Speed effects of deep brain stimulation for Parkinson's disease.
Identifieur interne : 002E97 ( Ncbi/Merge ); précédent : 002E96; suivant : 002E98Speed effects of deep brain stimulation for Parkinson's disease.
Auteurs : Fabian Klostermann [Allemagne] ; Michael Wahl ; Frank Marzinzik ; Jan Vesper ; Werner Sommer ; Gabriel CurioSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Choice Behavior (physiology), Deep Brain Stimulation, Electroencephalography, Evoked Potentials (physiology), Female, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (physiopathology), Parkinson Disease (therapy), Photic Stimulation, Psychomotor Performance (physiology), Reaction Time (physiology), Subthalamic Nucleus (physiopathology), Subthalamic Nucleus (surgery), Treatment Outcome.
- MESH :
- physiology : Choice Behavior, Evoked Potentials, Psychomotor Performance, Reaction Time.
- physiopathology : Parkinson Disease, Subthalamic Nucleus.
- surgery : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Aged, Analysis of Variance, Deep Brain Stimulation, Electroencephalography, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Photic Stimulation, Treatment Outcome.
Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) accelerates reaction time (RT) in patients with Parkinson's disease (PD), particularly in tasks in which decisions on the response side have to be made. This might indicate that DBS speeds up both motor and nonmotor operations. Therefore, we studied the extent to which modifications of different processing streams could explain changes of RT under subthalamic DBS. Ten PD patients on-DBS and off-DBS and 10 healthy subjects performed a choice-response task (CRT), requiring either right or left finger button presses. At the same time, EEG recordings were performed, so that RTs could be assessed together with lateralized readiness potentials (LRP), indicative of movement preparation. Additionally, an oddball task (OT) was run, in which right finger responses to target stimuli were recorded along with cognitive P300 responses. Generally, PD patients off-DBS had longer RTs than controls. Subthalamic DBS accelerated RT only in CRT. This could largely be explained by analog shortenings of LRP. No DBS-dependent changes were identified in OT, neither on the level of RT nor on the level of P300 latencies. It follows that RT accelerations under DBS of the STN are predominantly due to effects on the timing of motor instead of nonmotor processes. This starting point explains why DBS gains of response speed are low in tasks in which reactions are initiated from an advanced level of movement preparation (as in OT), and high whenever motor responses have to be raised from scratch (as in CRT).
DOI: 10.1002/mds.23381
PubMed: 20939077
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Speed effects of deep brain stimulation for Parkinson's disease.</title><author><name sortKey="Klostermann, Fabian" sort="Klostermann, Fabian" uniqKey="Klostermann F" first="Fabian" last="Klostermann">Fabian Klostermann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, CBF, Charité-University Medicine Berlin, Berlin, Germany. fabian.klostermann@charite.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, CBF, Charité-University Medicine Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Wahl, Michael" sort="Wahl, Michael" uniqKey="Wahl M" first="Michael" last="Wahl">Michael Wahl</name></author><author><name sortKey="Marzinzik, Frank" sort="Marzinzik, Frank" uniqKey="Marzinzik F" first="Frank" last="Marzinzik">Frank Marzinzik</name></author><author><name sortKey="Vesper, Jan" sort="Vesper, Jan" uniqKey="Vesper J" first="Jan" last="Vesper">Jan Vesper</name></author><author><name sortKey="Sommer, Werner" sort="Sommer, Werner" uniqKey="Sommer W" first="Werner" last="Sommer">Werner Sommer</name></author><author><name sortKey="Curio, Gabriel" sort="Curio, Gabriel" uniqKey="Curio G" first="Gabriel" last="Curio">Gabriel Curio</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.23381</idno><idno type="RBID">pubmed:20939077</idno><idno type="pmid">20939077</idno><idno type="wicri:Area/PubMed/Corpus">001520</idno><idno type="wicri:Area/PubMed/Curation">001520</idno><idno type="wicri:Area/PubMed/Checkpoint">001603</idno><idno type="wicri:Area/Ncbi/Merge">002E97</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Speed effects of deep brain stimulation for Parkinson's disease.</title><author><name sortKey="Klostermann, Fabian" sort="Klostermann, Fabian" uniqKey="Klostermann F" first="Fabian" last="Klostermann">Fabian Klostermann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, CBF, Charité-University Medicine Berlin, Berlin, Germany. fabian.klostermann@charite.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, CBF, Charité-University Medicine Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Wahl, Michael" sort="Wahl, Michael" uniqKey="Wahl M" first="Michael" last="Wahl">Michael Wahl</name></author><author><name sortKey="Marzinzik, Frank" sort="Marzinzik, Frank" uniqKey="Marzinzik F" first="Frank" last="Marzinzik">Frank Marzinzik</name></author><author><name sortKey="Vesper, Jan" sort="Vesper, Jan" uniqKey="Vesper J" first="Jan" last="Vesper">Jan Vesper</name></author><author><name sortKey="Sommer, Werner" sort="Sommer, Werner" uniqKey="Sommer W" first="Werner" last="Sommer">Werner Sommer</name></author><author><name sortKey="Curio, Gabriel" sort="Curio, Gabriel" uniqKey="Curio G" first="Gabriel" last="Curio">Gabriel Curio</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Choice Behavior (physiology)</term><term>Deep Brain Stimulation</term><term>Electroencephalography</term><term>Evoked Potentials (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Photic Stimulation</term><term>Psychomotor Performance (physiology)</term><term>Reaction Time (physiology)</term><term>Subthalamic Nucleus (physiopathology)</term><term>Subthalamic Nucleus (surgery)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Choice Behavior</term><term>Evoked Potentials</term><term>Psychomotor Performance</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Deep Brain Stimulation</term><term>Electroencephalography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Photic Stimulation</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the