Prevalence of Anxiety Disorders and Anxiety Subtypes in Patients With Parkinson's Disease
Identifieur interne : 002672 ( Ncbi/Merge ); précédent : 002671; suivant : 002673Prevalence of Anxiety Disorders and Anxiety Subtypes in Patients With Parkinson's Disease
Auteurs : Gregory M. Pontone [États-Unis] ; James R. Williams [États-Unis] ; Karen Anderson [États-Unis] ; Gary Chase ; Susanne Goldstein ; Stephen Grill ; Elaina S. Hirsch [États-Unis] ; Susan Lehmann [États-Unis] ; John T. Little [États-Unis] ; Russell L. Margolis [États-Unis] ; Peter V. Rabins [États-Unis] ; Howard Weiss [États-Unis] ; Laura Marsh [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2009.
English descriptors
- KwdEn :
- MESH :
- classification : Anxiety.
- complications : Parkinson Disease.
- epidemiology : Anxiety, Anxiety Disorders, Panic Disorder.
- etiology : Anxiety, Anxiety Disorders, Panic Disorder.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Prevalence.
Abstract
Anxiety disorders are common in Parkinson's Disease (PD), but are not well-characterized. This study determined the prevalence and clinical correlates of all DSM-IV-TR anxiety disorder diagnoses in a sample of 127 subjects with idiopathic PD who underwent comprehensive assessments administered by a psychiatrist and neurologist. A panel of six psychiatrists with expertise in geriatric psychiatry and/or movement disorders established by consensus all psychiatric diagnoses. Current and lifetime prevalence of at least one anxiety disorder diagnosis was 43% (n=55) and 49% (n=63), respectively. Anxiety Disorder Not Otherwise Specified, a DSM diagnosis used for anxiety disturbances not meeting criteria for defined subtypes, was the most common diagnosis (30% lifetime prevalence, n=38). Compared to non-anxious subjects, panic disorder (n=13) was associated with earlier age of PD onset [50.3(12.2) vs. 61.0(13.7) years, p<.01], higher rates of motor fluctuations [77% (10/13) vs. 39% (25/64), p=.01] and morning dystonia [38% (5/13) vs. 13% (8/62), p<.03]. This high prevalence of anxiety disorders, including disturbances often not meeting conventional diagnostic criteria, suggests that anxiety in PD is likely under-diagnosed and under-treated and refined characterization of anxiety disorders in PD is needed. In addition, certain anxiety subtypes may be clinically useful markers associated with disease impact in PD.
Url:
DOI: 10.1002/mds.22611
PubMed: 19425086
PubMed Central: 2830642
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Pontone</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Williams, James R" sort="Williams, James R" uniqKey="Williams J" first="James R." last="Williams">James R. Williams</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Anderson, Karen" sort="Anderson, Karen" uniqKey="Anderson K" first="Karen" last="Anderson">Karen Anderson</name><affiliation wicri:level="2"><nlm:aff id="A4">Departments of Psychiatry and Neurology, University of Maryland Medical Center, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Departments of Psychiatry and Neurology, University of Maryland Medical Center, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Chase, Gary" sort="Chase, Gary" uniqKey="Chase G" first="Gary" last="Chase">Gary Chase</name></author><author><name sortKey="Goldstein, Susanne" sort="Goldstein, Susanne" uniqKey="Goldstein S" first="Susanne" last="Goldstein">Susanne Goldstein</name></author><author><name sortKey="Grill, Stephen" sort="Grill, Stephen" uniqKey="Grill S" first="Stephen" last="Grill">Stephen Grill</name></author><author><name sortKey="Hirsch, Elaina S" sort="Hirsch, Elaina S" uniqKey="Hirsch E" first="Elaina S." last="Hirsch">Elaina S. Hirsch</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Lehmann, Susan" sort="Lehmann, Susan" uniqKey="Lehmann S" first="Susan" last="Lehmann">Susan Lehmann</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Little, John T" sort="Little, John T" uniqKey="Little J" first="John T." last="Little">John T. Little</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Departments of Psychiatry and Neurology, Georgetown University School of Medicine, Washington, DC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>Departments of Psychiatry and Neurology, Georgetown University School of Medicine, Washington</wicri:cityArea></affiliation></author><author><name sortKey="Margolis, Russell L" sort="Margolis, Russell L" uniqKey="Margolis R" first="Russell L." last="Margolis">Russell