Clinical correlates of similar pathologies in parkinsonian syndromes.
Identifieur interne : 002F40 ( Ncbi/Merge ); précédent : 002F39; suivant : 002F41Clinical correlates of similar pathologies in parkinsonian syndromes.
Auteurs : Yun Ju Christine Song [Australie] ; Yue Huang ; Glenda Margaret HallidaySource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Atrophy (pathology), Cell Death, Female, Humans, Male, Middle Aged, Multiple System Atrophy (pathology), Neurofilament Proteins (metabolism), Parkinsonian Disorders (pathology), Severity of Illness Index, Substantia Nigra (pathology), Supranuclear Palsy, Progressive (pathology), tau Proteins (metabolism).
- MESH :
- chemical , metabolism : Neurofilament Proteins, tau Proteins.
- pathology : Atrophy, Multiple System Atrophy, Parkinsonian Disorders, Substantia Nigra, Supranuclear Palsy, Progressive.
- Aged, Aged, 80 and over, Cell Death, Female, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
There have been no previous studies assessing the severity of regional atrophy, cell loss and lesion densities between the overlapping conditions of Parkinson's disease (PD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) and relating these pathologies to different clinical features.
DOI: 10.1002/mds.23336
PubMed: 21259341
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pubmed:21259341Le document en format XML
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<author><name sortKey="Song, Yun Ju Christine" sort="Song, Yun Ju Christine" uniqKey="Song Y" first="Yun Ju Christine" last="Song">Yun Ju Christine Song</name>
<affiliation wicri:level="1"><nlm:affiliation>Neuroscience Research Australia and University of New South Wales, Randwick, New South Wales, Australia.</nlm:affiliation>
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<author><name sortKey="Huang, Yue" sort="Huang, Yue" uniqKey="Huang Y" first="Yue" last="Huang">Yue Huang</name>
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<author><name sortKey="Halliday, Glenda Margaret" sort="Halliday, Glenda Margaret" uniqKey="Halliday G" first="Glenda Margaret" last="Halliday">Glenda Margaret Halliday</name>
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<affiliation wicri:level="1"><nlm:affiliation>Neuroscience Research Australia and University of New South Wales, Randwick, New South Wales, Australia.</nlm:affiliation>
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<term>Atrophy (pathology)</term>
<term>Cell Death</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple System Atrophy (pathology)</term>
<term>Neurofilament Proteins (metabolism)</term>
<term>Parkinsonian Disorders (pathology)</term>
<term>Severity of Illness Index</term>
<term>Substantia Nigra (pathology)</term>
<term>Supranuclear Palsy, Progressive (pathology)</term>
<term>tau Proteins (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Neurofilament Proteins</term>
<term>tau Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Atrophy</term>
<term>Multiple System Atrophy</term>
<term>Parkinsonian Disorders</term>
<term>Substantia Nigra</term>
<term>Supranuclear Palsy, Progressive</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cell Death</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">There have been no previous studies assessing the severity of regional atrophy, cell loss and lesion densities between the overlapping conditions of Parkinson's disease (PD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) and relating these pathologies to different clinical features.</div>
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<Month>04</Month>
<Day>04</Day>
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<DateCompleted><Year>2011</Year>
<Month>07</Month>
<Day>29</Day>
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<Issue>3</Issue>
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<Month>Feb</Month>
<Day>15</Day>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
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<ArticleTitle>Clinical correlates of similar pathologies in parkinsonian syndromes.</ArticleTitle>
<Pagination><MedlinePgn>499-506</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23336</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">There have been no previous studies assessing the severity of regional atrophy, cell loss and lesion densities between the overlapping conditions of Parkinson's disease (PD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) and relating these pathologies to different clinical features.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Clinical indices and basal ganglia, brainstem, and cerebellar pathology from 43 longitudinally studied cases (PD = 8, PSP = 15, MSA = 12, controls = 8) were compared. A point-counting method was used to evaluate subregional volumes, and α-synuclein and phospho-tau immunohistochemistry was used to assess pathological inclusions and stage disease severity. Logistic regression analyses were used to identify pathological associations with clinical features.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">All PD, PSP, and MSA cases had severe degeneration of the substantia nigra. Clinical features correlated with tissue loss and the severity of inclusion pathologies. Levodopa responsiveness and a lack of resting tremor was associated with preservation of pallidal volume, the presence of gait ataxia was associated with atrophy of the putamen, and the parkinsonian-plus phenotype with early falls and supranuclear vertical gaze abnormalities had more substantial midbrain atrophy and greater inclusion pathology in the caudate nucleus.</AbstractText>
<AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">This is the first study to compare the severity of regional pathologies across parkinsonian conditions. The data show that tissue loss and inclusion densities in certain regions correlate with clinical indices, with regional volume changes likely to be the best indicator of clinical progression of disease.</AbstractText>
<CopyrightInformation>Copyright © 2011 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Song</LastName>
<ForeName>Yun Ju Christine</ForeName>
<Initials>YJ</Initials>
<AffiliationInfo><Affiliation>Neuroscience Research Australia and University of New South Wales, Randwick, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Halliday</LastName>
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