MovDisordV3, Ncbi, Merge, bibRecord, 002220

Huntington CAG repeat size does not modify onset age in familial Parkinson’s disease: The GenePD Study

Identifieur interne : 002220 ( Ncbi/Merge ); précédent : 002219; suivant : 002221

Huntington CAG repeat size does not modify onset age in familial Parkinson’s disease: The GenePD Study

Auteurs : Christopher F. Mcnicoll [États-Unis] ; Jeanne C. Latourelle [États-Unis] ; Marcy E. Macdonald [États-Unis] ; Mark F. Lew [États-Unis] ; Oksana Suchowersky [Canada] ; Christine Klein [Allemagne] ; Lawrence I. Golbe [États-Unis] ; Margery H. Mark [États-Unis] ; John H. Growdon [États-Unis] ; G. Frederick Wooten [États-Unis] ; Ray L. Watts ; Mark Guttman [Canada] ; Brad A. Racette [États-Unis] ; Joel S. Perlmutter [États-Unis] ; Anwar Ahmed ; Holly A. Shill ; Carlos Singer [États-Unis] ; Marie H. Saint-Hilaire [États-Unis] ; Tiffany Massood [États-Unis] ; Karen W. Huskey [États-Unis] ; Anita L. Destefano [États-Unis] ; Tammy Gillis [États-Unis] ; Jayalakshmi Mysore [États-Unis] ; Stefano Goldwurm [Italie] ; Gianni Pezzoli [Italie] ; Kenneth B. Baker [États-Unis] ; Ilia Itin [États-Unis] ; Irene Litvan [États-Unis] ; Garth Nicholson [Australie] ; Alastair Corbett [Australie] ; Martha Nance [États-Unis] ; Edward Drasby [États-Unis] ; Stuart Isaacson [États-Unis] ; David J. Burn [Royaume-Uni] ; Patrick F. Chinnery [Royaume-Uni] ; Peter P. Pramstaller [Italie] ; Jomana Al-Hinti [États-Unis] ; Anette T. Moller [Danemark] ; Karen Ostergaard [Danemark] ; Scott J. Sherman [États-Unis] ; Richard Roxburgh [Nouvelle-Zélande] ; Barry Snow [Nouvelle-Zélande] ; John T. Slevin [États-Unis] ; Franca Cambi [États-Unis] ; James F. Gusella [États-Unis] ; Richard H. Myers [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2008.

RBID : PMC:2655323

English descriptors

KwdEn :
- Adult, Age of Onset, Aged, Aged, 80 and over, Family Health, Female, Genotype, Humans, Huntington Disease (epidemiology), Huntington Disease (genetics), Male, Middle Aged, Nerve Tissue Proteins (genetics), Nuclear Proteins (genetics), Parkinson Disease (genetics), Parkinson Disease (physiopathology), Trinucleotide Repeats (genetics).
MESH :
- chemical , genetics : Nerve Tissue Proteins, Nuclear Proteins.
- epidemiology : Huntington Disease.
- genetics : Huntington Disease, Parkinson Disease, Trinucleotide Repeats.
- physiopathology : Parkinson Disease.
- Adult, Age of Onset, Aged, Aged, 80 and over, Family Health, Female, Genotype, Humans, Male, Middle Aged.

Abstract

The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (HD) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson’s disease (PD) and therefore, we evaluated the relationship of the HD CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n=495) with known onset ages from 248 families, were genotyped for the HD CAG repeat. Genotyping failed in 11 cases leaving 484 for analysis, including 35 LRRK2 carriers. All cases had HD CAG repeats (range 15 to 34) below the clinical range for HD, although 5.2 percent of the sample (n=25) had repeats in the intermediate range (the intermediate range lower limit=27; upper limit=35 repeats), suggesting that the prevalence of intermediate allele carriers in the general population is significant. No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655323

DOI: 10.1002/mds.22186
PubMed: 18649400
PubMed Central: 2655323

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Le document en format XML

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<author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L." last="Watts">Ray L. Watts</name>
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<author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
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<placeName><region type="state">Missouri (État)</region>
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<author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
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<placeName><region type="state">Missouri (État)</region>
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<author><name sortKey="Ahmed, Anwar" sort="Ahmed, Anwar" uniqKey="Ahmed A" first="Anwar" last="Ahmed">Anwar Ahmed</name>
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<author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A." last="Shill">Holly A. Shill</name>
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<author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name>
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<placeName><region type="state">Floride</region>
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<wicri:cityArea>Department of Neurology, University of Miami, Miami</wicri:cityArea>
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<author><name sortKey="Saint Hilaire, Marie H" sort="Saint Hilaire, Marie H" uniqKey="Saint Hilaire M" first="Marie H." last="Saint-Hilaire">Marie H. Saint-Hilaire</name>
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<placeName><region type="state">Massachusetts</region>
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<author><name sortKey="Massood, Tiffany" sort="Massood, Tiffany" uniqKey="Massood T" first="Tiffany" last="Massood">Tiffany Massood</name>
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<placeName><region type="state">Massachusetts</region>
</placeName>
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<author><name sortKey="Huskey, Karen W" sort="Huskey, Karen W" uniqKey="Huskey K" first="Karen W." last="Huskey">Karen W. Huskey</name>
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<placeName><region type="state">Massachusetts</region>
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<author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
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</author>
<author><name sortKey="Gillis, Tammy" sort="Gillis, Tammy" uniqKey="Gillis T" first="Tammy" last="Gillis">Tammy Gillis</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
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<author><name sortKey="Mysore, Jayalakshmi" sort="Mysore, Jayalakshmi" uniqKey="Mysore J" first="Jayalakshmi" last="Mysore">Jayalakshmi Mysore</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name>
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</author>
<author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Baker, Kenneth B" sort="Baker, Kenneth B" uniqKey="Baker K" first="Kenneth B." last="Baker">Kenneth B. Baker</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Itin, Ilia" sort="Itin, Ilia" uniqKey="Itin I" first="Ilia" last="Itin">Ilia Itin</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Neurology, University of Louisville School of Medicine, Louisville, KY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Louisville School of Medicine, Louisville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nicholson, Garth" sort="Nicholson, Garth" uniqKey="Nicholson G" first="Garth" last="Nicholson">Garth Nicholson</name>
<affiliation wicri:level="3"><nlm:aff id="A19">Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Corbett, Alastair" sort="Corbett, Alastair" uniqKey="Corbett A" first="Alastair" last="Corbett">Alastair Corbett</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nance, Martha" sort="Nance, Martha" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name>
<affiliation wicri:level="2"><nlm:aff id="A20">Struthers Parkinson’s Center, Park Nicollet Clinic, Golden Valley, MN</nlm:aff>
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<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Struthers Parkinson’s Center, Park Nicollet Clinic, Golden Valley</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Drasby, Edward" sort="Drasby, Edward" uniqKey="Drasby E" first="Edward" last="Drasby">Edward Drasby</name>
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<placeName><region type="state">Maine (État)</region>