subthalamic nucleus (STN) accelerates reaction time (RT) in patients with Parkinson's disease (PD), particularly in tasks in which decisions on the response side have to be made. This might indicate that DBS speeds up both motor and nonmotor operations. Therefore, we studied the extent to which modifications of different processing streams could explain changes of RT under subthalamic DBS. Ten PD patients on-DBS and off-DBS and 10 healthy subjects performed a choice-response task (CRT), requiring either right or left finger button presses. At the same time, EEG recordings were performed, so that RTs could be assessed together with lateralized readiness potentials (LRP), indicative of movement preparation. Additionally, an oddball task (OT) was run, in which right finger responses to target stimuli were recorded along with cognitive P300 responses. Generally, PD patients off-DBS had longer RTs than controls. Subthalamic DBS accelerated RT only in CRT. This could largely be explained by analog shortenings of LRP. No DBS-dependent changes were identified in OT, neither on the level of RT nor on the level of P300 latencies. It follows that RT accelerations under DBS of the STN are predominantly due to effects on the timing of motor instead of nonmotor processes. This starting point explains why DBS gains of response speed are low in tasks in which reactions are initiated from an advanced level of movement preparation (as in OT), and high whenever motor responses have to be raised from scratch (as in CRT).</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20939077</PMID><DateCreated><Year>2010</Year><Month>12</Month><Day>17</Day></DateCreated><DateCompleted><Year>2011</Year><Month>04</Month><Day>08</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>16</Issue><PubDate><Year>2010</Year><Month>Dec</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Speed effects of deep brain stimulation for Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>2762-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23381</ELocationID><Abstract><AbstractText>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) accelerates reaction time (RT) in patients with Parkinson's disease (PD), particularly in tasks in which decisions on the response side have to be made. This might indicate that DBS speeds up both motor and nonmotor operations. Therefore, we studied the extent to which modifications of different processing streams could explain changes of RT under subthalamic DBS. Ten PD patients on-DBS and off-DBS and 10 healthy subjects performed a choice-response task (CRT), requiring either right or left finger button presses. At the same time, EEG recordings were performed, so that RTs could be assessed together with lateralized readiness potentials (LRP), indicative of movement preparation. Additionally, an oddball task (OT) was run, in which right finger responses to target stimuli were recorded along with cognitive P300 responses. Generally, PD patients off-DBS had longer RTs than controls. Subthalamic DBS accelerated RT only in CRT. This could largely be explained by analog shortenings of LRP. No DBS-dependent changes were identified in OT, neither on the level of RT nor on the level of P300 latencies. It follows that RT accelerations under DBS of the STN are predominantly due to effects on the timing of motor instead of nonmotor processes. This starting point explains why DBS gains of response speed are low in tasks in which reactions are initiated from an advanced level of movement preparation (as in OT), and high whenever motor responses have to be raised from scratch (as in CRT).</AbstractText><CopyrightInformation>© 2010 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Klostermann</LastName><ForeName>Fabian</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Neurology, CBF, Charité-University Medicine Berlin, Berlin, Germany. fabian.klostermann@charite.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wahl</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Marzinzik</LastName><ForeName>Frank</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Vesper</LastName><ForeName>Jan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Sommer</LastName><ForeName>Werner</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Curio</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000704">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002755">Choice Behavior</DescriptorName><QualifierName MajorTopicYN="Y" 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MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010775">Photic Stimulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011597">Psychomotor Performance</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011930">Reaction Time</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020531">Subthalamic Nucleus</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000601">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016896">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>10</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>10</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.23381</ArticleId><ArticleId IdType="pubmed">20939077</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Berlin</li></region><settlement><li>Berlin</li></settlement></list><tree><noCountry><name sortKey="Curio, Gabriel" sort="Curio, Gabriel" uniqKey="Curio G" first="Gabriel" last="Curio">Gabriel Curio</name><name sortKey="Marzinzik, Frank" sort="Marzinzik, Frank" uniqKey="Marzinzik F" first="Frank" last="Marzinzik">Frank Marzinzik</name><name sortKey="Sommer, Werner" sort="Sommer, Werner" uniqKey="Sommer W" first="Werner" last="Sommer">Werner Sommer</name><name sortKey="Vesper, Jan" sort="Vesper, Jan" uniqKey="Vesper J" first="Jan" last="Vesper">Jan Vesper</name><name sortKey="Wahl, Michael" sort="Wahl, Michael" uniqKey="Wahl M" first="Michael" last="Wahl">Michael Wahl</name></noCountry><country name="Allemagne"><region name="Berlin"><name sortKey="Klostermann, Fabian" sort="Klostermann, Fabian" uniqKey="Klostermann F" first="Fabian" last="Klostermann">Fabian Klostermann</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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