Multicenter study on deep brain stimulation in Parkinson's disease: an independent assessment of reported adverse events at 4 years.
Identifieur interne : 001F56 ( Ncbi/Merge ); précédent : 001F55; suivant : 001F57Multicenter study on deep brain stimulation in Parkinson's disease: an independent assessment of reported adverse events at 4 years.
Auteurs : Marwan I. Hariz [Royaume-Uni] ; Stig Rehncrona ; Niall P. Quinn ; Johannes D. Speelman ; Carin WensingSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Case-Control Studies, Deep Brain Stimulation (adverse effects), Deep Brain Stimulation (methods), Female, Gait Disorders, Neurologic (etiology), Globus Pallidus (physiology), Globus Pallidus (radiation effects), Humans, Longitudinal Studies, Male, Mental Disorders (etiology), Middle Aged, Neurologic Examination, Parkinson Disease (therapy), Subthalamic Nucleus (physiology), Subthalamic Nucleus (radiation effects).
- MESH :
- adverse effects : Deep Brain Stimulation.
- etiology : Gait Disorders, Neurologic, Mental Disorders.
- methods : Deep Brain Stimulation.
- physiology : Globus Pallidus, Subthalamic Nucleus.
- radiation effects : Globus Pallidus, Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Aged, Case-Control Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neurologic Examination.
Abstract
Ongoing adverse events (AEs) at 4-years postsurgery in 69 patients with advanced Parkinson's disease (PD) who received deep brain stimulation (DBS) of the subthalamic nucleus (STN) (n = 49) or the internal globus pallidus (GPi) (n = 20), in the framework of a subset of eight centers of a multicenter study, were analyzed by an independent ad hoc committee. At baseline, the patients' age, sex, disease duration, and clinical condition were virtually identical, as was the duration of follow-up. There were 64 AEs reported in 53% of STN DBS patients and eight AEs reported in 35% of GPi DBS patients. Most of the AEs were not deemed severe and were reported to be present "both with and without stimulation." The majority of the AEs affected patients' cognitive, psychiatric and behavioral status, as well as speech, gait, and balance, and most of these AEs occurred in STN DBS patients. When comparing patients who exhibited AEs with those who did not, it was found that in the STN DBS group, the patients with AEs had a longer disease duration, as well as more gait disorders and psychiatric disturbances at baseline.
DOI: 10.1002/mds.21888
PubMed: 18067188
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Hariz</name><affiliation wicri:level="3"><nlm:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom. m.hariz@ion.ucl.ac.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name></author><author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P" last="Quinn">Niall P. Quinn</name></author><author><name sortKey="Speelman, Johannes D" sort="Speelman, Johannes D" uniqKey="Speelman J" first="Johannes D" last="Speelman">Johannes D. 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At baseline, the patients' age, sex, disease duration, and clinical condition were virtually identical, as was the duration of follow-up. There were 64 AEs reported in 53% of STN DBS patients and eight AEs reported in 35% of GPi DBS patients. Most of the AEs were not deemed severe and were reported to be present "both with and without stimulation." The majority of the AEs affected patients' cognitive, psychiatric and behavioral status, as well as speech, gait, and balance, and most of these AEs occurred in STN DBS patients. When comparing patients who exhibited AEs with those who did not, it was found that in the STN DBS group, the patients with AEs had a longer disease duration, as well as more gait disorders and psychiatric disturbances at baseline.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18067188</PMID><DateCreated><Year>2008</Year><Month>03</Month><Day>04</Day></DateCreated><DateCompleted><Year>2008</Year><Month>05</Month><Day>08</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>3</Issue><PubDate><Year>2008</Year><Month>Feb</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. 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The majority of the AEs affected patients' cognitive, psychiatric and behavioral status, as well as speech, gait, and balance, and most of these AEs occurred in STN DBS patients. 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Quinn</name><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><name sortKey="Speelman, Johannes D" sort="Speelman, Johannes D" uniqKey="Speelman J" first="Johannes D" last="Speelman">Johannes D. Speelman</name><name sortKey="Wensing, Carin" sort="Wensing, Carin" uniqKey="Wensing C" first="Carin" last="Wensing">Carin Wensing</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I" last="Hariz">Marwan I. Hariz</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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