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<wicri:cityArea>Port City Neurology, Scarborough</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Isaacson, Stuart" sort="Isaacson, Stuart" uniqKey="Isaacson S" first="Stuart" last="Isaacson">Stuart Isaacson</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Parkinson’s Disease and Movement Disorder Center of Boca Raton, Boca Raton, FL</nlm:aff>
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<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Parkinson’s Disease and Movement Disorder Center of Boca Raton, Boca Raton</wicri:cityArea>
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</author>
<author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute for Ageing and Health, Newcastle upon Tyne</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Chinnery, Patrick F" sort="Chinnery, Patrick F" uniqKey="Chinnery P" first="Patrick F." last="Chinnery">Patrick F. Chinnery</name>
<affiliation wicri:level="1"><nlm:aff id="A24">Regional Neurosciences Centre, Newcastle University, Newcastle upon Tyne, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Regional Neurosciences Centre, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name>
<affiliation wicri:level="1"><nlm:aff id="A25">Department of Neurology, General Regional Hospital Bolzano, Bolzano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, General Regional Hospital Bolzano, Bolzano</wicri:regionArea>
<wicri:noRegion>Bolzano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Hinti, Jomana" sort="Al Hinti, Jomana" uniqKey="Al Hinti J" first="Jomana" last="Al-Hinti">Jomana Al-Hinti</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Department of Neurology, University of Arkansas for Medical Sciences, AR</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arkansas</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Arkansas for Medical Sciences</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Moller, Anette T" sort="Moller, Anette T" uniqKey="Moller A" first="Anette T." last="Moller">Anette T. Moller</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Department of Neurology, Aarhus University Hospital, Aarhus, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Neurology, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ostergaard, Karen" sort="Ostergaard, Karen" uniqKey="Ostergaard K" first="Karen" last="Ostergaard">Karen Ostergaard</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Department of Neurology, Aarhus University Hospital, Aarhus, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Neurology, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sherman, Scott J" sort="Sherman, Scott J" uniqKey="Sherman S" first="Scott J." last="Sherman">Scott J. Sherman</name>
<affiliation wicri:level="2"><nlm:aff id="A28">Department of Neurology, University of Arizona, Tucson, AZ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Arizona, Tucson</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Roxburgh, Richard" sort="Roxburgh, Richard" uniqKey="Roxburgh R" first="Richard" last="Roxburgh">Richard Roxburgh</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Neurology, Auckland City Hospital, Auckland, New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Neurology, Auckland City Hospital, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Snow, Barry" sort="Snow, Barry" uniqKey="Snow B" first="Barry" last="Snow">Barry Snow</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Neurology, Auckland City Hospital, Auckland, New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Neurology, Auckland City Hospital, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Slevin, John T" sort="Slevin, John T" uniqKey="Slevin J" first="John T." last="Slevin">John T. Slevin</name>
<affiliation wicri:level="2"><nlm:aff id="A30">Department of Neurology, University of Kentucky College of Medicine, Lexington, KY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Kentucky College of Medicine, Lexington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
<affiliation wicri:level="2"><nlm:aff id="A30">Department of Neurology, University of Kentucky College of Medicine, Lexington, KY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Kentucky College of Medicine, Lexington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gusella, James F" sort="Gusella, James F" uniqKey="Gusella J" first="James F." last="Gusella">James F. Gusella</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H." last="Myers">Richard H. Myers</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18649400</idno>
<idno type="pmc">2655323</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655323</idno>
<idno type="RBID">PMC:2655323</idno>
<idno type="doi">10.1002/mds.22186</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">000030</idno>
<idno type="wicri:Area/Pmc/Curation">000030</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000445</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">002143</idno>
<idno type="wicri:Area/PubMed/Curation">002143</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002258</idno>
<idno type="wicri:Area/Ncbi/Merge">002220</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Huntington CAG repeat size does not modify onset age in familial Parkinson’s disease: The <italic>Gene</italic>
PD Study</title>
<author><name sortKey="Mcnicoll, Christopher F" sort="Mcnicoll, Christopher F" uniqKey="Mcnicoll C" first="Christopher F." last="Mcnicoll">Christopher F. Mcnicoll</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Latourelle, Jeanne C" sort="Latourelle, Jeanne C" uniqKey="Latourelle J" first="Jeanne C." last="Latourelle">Jeanne C. Latourelle</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Macdonald, Marcy E" sort="Macdonald, Marcy E" uniqKey="Macdonald M" first="Marcy E." last="Macdonald">Marcy E. Macdonald</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F." last="Lew">Mark F. Lew</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurology, University of Southern California, Los Angeles, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name>
<affiliation wicri:level="4"><nlm:aff id="A6">Departments of Clinical Neurosciences and Medical Genetics, University of Calgary, Calgary, Alberta, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary, Calgary, Alberta</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Neurology, Medical University of Lübeck, Lübeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical University of Lübeck, Lübeck</wicri:regionArea>
<wicri:noRegion>Lübeck</wicri:noRegion>
<wicri:noRegion>Lübeck</wicri:noRegion>
<wicri:noRegion>Lübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I." last="Golbe">Lawrence I. Golbe</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H." last="Mark">Margery H. Mark</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology, Massachusetts General Hospital, Harvard Medical School Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Massachusetts General Hospital, Harvard Medical School Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wooten, G Frederick" sort="Wooten, G Frederick" uniqKey="Wooten G" first="G. Frederick" last="Wooten">G. Frederick Wooten</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Neurology, University of Virginia Health System, Charlottesville, VA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Virginia Health System, Charlottesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L." last="Watts">Ray L. Watts</name>
<affiliation><nlm:aff id="A10">Department of Neurology, University of Alabama at Birmingham, Birmingham AL</nlm:aff>
<wicri:noCountry code="subfield">Birmingham AL</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
