Globus pallidus stimulation improves both motor and nonmotor aspects of quality of life in advanced Parkinson's disease.
Identifieur interne : 001D72 ( Ncbi/Merge ); précédent : 001D71; suivant : 001D73Globus pallidus stimulation improves both motor and nonmotor aspects of quality of life in advanced Parkinson's disease.
Auteurs : Julian P. Rodrigues [Australie] ; Susan E. Walters ; Peter Watson ; Rick Stell ; Frank L. MastagliaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Activities of Daily Living (psychology), Affective Symptoms (physiopathology), Affective Symptoms (psychology), Affective Symptoms (therapy), Aged, Deep Brain Stimulation, Dominance, Cerebral (physiology), Dyskinesias (physiopathology), Dyskinesias (psychology), Dyskinesias (therapy), Female, Globus Pallidus (physiopathology), Humans, Hypokinesia (physiopathology), Hypokinesia (psychology), Hypokinesia (therapy), Male, Middle Aged, Mobility Limitation, Muscle Rigidity (physiopathology), Muscle Rigidity (psychology), Muscle Rigidity (therapy), Neurologic Examination, Neuronavigation, Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson Disease (therapy), Quality of Life (psychology), Sick Role.
- MESH :
- physiology : Dominance, Cerebral.
- physiopathology : Affective Symptoms, Dyskinesias, Globus Pallidus, Hypokinesia, Muscle Rigidity, Parkinson Disease.
- psychology : Activities of Daily Living, Affective Symptoms, Dyskinesias, Hypokinesia, Muscle Rigidity, Parkinson Disease, Quality of Life.
- therapy : Affective Symptoms, Dyskinesias, Hypokinesia, Muscle Rigidity, Parkinson Disease.
- Aged, Deep Brain Stimulation, Female, Humans, Male, Middle Aged, Mobility Limitation, Neurologic Examination, Neuronavigation, Sick Role.
Abstract
Our purpose was to measure the change in quality of life (QoL) following deep brain stimulation of the globus pallidus interna (GPi-DBS) in advanced Parkinson 's disease (PD), and identifies any associations with changes in motor features of the disease. Eleven patients (age range 54-69 years, 2 women) underwent GPi-DBS (4 unilateral, 7 bilateral). Outcome measures included assessment of PD-specific QoL (mean 8 months postsurgery) using the PDQ-39 questionnaire, and standard motor assessments. Off-period UPDRS III motor scores fell by (43 +/- 8)% (mean +/- SEM). Dyskinesia severity was reduced on the abnormal involuntary movement scale by (80 +/- 3)% and UPDRS IVa by (58 +/- 8)%. QoL as assessed by the PDQ39SI improved by (30 +/- 5)%, with significant improvements in mobility, activities of daily living, bodily discomfort, emotional wellbeing, communication, and cognitions subscales. Bilateral and unilateral groups demonstrated equivalent PDQ39SI improvement. QoL improvement was highly correlated with dyskinesia reduction but not reduction in UPDRS score or age at surgery. GPi-DBS markedly improves QoL in advanced PD. The impacts are broad and improve QoL domains not directly affected by the motor symptoms of the disease. Reduced dyskinesia plays a major role in the improvement of QoL in GPi-DBS treated patients.
