Elemental mercury poisoning probably causes cortical myoclonus.
Identifieur interne : 001E03 ( Ncbi/Merge ); précédent : 001E02; suivant : 001E04Elemental mercury poisoning probably causes cortical myoclonus.
Auteurs : Mona Ragothaman [Inde] ; Girish Kulkarni ; Valappil V. Ashraf ; Pramod K. Pal ; Yasha Chickabasavaiah ; Susarla K. Shankar ; Srikanth S. Govindappa ; Parthasarthy Satishchandra ; Uday B. MuthaneSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Cerebellar Ataxia (chemically induced), Cerebellar Ataxia (diagnosis), Cerebral Cortex (drug effects), Disease Progression, Dysarthria (chemically induced), Dysarthria (diagnosis), Electromyography (drug effects), Epilepsy, Tonic-Clonic (chemically induced), Epilepsy, Tonic-Clonic (diagnosis), Evoked Potentials, Somatosensory (drug effects), Female, Foreign Bodies (pathology), Giant Cells, Foreign-Body (pathology), Humans, Injections, Intravenous, Mercury (administration & dosage), Mercury Poisoning (diagnosis), Mercury Poisoning (pathology), Myoclonus (chemically induced), Myoclonus (diagnosis), Psychomotor Disorders (chemically induced), Psychomotor Disorders (diagnosis), Skin (drug effects), Skin (pathology).
- MESH :
- chemical , administration & dosage : Mercury.
- chemically induced : Cerebellar Ataxia, Dysarthria, Epilepsy, Tonic-Clonic, Myoclonus, Psychomotor Disorders.
- diagnosis : Cerebellar Ataxia, Dysarthria, Epilepsy, Tonic-Clonic, Mercury Poisoning, Myoclonus, Psychomotor Disorders.
- drug effects : Cerebral Cortex, Electromyography, Evoked Potentials, Somatosensory, Skin.
- pathology : Foreign Bodies, Giant Cells, Foreign-Body, Mercury Poisoning, Skin.
- Adult, Disease Progression, Female, Humans, Injections, Intravenous.
Abstract
Mercury toxicity causes postural tremors, commonly referred to as "mercurial tremors," and cerebellar dysfunction. A 23-year woman, 2 years after injecting herself with elemental mercury developed disabling generalized myoclonus and ataxia. Electrophysiological studies confirmed the myoclonus was probably of cortical origin. Her deficits progressed over 2 years and improved after subcutaneous mercury deposits at the injection site were surgically cleared. Myoclonus of cortical origin has never been described in mercury poisoning. It is important to ask patients presenting with jerks about exposure to elemental mercury even if they have a progressive illness, as it is a potentially reversible condition as in our patient.
DOI: 10.1002/mds.21641
PubMed: 17708573
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pubmed:17708573Le document en format XML
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<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, National Institute of Mental Health & Neurosciences, Bangalore, India.</nlm:affiliation>
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<author><name sortKey="Pal, Pramod K" sort="Pal, Pramod K" uniqKey="Pal P" first="Pramod K" last="Pal">Pramod K. Pal</name>
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<author><name sortKey="Chickabasavaiah, Yasha" sort="Chickabasavaiah, Yasha" uniqKey="Chickabasavaiah Y" first="Yasha" last="Chickabasavaiah">Yasha Chickabasavaiah</name>
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<author><name sortKey="Shankar, Susarla K" sort="Shankar, Susarla K" uniqKey="Shankar S" first="Susarla K" last="Shankar">Susarla K. Shankar</name>
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<author><name sortKey="Govindappa, Srikanth S" sort="Govindappa, Srikanth S" uniqKey="Govindappa S" first="Srikanth S" last="Govindappa">Srikanth S. Govindappa</name>
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<author><name sortKey="Satishchandra, Parthasarthy" sort="Satishchandra, Parthasarthy" uniqKey="Satishchandra P" first="Parthasarthy" last="Satishchandra">Parthasarthy Satishchandra</name>
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<author><name sortKey="Kulkarni, Girish" sort="Kulkarni, Girish" uniqKey="Kulkarni G" first="Girish" last="Kulkarni">Girish Kulkarni</name>
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<author><name sortKey="Pal, Pramod K" sort="Pal, Pramod K" uniqKey="Pal P" first="Pramod K" last="Pal">Pramod K. Pal</name>
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<author><name sortKey="Chickabasavaiah, Yasha" sort="Chickabasavaiah, Yasha" uniqKey="Chickabasavaiah Y" first="Yasha" last="Chickabasavaiah">Yasha Chickabasavaiah</name>