<affiliation wicri:level="4"><nlm:aff id="A11">Department of Medicine, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Racette, Brad A" sort="Racette, Brad A" uniqKey="Racette B" first="Brad A." last="Racette">Brad A. Racette</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Department of Neurology, Washington University School of Medicine, Saint Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Department of Neurology, Washington University School of Medicine, Saint Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Department of Neurology, Washington University School of Medicine, Saint Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Department of Neurology, Washington University School of Medicine, Saint Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ahmed, Anwar" sort="Ahmed, Anwar" uniqKey="Ahmed A" first="Anwar" last="Ahmed">Anwar Ahmed</name>
<affiliation><nlm:aff id="A13">Barrow Neurological Institute, Phoenix AZ</nlm:aff>
<wicri:noCountry code="subfield">Phoenix AZ</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A." last="Shill">Holly A. Shill</name>
<affiliation><nlm:aff id="A14">Sun Health Research Institute, Sun City AZ</nlm:aff>
<wicri:noCountry code="subfield">Sun City AZ</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Neurology, University of Miami, Miami, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Miami, Miami</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Saint Hilaire, Marie H" sort="Saint Hilaire, Marie H" uniqKey="Saint Hilaire M" first="Marie H." last="Saint-Hilaire">Marie H. Saint-Hilaire</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Massood, Tiffany" sort="Massood, Tiffany" uniqKey="Massood T" first="Tiffany" last="Massood">Tiffany Massood</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Huskey, Karen W" sort="Huskey, Karen W" uniqKey="Huskey K" first="Karen W." last="Huskey">Karen W. Huskey</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Biostatistics, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Biostatistics, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gillis, Tammy" sort="Gillis, Tammy" uniqKey="Gillis T" first="Tammy" last="Gillis">Tammy Gillis</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mysore, Jayalakshmi" sort="Mysore, Jayalakshmi" uniqKey="Mysore J" first="Jayalakshmi" last="Mysore">Jayalakshmi Mysore</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baker, Kenneth B" sort="Baker, Kenneth B" uniqKey="Baker K" first="Kenneth B." last="Baker">Kenneth B. Baker</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Itin, Ilia" sort="Itin, Ilia" uniqKey="Itin I" first="Ilia" last="Itin">Ilia Itin</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Neurology, University of Louisville School of Medicine, Louisville, KY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Louisville School of Medicine, Louisville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nicholson, Garth" sort="Nicholson, Garth" uniqKey="Nicholson G" first="Garth" last="Nicholson">Garth Nicholson</name>
<affiliation wicri:level="3"><nlm:aff id="A19">Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Corbett, Alastair" sort="Corbett, Alastair" uniqKey="Corbett A" first="Alastair" last="Corbett">Alastair Corbett</name>
<affiliation wicri:level="3"><nlm:aff id="A19">Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nance, Martha" sort="Nance, Martha" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name>
<affiliation wicri:level="2"><nlm:aff id="A20">Struthers Parkinson’s Center, Park Nicollet Clinic, Golden Valley, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Struthers Parkinson’s Center, Park Nicollet Clinic, Golden Valley</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Drasby, Edward" sort="Drasby, Edward" uniqKey="Drasby E" first="Edward" last="Drasby">Edward Drasby</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Port City Neurology, Scarborough, ME</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maine (État)</region>
</placeName>
<wicri:cityArea>Port City Neurology, Scarborough</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Isaacson, Stuart" sort="Isaacson, Stuart" uniqKey="Isaacson S" first="Stuart" last="Isaacson">Stuart Isaacson</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Parkinson’s Disease and Movement Disorder Center of Boca Raton, Boca Raton, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Parkinson’s Disease and Movement Disorder Center of Boca Raton, Boca Raton</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name>
<affiliation wicri:level="1"><nlm:aff id="A23">Institute for Ageing and Health, Newcastle upon Tyne, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute for Ageing and Health, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chinnery, Patrick F" sort="Chinnery, Patrick F" uniqKey="Chinnery P" first="Patrick F." last="Chinnery">Patrick F. Chinnery</name>
<affiliation wicri:level="1"><nlm:aff id="A24">Regional Neurosciences Centre, Newcastle University, Newcastle upon Tyne, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Regional Neurosciences Centre, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name>
<affiliation wicri:level="1"><nlm:aff id="A25">Department of Neurology, General Regional Hospital Bolzano, Bolzano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, General Regional Hospital Bolzano, Bolzano</wicri:regionArea>
<wicri:noRegion>Bolzano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Hinti, Jomana" sort="Al Hinti, Jomana" uniqKey="Al Hinti J" first="Jomana" last="Al-Hinti">Jomana Al-Hinti</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Department of Neurology, University of Arkansas for Medical Sciences, AR</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arkansas</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Arkansas for Medical Sciences</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Moller, Anette T" sort="Moller, Anette T" uniqKey="Moller A" first="Anette T." last="Moller">Anette T. Moller</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Department of Neurology, Aarhus University Hospital, Aarhus, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Neurology, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ostergaard, Karen" sort="Ostergaard, Karen" uniqKey="Ostergaard K" first="Karen" last="Ostergaard">Karen Ostergaard</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Department of Neurology, Aarhus University Hospital, Aarhus, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Neurology, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sherman, Scott J" sort="Sherman, Scott J" uniqKey="Sherman S" first="Scott J." last="Sherman">Scott J. Sherman</name>
<affiliation wicri:level="2"><nlm:aff id="A28">Department of Neurology, University of Arizona, Tucson, AZ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Arizona, Tucson</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Roxburgh, Richard" sort="Roxburgh, Richard" uniqKey="Roxburgh R" first="Richard" last="Roxburgh">Richard Roxburgh</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Neurology, Auckland City Hospital, Auckland, New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Neurology, Auckland City Hospital, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Snow, Barry" sort="Snow, Barry" uniqKey="Snow B" first="Barry" last="Snow">Barry Snow</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Neurology, Auckland City Hospital, Auckland, New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Neurology, Auckland City Hospital, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Slevin, John T" sort="Slevin, John T" uniqKey="Slevin J" first="John T." last="Slevin">John T. Slevin</name>
<affiliation wicri:level="2"><nlm:aff id="A30">Department of Neurology, University of Kentucky College of Medicine, Lexington, KY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Kentucky College of Medicine, Lexington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