DOI: 10.1002/mds.21427
PubMed: 17659634
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002587
- to stream PubMed, to step Curation: 002587
- to stream PubMed, to step Checkpoint: 002796
Links to Exploration step
pubmed:17659634Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Globus pallidus stimulation improves both motor and nonmotor aspects of quality of life in advanced Parkinson's disease.</title><author><name sortKey="Rodrigues, Julian P" sort="Rodrigues, Julian P" uniqKey="Rodrigues J" first="Julian P" last="Rodrigues">Julian P. Rodrigues</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute, University of Western Australia, Nedlands, Western Australia, Australia. jrod@cyllene.uwa.edu.au</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute, University of Western Australia, Nedlands, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Walters, Susan E" sort="Walters, Susan E" uniqKey="Walters S" first="Susan E" last="Walters">Susan E. Walters</name></author><author><name sortKey="Watson, Peter" sort="Watson, Peter" uniqKey="Watson P" first="Peter" last="Watson">Peter Watson</name></author><author><name sortKey="Stell, Rick" sort="Stell, Rick" uniqKey="Stell R" first="Rick" last="Stell">Rick Stell</name></author><author><name sortKey="Mastaglia, Frank L" sort="Mastaglia, Frank L" uniqKey="Mastaglia F" first="Frank L" last="Mastaglia">Frank L. Mastaglia</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21427</idno><idno type="RBID">pubmed:17659634</idno><idno type="pmid">17659634</idno><idno type="wicri:Area/PubMed/Corpus">002587</idno><idno type="wicri:Area/PubMed/Curation">002587</idno><idno type="wicri:Area/PubMed/Checkpoint">002796</idno><idno type="wicri:Area/Ncbi/Merge">001D72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Globus pallidus stimulation improves both motor and nonmotor aspects of quality of life in advanced Parkinson's disease.</title><author><name sortKey="Rodrigues, Julian P" sort="Rodrigues, Julian P" uniqKey="Rodrigues J" first="Julian P" last="Rodrigues">Julian P. Rodrigues</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute, University of Western Australia, Nedlands, Western Australia, Australia. jrod@cyllene.uwa.edu.au</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute, University of Western Australia, Nedlands, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Walters, Susan E" sort="Walters, Susan E" uniqKey="Walters S" first="Susan E" last="Walters">Susan E. Walters</name></author><author><name sortKey="Watson, Peter" sort="Watson, Peter" uniqKey="Watson P" first="Peter" last="Watson">Peter Watson</name></author><author><name sortKey="Stell, Rick" sort="Stell, Rick" uniqKey="Stell R" first="Rick" last="Stell">Rick Stell</name></author><author><name sortKey="Mastaglia, Frank L" sort="Mastaglia, Frank L" uniqKey="Mastaglia F" first="Frank L" last="Mastaglia">Frank L. Mastaglia</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living (psychology)</term><term>Affective Symptoms (physiopathology)</term><term>Affective Symptoms (psychology)</term><term>Affective Symptoms (therapy)</term><term>Aged</term><term>Deep Brain Stimulation</term><term>Dominance, Cerebral (physiology)</term><term>Dyskinesias (physiopathology)</term><term>Dyskinesias (psychology)</term><term>Dyskinesias (therapy)</term><term>Female</term><term>Globus Pallidus (physiopathology)</term><term>Humans</term><term>Hypokinesia (physiopathology)</term><term>Hypokinesia (psychology)</term><term>Hypokinesia (therapy)</term><term>Male</term><term>Middle Aged</term><term>Mobility Limitation</term><term>Muscle Rigidity (physiopathology)</term><term>Muscle Rigidity (psychology)</term><term>Muscle Rigidity (therapy)</term><term>Neurologic Examination</term><term>Neuronavigation</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (therapy)</term><term>Quality of Life (psychology)</term><term>Sick Role</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dominance, Cerebral</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Affective Symptoms</term><term>Dyskinesias</term><term>Globus Pallidus</term><term>Hypokinesia</term><term>Muscle Rigidity</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Activities of Daily Living</term><term>Affective Symptoms</term><term>Dyskinesias</term><term>Hypokinesia</term><term>Muscle Rigidity</term><term>Parkinson Disease</term><term>Quality of Life</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Affective Symptoms</term><term>Dyskinesias</term><term>Hypokinesia</term><term>Muscle Rigidity</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mobility Limitation</term><term>Neurologic Examination</term><term>Neuronavigation</term><term>Sick Role</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Our purpose was to measure the change in quality of life (QoL) following deep brain stimulation of the globus pallidus interna (GPi-DBS) in advanced Parkinson 's disease (PD), and identifies any associations with changes in motor features of the disease. Eleven patients (age range 54-69 years, 2 women) underwent GPi-DBS (4 unilateral, 7 bilateral). Outcome measures included assessment of PD-specific QoL (mean 8 months postsurgery) using the PDQ-39 questionnaire, and standard motor assessments. Off-period UPDRS III motor scores fell by (43 +/- 8)% (mean +/- SEM). Dyskinesia severity was reduced on the abnormal involuntary movement scale by (80 +/- 3)% and UPDRS IVa by (58 +/- 8)%. QoL as assessed by the PDQ39SI improved by (30 +/- 5)%, with significant improvements in mobility, activities of daily living, bodily discomfort, emotional wellbeing, communication, and cognitions subscales. Bilateral and unilateral groups demonstrated equivalent PDQ39SI improvement. QoL improvement was highly correlated with dyskinesia reduction but not reduction in UPDRS score or age at surgery. GPi-DBS markedly improves QoL in advanced PD. The impacts are broad and improve QoL domains not directly affected by the motor symptoms of the disease. Reduced dyskinesia plays a major role in the improvement of QoL in GPi-DBS treated patients.