Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulation.
Identifieur interne : 002338 ( Ncbi/Merge ); précédent : 002337; suivant : 002339Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulation.
Auteurs : Elina Tripoliti [Royaume-Uni] ; Ludvic Zrinzo ; Irene Martinez-Torres ; Stephen Tisch ; Eleanor Frost ; Ellie Borrell ; Marwan I. Hariz ; Patricia LimousinSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Acoustics, Aged, Analysis of Variance, Antibodies, Monoclonal, Biophysical Processes, Deep Brain Stimulation (methods), Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Movement (physiology), Neurologic Examination, Neuropsychological Tests, Parkinson Disease (physiopathology), Parkinson Disease (therapy), Recombinant Fusion Proteins, Severity of Illness Index, Speech (physiology), Subthalamic Nucleus (physiology).
- MESH :
- chemical : Antibodies, Monoclonal, Recombinant Fusion Proteins.
- methods : Deep Brain Stimulation.
- physiology : Movement, Speech, Subthalamic Nucleus.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Acoustics, Aged, Analysis of Variance, Biophysical Processes, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Severity of Illness Index.
Abstract
Subthalamic nucleus deep brain stimulation (STN-DBS) is particularly effective in improving limb symptoms in Parkinson's disease. However, speech shows a variable response. Contact site and amplitude of stimulation have been suggested as possible factors influencing speech. In this double blind study, we assessed 14 patients post bilateral STN-DBS, without medication. Six conditions were studied in random order as follows: stimulation inside the STN at low voltage (2 V) and at high voltage (4 V); above the STN at 2 V and at 4 V, at usual clinical parameters, and off-stimulation. The site of stimulation was defined on the postoperative stereotactic MRI data. Speech protocol consisted of the assessment of intelligibility of the dysarthric speech, maximum sustained phonation, and a 1-minute monologue. Movement was assessed using the UPDRS-III. Stimulation at 4 V significantly reduced the speech intelligibility (P = 0.004) independently from the site of stimulation. Stimulation at 4 V significantly improved the motor function. Stimulation inside the nucleus was significantly more effective than outside the nucleus (P = 0.0006). The significant improvement in movement coupled with significant deterioration in speech intelligibility when patients are stimulated inside the nucleus at high voltage indicates a critical role for electrical stimulation parameters in speech motor control.
DOI: 10.1002/mds.22296
PubMed: 18785648
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Hariz</name></author><author><name sortKey="Limousin, Patricia" sort="Limousin, Patricia" uniqKey="Limousin P" first="Patricia" last="Limousin">Patricia Limousin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.22296</idno><idno type="RBID">pubmed:18785648</idno><idno type="pmid">18785648</idno><idno type="wicri:Area/PubMed/Corpus">002025</idno><idno type="wicri:Area/PubMed/Curation">002025</idno><idno type="wicri:Area/PubMed/Checkpoint">002320</idno><idno type="wicri:Area/Ncbi/Merge">002338</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulation.</title><author><name sortKey="Tripoliti, Elina" sort="Tripoliti, Elina" uniqKey="Tripoliti E" first="Elina" last="Tripoliti">Elina Tripoliti</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Functional Neurosurgery, Sobell Department, Institute of Neurology, London, United Kingdom. e.tripoliti@ion.ucl.ac.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Unit of Functional Neurosurgery, Sobell Department, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Zrinzo, Ludvic" sort="Zrinzo, Ludvic" uniqKey="Zrinzo L" first="Ludvic" last="Zrinzo">Ludvic Zrinzo</name></author><author><name sortKey="Martinez Torres, Irene" sort="Martinez Torres, Irene" uniqKey="Martinez Torres I" first="Irene" last="Martinez-Torres">Irene Martinez-Torres</name></author><author><name sortKey="Tisch, Stephen" sort="Tisch, Stephen" uniqKey="Tisch S" first="Stephen" last="Tisch">Stephen Tisch</name></author><author><name sortKey="Frost, Eleanor" sort="Frost, Eleanor" uniqKey="Frost E" first="Eleanor" last="Frost">Eleanor Frost</name></author><author><name sortKey="Borrell, Ellie" sort="Borrell, Ellie" uniqKey="Borrell E" first="Ellie" last="Borrell">Ellie Borrell</name></author><author><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I" last="Hariz">Marwan I. Hariz</name></author><author><name sortKey="Limousin, Patricia" sort="Limousin, Patricia" uniqKey="Limousin P" first="Patricia" last="Limousin">Patricia Limousin</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustics</term><term>Aged</term><term>Analysis of Variance</term><term>Antibodies, Monoclonal</term><term>Biophysical Processes</term><term>Deep Brain Stimulation (methods)</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Movement (physiology)</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Recombinant Fusion Proteins</term><term>Severity of Illness Index</term><term>Speech (physiology)</term><term>Subthalamic Nucleus (physiology)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Recombinant Fusion Proteins</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term><term>Speech</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acoustics</term><term>Aged</term><term>Analysis of Variance</term><term>Biophysical Processes</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Subthalamic