Dopa-responsive pseudo-orthostatic tremor in parkinsonism.
Identifieur interne : 001D14 ( Ncbi/Merge ); précédent : 001D13; suivant : 001D15Dopa-responsive pseudo-orthostatic tremor in parkinsonism.
Auteurs : Astrid Thomas [Italie] ; Laura Bonanni ; Angelo Antonini ; Paolo Barone ; Marco OnofrjSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Dihydroxyphenylalanine, Dopamine Agents.
- chemically induced : Tremor.
- classification : Tremor.
- drug therapy : Parkinsonian Disorders.
- genetics : Parkinsonian Disorders, Tremor.
- Adult, Female, Humans, Male, Middle Aged.
Abstract
In four patients an inabilitating standing tremor appeared years before that parkinsonian symptoms were evidenced. This tremor was refractory to gabapentin and dramatically responded to Levodopa administration. Its dominant frequency was 6.2 to 6.9 Hz with sporadic subharmonics at 8 to 18 Hz. Three patients were affected by different genetic mutations (Park 2, Park 6, mtDNA deletion) in one no genetic or metabolic alterations could be evidenced. All patients had dopamine transporter abnormalities. We suggest that the term "Pseudo-Orthostatic Tremor" could be used to define this Dopa responsive, 6 to 7 Hz standing tremor.
DOI: 10.1002/mds.21621
PubMed: 17579364
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pubmed:17579364Le document en format XML
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<author><name sortKey="Thomas, Astrid" sort="Thomas, Astrid" uniqKey="Thomas A" first="Astrid" last="Thomas">Astrid Thomas</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oncology and Neuroscience, Neurophysiopathology, University G. D'Annunzio Chieti-Pescara, Italy.</nlm:affiliation>
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<author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
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<author><name sortKey="Onofrj, Marco" sort="Onofrj, Marco" uniqKey="Onofrj M" first="Marco" last="Onofrj">Marco Onofrj</name>
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<front><div type="abstract" xml:lang="en">In four patients an inabilitating standing tremor appeared years before that parkinsonian symptoms were evidenced. This tremor was refractory to gabapentin and dramatically responded to Levodopa administration. Its dominant frequency was 6.2 to 6.9 Hz with sporadic subharmonics at 8 to 18 Hz. Three patients were affected by different genetic mutations (Park 2, Park 6, mtDNA deletion) in one no genetic or metabolic alterations could be evidenced. All patients had dopamine transporter abnormalities. We suggest that the term "Pseudo-Orthostatic Tremor" could be used to define this Dopa responsive, 6 to 7 Hz standing tremor.</div>
</front>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<ArticleTitle>Dopa-responsive pseudo-orthostatic tremor in parkinsonism.</ArticleTitle>
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<Abstract><AbstractText>In four patients an inabilitating standing tremor appeared years before that parkinsonian symptoms were evidenced. This tremor was refractory to gabapentin and dramatically responded to Levodopa administration. Its dominant frequency was 6.2 to 6.9 Hz with sporadic subharmonics at 8 to 18 Hz. Three patients were affected by different genetic mutations (Park 2, Park 6, mtDNA deletion) in one no genetic or metabolic alterations could be evidenced. All patients had dopamine transporter abnormalities. We suggest that the term "Pseudo-Orthostatic Tremor" could be used to define this Dopa responsive, 6 to 7 Hz standing tremor.</AbstractText>
<CopyrightInformation>Copyright (c) 2007 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Thomas</LastName>
<ForeName>Astrid</ForeName>
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<tree><noCountry><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name>
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<name sortKey="Bonanni, Laura" sort="Bonanni, Laura" uniqKey="Bonanni L" first="Laura" last="Bonanni">Laura Bonanni</name>
<name sortKey="Onofrj, Marco" sort="Onofrj, Marco" uniqKey="Onofrj M" first="Marco" last="Onofrj">Marco Onofrj</name>
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