Anatomy, physiology, and pathophysiology of the pedunculopontine nucleus.
Identifieur interne : 002469 ( Ncbi/Merge ); précédent : 002468; suivant : 002470Anatomy, physiology, and pathophysiology of the pedunculopontine nucleus.
Auteurs : Ned Jenkinson [Royaume-Uni] ; Dipanker Nandi ; Kalai Muthusamy ; Nicola J. Ray ; Ralph Gregory ; John F. Stein ; Tipu Z. AzizSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Animals, Electric Stimulation (methods), Humans, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Pedunculopontine Tegmental Nucleus (anatomy & histology), Pedunculopontine Tegmental Nucleus (physiology), Pedunculopontine Tegmental Nucleus (physiopathology).
- MESH :
- anatomy & histology : Pedunculopontine Tegmental Nucleus.
- diagnosis : Parkinson Disease.
- methods : Electric Stimulation.
- physiology : Pedunculopontine Tegmental Nucleus.
- physiopathology : Parkinson Disease, Pedunculopontine Tegmental Nucleus.
- therapy : Parkinson Disease.
- Animals, Humans.
Abstract
The pedunculopontine nucleus is composed of cholinergic and non-cholinergic neurones and is located in the caudal pontomesencephalic tegmentum. Evidence suggests that the nucleus plays a role in the production and control of movement. The nucleus has dense interconnections with the basal ganglia, as well as with other areas of the brain associated with motor control. Electrical stimulation of the pedunculopontine nucleus in the decerebrate cat or rat produces organized locomotor movements. Physiological studies show that the pedunculopontine nucleus modulates its activity in response to locomotion, as well as voluntary arm and eye movements. Degeneration of the pedunculopontine nucleus is seen in post-mortem brains in humans with Parkinson's disease and Parkinsonian syndromes. In animal models of Parkinson's disease, metabolic changes are seen in the pedunculopontine nucleus, and chemical inhibition or mechanical disruption of the nucleus can produce an akinetic state in animals and man. In this paper we review the literature in support of the suggestion that some of the symptoms of Parkinson's disease are caused by dysfunction of the pedunculopontine nucleus. In accordance with this view, direct stimulation of the nucleus can ameliorate some symptoms of the disease, as demonstrated in both experimental animals and man.
DOI: 10.1002/mds.22189
PubMed: 19097193
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Ray</name></author><author><name sortKey="Gregory, Ralph" sort="Gregory, Ralph" uniqKey="Gregory R" first="Ralph" last="Gregory">Ralph Gregory</name></author><author><name sortKey="Stein, John F" sort="Stein, John F" uniqKey="Stein J" first="John F" last="Stein">John F. Stein</name></author><author><name sortKey="Aziz, Tipu Z" sort="Aziz, Tipu Z" uniqKey="Aziz T" first="Tipu Z" last="Aziz">Tipu Z. 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Ray</name></author><author><name sortKey="Gregory, Ralph" sort="Gregory, Ralph" uniqKey="Gregory R" first="Ralph" last="Gregory">Ralph Gregory</name></author><author><name sortKey="Stein, John F" sort="Stein, John F" uniqKey="Stein J" first="John F" last="Stein">John F. Stein</name></author><author><name sortKey="Aziz, Tipu Z" sort="Aziz, Tipu Z" uniqKey="Aziz T" first="Tipu Z" last="Aziz">Tipu Z. Aziz</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Electric Stimulation (methods)</term><term>Humans</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Pedunculopontine Tegmental Nucleus (anatomy & histology)</term><term>Pedunculopontine Tegmental Nucleus (physiology)</term><term>Pedunculopontine Tegmental Nucleus (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Pedunculopontine Tegmental Nucleus</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Pedunculopontine Tegmental Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Pedunculopontine Tegmental Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pedunculopontine nucleus is composed of cholinergic and non-cholinergic neurones and is located in the caudal pontomesencephalic tegmentum. Evidence suggests that the nucleus plays a role in the production and control of movement. The nucleus has dense interconnections with the basal ganglia, as well as with other areas of the brain associated with motor control. Electrical stimulation of the pedunculopontine nucleus in the decerebrate cat or rat produces organized locomotor movements. Physiological studies show that the pedunculopontine nucleus modulates its activity in response to locomotion, as well as voluntary arm and eye movements. Degeneration of the pedunculopontine nucleus is seen in post-mortem brains in humans with Parkinson's disease and Parkinsonian syndromes. In animal models of Parkinson's disease, metabolic changes are seen in the pedunculopontine nucleus, and chemical inhibition or mechanical disruption of the nucleus can produce an akinetic state in animals and man. In this paper we review the literature in support of the suggestion that some of the symptoms of Parkinson's disease are caused by dysfunction of the pedunculopontine nucleus. In accordance with this view, direct stimulation of the nucleus can ameliorate some symptoms of the disease, as demonstrated in both experimental animals and man.