Multiple system atrophy is associated with changes in peripheral insulin-like growth factor system.
Identifieur interne : 002D70 ( Ncbi/Merge ); précédent : 002D69; suivant : 002D71Multiple system atrophy is associated with changes in peripheral insulin-like growth factor system.
Auteurs : Maria Teresa Pellecchia [Italie] ; Rosario Pivonello ; Katia Longo ; Michela Manfredi ; Alessandro Tessitore ; Marianna Amboni ; Claudia Pivonello ; Mariangela Rocco ; Autilia Cozzolino ; Annamaria Colao ; Paolo BaroneSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Enzyme-Linked Immunosorbent Assay, Female, Humans, Insulin (blood), Insulin-Like Growth Factor Binding Protein 1 (blood), Insulin-Like Growth Factor Binding Protein 3 (blood), Male, Middle Aged, Multiple System Atrophy (blood), Sex Factors, Somatomedins (metabolism), Statistics, Nonparametric.
- MESH :
- chemical , blood : Insulin, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Protein 3.
- blood : Multiple System Atrophy.
- chemical , metabolism : Somatomedins.
- Aged, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Sex Factors, Statistics, Nonparametric.
Abstract
Insulin-like growth factors (IGF-I and IGF-II) have been shown to have several neurotrophic actions and IGF system may be impaired in neurodegenerative disorders. The aim of this study was to investigate the IGF system in patients with MSA and to evaluate correlations between this endocrine system and clinical features of the disease. Serum levels of IGF-I, IGF-II, insulin, IGF-binding protein 1 (BP1), and IGF-binding protein 3 (BP3) were measured in 25 patients with probable MSA and 25 age, sex and BMI-matched healthy controls. Clinical status of each patient was evaluated with the Unified Multiple System Atrophy Rating Scale (UMSARS) Part II and the Hoehn and Yahr rating scale. IGF-I levels were significantly higher in MSA (164.1 + 66.2 μg/L) than in healthy controls (111.7 + 60.3 μg/L; p = 0.001). Insulin levels were significantly higher in MSA patients (21.9 ± 14.4 μU/mL) than in healthy controls (13.3 ± 5.1 μU/mL, p = 0.048). No significant difference was found in serum IGF-II, IGF-BP1, and IGF- BP3 levels between patients with MSA and healthy controls. There was a trend toward significantly higher IGF-II levels in MSA patients with UMSARS score <26 (1026.3 ± 442.6 μg/L) than MSA patients with UMSARS score >26 (796.1 ± 234 μg/L, p = 0.055). The results of this study demonstrated that IGF system is altered in MSA. The degenerative process in MSA could lead to a compensatory increase in IGF-I and insulin in an attempt to provide additional support to degenerating neurons.
DOI: 10.1002/mds.23320
PubMed: 20683839
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sortKey="Manfredi, Michela" sort="Manfredi, Michela" uniqKey="Manfredi M" first="Michela" last="Manfredi">Michela Manfredi</name></author><author><name sortKey="Tessitore, Alessandro" sort="Tessitore, Alessandro" uniqKey="Tessitore A" first="Alessandro" last="Tessitore">Alessandro Tessitore</name></author><author><name sortKey="Amboni, Marianna" sort="Amboni, Marianna" uniqKey="Amboni M" first="Marianna" last="Amboni">Marianna Amboni</name></author><author><name sortKey="Pivonello, Claudia" sort="Pivonello, Claudia" uniqKey="Pivonello C" first="Claudia" last="Pivonello">Claudia Pivonello</name></author><author><name sortKey="Rocco, Mariangela" sort="Rocco, Mariangela" uniqKey="Rocco M" first="Mariangela" last="Rocco">Mariangela Rocco</name></author><author><name sortKey="Cozzolino, Autilia" sort="Cozzolino, Autilia" uniqKey="Cozzolino A" first="Autilia" last="Cozzolino">Autilia Cozzolino</name></author><author><name sortKey="Colao, Annamaria" sort="Colao, Annamaria" uniqKey="Colao A" first="Annamaria" last="Colao">Annamaria Colao</name></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.23320</idno><idno type="RBID">pubmed:20683839</idno><idno type="pmid">20683839</idno><idno type="wicri:Area/PubMed/Corpus">001647</idno><idno type="wicri:Area/PubMed/Curation">001647</idno><idno type="wicri:Area/PubMed/Checkpoint">001766</idno><idno type="wicri:Area/Ncbi/Merge">002D70</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Multiple system atrophy is associated with changes in peripheral insulin-like growth factor system.