Potential role of high-field MRI for studies in Parkinson's disease.
Identifieur interne : 002866 ( Ncbi/Merge ); précédent : 002865; suivant : 002867Potential role of high-field MRI for studies in Parkinson's disease.
Auteurs : Norbert Schuff [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Iron.
- chemical , metabolism : Iron.
- methods : Magnetic Resonance Imaging.
- pathology : Parkinson Disease.
- physiology : Cerebrovascular Circulation.
- physiopathology : Parkinson Disease.
- Brain Chemistry, Diffusion Magnetic Resonance Imaging, Humans, Magnetic Resonance Spectroscopy, Spin Labels.
Abstract
Recent advancements in high field magnetic resonance imaging (MRI) technology (3 T and higher), providing increased signal sensitivity and images with more prominent contrasts intrinsic to the brain, offer new opportunities for assessing brain alterations in Parkinson's disease (PD). In this article, the principle benefits of high field MRI for PD research are described and new findings at high magnetic fields are reviewed. Several high field MRI methodologies, including structural MRI, imaging of brain iron, diffusion tensor imaging, arterial spin labeling perfusion imaging, rotating frame imaging, and magnetic resonance spectroscopy, are critically reviewed for their potential roles in studies of PD.
DOI: 10.1002/mds.22647
PubMed: 19877239
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pubmed:19877239Le document en format XML
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<term>Humans</term>
<term>Iron (chemistry)</term>
<term>Iron (metabolism)</term>
<term>Magnetic Resonance Imaging (methods)</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Spin Labels</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Iron</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Brain Chemistry</term>
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<front><div type="abstract" xml:lang="en">Recent advancements in high field magnetic resonance imaging (MRI) technology (3 T and higher), providing increased signal sensitivity and images with more prominent contrasts intrinsic to the brain, offer new opportunities for assessing brain alterations in Parkinson's disease (PD). In this article, the principle benefits of high field MRI for PD research are described and new findings at high magnetic fields are reviewed. Several high field MRI methodologies, including structural MRI, imaging of brain iron, diffusion tensor imaging, arterial spin labeling perfusion imaging, rotating frame imaging, and magnetic resonance spectroscopy, are critically reviewed for their potential roles in studies of PD.</div>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<CopyrightInformation>Copyright 2009 Movement Disorder Society</CopyrightInformation>
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