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17659634</PMID><DateCreated><Year>2007</Year><Month>11</Month><Day>05</Day></DateCreated><DateCompleted><Year>2008</Year><Month>03</Month><Day>21</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>13</Issue><PubDate><Year>2007</Year><Month>Oct</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Globus pallidus stimulation improves both motor and nonmotor aspects of quality of life in advanced Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1866-70</MedlinePgn></Pagination><Abstract><AbstractText>Our purpose was to measure the change in quality of life (QoL) following deep brain stimulation of the globus pallidus interna (GPi-DBS) in advanced Parkinson 's disease (PD), and identifies any associations with changes in motor features of the disease. Eleven patients (age range 54-69 years, 2 women) underwent GPi-DBS (4 unilateral, 7 bilateral). Outcome measures included assessment of PD-specific QoL (mean 8 months postsurgery) using the PDQ-39 questionnaire, and standard motor assessments. Off-period UPDRS III motor scores fell by (43 +/- 8)% (mean +/- SEM). Dyskinesia severity was reduced on the abnormal involuntary movement scale by (80 +/- 3)% and UPDRS IVa by (58 +/- 8)%. QoL as assessed by the PDQ39SI improved by (30 +/- 5)%, with significant improvements in mobility, activities of daily living, bodily discomfort, emotional wellbeing, communication, and cognitions subscales. Bilateral and unilateral groups demonstrated equivalent PDQ39SI improvement. QoL improvement was highly correlated with dyskinesia reduction but not reduction in UPDRS score or age at surgery. GPi-DBS markedly improves QoL in advanced PD. The impacts are broad and improve QoL domains not directly affected by the motor symptoms of the disease. Reduced dyskinesia plays a major role in the improvement of QoL in GPi-DBS treated patients.</AbstractText><CopyrightInformation>2007 Movement Disorder Society</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rodrigues</LastName><ForeName>Julian P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute, University of Western Australia, Nedlands, Western Australia, Australia. jrod@cyllene.uwa.edu.au</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walters</LastName><ForeName>Susan E</ForeName><Initials>SE</Initials></Author><Author ValidYN="Y"><LastName>Watson</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Stell</LastName><ForeName>Rick</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Mastaglia</LastName><ForeName>Frank L</ForeName><Initials>FL</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000203">Activities of Daily Living</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000342">Affective Symptoms</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D046690">Deep Brain Stimulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004292">Dominance, Cerebral</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020820">Dyskinesias</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005917">Globus Pallidus</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018476">Hypokinesia</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D051346">Mobility Limitation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009127">Muscle Rigidity</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009460">Neurologic Examination</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D038361">Neuronavigation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011788">Quality of Life</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012803">Sick Role</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>7</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>3</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>7</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.21427</ArticleId><ArticleId IdType="pubmed">17659634</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Mastaglia, Frank L" sort="Mastaglia, Frank L" uniqKey="Mastaglia F" first="Frank L" last="Mastaglia">Frank L. Mastaglia</name><name sortKey="Stell, Rick" sort="Stell, Rick" uniqKey="Stell R" first="Rick" last="Stell">Rick Stell</name><name sortKey="Walters, Susan E" sort="Walters, Susan E" uniqKey="Walters S" first="Susan E" last="Walters">Susan E. Walters</name><name sortKey="Watson, Peter" sort="Watson, Peter" uniqKey="Watson P" first="Peter" last="Watson">Peter Watson</name></noCountry><country name="Australie"><noRegion><name sortKey="Rodrigues, Julian P" sort="Rodrigues, Julian P" uniqKey="Rodrigues J" first="Julian P" last="Rodrigues">Julian P. Rodrigues</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D72 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001D72 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= pubmed:17659634
|texte= Globus pallidus stimulation improves both motor and nonmotor aspects of quality of life in advanced Parkinson's disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:17659634" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |