Neurological symptoms in patients with biopsy proven celiac disease.
Identifieur interne : 002848 ( Ncbi/Merge ); précédent : 002847; suivant : 002849Neurological symptoms in patients with biopsy proven celiac disease.
Auteurs : Katrin Bürk [Allemagne] ; Marie-Louise Farecki ; Georg Lamprecht ; Guenter Roth ; Patrice Decker ; Michael Weller ; Hans-Georg Rammensee ; Wolfang OertelSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- MESH :
- complications : Celiac Disease.
- diagnosis : Celiac Disease.
- etiology : Nervous System Diseases.
- methods : Biopsy, Neurologic Examination.
- Adult, Aged, Female, Humans, Male, Middle Aged.
Abstract
In celiac disease (CD), the gut is the typical manifestation site but atypical neurological presentations are thought to occur in 6 to 10% with cerebellar ataxia being the most frequent symptom. Most studies in this field are focused on patients under primary neurological care. To exclude such an observation bias, patients with biopsy proven celiac disease were screened for neurological disease. A total of 72 patients with biopsy proven celiac disease (CD) (mean age 51 +/- 15 years, mean disease duration 8 +/- 11 years) were recruited through advertisements. All participants adhered to a gluten-free diet. Patients were interviewed following a standard questionnaire and examined clinically for neurological symptoms. Medical history revealed neurological disorders such as migraine (28%), carpal tunnel syndrome (20%), vestibular dysfunction (8%), seizures (6%), and myelitis (3%). Interestingly, 35% of patients with CD reported of a history of psychiatric disease including depression, personality changes, or even psychosis. Physical examination yielded stance and gait problems in about one third of patients that could be attributed to afferent ataxia in 26%, vestibular dysfunction in 6%, and cerebellar ataxia in 6%. Other motor features such as basal ganglia symptoms, pyramidal tract signs, tics, and myoclonus were infrequent. 35% of patients with CD showed deep sensory loss and reduced ankle reflexes in 14%. Gait disturbances in CD do not only result from cerebellar ataxia but also from proprioceptive or vestibular impairment. Neurological problems may even develop despite strict adherence to a gluten-free diet.
DOI: 10.1002/mds.22821
PubMed: 19845007
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first="Georg" last="Lamprecht">Georg Lamprecht</name></author><author><name sortKey="Roth, Guenter" sort="Roth, Guenter" uniqKey="Roth G" first="Guenter" last="Roth">Guenter Roth</name></author><author><name sortKey="Decker, Patrice" sort="Decker, Patrice" uniqKey="Decker P" first="Patrice" last="Decker">Patrice Decker</name></author><author><name sortKey="Weller, Michael" sort="Weller, Michael" uniqKey="Weller M" first="Michael" last="Weller">Michael Weller</name></author><author><name sortKey="Rammensee, Hans Georg" sort="Rammensee, Hans Georg" uniqKey="Rammensee H" first="Hans-Georg" last="Rammensee">Hans-Georg Rammensee</name></author><author><name sortKey="Oertel, Wolfang" sort="Oertel, Wolfang" uniqKey="Oertel W" first="Wolfang" last="Oertel">Wolfang Oertel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22821</idno><idno type="RBID">pubmed:19845007</idno><idno 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sortKey="Farecki, Marie Louise" sort="Farecki, Marie Louise" uniqKey="Farecki M" first="Marie-Louise" last="Farecki">Marie-Louise Farecki</name></author><author><name sortKey="Lamprecht, Georg" sort="Lamprecht, Georg" uniqKey="Lamprecht G" first="Georg" last="Lamprecht">Georg Lamprecht</name></author><author><name sortKey="Roth, Guenter" sort="Roth, Guenter" uniqKey="Roth G" first="Guenter" last="Roth">Guenter Roth</name></author><author><name sortKey="Decker, Patrice" sort="Decker, Patrice" uniqKey="Decker P" first="Patrice" last="Decker">Patrice Decker</name></author><author><name sortKey="Weller, Michael" sort="Weller, Michael" uniqKey="Weller M" first="Michael" last="Weller">Michael Weller</name></author><author><name sortKey="Rammensee, Hans Georg" sort="Rammensee, Hans Georg" uniqKey="Rammensee H" first="Hans-Georg" last="Rammensee">Hans-Georg Rammensee</name></author><author><name sortKey="Oertel, Wolfang" sort="Oertel, Wolfang" uniqKey="Oertel W" first="Wolfang" last="Oertel">Wolfang Oertel</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biopsy (methods)</term><term>Celiac Disease (complications)</term><term>Celiac Disease (diagnosis)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nervous System Diseases (etiology)</term><term>Neurologic Examination (methods)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Celiac Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Celiac Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Biopsy</term><term>Neurologic Examination</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In celiac disease (CD), the gut is the typical manifestation site but atypical neurological presentations are thought to occur in 6 to 10% with cerebellar ataxia being the most frequent symptom. Most studies in this field are focused on patients under primary neurological care. To exclude such an observation bias, patients with biopsy proven celiac disease were screened for neurological disease. A total of 72 patients with biopsy proven celiac disease (CD) (mean age 51 +/- 15 years, mean disease duration 8 +/- 11 years) were recruited through advertisements. All participants adhered to a gluten-free diet. Patients were interviewed following a standard questionnaire and examined clinically for neurological symptoms. Medical history revealed neurological disorders such as migraine (28%), carpal tunnel syndrome (20%), vestibular dysfunction (8%), seizures (6%), and myelitis (3%). Interestingly, 35% of patients with CD reported of a history of psychiatric disease including depression, personality changes, or even psychosis. Physical examination yielded stance and gait problems in about one third of patients that could be attributed to afferent ataxia in 26%, vestibular dysfunction in 6%, and cerebellar ataxia in 6%. Other motor features such as basal ganglia symptoms, pyramidal tract signs, tics, and myoclonus were infrequent. 35% of patients with CD showed deep sensory loss and reduced ankle reflexes in 14%. Gait disturbances in CD do not only result from cerebellar ataxia but also from proprioceptive or vestibular impairment. Neurological problems may even develop despite strict adherence to a gluten-free diet.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19845007</PMID><DateCreated><Year>2009</Year><Month>12</Month><Day>28</Day></DateCreated><DateCompleted><Year>2010</Year><Month>03</Month><Day>04</Day></DateCompleted><DateRevised><Year>2010</Year><Month>05</Month><Day>03</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>16</Issue><PubDate><Year>2009</Year><Month>Dec</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Neurological symptoms in patients with biopsy proven celiac disease.</ArticleTitle><Pagination><MedlinePgn>2358-62</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22821</ELocationID><Abstract><AbstractText>In celiac disease (CD), the gut is the typical manifestation site but atypical neurological presentations are thought to occur in 6 to 10% with cerebellar ataxia being the most frequent symptom. Most studies in this field are focused on patients under primary neurological care. To exclude such an observation bias, patients with biopsy proven celiac disease were screened for neurological disease. A total of 72 patients with biopsy proven celiac disease (CD) (mean age 51 +/- 15 years, mean disease duration 8 +/- 11 years) were recruited through advertisements. All participants adhered to a gluten-free diet. Patients were interviewed following a standard questionnaire and examined clinically for neurological symptoms. Medical history revealed neurological disorders such as migraine (28%), carpal tunnel syndrome (20%), vestibular dysfunction (8%), seizures (6%), and myelitis (3%). Interestingly, 35% of patients with CD reported of a history of psychiatric disease including depression, personality changes, or even psychosis. Physical examination yielded stance and gait problems in about one third of patients that could be attributed to afferent ataxia in 26%, vestibular dysfunction in 6%, and cerebellar ataxia in 6%. Other motor features such as basal ganglia symptoms, pyramidal tract signs, tics, and myoclonus were infrequent. 35% of patients with CD showed deep sensory loss and reduced ankle reflexes in 14%. Gait disturbances in CD do not only result from cerebellar ataxia but also from proprioceptive or vestibular impairment. Neurological problems may even develop despite strict adherence to a gluten-free diet.</AbstractText><CopyrightInformation>(c) 2009 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bürk</LastName><ForeName>Katrin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Marburg, Marburg, Germany. buerk@ngi.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farecki</LastName><ForeName>Marie-Louise</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Lamprecht</LastName><ForeName>Georg</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Roth</LastName><ForeName>Guenter</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Decker</LastName><ForeName>Patrice</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Weller</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Rammensee</LastName><ForeName>Hans-Georg</ForeName><Initials>HG</Initials></Author><Author ValidYN="Y"><LastName>Oertel</LastName><ForeName>Wolfang</ForeName><Initials>W</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Mov Disord. 2010 Apr 30;25(6):799-800</RefSource><PMID Version="1">20437547</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001706">Biopsy</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002446">Celiac Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009422">Nervous System Diseases</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009460">Neurologic Examination</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>10</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>10</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>3</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.22821</ArticleId><ArticleId IdType="pubmed">19845007</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>District de Giessen</li><li>Hesse (Land)</li></region><settlement><li>Marbourg</li></settlement></list><tree><noCountry><name sortKey="Decker, Patrice" sort="Decker, Patrice" uniqKey="Decker P" first="Patrice" last="Decker">Patrice Decker</name><name sortKey="Farecki, Marie Louise" sort="Farecki, Marie Louise" uniqKey="Farecki M" first="Marie-Louise" last="Farecki">Marie-Louise Farecki</name><name sortKey="Lamprecht, Georg" sort="Lamprecht, Georg" uniqKey="Lamprecht G" first="Georg" last="Lamprecht">Georg Lamprecht</name><name sortKey="Oertel, Wolfang" sort="Oertel, Wolfang" uniqKey="Oertel W" first="Wolfang" last="Oertel">Wolfang Oertel</name><name sortKey="Rammensee, Hans Georg" sort="Rammensee, Hans Georg" uniqKey="Rammensee H" first="Hans-Georg" last="Rammensee">Hans-Georg Rammensee</name><name sortKey="Roth, Guenter" sort="Roth, Guenter" uniqKey="Roth G" first="Guenter" last="Roth">Guenter Roth</name><name sortKey="Weller, Michael" sort="Weller, Michael" uniqKey="Weller M" first="Michael" last="Weller">Michael Weller</name></noCountry><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Burk, Katrin" sort="Burk, Katrin" uniqKey="Burk K" first="Katrin" last="Bürk">Katrin Bürk</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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