</title><author><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurological Sciences, Federico II University, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, Federico II University, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Pivonello, Rosario" sort="Pivonello, Rosario" uniqKey="Pivonello R" first="Rosario" last="Pivonello">Rosario Pivonello</name></author><author><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name></author><author><name sortKey="Manfredi, Michela" sort="Manfredi, Michela" uniqKey="Manfredi M" first="Michela" last="Manfredi">Michela Manfredi</name></author><author><name sortKey="Tessitore, Alessandro" sort="Tessitore, Alessandro" uniqKey="Tessitore A" first="Alessandro" last="Tessitore">Alessandro Tessitore</name></author><author><name sortKey="Amboni, Marianna" sort="Amboni, Marianna" uniqKey="Amboni M" first="Marianna" last="Amboni">Marianna Amboni</name></author><author><name sortKey="Pivonello, Claudia" sort="Pivonello, Claudia" uniqKey="Pivonello C" first="Claudia" last="Pivonello">Claudia Pivonello</name></author><author><name sortKey="Rocco, Mariangela" sort="Rocco, Mariangela" uniqKey="Rocco M" first="Mariangela" last="Rocco">Mariangela Rocco</name></author><author><name sortKey="Cozzolino, Autilia" sort="Cozzolino, Autilia" uniqKey="Cozzolino A" first="Autilia" last="Cozzolino">Autilia Cozzolino</name></author><author><name sortKey="Colao, Annamaria" sort="Colao, Annamaria" uniqKey="Colao A" first="Annamaria" last="Colao">Annamaria Colao</name></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Insulin (blood)</term><term>Insulin-Like Growth Factor Binding Protein 1 (blood)</term><term>Insulin-Like Growth Factor Binding Protein 3 (blood)</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (blood)</term><term>Sex Factors</term><term>Somatomedins (metabolism)</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Insulin</term><term>Insulin-Like Growth Factor Binding Protein 1</term><term>Insulin-Like Growth Factor Binding Protein 3</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Somatomedins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Sex Factors</term><term>Statistics, Nonparametric</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Insulin-like growth factors (IGF-I and IGF-II) have been shown to have several neurotrophic actions and IGF system may be impaired in neurodegenerative disorders. The aim of this study was to investigate the IGF system in patients with MSA and to evaluate correlations between this endocrine system and clinical features of the disease. Serum levels of IGF-I, IGF-II, insulin, IGF-binding protein 1 (BP1), and IGF-binding protein 3 (BP3) were measured in 25 patients with probable MSA and 25 age, sex and BMI-matched healthy controls. Clinical status of each patient was evaluated with the Unified Multiple System Atrophy Rating Scale (UMSARS) Part II and the Hoehn and Yahr rating scale. IGF-I levels were significantly higher in MSA (164.1 + 66.2 μg/L) than in healthy controls (111.7 + 60.3 μg/L; p = 0.001). Insulin levels were significantly higher in MSA patients (21.9 ± 14.4 μU/mL) than in healthy controls (13.3 ± 5.1 μU/mL, p = 0.048). No significant difference was found in serum IGF-II, IGF-BP1, and IGF- BP3 levels between patients with MSA and healthy controls. There was a trend toward significantly higher IGF-II levels in MSA patients with UMSARS score <26 (1026.3 ± 442.6 μg/L) than MSA patients with UMSARS score >26 (796.1 ± 234 μg/L, p = 0.055). The results of this study demonstrated that IGF system is altered in MSA. The degenerative process in MSA could lead to a compensatory increase in IGF-I and insulin in an attempt to provide additional support to degenerating neurons.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20683839</PMID><DateCreated><Year>2010</Year><Month>11</Month><Day>11</Day></DateCreated><DateCompleted><Year>2011</Year><Month>02</Month><Day>25</Day></DateCompleted><DateRevised><Year>2011</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>15</Issue><PubDate><Year>2010</Year><Month>Nov</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Multiple system atrophy is associated with changes in peripheral insulin-like growth factor system.</ArticleTitle><Pagination><MedlinePgn>2621-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23320</ELocationID><Abstract><AbstractText>Insulin-like growth factors (IGF-I and IGF-II) have been shown to have several neurotrophic actions and IGF system may be impaired in neurodegenerative disorders. The aim of this study was to investigate the IGF system in patients with MSA and to evaluate correlations between this endocrine system and clinical features of the disease. Serum levels of IGF-I, IGF-II, insulin, IGF-binding protein 1 (BP1), and IGF-binding protein 3 (BP3) were measured in 25 patients with probable MSA and 25 age, sex and BMI-matched healthy controls. Clinical status of each patient was evaluated with the Unified Multiple System Atrophy Rating Scale (UMSARS) Part II and the Hoehn and Yahr rating scale. IGF-I levels were significantly higher in MSA (164.1 + 66.2 μg/L) than in healthy controls (111.7 + 60.3 μg/L; p = 0.001). Insulin levels were significantly higher in MSA patients (21.9 ± 14.4 μU/mL) than in healthy controls (13.3 ± 5.1 μU/mL, p = 0.048). No significant difference was found in serum IGF-II, IGF-BP1, and IGF- BP3 levels between patients with MSA and healthy controls. There was a trend toward significantly higher IGF-II levels in MSA patients with UMSARS score <26 (1026.3 ± 442.6 μg/L) than MSA patients with UMSARS score >26 (796.1 ± 234 μg/L, p = 0.055). The results of this study demonstrated that IGF system is altered in MSA. The degenerative process in MSA could lead to a compensatory increase in IGF-I and insulin in an attempt to provide additional support to degenerating neurons.</AbstractText><CopyrightInformation>© 2010 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pellecchia</LastName><ForeName>Maria Teresa</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Department of Neurological Sciences, Federico II University, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pivonello</LastName><ForeName>Rosario</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Longo</LastName><ForeName>Katia</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Manfredi</LastName><ForeName>Michela</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Tessitore</LastName><ForeName>Alessandro</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Amboni</LastName><ForeName>Marianna</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Pivonello</LastName><ForeName>Claudia</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Rocco</LastName><ForeName>Mariangela</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Cozzolino</LastName><ForeName>Autilia</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Colao</LastName><ForeName>Annamaria</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Barone</LastName><ForeName>Paolo</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007328">Insulin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018970">Insulin-Like Growth Factor Binding Protein 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018972">Insulin-Like Growth Factor Binding Protein 3</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013002">Somatomedins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004797">Enzyme-Linked Immunosorbent Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007328">Insulin</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018970">Insulin-Like Growth Factor Binding Protein 1</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018972">Insulin-Like Growth Factor Binding Protein 3</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019578">Multiple System Atrophy</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012737">Sex Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013002">Somatomedins</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018709">Statistics, Nonparametric</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>8</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>8</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>2</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.23320</ArticleId><ArticleId IdType="pubmed">20683839</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Amboni, Marianna" sort="Amboni, Marianna" uniqKey="Amboni M" first="Marianna" last="Amboni">Marianna Amboni</name><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><name sortKey="Colao, Annamaria" sort="Colao, Annamaria" uniqKey="Colao A" first="Annamaria" last="Colao">Annamaria Colao</name><name sortKey="Cozzolino, Autilia" sort="Cozzolino, Autilia" uniqKey="Cozzolino A" first="Autilia" last="Cozzolino">Autilia Cozzolino</name><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name><name sortKey="Manfredi, Michela" sort="Manfredi, Michela" uniqKey="Manfredi M" first="Michela" last="Manfredi">Michela Manfredi</name><name sortKey="Pivonello, Claudia" sort="Pivonello, Claudia" uniqKey="Pivonello C" first="Claudia" last="Pivonello">Claudia Pivonello</name><name sortKey="Pivonello, Rosario" sort="Pivonello, Rosario" uniqKey="Pivonello R" first="Rosario" last="Pivonello">Rosario Pivonello</name><name sortKey="Rocco, Mariangela" sort="Rocco, Mariangela" uniqKey="Rocco M" first="Mariangela" last="Rocco">Mariangela Rocco</name><name sortKey="Tessitore, Alessandro" sort="Tessitore, Alessandro" uniqKey="Tessitore A" first="Alessandro" last="Tessitore">Alessandro Tessitore</name></noCountry><country name="Italie"><noRegion><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name></noRegion></country></tree></affiliations></record>Pour 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