High frequency extradural motor cortex stimulation transiently improves axial symptoms in a patient with Parkinson's disease.
Identifieur interne : 002252 ( Ncbi/Merge ); précédent : 002251; suivant : 002253High frequency extradural motor cortex stimulation transiently improves axial symptoms in a patient with Parkinson's disease.
Auteurs : Alfonso Fasano [Italie] ; Carla Piano ; Celestino De Simone ; Beatrice Cioni ; Daniela Di Giuda ; Massimiliano Zinno ; Antonio Daniele ; Mario Meglio ; Alessandro Giordano ; Anna Rita BentivoglioSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Cognition (physiology), Deep Brain Stimulation (methods), Female, Follow-Up Studies, Humans, Motor Cortex (physiopathology), Movement Disorders (etiology), Movement Disorders (radionuclide imaging), Movement Disorders (therapy), Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (radionuclide imaging), Tomography, Emission-Computed, Single-Photon (methods).
- MESH :
- complications : Parkinson Disease.
- etiology : Movement Disorders.
- methods : Deep Brain Stimulation, Tomography, Emission-Computed, Single-Photon.
- physiology : Cognition.
- physiopathology : Motor Cortex.
- radionuclide imaging : Movement Disorders, Parkinson Disease.
- therapy : Movement Disorders.
- Aged, Female, Follow-Up Studies, Humans, Neuropsychological Tests.
Abstract
In a primate model of Parkinson's disease (PD), the benefit of extradural motor cortex stimulation (EMCS) was associated with high-frequency stimulation (130 Hz), whereas no significant motor improvement was achieved at 10 Hz or intermediate frequencies of stimulation. We report the case of a 72-year-old female patient affected by severe PD who underwent bilateral EMCS. In baseline med-off condition the patient was unable to arise from a chair and to stand without assistance. Stimulation at 3 and 60 Hz failed to provide any improvement of symptoms, whereas, when stimulating at 130 Hz, axial akinesia and walking improved consistently: the patient, in med-off condition, was able to arise from chair and to walk without assistance. The patient underwent two brain 99mTc- Ethylcysteinate Dimer-SPECT studies: semiquantitative and Statistical Parametric Mapping revealed that the regional cerebral perfusion was significantly increased in the supplementary motor area during stimulation at 130 Hz. After five months, the benefit of EMCS gradually disappeared.
DOI: 10.1002/mds.21977
PubMed: 18709668
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first="Celestino" last="De Simone">Celestino De Simone</name></author><author><name sortKey="Cioni, Beatrice" sort="Cioni, Beatrice" uniqKey="Cioni B" first="Beatrice" last="Cioni">Beatrice Cioni</name></author><author><name sortKey="Di Giuda, Daniela" sort="Di Giuda, Daniela" uniqKey="Di Giuda D" first="Daniela" last="Di Giuda">Daniela Di Giuda</name></author><author><name sortKey="Zinno, Massimiliano" sort="Zinno, Massimiliano" uniqKey="Zinno M" first="Massimiliano" last="Zinno">Massimiliano Zinno</name></author><author><name sortKey="Daniele, Antonio" sort="Daniele, Antonio" uniqKey="Daniele A" first="Antonio" last="Daniele">Antonio Daniele</name></author><author><name sortKey="Meglio, Mario" sort="Meglio, Mario" uniqKey="Meglio M" first="Mario" last="Meglio">Mario Meglio</name></author><author><name sortKey="Giordano, Alessandro" sort="Giordano, Alessandro" uniqKey="Giordano A" first="Alessandro" last="Giordano">Alessandro Giordano</name></author><author><name sortKey="Bentivoglio, 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Cuore, Roma, Italia. alfonso.fasano@rm.unicatt.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Neurologia, Università Cattolica del Sacro Cuore, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Piano, Carla" sort="Piano, Carla" uniqKey="Piano C" first="Carla" last="Piano">Carla Piano</name></author><author><name sortKey="De Simone, Celestino" sort="De Simone, Celestino" uniqKey="De Simone C" first="Celestino" last="De Simone">Celestino De Simone</name></author><author><name sortKey="Cioni, Beatrice" sort="Cioni, Beatrice" uniqKey="Cioni B" first="Beatrice" last="Cioni">Beatrice Cioni</name></author><author><name sortKey="Di Giuda, Daniela" sort="Di Giuda, Daniela" uniqKey="Di Giuda D" first="Daniela" last="Di Giuda">Daniela Di Giuda</name></author><author><name sortKey="Zinno, Massimiliano" sort="Zinno, Massimiliano" uniqKey="Zinno M" first="Massimiliano" last="Zinno">Massimiliano Zinno</name></author><author><name sortKey="Daniele, Antonio" sort="Daniele, Antonio" uniqKey="Daniele A" first="Antonio" last="Daniele">Antonio Daniele</name></author><author><name sortKey="Meglio, Mario" sort="Meglio, Mario" uniqKey="Meglio M" first="Mario" last="Meglio">Mario Meglio</name></author><author><name sortKey="Giordano, Alessandro" sort="Giordano, Alessandro" uniqKey="Giordano A" first="Alessandro" last="Giordano">Alessandro Giordano</name></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cognition (physiology)</term><term>Deep Brain Stimulation (methods)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Motor Cortex (physiopathology)</term><term>Movement Disorders (etiology)</term><term>Movement Disorders (radionuclide imaging)</term><term>Movement Disorders (therapy)</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cognition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Movement Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In a primate model of Parkinson's disease (PD), the benefit of extradural motor cortex stimulation (EMCS) was associated with high-frequency stimulation (130 Hz), whereas no significant motor improvement was achieved at 10 Hz or intermediate frequencies of stimulation. We report the case of a 72-year-old female patient affected by severe PD who underwent bilateral EMCS. In baseline med-off condition the patient was unable to arise from a chair and to stand without assistance. Stimulation at 3 and 60 Hz failed to provide any improvement of symptoms, whereas, when stimulating at 130 Hz, axial akinesia and walking improved consistently: the patient, in med-off condition, was able to arise from chair and to walk without assistance. The patient underwent two brain 99mTc- Ethylcysteinate Dimer-SPECT studies: semiquantitative and Statistical Parametric Mapping revealed that the regional cerebral perfusion was significantly increased in the supplementary motor area during stimulation at 130 Hz. After five months, the benefit of EMCS gradually disappeared.