L. Margolis</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Rabins, Peter V" sort="Rabins, Peter V" uniqKey="Rabins P" first="Peter V." last="Rabins">Peter V. Rabins</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Weiss, Howard" sort="Weiss, Howard" uniqKey="Weiss H" first="Howard" last="Weiss">Howard Weiss</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurology and Neurological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Neurology and Neurological Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Marsh, Laura" sort="Marsh, Laura" uniqKey="Marsh L" first="Laura" last="Marsh">Laura Marsh</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurology and Neurological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Neurology and Neurological Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Anxiety (classification)</term><term>Anxiety (epidemiology)</term><term>Anxiety (etiology)</term><term>Anxiety Disorders (epidemiology)</term><term>Anxiety Disorders (etiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Panic Disorder (epidemiology)</term><term>Panic Disorder (etiology)</term><term>Parkinson Disease (complications)</term><term>Prevalence</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Anxiety</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Anxiety</term><term>Anxiety Disorders</term><term>Panic Disorder</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Anxiety</term><term>Anxiety Disorders</term><term>Panic Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Anxiety disorders are common in Parkinson's Disease (PD), but are not well-characterized. This study determined the prevalence and clinical correlates of all DSM-IV-TR anxiety disorder diagnoses in a sample of 127 subjects with idiopathic PD who underwent comprehensive assessments administered by a psychiatrist and neurologist. A panel of six psychiatrists with expertise in geriatric psychiatry and/or movement disorders established by consensus all psychiatric diagnoses. Current and lifetime prevalence of at least one anxiety disorder diagnosis was 43% (n=55) and 49% (n=63), respectively. Anxiety Disorder Not Otherwise Specified, a DSM diagnosis used for anxiety disturbances not meeting criteria for defined subtypes, was the most common diagnosis (30% lifetime prevalence, n=38). Compared to non-anxious subjects, panic disorder (n=13) was associated with earlier age of PD onset [50.3(12.2) vs. 61.0(13.7) years, p<.01], higher rates of motor fluctuations [77% (10/13) vs. 39% (25/64), p=.01] and morning dystonia [38% (5/13) vs. 13% (8/62), p<.03]. This high prevalence of anxiety disorders, including disturbances often not meeting conventional diagnostic criteria, suggests that anxiety in PD is likely under-diagnosed and under-treated and refined characterization of anxiety disorders in PD is needed. In addition, certain anxiety subtypes may be clinically useful markers associated with disease impact in PD.</p></div></front></TEI><double pmid="19425086"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prevalence of Anxiety Disorders and Anxiety Subtypes in Patients With Parkinson's Disease</title><author><name sortKey="Pontone, Gregory M" sort="Pontone, Gregory M" uniqKey="Pontone G" first="Gregory M." last="Pontone">Gregory M. Pontone</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Williams, James R" sort="Williams, James R" uniqKey="Williams J" first="James R." last="Williams">James R. Williams</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Anderson, Karen" sort="Anderson, Karen" uniqKey="Anderson K" first="Karen" last="Anderson">Karen Anderson</name><affiliation wicri:level="2"><nlm:aff id="A4">Departments of Psychiatry and Neurology, University of Maryland Medical Center, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Departments of Psychiatry and Neurology, University of Maryland Medical Center, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Chase, Gary" sort="Chase, Gary" uniqKey="Chase G" first="Gary" last="Chase">Gary Chase</name></author><author><name sortKey="Goldstein, Susanne" sort="Goldstein, Susanne" uniqKey="Goldstein S" first="Susanne" last="Goldstein">Susanne Goldstein</name></author><author><name sortKey="Grill, Stephen" sort="Grill, Stephen" uniqKey="Grill S" first="Stephen" last="Grill">Stephen Grill</name></author><author><name sortKey="Hirsch, Elaina S" sort="Hirsch, Elaina S" uniqKey="Hirsch E" first="Elaina S." last="Hirsch">Elaina