MovDisordV3, Ncbi, Merge, bibRecord, 001C05

GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma.

Identifieur interne : 001C05 ( Ncbi/Merge ); précédent : 001C04; suivant : 001C06

GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma.

Auteurs : John C. Mchugh [Irlande (pays)] ; Brian Murray ; Radhakrishnan Renganathan ; Sean Connolly ; Tim Lynch

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2007.

RBID : pubmed:17486640

English descriptors

KwdEn :
- Carcinoma (complications), Electromyography (methods), Glutamate Decarboxylase (metabolism), Humans, Kidney Neoplasms (complications), Male, Middle Aged, Muscle, Skeletal (physiopathology), Paraneoplastic Syndromes (etiology), Paraneoplastic Syndromes (metabolism).
MESH :
- chemical , metabolism : Glutamate Decarboxylase.
- complications : Carcinoma, Kidney Neoplasms.
- etiology : Paraneoplastic Syndromes.
- metabolism : Paraneoplastic Syndromes.
- methods : Electromyography.
- physiopathology : Muscle, Skeletal.
- Humans, Male, Middle Aged.

Abstract

Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti-GAD positive PSPS in a 53-year-old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS.

DOI: 10.1002/mds.21374
PubMed: 17486640

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002734
to stream PubMed, to step Curation: 002734
to stream PubMed, to step Checkpoint: 002806

Links to Exploration step

pubmed:17486640

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma.</title>
<author><name sortKey="Mchugh, John C" sort="Mchugh, John C" uniqKey="Mchugh J" first="John C" last="Mchugh">John C. Mchugh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Mater Misericordiae University Hospital, Dublin, Ireland. drjohnmchugh@ireland.com</nlm:affiliation>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Department of Neurology, Mater Misericordiae University Hospital, Dublin</wicri:regionArea>
<wicri:noRegion>Dublin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Murray, Brian" sort="Murray, Brian" uniqKey="Murray B" first="Brian" last="Murray">Brian Murray</name>
</author>
<author><name sortKey="Renganathan, Radhakrishnan" sort="Renganathan, Radhakrishnan" uniqKey="Renganathan R" first="Radhakrishnan" last="Renganathan">Radhakrishnan Renganathan</name>
</author>
<author><name sortKey="Connolly, Sean" sort="Connolly, Sean" uniqKey="Connolly S" first="Sean" last="Connolly">Sean Connolly</name>
</author>
<author><name sortKey="Lynch, Tim" sort="Lynch, Tim" uniqKey="Lynch T" first="Tim" last="Lynch">Tim Lynch</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2007">2007</date>
<idno type="doi">10.1002/mds.21374</idno>
<idno type="RBID">pubmed:17486640</idno>
<idno type="pmid">17486640</idno>
<idno type="wicri:Area/PubMed/Corpus">002734</idno>
<idno type="wicri:Area/PubMed/Curation">002734</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002806</idno>
<idno type="wicri:Area/Ncbi/Merge">001C05</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma.</title>
<author><name sortKey="Mchugh, John C" sort="Mchugh, John C" uniqKey="Mchugh J" first="John C" last="Mchugh">John C. Mchugh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Mater Misericordiae University Hospital, Dublin, Ireland. drjohnmchugh@ireland.com</nlm:affiliation>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Department of Neurology, Mater Misericordiae University Hospital, Dublin</wicri:regionArea>
<wicri:noRegion>Dublin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Murray, Brian" sort="Murray, Brian" uniqKey="Murray B" first="Brian" last="Murray">Brian Murray</name>
</author>
<author><name sortKey="Renganathan, Radhakrishnan" sort="Renganathan, Radhakrishnan" uniqKey="Renganathan R" first="Radhakrishnan" last="Renganathan">Radhakrishnan Renganathan</name>
</author>
<author><name sortKey="Connolly, Sean" sort="Connolly, Sean" uniqKey="Connolly S" first="Sean" last="Connolly">Sean Connolly</name>
</author>
<author><name sortKey="Lynch, Tim" sort="Lynch, Tim" uniqKey="Lynch T" first="Tim" last="Lynch">Tim Lynch</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2007" type="published">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carcinoma (complications)</term>
<term>Electromyography (methods)</term>
<term>Glutamate Decarboxylase (metabolism)</term>
<term>Humans</term>
<term>Kidney Neoplasms (complications)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Muscle, Skeletal (physiopathology)</term>
<term>Paraneoplastic Syndromes (etiology)</term>
<term>Paraneoplastic Syndromes (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glutamate Decarboxylase</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Carcinoma</term>
<term>Kidney Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Paraneoplastic Syndromes</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Paraneoplastic Syndromes</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electromyography</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti-GAD positive PSPS in a 53-year-old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17486640</PMID>
<DateCreated><Year>2007</Year>
<Month>07</Month>
<Day>30</Day>
</DateCreated>
<DateCompleted><Year>2008</Year>
<Month>04</Month>
<Day>16</Day>
</DateCompleted>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>22</Volume>
<Issue>9</Issue>
<PubDate><Year>2007</Year>
<Month>Jul</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma.</ArticleTitle>
<Pagination><MedlinePgn>1343-6</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti-GAD positive PSPS in a 53-year-old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS.</AbstractText>
<CopyrightInformation>2007 Movement Disorder Society</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McHugh</LastName>
<ForeName>John C</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Mater Misericordiae University Hospital, Dublin, Ireland. drjohnmchugh@ireland.com</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Murray</LastName>
<ForeName>Brian</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Renganathan</LastName>
<ForeName>Radhakrishnan</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Connolly</LastName>
<ForeName>Sean</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lynch</LastName>
<ForeName>Tim</ForeName>
<Initials>T</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>EC 4.1.1.15</RegistryNumber>
<NameOfSubstance UI="D005968">Glutamate Decarboxylase</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002277">Carcinoma</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D004576">Electromyography</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005968">Glutamate Decarboxylase</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D007680">Kidney Neoplasms</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D018482">Muscle, Skeletal</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010257">Paraneoplastic Syndromes</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year>
<Month>5</Month>
<Day>9</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2008</Year>
<Month>4</Month>
<Day>17</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2007</Year>
<Month>5</Month>
<Day>9</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="doi">10.1002/mds.21374</ArticleId>
<ArticleId IdType="pubmed">17486640</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Irlande (pays)</li>
</country>
</list>
<tree><noCountry><name sortKey="Connolly, Sean" sort="Connolly, Sean" uniqKey="Connolly S" first="Sean" last="Connolly">Sean Connolly</name>
<name sortKey="Lynch, Tim" sort="Lynch, Tim" uniqKey="Lynch T" first="Tim" last="Lynch">Tim Lynch</name>
<name sortKey="Murray, Brian" sort="Murray, Brian" uniqKey="Murray B" first="Brian" last="Murray">Brian Murray</name>
<name sortKey="Renganathan, Radhakrishnan" sort="Renganathan, Radhakrishnan" uniqKey="Renganathan R" first="Radhakrishnan" last="Renganathan">Radhakrishnan Renganathan</name>
</noCountry>
<country name="Irlande (pays)"><noRegion><name sortKey="Mchugh, John C" sort="Mchugh, John C" uniqKey="Mchugh J" first="John C" last="Mchugh">John C. Mchugh</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C05 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001C05 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Ncbi
   |étape=   Merge
   |type=    RBID
   |clé=     pubmed:17486640
   |texte=   GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i   -Sk "pubmed:17486640" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a MovDisordV3

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma.

GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki