Visual hallucinations and altered visual information processing in Parkinson disease and dementia with Lewy bodies.
Identifieur interne : 002970 ( Ncbi/Merge ); précédent : 002969; suivant : 002971Visual hallucinations and altered visual information processing in Parkinson disease and dementia with Lewy bodies.
Auteurs : Akira Kurita [Japon] ; Maiko Murakami ; Satoshi Takagi ; Masato Matsushima ; Masahiko SuzukiSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Alzheimer Disease (physiopathology), Alzheimer Disease (psychology), Auditory Perception, Brain (physiopathology), Brain Mapping, Cognition, Dementia (diagnosis), Dementia (physiopathology), Dementia (psychology), Discrimination (Psychology), Electroencephalography, Evoked Potentials, Female, Hallucinations (physiopathology), Hallucinations (psychology), Humans, Lewy Body Disease (physiopathology), Lewy Body Disease (psychology), Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (physiopathology), Parkinson Disease (psychology), Psychiatric Status Rating Scales, Psychomotor Performance, Reaction Time, Visual Perception.
- MESH :
- diagnosis : Dementia.
- physiopathology : Alzheimer Disease, Brain, Dementia, Hallucinations, Lewy Body Disease, Parkinson Disease.
- psychology : Alzheimer Disease, Dementia, Hallucinations, Lewy Body Disease, Parkinson Disease.
- Aged, Aged, 80 and over, Auditory Perception, Brain Mapping, Cognition, Discrimination (Psychology), Electroencephalography, Evoked Potentials, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Psychomotor Performance, Reaction Time, Visual Perception.
Abstract
Visual hallucinations (VHs) are common in dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD), while auditory hallucinations are rare. To neurophysiologically investigate the pathophysiology of VHs in these disorders, we studied event-related potentials (ERPs) of DLB, PDD, and Alzheimer's disease (AD) patients. We compared visual and auditory ERP latencies among PDD patients with and without VHs (PDD-H: 11, PDD-N: 6), DLB patients (24), and AD patients (21). To elicit visual and auditory ERPs, a facial discrimination paradigm and a conventional auditory odd-ball paradigm, respectively, were used. The mean visual P3 latencies in the PDD-H and DLB groups were significantly longer than that in the AD group, while the mean auditory P3 latencies in all four patient groups were comparable. The mean visual P2 latencies in the PDD-N, PDD-H, and DLB groups were significantly longer than that in the control group. Our findings suggest that visual cognitive functions are selectively impaired in hallucinatory patients with DLB and PDD. VHs may be associated in part with predominant visual cognitive impairments attributable to PDD and DLB pathologies. Our findings also suggest that the impairments occur at the early stage of facial information processing.
DOI: 10.1002/mds.22919
PubMed: 20063433
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Visual hallucinations and altered visual information processing in Parkinson disease and dementia with Lewy bodies.</title><author><name sortKey="Kurita, Akira" sort="Kurita, Akira" uniqKey="Kurita A" first="Akira" last="Kurita">Akira Kurita</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Jikei University School of Medicine, Kashiwa Hospital, Tokyo, Japan. a-kurita@jikei.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Jikei University School of Medicine, Kashiwa Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Murakami, Maiko" sort="Murakami, Maiko" uniqKey="Murakami M" first="Maiko" last="Murakami">Maiko Murakami</name></author><author><name sortKey="Takagi, Satoshi" sort="Takagi, Satoshi" uniqKey="Takagi S" first="Satoshi" last="Takagi">Satoshi Takagi</name></author><author><name sortKey="Matsushima, Masato" sort="Matsushima, Masato" uniqKey="Matsushima M" first="Masato" last="Matsushima">Masato Matsushima</name></author><author><name sortKey="Suzuki, Masahiko" sort="Suzuki, Masahiko" uniqKey="Suzuki M" first="Masahiko" last="Suzuki">Masahiko Suzuki</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.22919</idno><idno type="RBID">pubmed:20063433</idno><idno type="pmid">20063433</idno><idno type="wicri:Area/PubMed/Corpus">001A32</idno><idno type="wicri:Area/PubMed/Curation">001A32</idno><idno type="wicri:Area/PubMed/Checkpoint">001522</idno><idno type="wicri:Area/Ncbi/Merge">002970</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Visual hallucinations and altered visual information processing in Parkinson disease and dementia with Lewy bodies.</title><author><name sortKey="Kurita, Akira" sort="Kurita, Akira" uniqKey="Kurita A" first="Akira" last="Kurita">Akira Kurita</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Jikei University School of Medicine, Kashiwa Hospital, Tokyo, Japan. a-kurita@jikei.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Jikei University School of Medicine, Kashiwa Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Murakami, Maiko" sort="Murakami, Maiko" uniqKey="Murakami M" first="Maiko" last="Murakami">Maiko Murakami</name></author><author><name sortKey="Takagi, Satoshi" sort="Takagi, Satoshi" uniqKey="Takagi S" first="Satoshi" last="Takagi">Satoshi Takagi</name></author><author><name sortKey="Matsushima, Masato" sort="Matsushima, Masato" uniqKey="Matsushima M" first="Masato" last="Matsushima">Masato Matsushima</name></author><author><name sortKey="Suzuki, Masahiko" sort="Suzuki, Masahiko" uniqKey="Suzuki M" first="Masahiko" last="Suzuki">Masahiko Suzuki</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alzheimer Disease (physiopathology)</term><term>Alzheimer Disease (psychology)</term><term>Auditory Perception</term><term>Brain (physiopathology)</term><term>Brain Mapping</term><term>Cognition</term><term>Dementia (diagnosis)</term><term>Dementia (physiopathology)</term><term>Dementia (psychology)</term><term>Discrimination (Psychology)</term><term>Electroencephalography</term><term>Evoked Potentials</term><term>Female</term><term>Hallucinations (physiopathology)</term><term>Hallucinations (psychology)</term><term>Humans</term><term>Lewy Body Disease (physiopathology)</term><term>Lewy Body Disease (psychology)</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Psychiatric Status Rating Scales</term><term>Psychomotor Performance</term><term>Reaction Time</term><term>Visual Perception</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dementia</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Alzheimer Disease</term><term>Brain</term><term>Dementia</term><term>Hallucinations</term><term>Lewy Body Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Alzheimer Disease</term><term>Dementia</term><term>Hallucinations</term><term>Lewy Body Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Auditory Perception</term><term>Brain Mapping</term><term>Cognition</term><term>Discrimination (Psychology)</term><term>Electroencephalography</term><term>Evoked Potentials</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Psychiatric Status Rating Scales</term><term>Psychomotor Performance</term><term>Reaction Time</term><term>Visual Perception</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Visual hallucinations (VHs) are common in dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD), while auditory hallucinations are rare. To neurophysiologically investigate the pathophysiology of VHs in these disorders, we studied event-related potentials (ERPs) of DLB, PDD, and Alzheimer's disease (AD) patients. We compared visual and auditory ERP latencies among PDD patients with and without VHs (PDD-H: 11, PDD-N: 6), DLB patients (24), and AD patients (21). To elicit visual and auditory ERPs, a facial discrimination paradigm and a conventional auditory odd-ball paradigm, respectively, were used. The mean visual P3 latencies in the PDD-H and DLB groups were significantly longer than that in the AD group, while the mean auditory P3 latencies in all four patient groups were comparable. The mean visual P2 latencies in the PDD-N, PDD-H, and DLB groups were significantly longer than that in the control group. Our findings suggest that visual cognitive functions are selectively impaired in hallucinatory patients with DLB and PDD. VHs may be associated in part with predominant visual cognitive impairments attributable to PDD and DLB pathologies. Our findings also suggest that the impairments occur at the early stage of facial information processing.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20063433</PMID><DateCreated><Year>2010</Year><Month>03</Month><Day>02</Day></DateCreated><DateCompleted><Year>2010</Year><Month>06</Month><Day>16</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>2</Issue><PubDate><Year>2010</Year><Month>Jan</Month><Day>30</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Visual hallucinations and altered visual information processing in Parkinson disease and dementia with Lewy bodies.</ArticleTitle><Pagination><MedlinePgn>167-71</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22919</ELocationID><Abstract><AbstractText>Visual hallucinations (VHs) are common in dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD), while auditory hallucinations are rare. To neurophysiologically investigate the pathophysiology of VHs in these disorders, we studied event-related potentials (ERPs) of DLB, PDD, and Alzheimer's disease (AD) patients. We compared visual and auditory ERP latencies among PDD patients with and without VHs (PDD-H: 11, PDD-N: 6), DLB patients (24), and AD patients (21). To elicit visual and auditory ERPs, a facial discrimination paradigm and a conventional auditory odd-ball paradigm, respectively, were used. The mean visual P3 latencies in the PDD-H and DLB groups were significantly longer than that in the AD group, while the mean auditory P3 latencies in all four patient groups were comparable. The mean visual P2 latencies in the PDD-N, PDD-H, and DLB groups were significantly longer than that in the control group. Our findings suggest that visual cognitive functions are selectively impaired in hallucinatory patients with DLB and PDD. VHs may be associated in part with predominant visual cognitive impairments attributable to PDD and DLB pathologies. Our findings also suggest that the impairments occur at the early stage of facial information processing.</AbstractText><CopyrightInformation>(c) 2010 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kurita</LastName><ForeName>Akira</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, Jikei University School of Medicine, Kashiwa Hospital, Tokyo, Japan. a-kurita@jikei.ac.jp</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murakami</LastName><ForeName>Maiko</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Takagi</LastName><ForeName>Satoshi</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Matsushima</LastName><ForeName>Masato</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Suzuki</LastName><ForeName>Masahiko</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000544">Alzheimer Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" 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MajorTopicYN="N" UI="D004569">Electroencephalography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005071">Evoked Potentials</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006212">Hallucinations</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020961">Lewy Body Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011569">Psychiatric Status Rating Scales</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011597">Psychomotor Performance</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011930">Reaction Time</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D014796">Visual Perception</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>1</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>1</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>6</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.22919</ArticleId><ArticleId IdType="pubmed">20063433</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Matsushima, Masato" sort="Matsushima, Masato" uniqKey="Matsushima M" first="Masato" last="Matsushima">Masato Matsushima</name><name sortKey="Murakami, Maiko" sort="Murakami, Maiko" uniqKey="Murakami M" first="Maiko" last="Murakami">Maiko Murakami</name><name sortKey="Suzuki, Masahiko" sort="Suzuki, Masahiko" uniqKey="Suzuki M" first="Masahiko" last="Suzuki">Masahiko Suzuki</name><name sortKey="Takagi, Satoshi" sort="Takagi, Satoshi" uniqKey="Takagi S" first="Satoshi" last="Takagi">Satoshi Takagi</name></noCountry><country name="Japon"><noRegion><name sortKey="Kurita, Akira" sort="Kurita, Akira" uniqKey="Kurita A" first="Akira" last="Kurita">Akira Kurita</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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