S. Hirsch</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Lehmann, Susan" sort="Lehmann, Susan" uniqKey="Lehmann S" first="Susan" last="Lehmann">Susan Lehmann</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Little, John T" sort="Little, John T" uniqKey="Little J" first="John T." last="Little">John T. Little</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Departments of Psychiatry and Neurology, Georgetown University School of Medicine, Washington, DC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>Departments of Psychiatry and Neurology, Georgetown University School of Medicine, Washington</wicri:cityArea></affiliation></author><author><name sortKey="Margolis, Russell L" sort="Margolis, Russell L" uniqKey="Margolis R" first="Russell L." last="Margolis">Russell L. Margolis</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Rabins, Peter V" sort="Rabins, Peter V" uniqKey="Rabins P" first="Peter V." last="Rabins">Peter V. Rabins</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Weiss, Howard" sort="Weiss, Howard" uniqKey="Weiss H" first="Howard" last="Weiss">Howard Weiss</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurology and Neurological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Neurology and Neurological Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Marsh, Laura" sort="Marsh, Laura" uniqKey="Marsh L" first="Laura" last="Marsh">Laura Marsh</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurology and Neurological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Neurology and Neurological Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19425086</idno><idno type="pmc">2830642</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830642</idno><idno type="RBID">PMC:2830642</idno><idno type="doi">10.1002/mds.22611</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000059</idno><idno type="wicri:Area/Pmc/Curation">000059</idno><idno type="wicri:Area/Pmc/Checkpoint">000397</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prevalence of Anxiety Disorders and Anxiety Subtypes in Patients With Parkinson's Disease</title><author><name sortKey="Pontone, Gregory M" sort="Pontone, Gregory M" uniqKey="Pontone G" first="Gregory M." last="Pontone">Gregory M. Pontone</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Williams, James R" sort="Williams, James R" uniqKey="Williams J" first="James R." last="Williams">James R. Williams</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Anderson, Karen" sort="Anderson, Karen" uniqKey="Anderson K" first="Karen" last="Anderson">Karen Anderson</name><affiliation wicri:level="2"><nlm:aff id="A4">Departments of Psychiatry and Neurology, University of Maryland Medical Center, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Departments of Psychiatry and Neurology, University of Maryland Medical Center, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Chase, Gary" sort="Chase, Gary" uniqKey="Chase G" first="Gary" last="Chase">Gary Chase</name></author><author><name sortKey="Goldstein, Susanne" sort="Goldstein, Susanne" uniqKey="Goldstein S" first="Susanne" last="Goldstein">Susanne Goldstein</name></author><author><name sortKey="Grill, Stephen" sort="Grill, Stephen" uniqKey="Grill S" first="Stephen" last="Grill">Stephen Grill</name></author><author><name sortKey="Hirsch, Elaina S" sort="Hirsch, Elaina S" uniqKey="Hirsch E" first="Elaina S." last="Hirsch">Elaina S. Hirsch</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Lehmann, Susan" sort="Lehmann, Susan" uniqKey="Lehmann S" first="Susan" last="Lehmann">Susan Lehmann</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Little, John T" sort="Little, John T" uniqKey="Little J" first="John T." last="Little">John T. Little</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Departments of Psychiatry and Neurology, Georgetown University School of Medicine, Washington, DC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>Departments of Psychiatry and Neurology, Georgetown University School of Medicine, Washington</wicri:cityArea></affiliation></author><author><name sortKey="Margolis, Russell L" sort="Margolis, Russell L" uniqKey="Margolis R" first="Russell L." last="Margolis">Russell L. Margolis</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Rabins, Peter V" sort="Rabins, Peter V" uniqKey="Rabins P" first="Peter V." last="Rabins">Peter V. Rabins</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Weiss, Howard" sort="Weiss, Howard" uniqKey="Weiss