<affiliation wicri:level="2"><nlm:aff id="A30">Department of Neurology, University of Kentucky College of Medicine, Lexington, KY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Kentucky College of Medicine, Lexington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gusella, James F" sort="Gusella, James F" uniqKey="Gusella J" first="James F." last="Gusella">James F. Gusella</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H." last="Myers">Richard H. Myers</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Family Health</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Huntington Disease (epidemiology)</term>
<term>Huntington Disease (genetics)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nerve Tissue Proteins (genetics)</term>
<term>Nuclear Proteins (genetics)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Trinucleotide Repeats (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nerve Tissue Proteins</term>
<term>Nuclear Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Huntington Disease</term>
<term>Parkinson Disease</term>
<term>Trinucleotide Repeats</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Family Health</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (<italic>HD</italic>
) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson’s disease (PD) and therefore, we evaluated the relationship of the <italic>HD</italic>
 CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n=495) with known onset ages from 248 families, were genotyped for the <italic>HD</italic>
 CAG repeat. Genotyping failed in 11 cases leaving 484 for analysis, including 35 <italic>LRRK2</italic>
 carriers. All cases had <italic>HD</italic>
 CAG repeats (range 15 to 34) below the clinical range for HD, although 5.2 percent of the sample (n=25) had repeats in the intermediate range (the intermediate range lower limit=27; upper limit=35 repeats), suggesting that the prevalence of intermediate allele carriers in the general population is significant. No relation between the <italic>HD</italic>
 CAG repeat size and the age at onset for PD was found in this sample of familial PD.</p>
</div>
</front>
</TEI>
<double pmid="18649400"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Huntington CAG repeat size does not modify onset age in familial Parkinson’s disease: The <italic>Gene</italic>
PD Study</title>
<author><name sortKey="Mcnicoll, Christopher F" sort="Mcnicoll, Christopher F" uniqKey="Mcnicoll C" first="Christopher F." last="Mcnicoll">Christopher F. Mcnicoll</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Latourelle, Jeanne C" sort="Latourelle, Jeanne C" uniqKey="Latourelle J" first="Jeanne C." last="Latourelle">Jeanne C. Latourelle</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Macdonald, Marcy E" sort="Macdonald, Marcy E" uniqKey="Macdonald M" first="Marcy E." last="Macdonald">Marcy E. Macdonald</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F." last="Lew">Mark F. Lew</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurology, University of Southern California, Los Angeles, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name>
<affiliation wicri:level="4"><nlm:aff id="A6">Departments of Clinical Neurosciences and Medical Genetics, University of Calgary, Calgary, Alberta, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary, Calgary, Alberta</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Neurology, Medical University of Lübeck, Lübeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical University of Lübeck, Lübeck</wicri:regionArea>
<wicri:noRegion>Lübeck</wicri:noRegion>
<wicri:noRegion>Lübeck</wicri:noRegion>
<wicri:noRegion>Lübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I." last="Golbe">Lawrence I. Golbe</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H." last="Mark">Margery H. Mark</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology, Massachusetts General Hospital, Harvard Medical School Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Massachusetts General Hospital, Harvard Medical School Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wooten, G Frederick" sort="Wooten, G Frederick" uniqKey="Wooten G" first="G. Frederick" last="Wooten">G. Frederick Wooten</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Neurology, University of Virginia Health System, Charlottesville, VA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Virginia Health System, Charlottesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L." last="Watts">Ray L. Watts</name>
<affiliation><nlm:aff id="A10">Department of Neurology, University of Alabama at Birmingham, Birmingham AL</nlm:aff>
<wicri:noCountry code="subfield">Birmingham AL</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
<affiliation wicri:level="4"><nlm:aff id="A11">Department of Medicine, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Racette, Brad A" sort="Racette, Brad A" uniqKey="Racette B" first="Brad A." last="Racette">Brad A. Racette</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Department of Neurology, Washington University School of Medicine, Saint Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Department of Neurology, Washington University School of Medicine, Saint Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Department of Neurology, Washington University School of Medicine, Saint Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Department of Neurology, Washington University School of Medicine, Saint Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ahmed, Anwar" sort="Ahmed, Anwar" uniqKey="Ahmed A" first="Anwar" last="Ahmed">Anwar Ahmed</name>
<affiliation><nlm:aff id="A13">Barrow Neurological Institute, Phoenix AZ</nlm:aff>
<wicri:noCountry code="subfield">Phoenix AZ</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A." last="Shill">Holly A. Shill</name>
<affiliation><nlm:aff id="A14">Sun Health Research Institute, Sun City AZ</nlm:aff>
<wicri:noCountry code="subfield">Sun City AZ</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Neurology, University of Miami, Miami, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Miami, Miami</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Saint Hilaire, Marie H" sort="Saint Hilaire, Marie H" uniqKey="Saint Hilaire M" first="Marie H." last="Saint-Hilaire">Marie H. Saint-Hilaire</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Massood, Tiffany" sort="Massood, Tiffany" uniqKey="Massood T" first="Tiffany" last="Massood">Tiffany Massood</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Huskey, Karen W" sort="Huskey, Karen W" uniqKey="Huskey K" first="Karen W." last="Huskey">Karen W. Huskey</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Biostatistics, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Biostatistics, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gillis, Tammy" sort="Gillis, Tammy" uniqKey="Gillis T" first="Tammy" last="Gillis">Tammy Gillis</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mysore, Jayalakshmi" sort="Mysore, Jayalakshmi" uniqKey="Mysore J" first="Jayalakshmi" last="Mysore">Jayalakshmi Mysore</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baker, Kenneth B" sort="Baker, Kenneth B" uniqKey="Baker K" first="Kenneth B." last="Baker">Kenneth B. Baker</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Itin, Ilia" sort="Itin, Ilia" uniqKey="Itin I" first="Ilia" last="Itin">Ilia Itin</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Neurology, University of Louisville School of Medicine, Louisville, KY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Louisville School of Medicine, Louisville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nicholson, Garth" sort="Nicholson, Garth" uniqKey="Nicholson G" first="Garth" last="Nicholson">Garth Nicholson</name>
<affiliation wicri:level="3"><nlm:aff id="A19">Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Corbett, Alastair" sort="Corbett, Alastair" uniqKey="Corbett A" first="Alastair" last="Corbett">Alastair Corbett</name>
<affiliation wicri:level="3"><nlm:aff id="A19">Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nance, Martha" sort="Nance, Martha" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name>
