Postural sway and falls in Parkinson's disease: a regression approach.
Identifieur interne : 001D59 ( Ncbi/Merge ); précédent : 001D58; suivant : 001D60Postural sway and falls in Parkinson's disease: a regression approach.
Auteurs : Maarit Matinolli [Finlande] ; Juha T. Korpelainen ; Raija Korpelainen ; Kyösti A. Sotaniemi ; Minna Virranniemi ; Vilho V. MyllylSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Accidental Falls (statistics & numerical data), Activities of Daily Living, Aged, Aged, 80 and over, Antiparkinson Agents (therapeutic use), Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Neurologic Examination (instrumentation), Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Postural Balance, Questionnaires, Recurrence, Regression Analysis, Risk Factors, Signal Processing, Computer-Assisted (instrumentation).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- diagnosis : Parkinson Disease.
- drug therapy : Parkinson Disease.
- epidemiology : Parkinson Disease.
- instrumentation : Neurologic Examination, Signal Processing, Computer-Assisted.
- statistics & numerical data : Accidental Falls.
- Activities of Daily Living, Aged, Aged, 80 and over, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Postural Balance, Questionnaires, Recurrence, Regression Analysis, Risk Factors.
Abstract
A population-based study was designed to evaluate the clinical associates of postural sway and to identify the risk factors for falls in Parkinson's disease (PD). From a total population of 205,000 inhabitants, 215 PD patients were identified of which 120 home-dwelling cases were finally included in the study. Medical data were collected and patients were clinically examined and tested for static balance using an inclinometric device. Recent falls occurred in 40 (33%) of the subjects and 27 (23%) subjects were recurrent fallers. The fallers had a significantly larger sway area (P = 0.021) and a larger maximum deflection in anterior-posterior (P = 0.016) and lateral directions (P = 0.006) than the nonfallers. A significant correlation was found between the sway measures and the UPDRS total score, motor subcore and UPDRS "bradykinesia" item. A higher UPDRS total score (OR: 1.04, 95% CI: 1.01-1.07) and an increased sway area (OR: 1.25, 95% CI: 1.02-1.54) were independent risk factors for recent falling in PD. In addition, the duration and severity of PD, antiparkinsonian medication, recent falling and the use of a walking aid were associated with increased sway measures. The results can be used to identify PD patients who are at a risk of falling. Both antiparkinsonian medication and nonmedical treatment should be optimized to reduce falls in PD.
DOI: 10.1002/mds.21633
PubMed: 17595043
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Postural sway and falls in Parkinson's disease: a regression approach.</title><author><name sortKey="Matinolli, Maarit" sort="Matinolli, Maarit" uniqKey="Matinolli M" first="Maarit" last="Matinolli">Maarit Matinolli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Oulu, Oulu, Finland. hmkemppa@mail.student.oulu.fi</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Korpelainen, Juha T" sort="Korpelainen, Juha T" uniqKey="Korpelainen J" first="Juha T" last="Korpelainen">Juha T. Korpelainen</name></author><author><name sortKey="Korpelainen, Raija" sort="Korpelainen, Raija" uniqKey="Korpelainen R" first="Raija" last="Korpelainen">Raija Korpelainen</name></author><author><name sortKey="Sotaniemi, Kyosti A" sort="Sotaniemi, Kyosti A" uniqKey="Sotaniemi K" first="Kyösti A" last="Sotaniemi">Kyösti A. Sotaniemi</name></author><author><name sortKey="Virranniemi, Minna" sort="Virranniemi, Minna" uniqKey="Virranniemi M" first="Minna" last="Virranniemi">Minna Virranniemi</name></author><author><name sortKey="Myllyl, Vilho V" sort="Myllyl, Vilho V" uniqKey="Myllyl V" first="Vilho V" last="Myllyl">Vilho V. Myllyl</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21633</idno><idno type="RBID">pubmed:17595043</idno><idno type="pmid">17595043</idno><idno type="wicri:Area/PubMed/Corpus">002600</idno><idno type="wicri:Area/PubMed/Curation">002600</idno><idno type="wicri:Area/PubMed/Checkpoint">002639</idno><idno type="wicri:Area/Ncbi/Merge">001D59</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Postural sway and falls in Parkinson's disease: a regression approach.</title><author><name sortKey="Matinolli, Maarit" sort="Matinolli, Maarit" uniqKey="Matinolli M" first="Maarit" last="Matinolli">Maarit Matinolli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Oulu, Oulu, Finland. hmkemppa@mail.student.oulu.fi</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Korpelainen, Juha T" sort="Korpelainen, Juha T" uniqKey="Korpelainen J" first="Juha T" last="Korpelainen">Juha T. Korpelainen</name></author><author><name sortKey="Korpelainen, Raija" sort="Korpelainen, Raija" uniqKey="Korpelainen R" first="Raija" last="Korpelainen">Raija Korpelainen</name></author><author><name sortKey="Sotaniemi, Kyosti A" sort="Sotaniemi, Kyosti A" uniqKey="Sotaniemi K" first="Kyösti A" last="Sotaniemi">Kyösti A. Sotaniemi</name></author><author><name sortKey="Virranniemi, Minna" sort="Virranniemi, Minna" uniqKey="Virranniemi M" first="Minna" last="Virranniemi">Minna Virranniemi</name></author><author><name sortKey="Myllyl, Vilho V" sort="Myllyl, Vilho V" uniqKey="Myllyl V" first="Vilho V" last="Myllyl">Vilho V. Myllyl</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Accidental Falls (statistics & numerical data)</term><term>Activities of Daily Living</term><term>Aged</term><term>Aged, 80 and over</term><term>Antiparkinson Agents (therapeutic use)</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination (instrumentation)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (epidemiology)</term><term>Postural Balance</term><term>Questionnaires</term><term>Recurrence</term><term>Regression Analysis</term><term>Risk Factors</term><term>Signal Processing, Computer-Assisted (instrumentation)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Neurologic Examination</term><term>Signal Processing, Computer-Assisted</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Accidental Falls</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term><term>Aged</term><term>Aged, 80 and over</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Postural Balance</term><term>Questionnaires</term><term>Recurrence</term><term>Regression Analysis</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A