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19097193</PMID><DateCreated><Year>2009</Year><Month>03</Month><Day>03</Day></DateCreated><DateCompleted><Year>2009</Year><Month>07</Month><Day>27</Day></DateCompleted><DateRevised><Year>2014</Year><Month>02</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>3</Issue><PubDate><Year>2009</Year><Month>Feb</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Anatomy, physiology, and pathophysiology of the pedunculopontine nucleus.</ArticleTitle><Pagination><MedlinePgn>319-28</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22189</ELocationID><Abstract><AbstractText>The pedunculopontine nucleus is composed of cholinergic and non-cholinergic neurones and is located in the caudal pontomesencephalic tegmentum. Evidence suggests that the nucleus plays a role in the production and control of movement. The nucleus has dense interconnections with the basal ganglia, as well as with other areas of the brain associated with motor control. Electrical stimulation of the pedunculopontine nucleus in the decerebrate cat or rat produces organized locomotor movements. Physiological studies show that the pedunculopontine nucleus modulates its activity in response to locomotion, as well as voluntary arm and eye movements. Degeneration of the pedunculopontine nucleus is seen in post-mortem brains in humans with Parkinson's disease and Parkinsonian syndromes. In animal models of Parkinson's disease, metabolic changes are seen in the pedunculopontine nucleus, and chemical inhibition or mechanical disruption of the nucleus can produce an akinetic state in animals and man. In this paper we review the literature in support of the suggestion that some of the symptoms of Parkinson's disease are caused by dysfunction of the pedunculopontine nucleus. In accordance with this view, direct stimulation of the nucleus can ameliorate some symptoms of the disease, as demonstrated in both experimental animals and man.</AbstractText><CopyrightInformation>(c) 2008 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jenkinson</LastName><ForeName>Ned</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Oxford Functional Neurosurgery, John Radcliffe Hospital, Oxford, United Kingdom. ned.jenkinson@nds.ox.ac.uk</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nandi</LastName><ForeName>Dipanker</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Muthusamy</LastName><ForeName>Kalai</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Ray</LastName><ForeName>Nicola J</ForeName><Initials>NJ</Initials></Author><Author ValidYN="Y"><LastName>Gregory</LastName><ForeName>Ralph</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Stein</LastName><ForeName>John F</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Aziz</LastName><ForeName>Tipu Z</ForeName><Initials>TZ</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>G0200561</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0701698</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004558">Electric Stimulation</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D045042">Pedunculopontine Tegmental Nucleus</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000033">anatomy & histology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>12</Month><Day>20</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>12</Month><Day>20</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>7</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.22189</ArticleId><ArticleId IdType="pubmed">19097193</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Oxfordshire</li></region><settlement><li>Oxford</li></settlement></list><tree><noCountry><name sortKey="Aziz, Tipu Z" sort="Aziz, Tipu Z" uniqKey="Aziz T" first="Tipu Z" last="Aziz">Tipu Z. Aziz</name><name sortKey="Gregory, Ralph" sort="Gregory, Ralph" uniqKey="Gregory R" first="Ralph" last="Gregory">Ralph Gregory</name><name sortKey="Muthusamy, Kalai" sort="Muthusamy, Kalai" uniqKey="Muthusamy K" first="Kalai" last="Muthusamy">Kalai Muthusamy</name><name sortKey="Nandi, Dipanker" sort="Nandi, Dipanker" uniqKey="Nandi D" first="Dipanker" last="Nandi">Dipanker Nandi</name><name sortKey="Ray, Nicola J" sort="Ray, Nicola J" uniqKey="Ray N" first="Nicola J" last="Ray">Nicola J. Ray</name><name sortKey="Stein, John F" sort="Stein, John F" uniqKey="Stein J" first="John F" last="Stein">John F. Stein</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Jenkinson, Ned" sort="Jenkinson, Ned" uniqKey="Jenkinson N" first="Ned" last="Jenkinson">Ned Jenkinson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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