" uniqKey="Ozelius L" first="Laurie" last="Ozelius">Laurie Ozelius</name><affiliation wicri:level="2"><nlm:aff id="A3">Mount Sinai Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mount Sinai Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Raymond, Deborah" sort="Raymond, Deborah" uniqKey="Raymond D" first="Deborah" last="Raymond">Deborah Raymond</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21611978</idno><idno type="pmc">3972755</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972755</idno><idno type="RBID">PMC:3972755</idno><idno type="doi">10.1002/mds.23746</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000241</idno><idno type="wicri:Area/Pmc/Curation">000241</idno><idno type="wicri:Area/Pmc/Checkpoint">000252</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mood and Cognition in Leucine-rich Repeat Kinase 2 G2019S Parkinson’s Disease</title><author><name sortKey="Shanker, Vicki" sort="Shanker, Vicki" uniqKey="Shanker V" first="Vicki" last="Shanker">Vicki Shanker</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Groves, Mark" sort="Groves, Mark" uniqKey="Groves M" first="Mark" last="Groves">Mark Groves</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Heiman, Gary" sort="Heiman, Gary" uniqKey="Heiman G" first="Gary" last="Heiman">Gary Heiman</name><affiliation wicri:level="4"><nlm:aff id="A2">Rutgers University, Piscataway, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rutgers University, Piscataway</wicri:regionArea><orgName type="university">Université Rutgers</orgName><placeName><settlement type="city">New Brunswick (New Jersey))</settlement><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Palmese, Christina" sort="Palmese, Christina" uniqKey="Palmese C" first="Christina" last="Palmese">Christina Palmese</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Saunders Pullman, Rachel" sort="Saunders Pullman, Rachel" uniqKey="Saunders Pullman R" first="Rachel" last="Saunders-Pullman">Rachel Saunders-Pullman</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Ozelius, Laurie" sort="Ozelius, Laurie" uniqKey="Ozelius L" first="Laurie" last="Ozelius">Laurie Ozelius</name><affiliation wicri:level="2"><nlm:aff id="A3">Mount Sinai Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mount Sinai Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Raymond, Deborah" sort="Raymond, Deborah" uniqKey="Raymond D" first="Deborah" last="Raymond">Deborah Raymond</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name><affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Medical Center, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>INTRODUCTION</title><p id="P1">The behavioral and cognitive features of the leucine-rich repeat kinase G2019S mutation in Parkinson’s disease in the Ashkenazi Jewish population are not well described; therefore we sought to more systematically characterize these features using a semi-structured psychiatric interview and neuropsychological testing.</p></sec><sec id="S2"><title>METHODS</title><p id="P2">Twenty-one Ashkenazi Jewish patients having the leucine-rich repeat kinase G2019S mutation were compared with age, sex and gender matched Ashkenazi Jewish Parkinson’s disease patients without mutations.</p></sec><sec id="S3"><title>RESULTS</title><p id="P3">While overall rates of affective disorders were not greater in mutation carriers, the carriers exhibited a six-fold increased risk of pre-morbid affective disorders (OR 6.0, p=0.10) as determined by the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders–IV. Of interest, we identified two leucine-rich repeat kinase carriers with bipolar disorder; no mutation negative subjects had this diagnosis. Performance on the Hopkins Verbal Learning Test- Revised, Judgment of Line Orientation, and Frontal Assessment Battery was consistent with previous reports and did not differ between groups.</p></sec><sec id="S4"><title>DISCUSSION</title><p id="P4">Study findings suggest a possible association between pre-morbid mood disorders and leucine-rich repeat kinase Parkinson’s disease warranting further evaluation.</p></sec></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mood and cognition in leucine-rich repeat kinase 2 G2019S Parkinson's disease.