H" first="Howard" last="Weiss">Howard Weiss</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurology and Neurological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Neurology and Neurological Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Marsh, Laura" sort="Marsh, Laura" uniqKey="Marsh L" first="Laura" last="Marsh">Laura Marsh</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurology and Neurological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Neurology and Neurological Sciences, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Anxiety disorders are common in Parkinson's Disease (PD), but are not well-characterized. This study determined the prevalence and clinical correlates of all DSM-IV-TR anxiety disorder diagnoses in a sample of 127 subjects with idiopathic PD who underwent comprehensive assessments administered by a psychiatrist and neurologist. A panel of six psychiatrists with expertise in geriatric psychiatry and/or movement disorders established by consensus all psychiatric diagnoses. Current and lifetime prevalence of at least one anxiety disorder diagnosis was 43% (n=55) and 49% (n=63), respectively. Anxiety Disorder Not Otherwise Specified, a DSM diagnosis used for anxiety disturbances not meeting criteria for defined subtypes, was the most common diagnosis (30% lifetime prevalence, n=38). Compared to non-anxious subjects, panic disorder (n=13) was associated with earlier age of PD onset [50.3(12.2) vs. 61.0(13.7) years, p<.01], higher rates of motor fluctuations [77% (10/13) vs. 39% (25/64), p=.01] and morning dystonia [38% (5/13) vs. 13% (8/62), p<.03]. This high prevalence of anxiety disorders, including disturbances often not meeting conventional diagnostic criteria, suggests that anxiety in PD is likely under-diagnosed and under-treated and refined characterization of anxiety disorders in PD is needed. In addition, certain anxiety subtypes may be clinically useful markers associated with disease impact in PD.</p></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prevalence of anxiety disorders and anxiety subtypes in patients with Parkinson's disease.</title><author><name sortKey="Pontone, Gregory M" sort="Pontone, Gregory M" uniqKey="Pontone G" first="Gregory M" last="Pontone">Gregory M. Pontone</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287</wicri:regionArea><wicri:noRegion>Maryland 21287</wicri:noRegion></affiliation></author><author><name sortKey="Williams, James R" sort="Williams, James R" uniqKey="Williams J" first="James R" last="Williams">James R. Williams</name></author><author><name sortKey="Anderson, Karen E" sort="Anderson, Karen E" uniqKey="Anderson K" first="Karen E" last="Anderson">Karen E. Anderson</name></author><author><name sortKey="Chase, Gary" sort="Chase, Gary" uniqKey="Chase G" first="Gary" last="Chase">Gary Chase</name></author><author><name sortKey="Goldstein, Susanne A" sort="Goldstein, Susanne A" uniqKey="Goldstein S" first="Susanne A" last="Goldstein">Susanne A. Goldstein</name></author><author><name sortKey="Grill, Stephen" sort="Grill, Stephen" uniqKey="Grill S" first="Stephen" last="Grill">Stephen Grill</name></author><author><name sortKey="Hirsch, Elaina S" sort="Hirsch, Elaina S" uniqKey="Hirsch E" first="Elaina S" last="Hirsch">Elaina S. Hirsch</name></author><author><name sortKey="Lehmann, Susan" sort="Lehmann, Susan" uniqKey="Lehmann S" first="Susan" last="Lehmann">Susan Lehmann</name></author><author><name sortKey="Little, John T" sort="Little, John T" uniqKey="Little J" first="John T" last="Little">John T. Little</name></author><author><name sortKey="Margolis, Russell L" sort="Margolis, Russell L" uniqKey="Margolis R" first="Russell L" last="Margolis">Russell L. Margolis</name></author><author><name sortKey="Rabins, Peter V" sort="Rabins, Peter V" uniqKey="Rabins P" first="Peter V" last="Rabins">Peter V. Rabins</name></author><author><name sortKey="Weiss, Howard D" sort="Weiss, Howard D" uniqKey="Weiss H" first="Howard D" last="Weiss">Howard D. Weiss</name></author><author><name sortKey="Marsh, Laura" sort="Marsh, Laura" uniqKey="Marsh L" first="Laura" last="Marsh">Laura Marsh</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22611</idno><idno type="RBID">pubmed:19425086</idno><idno type="pmid">19425086</idno><idno type="wicri:Area/PubMed/Corpus">001D05</idno><idno type="wicri:Area/PubMed/Curation">001D05</idno><idno type="wicri:Area/PubMed/Checkpoint">001C28</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Prevalence of anxiety disorders and anxiety subtypes in patients with Parkinson's disease.