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<author><name sortKey="Shankar, Susarla K" sort="Shankar, Susarla K" uniqKey="Shankar S" first="Susarla K" last="Shankar">Susarla K. Shankar</name>
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<author><name sortKey="Govindappa, Srikanth S" sort="Govindappa, Srikanth S" uniqKey="Govindappa S" first="Srikanth S" last="Govindappa">Srikanth S. Govindappa</name>
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<author><name sortKey="Satishchandra, Parthasarthy" sort="Satishchandra, Parthasarthy" uniqKey="Satishchandra P" first="Parthasarthy" last="Satishchandra">Parthasarthy Satishchandra</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Cerebellar Ataxia (chemically induced)</term>
<term>Cerebellar Ataxia (diagnosis)</term>
<term>Cerebral Cortex (drug effects)</term>
<term>Disease Progression</term>
<term>Dysarthria (chemically induced)</term>
<term>Dysarthria (diagnosis)</term>
<term>Electromyography (drug effects)</term>
<term>Epilepsy, Tonic-Clonic (chemically induced)</term>
<term>Epilepsy, Tonic-Clonic (diagnosis)</term>
<term>Evoked Potentials, Somatosensory (drug effects)</term>
<term>Female</term>
<term>Foreign Bodies (pathology)</term>
<term>Giant Cells, Foreign-Body (pathology)</term>
<term>Humans</term>
<term>Injections, Intravenous</term>
<term>Mercury (administration & dosage)</term>
<term>Mercury Poisoning (diagnosis)</term>
<term>Mercury Poisoning (pathology)</term>
<term>Myoclonus (chemically induced)</term>
<term>Myoclonus (diagnosis)</term>
<term>Psychomotor Disorders (chemically induced)</term>
<term>Psychomotor Disorders (diagnosis)</term>
<term>Skin (drug effects)</term>
<term>Skin (pathology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Mercury</term>
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<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Cerebellar Ataxia</term>
<term>Dysarthria</term>
<term>Epilepsy, Tonic-Clonic</term>
<term>Myoclonus</term>
<term>Psychomotor Disorders</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cerebellar Ataxia</term>
<term>Dysarthria</term>
<term>Epilepsy, Tonic-Clonic</term>
<term>Mercury Poisoning</term>
<term>Myoclonus</term>
<term>Psychomotor Disorders</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cerebral Cortex</term>
<term>Electromyography</term>
<term>Evoked Potentials, Somatosensory</term>
<term>Skin</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Foreign Bodies</term>
<term>Giant Cells, Foreign-Body</term>
<term>Mercury Poisoning</term>
<term>Skin</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Injections, Intravenous</term>
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<front><div type="abstract" xml:lang="en">Mercury toxicity causes postural tremors, commonly referred to as "mercurial tremors," and cerebellar dysfunction. A 23-year woman, 2 years after injecting herself with elemental mercury developed disabling generalized myoclonus and ataxia. Electrophysiological studies confirmed the myoclonus was probably of cortical origin. Her deficits progressed over 2 years and improved after subcutaneous mercury deposits at the injection site were surgically cleared. Myoclonus of cortical origin has never been described in mercury poisoning. It is important to ask patients presenting with jerks about exposure to elemental mercury even if they have a progressive illness, as it is a potentially reversible condition as in our patient.</div>
</front>
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<Abstract><AbstractText>Mercury toxicity causes postural tremors, commonly referred to as "mercurial tremors," and cerebellar dysfunction. A 23-year woman, 2 years after injecting herself with elemental mercury developed disabling generalized myoclonus and ataxia. Electrophysiological studies confirmed the myoclonus was probably of cortical origin. Her deficits progressed over 2 years and improved after subcutaneous mercury deposits at the injection site were surgically cleared. Myoclonus of cortical origin has never been described in mercury poisoning. It is important to ask patients presenting with jerks about exposure to elemental mercury even if they have a progressive illness, as it is a potentially reversible condition as in our patient.</AbstractText>
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