population-based study was designed to evaluate the clinical associates of postural sway and to identify the risk factors for falls in Parkinson's disease (PD). From a total population of 205,000 inhabitants, 215 PD patients were identified of which 120 home-dwelling cases were finally included in the study. Medical data were collected and patients were clinically examined and tested for static balance using an inclinometric device. Recent falls occurred in 40 (33%) of the subjects and 27 (23%) subjects were recurrent fallers. The fallers had a significantly larger sway area (P = 0.021) and a larger maximum deflection in anterior-posterior (P = 0.016) and lateral directions (P = 0.006) than the nonfallers. A significant correlation was found between the sway measures and the UPDRS total score, motor subcore and UPDRS "bradykinesia" item. A higher UPDRS total score (OR: 1.04, 95% CI: 1.01-1.07) and an increased sway area (OR: 1.25, 95% CI: 1.02-1.54) were independent risk factors for recent falling in PD. In addition, the duration and severity of PD, antiparkinsonian medication, recent falling and the use of a walking aid were associated with increased sway measures. The results can be used to identify PD patients who are at a risk of falling. Both antiparkinsonian medication and nonmedical treatment should be optimized to reduce falls in PD.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17595043</PMID><DateCreated><Year>2007</Year><Month>11</Month><Day>05</Day></DateCreated><DateCompleted><Year>2008</Year><Month>03</Month><Day>21</Day></DateCompleted><DateRevised><Year>2008</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>13</Issue><PubDate><Year>2007</Year><Month>Oct</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Postural sway and falls in Parkinson's disease: a regression approach.</ArticleTitle><Pagination><MedlinePgn>1927-35</MedlinePgn></Pagination><Abstract><AbstractText>A population-based study was designed to evaluate the clinical associates of postural sway and to identify the risk factors for falls in Parkinson's disease (PD). From a total population of 205,000 inhabitants, 215 PD patients were identified of which 120 home-dwelling cases were finally included in the study. Medical data were collected and patients were clinically examined and tested for static balance using an inclinometric device. Recent falls occurred in 40 (33%) of the subjects and 27 (23%) subjects were recurrent fallers. The fallers had a significantly larger sway area (P = 0.021) and a larger maximum deflection in anterior-posterior (P = 0.016) and lateral directions (P = 0.006) than the nonfallers. A significant correlation was found between the sway measures and the UPDRS total score, motor subcore and UPDRS "bradykinesia" item. A higher UPDRS total score (OR: 1.04, 95% CI: 1.01-1.07) and an increased sway area (OR: 1.25, 95% CI: 1.02-1.54) were independent risk factors for recent falling in PD. In addition, the duration and severity of PD, antiparkinsonian medication, recent falling and the use of a walking aid were associated with increased sway measures. The results can be used to identify PD patients who are at a risk of falling. Both antiparkinsonian medication and nonmedical treatment should be optimized to reduce falls in PD.</AbstractText><CopyrightInformation>2007 Movement Disorder Society</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Matinolli</LastName><ForeName>Maarit</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Oulu, Oulu, Finland. hmkemppa@mail.student.oulu.fi</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Korpelainen</LastName><ForeName>Juha T</ForeName><Initials>JT</Initials></Author><Author ValidYN="Y"><LastName>Korpelainen</LastName><ForeName>Raija</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Sotaniemi</LastName><ForeName>Kyösti A</ForeName><Initials>KA</Initials></Author><Author ValidYN="Y"><LastName>Virranniemi</LastName><ForeName>Minna</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Myllylä</LastName><ForeName>Vilho V</ForeName><Initials>VV</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D000058">Accidental Falls</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000706">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000203">Activities of Daily Living</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000978">Antiparkinson Agents</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004359">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009460">Neurologic Examination</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000295">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D004856">Postural Balance</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011795">Questionnaires</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012008">Recurrence</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012044">Regression Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012307">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012815">Signal Processing, Computer-Assisted</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000295">instrumentation</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>6</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>3</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>6</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.21633</ArticleId><ArticleId IdType="pubmed">17595043</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Finlande</li></country></list><tree><noCountry><name sortKey="Korpelainen, Juha T" sort="Korpelainen, Juha T" uniqKey="Korpelainen J" first="Juha T" last="Korpelainen">Juha T. Korpelainen</name><name sortKey="Korpelainen, Raija" sort="Korpelainen, Raija" uniqKey="Korpelainen R" first="Raija" last="Korpelainen">Raija Korpelainen</name><name sortKey="Myllyl, Vilho V" sort="Myllyl, Vilho V" uniqKey="Myllyl V" first="Vilho V" last="Myllyl">Vilho V. Myllyl</name><name sortKey="Sotaniemi, Kyosti A" sort="Sotaniemi, Kyosti A" uniqKey="Sotaniemi K" first="Kyösti A" last="Sotaniemi">Kyösti A. Sotaniemi</name><name sortKey="Virranniemi, Minna" sort="Virranniemi, Minna" uniqKey="Virranniemi M" first="Minna" last="Virranniemi">Minna Virranniemi</name></noCountry><country name="Finlande"><noRegion><name sortKey="Matinolli, Maarit" sort="Matinolli, Maarit" uniqKey="Matinolli M" first="Maarit" last="Matinolli">Maarit Matinolli</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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