</title><author><name sortKey="Shanker, Vicki" sort="Shanker, Vicki" uniqKey="Shanker V" first="Vicki" last="Shanker">Vicki Shanker</name><affiliation wicri:level="2"><nlm:affiliation>Beth Israel Medical Center, 10 Union Square East, Suite 5H, New York, NY 10003, USA. vshanker@chpnet.org</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, 10 Union Square East, Suite 5H, New York, NY 10003</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Groves, Mark" sort="Groves, Mark" uniqKey="Groves M" first="Mark" last="Groves">Mark Groves</name></author><author><name sortKey="Heiman, Gary" sort="Heiman, Gary" uniqKey="Heiman G" first="Gary" last="Heiman">Gary Heiman</name></author><author><name sortKey="Palmese, Christina" sort="Palmese, Christina" uniqKey="Palmese C" first="Christina" last="Palmese">Christina Palmese</name></author><author><name sortKey="Saunders Pullman, Rachel" sort="Saunders Pullman, Rachel" uniqKey="Saunders Pullman R" first="Rachel" last="Saunders-Pullman">Rachel Saunders-Pullman</name></author><author><name sortKey="Ozelius, Laurie" sort="Ozelius, Laurie" uniqKey="Ozelius L" first="Laurie" last="Ozelius">Laurie Ozelius</name></author><author><name sortKey="Raymond, Deborah" sort="Raymond, Deborah" uniqKey="Raymond D" first="Deborah" last="Raymond">Deborah Raymond</name></author><author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1002/mds.23746</idno><idno type="RBID">pubmed:21611978</idno><idno type="pmid">21611978</idno><idno type="wicri:Area/PubMed/Corpus">001199</idno><idno type="wicri:Area/PubMed/Curation">001199</idno><idno type="wicri:Area/PubMed/Checkpoint">001228</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Mood and cognition in leucine-rich repeat kinase 2 G2019S Parkinson's disease.</title><author><name sortKey="Shanker, Vicki" sort="Shanker, Vicki" uniqKey="Shanker V" first="Vicki" last="Shanker">Vicki Shanker</name><affiliation wicri:level="2"><nlm:affiliation>Beth Israel Medical Center, 10 Union Square East, Suite 5H, New York, NY 10003, USA. vshanker@chpnet.org</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Medical Center, 10 Union Square East, Suite 5H, New York, NY 10003</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Groves, Mark" sort="Groves, Mark" uniqKey="Groves M" first="Mark" last="Groves">Mark Groves</name></author><author><name sortKey="Heiman, Gary" sort="Heiman, Gary" uniqKey="Heiman G" first="Gary" last="Heiman">Gary Heiman</name></author><author><name sortKey="Palmese, Christina" sort="Palmese, Christina" uniqKey="Palmese C" first="Christina" last="Palmese">Christina Palmese</name></author><author><name sortKey="Saunders Pullman, Rachel" sort="Saunders Pullman, Rachel" uniqKey="Saunders Pullman R" first="Rachel" last="Saunders-Pullman">Rachel Saunders-Pullman</name></author><author><name sortKey="Ozelius, Laurie" sort="Ozelius, Laurie" uniqKey="Ozelius L" first="Laurie" last="Ozelius">Laurie Ozelius</name></author><author><name sortKey="Raymond, Deborah" sort="Raymond, Deborah" uniqKey="Raymond D" first="Deborah" last="Raymond">Deborah Raymond</name></author><author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (genetics)</term><term>Female</term><term>Genetic Predisposition to Disease (genetics)</term><term>Glycine (genetics)</term><term>Humans</term><term>Jews (genetics)</term><term>Male</term><term>Middle Aged</term><term>Mood Disorders (etiology)</term><term>Mood Disorders (genetics)</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (genetics)</term><term>Protein-Serine-Threonine Kinases (genetics)</term><term>Psychiatric Status Rating Scales</term><term>Serine (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glycine</term><term>Protein-Serine-Threonine Kinases</term><term>Serine</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Mood Disorders</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cognition Disorders</term><term>Genetic Predisposition to Disease</term><term>Jews</term><term>Mood Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Psychiatric Status Rating Scales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The behavioral and cognitive features of the leucine-rich repeat kinase G2019S mutation in Parkinson's disease in the Ashkenazi Jewish population are not well described; therefore, we sought to more systematically characterize these features using a semistructured psychiatric interview and neuropsychological testing. Twenty-one Ashkenazi Jewish patients having the leucine-rich repeat kinase G2019S mutation were compared with age- and sex-matched Ashkenazi Jewish patients with Parkinson's disease without mutations. Although overall rates of affective disorders were not greater in mutation carriers, the carriers exhibited a 6-fold increased risk of premorbid affective disorders (odds ratio, 6.0; P = .10), as determined by the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders-IV. Of interest, we identified 2 leucine-rich repeat kinase carriers with bipolar disorder; no mutation-negative subjects had this diagnosis. Performance on the Hopkins Verbal Learning Test-Revised, Judgment of Line Orientation, and Frontal Assessment Battery was consistent with previous reports and did not differ between groups. Study findings suggest a possible association between premorbid mood disorders and leucine-rich repeat kinase Parkinson's disease, warranting further evaluation.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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