<affiliation wicri:level="2"><nlm:aff id="A20">Struthers Parkinson’s Center, Park Nicollet Clinic, Golden Valley, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Struthers Parkinson’s Center, Park Nicollet Clinic, Golden Valley</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Drasby, Edward" sort="Drasby, Edward" uniqKey="Drasby E" first="Edward" last="Drasby">Edward Drasby</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Port City Neurology, Scarborough, ME</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maine (État)</region>
</placeName>
<wicri:cityArea>Port City Neurology, Scarborough</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Isaacson, Stuart" sort="Isaacson, Stuart" uniqKey="Isaacson S" first="Stuart" last="Isaacson">Stuart Isaacson</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Parkinson’s Disease and Movement Disorder Center of Boca Raton, Boca Raton, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Parkinson’s Disease and Movement Disorder Center of Boca Raton, Boca Raton</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name>
<affiliation wicri:level="1"><nlm:aff id="A23">Institute for Ageing and Health, Newcastle upon Tyne, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute for Ageing and Health, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chinnery, Patrick F" sort="Chinnery, Patrick F" uniqKey="Chinnery P" first="Patrick F." last="Chinnery">Patrick F. Chinnery</name>
<affiliation wicri:level="1"><nlm:aff id="A24">Regional Neurosciences Centre, Newcastle University, Newcastle upon Tyne, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Regional Neurosciences Centre, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name>
<affiliation wicri:level="1"><nlm:aff id="A25">Department of Neurology, General Regional Hospital Bolzano, Bolzano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, General Regional Hospital Bolzano, Bolzano</wicri:regionArea>
<wicri:noRegion>Bolzano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Hinti, Jomana" sort="Al Hinti, Jomana" uniqKey="Al Hinti J" first="Jomana" last="Al-Hinti">Jomana Al-Hinti</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Department of Neurology, University of Arkansas for Medical Sciences, AR</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arkansas</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Arkansas for Medical Sciences</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Moller, Anette T" sort="Moller, Anette T" uniqKey="Moller A" first="Anette T." last="Moller">Anette T. Moller</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Department of Neurology, Aarhus University Hospital, Aarhus, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Neurology, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ostergaard, Karen" sort="Ostergaard, Karen" uniqKey="Ostergaard K" first="Karen" last="Ostergaard">Karen Ostergaard</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Department of Neurology, Aarhus University Hospital, Aarhus, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Neurology, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sherman, Scott J" sort="Sherman, Scott J" uniqKey="Sherman S" first="Scott J." last="Sherman">Scott J. Sherman</name>
<affiliation wicri:level="2"><nlm:aff id="A28">Department of Neurology, University of Arizona, Tucson, AZ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Arizona, Tucson</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Roxburgh, Richard" sort="Roxburgh, Richard" uniqKey="Roxburgh R" first="Richard" last="Roxburgh">Richard Roxburgh</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Neurology, Auckland City Hospital, Auckland, New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Neurology, Auckland City Hospital, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Snow, Barry" sort="Snow, Barry" uniqKey="Snow B" first="Barry" last="Snow">Barry Snow</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Neurology, Auckland City Hospital, Auckland, New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Neurology, Auckland City Hospital, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Slevin, John T" sort="Slevin, John T" uniqKey="Slevin J" first="John T." last="Slevin">John T. Slevin</name>
<affiliation wicri:level="2"><nlm:aff id="A30">Department of Neurology, University of Kentucky College of Medicine, Lexington, KY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Kentucky College of Medicine, Lexington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
<affiliation wicri:level="2"><nlm:aff id="A30">Department of Neurology, University of Kentucky College of Medicine, Lexington, KY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Kentucky College of Medicine, Lexington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gusella, James F" sort="Gusella, James F" uniqKey="Gusella J" first="James F." last="Gusella">James F. Gusella</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H." last="Myers">Richard H. Myers</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18649400</idno>
<idno type="pmc">2655323</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655323</idno>
<idno type="RBID">PMC:2655323</idno>
<idno type="doi">10.1002/mds.22186</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">000030</idno>
<idno type="wicri:Area/Pmc/Curation">000030</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000445</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Huntington CAG repeat size does not modify onset age in familial Parkinson’s disease: The <italic>Gene</italic>
PD Study</title>
<author><name sortKey="Mcnicoll, Christopher F" sort="Mcnicoll, Christopher F" uniqKey="Mcnicoll C" first="Christopher F." last="Mcnicoll">Christopher F. Mcnicoll</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Latourelle, Jeanne C" sort="Latourelle, Jeanne C" uniqKey="Latourelle J" first="Jeanne C." last="Latourelle">Jeanne C. Latourelle</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Macdonald, Marcy E" sort="Macdonald, Marcy E" uniqKey="Macdonald M" first="Marcy E." last="Macdonald">Marcy E. Macdonald</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F." last="Lew">Mark F. Lew</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurology, University of Southern California, Los Angeles, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name>
<affiliation wicri:level="4"><nlm:aff id="A6">Departments of Clinical Neurosciences and Medical Genetics, University of Calgary, Calgary, Alberta, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary, Calgary, Alberta</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Neurology, Medical University of Lübeck, Lübeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical University of Lübeck, Lübeck</wicri:regionArea>
<wicri:noRegion>Lübeck</wicri:noRegion>
<wicri:noRegion>Lübeck</wicri:noRegion>
<wicri:noRegion>Lübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I." last="Golbe">Lawrence I. Golbe</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H." last="Mark">Margery H. Mark</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology, Massachusetts General Hospital, Harvard Medical School Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Massachusetts General Hospital, Harvard Medical School Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wooten, G Frederick" sort="Wooten, G Frederick" uniqKey="Wooten G" first="G. Frederick" last="Wooten">G. Frederick Wooten</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Neurology, University of Virginia Health System, Charlottesville, VA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Virginia Health System, Charlottesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L." last="Watts">Ray L. Watts</name>
<affiliation><nlm:aff id="A10">Department of Neurology, University of Alabama at Birmingham, Birmingham AL</nlm:aff>