</title><author><name sortKey="Pontone, Gregory M" sort="Pontone, Gregory M" uniqKey="Pontone G" first="Gregory M" last="Pontone">Gregory M. Pontone</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287</wicri:regionArea><wicri:noRegion>Maryland 21287</wicri:noRegion></affiliation></author><author><name sortKey="Williams, James R" sort="Williams, James R" uniqKey="Williams J" first="James R" last="Williams">James R. Williams</name></author><author><name sortKey="Anderson, Karen E" sort="Anderson, Karen E" uniqKey="Anderson K" first="Karen E" last="Anderson">Karen E. Anderson</name></author><author><name sortKey="Chase, Gary" sort="Chase, Gary" uniqKey="Chase G" first="Gary" last="Chase">Gary Chase</name></author><author><name sortKey="Goldstein, Susanne A" sort="Goldstein, Susanne A" uniqKey="Goldstein S" first="Susanne A" last="Goldstein">Susanne A. Goldstein</name></author><author><name sortKey="Grill, Stephen" sort="Grill, Stephen" uniqKey="Grill S" first="Stephen" last="Grill">Stephen Grill</name></author><author><name sortKey="Hirsch, Elaina S" sort="Hirsch, Elaina S" uniqKey="Hirsch E" first="Elaina S" last="Hirsch">Elaina S. Hirsch</name></author><author><name sortKey="Lehmann, Susan" sort="Lehmann, Susan" uniqKey="Lehmann S" first="Susan" last="Lehmann">Susan Lehmann</name></author><author><name sortKey="Little, John T" sort="Little, John T" uniqKey="Little J" first="John T" last="Little">John T. Little</name></author><author><name sortKey="Margolis, Russell L" sort="Margolis, Russell L" uniqKey="Margolis R" first="Russell L" last="Margolis">Russell L. Margolis</name></author><author><name sortKey="Rabins, Peter V" sort="Rabins, Peter V" uniqKey="Rabins P" first="Peter V" last="Rabins">Peter V. Rabins</name></author><author><name sortKey="Weiss, Howard D" sort="Weiss, Howard D" uniqKey="Weiss H" first="Howard D" last="Weiss">Howard D. Weiss</name></author><author><name sortKey="Marsh, Laura" sort="Marsh, Laura" uniqKey="Marsh L" first="Laura" last="Marsh">Laura Marsh</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Anxiety (classification)</term><term>Anxiety (epidemiology)</term><term>Anxiety (etiology)</term><term>Anxiety Disorders (epidemiology)</term><term>Anxiety Disorders (etiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Panic Disorder (epidemiology)</term><term>Panic Disorder (etiology)</term><term>Parkinson Disease (complications)</term><term>Prevalence</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Anxiety</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Anxiety</term><term>Anxiety Disorders</term><term>Panic Disorder</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Anxiety</term><term>Anxiety Disorders</term><term>Panic Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Anxiety disorders are common in Parkinson's disease (PD), but are not well characterized. This study determined the prevalence and clinical correlates of all DSM-IV-TR anxiety disorder diagnoses in a sample of 127 subjects with idiopathic PD who underwent comprehensive assessments administered by a psychiatrist and neurologist. A panel of six psychiatrists with expertise in geriatric psychiatry and/or movement disorders established by consensus all psychiatric diagnoses. Current and lifetime prevalence of at least one anxiety disorder diagnosis was 43% (n = 55) and 49% (n = 63), respectively. Anxiety disorder not otherwise specified, a DSM diagnosis used for anxiety disturbances not meeting criteria for defined subtypes, was the most common diagnosis (30% lifetime prevalence, n = 38). Compared with nonanxious subjects, panic disorder (n = 13) was associated with earlier age of PD onset [50.3 (12.2) vs. 61.0 (13.7) years, P < 0.01], higher rates of motor fluctuations [77% (10/13) vs. 39% (25/64), P = 0.01] and morning dystonia [38% (5/13) vs. 13% (8/62), P < 0.03]. This high prevalence of anxiety disorders, including disturbances often not meeting conventional diagnostic criteria, suggests that anxiety in PD is likely underdiagnosed and undertreated and refined characterization of anxiety disorders in PD is needed. In addition, certain anxiety subtypes may be clinically useful markers associated with disease impact in PD.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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