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18709668</PMID><DateCreated><Year>2008</Year><Month>11</Month><Day>04</Day></DateCreated><DateCompleted><Year>2009</Year><Month>04</Month><Day>08</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>13</Issue><PubDate><Year>2008</Year><Month>Oct</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>High frequency extradural motor cortex stimulation transiently improves axial symptoms in a patient with Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1916-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.21977</ELocationID><Abstract><AbstractText>In a primate model of Parkinson's disease (PD), the benefit of extradural motor cortex stimulation (EMCS) was associated with high-frequency stimulation (130 Hz), whereas no significant motor improvement was achieved at 10 Hz or intermediate frequencies of stimulation. We report the case of a 72-year-old female patient affected by severe PD who underwent bilateral EMCS. In baseline med-off condition the patient was unable to arise from a chair and to stand without assistance. Stimulation at 3 and 60 Hz failed to provide any improvement of symptoms, whereas, when stimulating at 130 Hz, axial akinesia and walking improved consistently: the patient, in med-off condition, was able to arise from chair and to walk without assistance. The patient underwent two brain 99mTc- Ethylcysteinate Dimer-SPECT studies: semiquantitative and Statistical Parametric Mapping revealed that the regional cerebral perfusion was significantly increased in the supplementary motor area during stimulation at 130 Hz. After five months, the benefit of EMCS gradually disappeared.</AbstractText><CopyrightInformation>(c) 2008 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fasano</LastName><ForeName>Alfonso</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Istituto di Neurologia, Università Cattolica del Sacro Cuore, Roma, Italia. alfonso.fasano@rm.unicatt.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Piano</LastName><ForeName>Carla</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>De Simone</LastName><ForeName>Celestino</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Cioni</LastName><ForeName>Beatrice</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Di Giuda</LastName><ForeName>Daniela</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Zinno</LastName><ForeName>Massimiliano</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Daniele</LastName><ForeName>Antonio</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Meglio</LastName><ForeName>Mario</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Giordano</LastName><ForeName>Alessandro</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Bentivoglio</LastName><ForeName>Anna Rita</ForeName><Initials>AR</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003071">Cognition</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D046690">Deep Brain Stimulation</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005500">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009044">Motor Cortex</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009069">Movement Disorders</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015899">Tomography, Emission-Computed, Single-Photon</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>8</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>4</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>8</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.21977</ArticleId><ArticleId IdType="pubmed">18709668</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><noCountry><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><name sortKey="Cioni, Beatrice" sort="Cioni, Beatrice" uniqKey="Cioni B" first="Beatrice" last="Cioni">Beatrice Cioni</name><name sortKey="Daniele, Antonio" sort="Daniele, Antonio" uniqKey="Daniele A" first="Antonio" last="Daniele">Antonio Daniele</name><name sortKey="De Simone, Celestino" sort="De Simone, Celestino" uniqKey="De Simone C" first="Celestino" last="De Simone">Celestino De Simone</name><name sortKey="Di Giuda, Daniela" sort="Di Giuda, Daniela" uniqKey="Di Giuda D" first="Daniela" last="Di Giuda">Daniela Di Giuda</name><name sortKey="Giordano, Alessandro" sort="Giordano, Alessandro" uniqKey="Giordano A" first="Alessandro" last="Giordano">Alessandro Giordano</name><name sortKey="Meglio, Mario" sort="Meglio, Mario" uniqKey="Meglio M" first="Mario" last="Meglio">Mario Meglio</name><name sortKey="Piano, Carla" sort="Piano, Carla" uniqKey="Piano C" first="Carla" last="Piano">Carla Piano</name><name sortKey="Zinno, Massimiliano" sort="Zinno, Massimiliano" uniqKey="Zinno M" first="Massimiliano" last="Zinno">Massimiliano Zinno</name></noCountry><country name="Italie"><region name="Latium"><name sortKey="Fasano, Alfonso" sort="Fasano, Alfonso" uniqKey="Fasano A" first="Alfonso" last="Fasano">Alfonso Fasano</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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