<wicri:noCountry code="subfield">Birmingham AL</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
<affiliation wicri:level="4"><nlm:aff id="A11">Department of Medicine, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Racette, Brad A" sort="Racette, Brad A" uniqKey="Racette B" first="Brad A." last="Racette">Brad A. Racette</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Department of Neurology, Washington University School of Medicine, Saint Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Department of Neurology, Washington University School of Medicine, Saint Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Department of Neurology, Washington University School of Medicine, Saint Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Department of Neurology, Washington University School of Medicine, Saint Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ahmed, Anwar" sort="Ahmed, Anwar" uniqKey="Ahmed A" first="Anwar" last="Ahmed">Anwar Ahmed</name>
<affiliation><nlm:aff id="A13">Barrow Neurological Institute, Phoenix AZ</nlm:aff>
<wicri:noCountry code="subfield">Phoenix AZ</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A." last="Shill">Holly A. Shill</name>
<affiliation><nlm:aff id="A14">Sun Health Research Institute, Sun City AZ</nlm:aff>
<wicri:noCountry code="subfield">Sun City AZ</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Neurology, University of Miami, Miami, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Miami, Miami</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Saint Hilaire, Marie H" sort="Saint Hilaire, Marie H" uniqKey="Saint Hilaire M" first="Marie H." last="Saint-Hilaire">Marie H. Saint-Hilaire</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Massood, Tiffany" sort="Massood, Tiffany" uniqKey="Massood T" first="Tiffany" last="Massood">Tiffany Massood</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Huskey, Karen W" sort="Huskey, Karen W" uniqKey="Huskey K" first="Karen W." last="Huskey">Karen W. Huskey</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Biostatistics, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Biostatistics, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gillis, Tammy" sort="Gillis, Tammy" uniqKey="Gillis T" first="Tammy" last="Gillis">Tammy Gillis</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mysore, Jayalakshmi" sort="Mysore, Jayalakshmi" uniqKey="Mysore J" first="Jayalakshmi" last="Mysore">Jayalakshmi Mysore</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baker, Kenneth B" sort="Baker, Kenneth B" uniqKey="Baker K" first="Kenneth B." last="Baker">Kenneth B. Baker</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Itin, Ilia" sort="Itin, Ilia" uniqKey="Itin I" first="Ilia" last="Itin">Ilia Itin</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Neurology, University of Louisville School of Medicine, Louisville, KY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Louisville School of Medicine, Louisville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nicholson, Garth" sort="Nicholson, Garth" uniqKey="Nicholson G" first="Garth" last="Nicholson">Garth Nicholson</name>
<affiliation wicri:level="3"><nlm:aff id="A19">Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Corbett, Alastair" sort="Corbett, Alastair" uniqKey="Corbett A" first="Alastair" last="Corbett">Alastair Corbett</name>
<affiliation wicri:level="3"><nlm:aff id="A19">Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nance, Martha" sort="Nance, Martha" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name>
<affiliation wicri:level="2"><nlm:aff id="A20">Struthers Parkinson’s Center, Park Nicollet Clinic, Golden Valley, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Struthers Parkinson’s Center, Park Nicollet Clinic, Golden Valley</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Drasby, Edward" sort="Drasby, Edward" uniqKey="Drasby E" first="Edward" last="Drasby">Edward Drasby</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Port City Neurology, Scarborough, ME</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maine (État)</region>
</placeName>
<wicri:cityArea>Port City Neurology, Scarborough</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Isaacson, Stuart" sort="Isaacson, Stuart" uniqKey="Isaacson S" first="Stuart" last="Isaacson">Stuart Isaacson</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Parkinson’s Disease and Movement Disorder Center of Boca Raton, Boca Raton, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Parkinson’s Disease and Movement Disorder Center of Boca Raton, Boca Raton</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name>
<affiliation wicri:level="1"><nlm:aff id="A23">Institute for Ageing and Health, Newcastle upon Tyne, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute for Ageing and Health, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chinnery, Patrick F" sort="Chinnery, Patrick F" uniqKey="Chinnery P" first="Patrick F." last="Chinnery">Patrick F. Chinnery</name>
<affiliation wicri:level="1"><nlm:aff id="A24">Regional Neurosciences Centre, Newcastle University, Newcastle upon Tyne, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Regional Neurosciences Centre, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name>
<affiliation wicri:level="1"><nlm:aff id="A25">Department of Neurology, General Regional Hospital Bolzano, Bolzano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, General Regional Hospital Bolzano, Bolzano</wicri:regionArea>
<wicri:noRegion>Bolzano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Hinti, Jomana" sort="Al Hinti, Jomana" uniqKey="Al Hinti J" first="Jomana" last="Al-Hinti">Jomana Al-Hinti</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Department of Neurology, University of Arkansas for Medical Sciences, AR</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arkansas</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Arkansas for Medical Sciences</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Moller, Anette T" sort="Moller, Anette T" uniqKey="Moller A" first="Anette T." last="Moller">Anette T. Moller</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Department of Neurology, Aarhus University Hospital, Aarhus, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Neurology, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ostergaard, Karen" sort="Ostergaard, Karen" uniqKey="Ostergaard K" first="Karen" last="Ostergaard">Karen Ostergaard</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Department of Neurology, Aarhus University Hospital, Aarhus, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Neurology, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sherman, Scott J" sort="Sherman, Scott J" uniqKey="Sherman S" first="Scott J." last="Sherman">Scott J. Sherman</name>
<affiliation wicri:level="2"><nlm:aff id="A28">Department of Neurology, University of Arizona, Tucson, AZ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Arizona, Tucson</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Roxburgh, Richard" sort="Roxburgh, Richard" uniqKey="Roxburgh R" first="Richard" last="Roxburgh">Richard Roxburgh</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Neurology, Auckland City Hospital, Auckland, New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Neurology, Auckland City Hospital, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Snow, Barry" sort="Snow, Barry" uniqKey="Snow B" first="Barry" last="Snow">Barry Snow</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Neurology, Auckland City Hospital, Auckland, New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Neurology, Auckland City Hospital, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Slevin, John T" sort="Slevin, John T" uniqKey="Slevin J" first="John T." last="Slevin">John T. Slevin</name>
<affiliation wicri:level="2"><nlm:aff id="A30">Department of Neurology, University of Kentucky College of Medicine, Lexington, KY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Kentucky College of Medicine, Lexington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