nucleus deep brain stimulation (STN-DBS) is particularly effective in improving limb symptoms in Parkinson's disease. However, speech shows a variable response. Contact site and amplitude of stimulation have been suggested as possible factors influencing speech. In this double blind study, we assessed 14 patients post bilateral STN-DBS, without medication. Six conditions were studied in random order as follows: stimulation inside the STN at low voltage (2 V) and at high voltage (4 V); above the STN at 2 V and at 4 V, at usual clinical parameters, and off-stimulation. The site of stimulation was defined on the postoperative stereotactic MRI data. Speech protocol consisted of the assessment of intelligibility of the dysarthric speech, maximum sustained phonation, and a 1-minute monologue. Movement was assessed using the UPDRS-III. Stimulation at 4 V significantly reduced the speech intelligibility (P = 0.004) independently from the site of stimulation. Stimulation at 4 V significantly improved the motor function. Stimulation inside the nucleus was significantly more effective than outside the nucleus (P = 0.0006). The significant improvement in movement coupled with significant deterioration in speech intelligibility when patients are stimulated inside the nucleus at high voltage indicates a critical role for electrical stimulation parameters in speech motor control.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18785648</PMID><DateCreated><Year>2008</Year><Month>12</Month><Day>29</Day></DateCreated><DateCompleted><Year>2009</Year><Month>04</Month><Day>08</Day></DateCompleted><DateRevised><Year>2012</Year><Month>01</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>16</Issue><PubDate><Year>2008</Year><Month>Dec</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. 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The site of stimulation was defined on the postoperative stereotactic MRI data. Speech protocol consisted of the assessment of intelligibility of the dysarthric speech, maximum sustained phonation, and a 1-minute monologue. Movement was assessed using the UPDRS-III. Stimulation at 4 V significantly reduced the speech intelligibility (P = 0.004) independently from the site of stimulation. Stimulation at 4 V significantly improved the motor function. Stimulation inside the nucleus was significantly more effective than outside the nucleus (P = 0.0006). The significant improvement in movement coupled with significant deterioration in speech intelligibility when patients are stimulated inside the nucleus at high voltage indicates a critical role for electrical stimulation parameters in speech motor control.</AbstractText><CopyrightInformation>(c) 2008 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tripoliti</LastName><ForeName>Elina</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Unit of Functional Neurosurgery, Sobell Department, Institute of Neurology, London, United Kingdom. e.tripoliti@ion.ucl.ac.uk</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zrinzo</LastName><ForeName>Ludvic</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Martinez-Torres</LastName><ForeName>Irene</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Tisch</LastName><ForeName>Stephen</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Frost</LastName><ForeName>Eleanor</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Borrell</LastName><ForeName>Ellie</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Hariz</LastName><ForeName>Marwan I</ForeName><Initials>MI</Initials></Author><Author ValidYN="Y"><LastName>Limousin</LastName><ForeName>Patricia</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>G-4070</GrantID><Agency>Parkinson's UK</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01-NS40902</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType 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UI="D013060">Speech</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020531">Subthalamic Nucleus</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>9</Month><Day>13</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>4</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>9</Month><Day>13</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.22296</ArticleId><ArticleId IdType="pubmed">18785648</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><noCountry><name sortKey="Borrell, Ellie" sort="Borrell, Ellie" uniqKey="Borrell E" first="Ellie" last="Borrell">Ellie Borrell</name><name sortKey="Frost, Eleanor" sort="Frost, Eleanor" uniqKey="Frost E" first="Eleanor" last="Frost">Eleanor Frost</name><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I" last="Hariz">Marwan I. Hariz</name><name sortKey="Limousin, Patricia" sort="Limousin, Patricia" uniqKey="Limousin P" first="Patricia" last="Limousin">Patricia Limousin</name><name sortKey="Martinez Torres, Irene" sort="Martinez Torres, Irene" uniqKey="Martinez Torres I" first="Irene" last="Martinez-Torres">Irene Martinez-Torres</name><name sortKey="Tisch, Stephen" sort="Tisch, Stephen" uniqKey="Tisch S" first="Stephen" last="Tisch">Stephen Tisch</name><name sortKey="Zrinzo, Ludvic" sort="Zrinzo, Ludvic" uniqKey="Zrinzo L" first="Ludvic" last="Zrinzo">Ludvic Zrinzo</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Tripoliti, Elina" sort="Tripoliti, Elina" uniqKey="Tripoliti E" first="Elina" last="Tripoliti">Elina Tripoliti</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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