<affiliation wicri:level="2"><nlm:aff id="A30">Department of Neurology, University of Kentucky College of Medicine, Lexington, KY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Kentucky College of Medicine, Lexington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gusella, James F" sort="Gusella, James F" uniqKey="Gusella J" first="James F." last="Gusella">James F. Gusella</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H." last="Myers">Richard H. Myers</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (<italic>HD</italic>
) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson’s disease (PD) and therefore, we evaluated the relationship of the <italic>HD</italic>
 CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n=495) with known onset ages from 248 families, were genotyped for the <italic>HD</italic>
 CAG repeat. Genotyping failed in 11 cases leaving 484 for analysis, including 35 <italic>LRRK2</italic>
 carriers. All cases had <italic>HD</italic>
 CAG repeats (range 15 to 34) below the clinical range for HD, although 5.2 percent of the sample (n=25) had repeats in the intermediate range (the intermediate range lower limit=27; upper limit=35 repeats), suggesting that the prevalence of intermediate allele carriers in the general population is significant. No relation between the <italic>HD</italic>
 CAG repeat size and the age at onset for PD was found in this sample of familial PD.</p>
</div>
</front>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: the GenePD study.</title>
<author><name sortKey="Mcnicoll, Christopher F" sort="Mcnicoll, Christopher F" uniqKey="Mcnicoll C" first="Christopher F" last="Mcnicoll">Christopher F. Mcnicoll</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts 02118, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts 02118</wicri:regionArea>
<wicri:noRegion>Massachusetts 02118</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Latourelle, Jeanne C" sort="Latourelle, Jeanne C" uniqKey="Latourelle J" first="Jeanne C" last="Latourelle">Jeanne C. Latourelle</name>
</author>
<author><name sortKey="Macdonald, Marcy E" sort="Macdonald, Marcy E" uniqKey="Macdonald M" first="Marcy E" last="Macdonald">Marcy E. Macdonald</name>
</author>
<author><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F" last="Lew">Mark F. Lew</name>
</author>
<author><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name>
</author>
<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
</author>
<author><name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I" last="Golbe">Lawrence I. Golbe</name>
</author>
<author><name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H" last="Mark">Margery H. Mark</name>
</author>
<author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H" last="Growdon">John H. Growdon</name>
</author>
<author><name sortKey="Wooten, G Frederick" sort="Wooten, G Frederick" uniqKey="Wooten G" first="G Frederick" last="Wooten">G Frederick Wooten</name>
</author>
<author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L" last="Watts">Ray L. Watts</name>
</author>
<author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
</author>
<author><name sortKey="Racette, Brad A" sort="Racette, Brad A" uniqKey="Racette B" first="Brad A" last="Racette">Brad A. Racette</name>
</author>
<author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name>
</author>
<author><name sortKey="Ahmed, Anwar" sort="Ahmed, Anwar" uniqKey="Ahmed A" first="Anwar" last="Ahmed">Anwar Ahmed</name>
</author>
<author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A" last="Shill">Holly A. Shill</name>
</author>
<author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name>
</author>
<author><name sortKey="Saint Hilaire, Marie H" sort="Saint Hilaire, Marie H" uniqKey="Saint Hilaire M" first="Marie H" last="Saint-Hilaire">Marie H. Saint-Hilaire</name>
</author>
<author><name sortKey="Massood, Tiffany" sort="Massood, Tiffany" uniqKey="Massood T" first="Tiffany" last="Massood">Tiffany Massood</name>
</author>
<author><name sortKey="Huskey, Karen W" sort="Huskey, Karen W" uniqKey="Huskey K" first="Karen W" last="Huskey">Karen W. Huskey</name>
</author>
<author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L" last="Destefano">Anita L. Destefano</name>
</author>
<author><name sortKey="Gillis, Tammy" sort="Gillis, Tammy" uniqKey="Gillis T" first="Tammy" last="Gillis">Tammy Gillis</name>
</author>
<author><name sortKey="Mysore, Jayalakshmi" sort="Mysore, Jayalakshmi" uniqKey="Mysore J" first="Jayalakshmi" last="Mysore">Jayalakshmi Mysore</name>
</author>
<author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name>
</author>
<author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name>
</author>
<author><name sortKey="Baker, Kenneth B" sort="Baker, Kenneth B" uniqKey="Baker K" first="Kenneth B" last="Baker">Kenneth B. Baker</name>
</author>
<author><name sortKey="Itin, Ilia" sort="Itin, Ilia" uniqKey="Itin I" first="Ilia" last="Itin">Ilia Itin</name>
</author>
<author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name>
</author>
<author><name sortKey="Nicholson, Garth" sort="Nicholson, Garth" uniqKey="Nicholson G" first="Garth" last="Nicholson">Garth Nicholson</name>
</author>
<author><name sortKey="Corbett, Alastair" sort="Corbett, Alastair" uniqKey="Corbett A" first="Alastair" last="Corbett">Alastair Corbett</name>
</author>
<author><name sortKey="Nance, Martha" sort="Nance, Martha" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name>
</author>
<author><name sortKey="Drasby, Edward" sort="Drasby, Edward" uniqKey="Drasby E" first="Edward" last="Drasby">Edward Drasby</name>
</author>
<author><name sortKey="Isaacson, Stuart" sort="Isaacson, Stuart" uniqKey="Isaacson S" first="Stuart" last="Isaacson">Stuart Isaacson</name>
</author>
<author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name>
</author>
<author><name sortKey="Chinnery, Patrick F" sort="Chinnery, Patrick F" uniqKey="Chinnery P" first="Patrick F" last="Chinnery">Patrick F. Chinnery</name>
</author>
<author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P" last="Pramstaller">Peter P. Pramstaller</name>
</author>
<author><name sortKey="Al Hinti, Jomana" sort="Al Hinti, Jomana" uniqKey="Al Hinti J" first="Jomana" last="Al-Hinti">Jomana Al-Hinti</name>
</author>
<author><name sortKey="Moller, Anette T" sort="Moller, Anette T" uniqKey="Moller A" first="Anette T" last="Moller">Anette T. Moller</name>
</author>
<author><name sortKey="Ostergaard, Karen" sort="Ostergaard, Karen" uniqKey="Ostergaard K" first="Karen" last="Ostergaard">Karen Ostergaard</name>
</author>
<author><name sortKey="Sherman, Scott J" sort="Sherman, Scott J" uniqKey="Sherman S" first="Scott J" last="Sherman">Scott J. Sherman</name>
</author>
<author><name sortKey="Roxburgh, Richard" sort="Roxburgh, Richard" uniqKey="Roxburgh R" first="Richard" last="Roxburgh">Richard Roxburgh</name>
</author>
<author><name sortKey="Snow, Barry" sort="Snow, Barry" uniqKey="Snow B" first="Barry" last="Snow">Barry Snow</name>
</author>
<author><name sortKey="Slevin, John T" sort="Slevin, John T" uniqKey="Slevin J" first="John T" last="Slevin">John T. Slevin</name>
</author>
<author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
</author>
<author><name sortKey="Gusella, James F" sort="Gusella, James F" uniqKey="Gusella J" first="James F" last="Gusella">James F. Gusella</name>
</author>
<author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H" last="Myers">Richard H. Myers</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2008">2008</date>
<idno type="doi">10.1002/mds.22186</idno>
<idno type="RBID">pubmed:18649400</idno>
<idno type="pmid">18649400</idno>
<idno type="wicri:Area/PubMed/Corpus">002143</idno>
<idno type="wicri:Area/PubMed/Curation">002143</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002258</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: the GenePD study.</title>
<author><name sortKey="Mcnicoll, Christopher F" sort="Mcnicoll, Christopher F" uniqKey="Mcnicoll C" first="Christopher F" last="Mcnicoll">Christopher F. Mcnicoll</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts 02118, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts 02118</wicri:regionArea>
<wicri:noRegion>Massachusetts 02118</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Latourelle, Jeanne C" sort="Latourelle, Jeanne C" uniqKey="Latourelle J" first="Jeanne C" last="Latourelle">Jeanne C. Latourelle</name>
</author>
<author><name sortKey="Macdonald, Marcy E" sort="Macdonald, Marcy E" uniqKey="Macdonald M" first="Marcy E" last="Macdonald">Marcy E. Macdonald</name>
</author>
<author><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F" last="Lew">Mark F. Lew</name>
</author>
<author><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name>
</author>
<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
</author>
<author><name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I" last="Golbe">Lawrence I. Golbe</name>
</author>
<author><name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H" last="Mark">Margery H. Mark</name>
</author>
<author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H" last="Growdon">John H. Growdon</name>
</author>
<author><name sortKey="Wooten, G Frederick" sort="Wooten, G Frederick" uniqKey="Wooten G" first="G Frederick" last="Wooten">G Frederick Wooten</name>
</author>
<author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L" last="Watts">Ray L. Watts</name>
</author>
<author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
</author>
<author><name sortKey="Racette, Brad A" sort="Racette, Brad A" uniqKey="Racette B" first="Brad A" last="Racette">Brad A. Racette</name>
</author>
<author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name>
</author>
<author><name sortKey="Ahmed, Anwar" sort="Ahmed, Anwar" uniqKey="Ahmed A" first="Anwar" last="Ahmed">Anwar Ahmed</name>
</author>
<author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A" last="Shill">Holly A. Shill</name>
</author>
<author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name>
</author>
<author><name sortKey="Saint Hilaire, Marie H" sort="Saint Hilaire, Marie H" uniqKey="Saint Hilaire M" first="Marie H" last="Saint-Hilaire">Marie H. Saint-Hilaire</name>
</author>
<author><name sortKey="Massood, Tiffany" sort="Massood, Tiffany" uniqKey="Massood T" first="Tiffany" last="Massood">Tiffany Massood</name>
</author>
<author><name sortKey="Huskey, Karen W" sort="Huskey, Karen W" uniqKey="Huskey K" first="Karen W" last="Huskey">Karen W. Huskey</name>
</author>
<author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L" last="Destefano">Anita L. Destefano</name>
</author>
<author><name sortKey="Gillis, Tammy" sort="Gillis, Tammy" uniqKey="Gillis T" first="Tammy" last="Gillis">Tammy Gillis</name>
</author>
<author><name sortKey="Mysore, Jayalakshmi" sort="Mysore, Jayalakshmi" uniqKey="Mysore J" first="Jayalakshmi" last="Mysore">Jayalakshmi Mysore</name>
</author>
<author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name>
</author>
<author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name>
</author>
<author><name sortKey="Baker, Kenneth B" sort="Baker, Kenneth B" uniqKey="Baker K" first="Kenneth B" last="Baker">Kenneth B. Baker</name>
</author>
<author><name sortKey="Itin, Ilia" sort="Itin, Ilia" uniqKey="Itin I" first="Ilia" last="Itin">Ilia Itin</name>
</author>
<author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name>
</author>
<author><name sortKey="Nicholson, Garth" sort="Nicholson, Garth" uniqKey="Nicholson G" first="Garth" last="Nicholson">Garth Nicholson</name>
</author>
<author><name sortKey="Corbett, Alastair" sort="Corbett, Alastair" uniqKey="Corbett A" first="Alastair" last="Corbett">Alastair Corbett</name>
</author>
<author><name sortKey="Nance, Martha" sort="Nance, Martha" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name>
</author>
<author><name sortKey="Drasby, Edward" sort="Drasby, Edward" uniqKey="Drasby E" first="Edward" last="Drasby">Edward Drasby</name>
</author>
<author><name sortKey="Isaacson, Stuart" sort="Isaacson, Stuart" uniqKey="Isaacson S" first="Stuart" last="Isaacson">Stuart Isaacson</name>
</author>
<author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name>
</author>
<author><name sortKey="Chinnery, Patrick F" sort="Chinnery, Patrick F" uniqKey="Chinnery P" first="Patrick F" last="Chinnery">Patrick F. Chinnery</name>
</author>
<author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P" last="Pramstaller">Peter P. Pramstaller</name>
</author>
<author><name sortKey="Al Hinti, Jomana" sort="Al Hinti, Jomana" uniqKey="Al Hinti J" first="Jomana" last="Al-Hinti">Jomana Al-Hinti</name>
</author>
<author><name sortKey="Moller, Anette T" sort="Moller, Anette T" uniqKey="Moller A" first="Anette T" last="Moller">Anette T. Moller</name>
</author>
<author><name sortKey="Ostergaard, Karen" sort="Ostergaard, Karen" uniqKey="Ostergaard K" first="Karen" last="Ostergaard">Karen Ostergaard</name>
</author>
<author><name sortKey="Sherman, Scott J" sort="Sherman, Scott J" uniqKey="Sherman S" first="Scott J" last="Sherman">Scott J. Sherman</name>
</author>
<author><name sortKey="Roxburgh, Richard" sort="Roxburgh, Richard" uniqKey="Roxburgh R" first="Richard" last="Roxburgh">Richard Roxburgh</name>
</author>
<author><name sortKey="Snow, Barry" sort="Snow, Barry" uniqKey="Snow B" first="Barry" last="Snow">Barry Snow</name>
</author>
<author><name sortKey="Slevin, John T" sort="Slevin, John T" uniqKey="Slevin J" first="John T" last="Slevin">John T. Slevin</name>
</author>
<author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
</author>
<author><name sortKey="Gusella, James F" sort="Gusella, James F" uniqKey="Gusella J" first="James F" last="Gusella">James F. Gusella</name>
</author>
<author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H" last="Myers">Richard H. Myers</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2008" type="published">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Family Health</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Huntington Disease (epidemiology)</term>
<term>Huntington Disease (genetics)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nerve Tissue Proteins (genetics)</term>
<term>Nuclear Proteins (genetics)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Trinucleotide Repeats (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nerve Tissue Proteins</term>
<term>Nuclear Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Huntington Disease</term>
<term>Parkinson Disease</term>
<term>Trinucleotide Repeats</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Family Health</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (HD) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson's disease (PD), and therefore, we evaluated the relationship of the HD CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n = 495), with known onset ages from 248 families, were genotyped for the HD CAG repeat. Genotyping failed in 11 cases leaving 484 for analysis, including 35 LRRK2 carriers. All cases had HD CAG repeats (range, 15-34) below the clinical range for HD, although 5.2% of the sample (n = 25) had repeats in the intermediate range (the intermediate range lower limit = 27; upper limit = 35 repeats), suggesting that the prevalence of intermediate allele carriers in the general population is significant. No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD.</div>
</front>
</TEI>
</pubmed>
</double>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Huntington CAG repeat size does not modify onset age in familial Parkinson’s disease: The GenePD Study

Huntington CAG repeat size does not modify onset age in familial Parkinson’s disease: The GenePD Study

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