GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma.
Identifieur interne : 001C05 ( Ncbi/Merge ); précédent : 001C04; suivant : 001C06GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma.
Auteurs : John C. Mchugh [Irlande (pays)] ; Brian Murray ; Radhakrishnan Renganathan ; Sean Connolly ; Tim LynchSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Glutamate Decarboxylase.
- complications : Carcinoma, Kidney Neoplasms.
- etiology : Paraneoplastic Syndromes.
- metabolism : Paraneoplastic Syndromes.
- methods : Electromyography.
- physiopathology : Muscle, Skeletal.
- Humans, Male, Middle Aged.
Abstract
Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti-GAD positive PSPS in a 53-year-old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS.
DOI: 10.1002/mds.21374
PubMed: 17486640
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pubmed:17486640Le document en format XML
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<author><name sortKey="Mchugh, John C" sort="Mchugh, John C" uniqKey="Mchugh J" first="John C" last="Mchugh">John C. Mchugh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Mater Misericordiae University Hospital, Dublin, Ireland. drjohnmchugh@ireland.com</nlm:affiliation>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Department of Neurology, Mater Misericordiae University Hospital, Dublin</wicri:regionArea>
<wicri:noRegion>Dublin</wicri:noRegion>
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<author><name sortKey="Murray, Brian" sort="Murray, Brian" uniqKey="Murray B" first="Brian" last="Murray">Brian Murray</name>
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<author><name sortKey="Renganathan, Radhakrishnan" sort="Renganathan, Radhakrishnan" uniqKey="Renganathan R" first="Radhakrishnan" last="Renganathan">Radhakrishnan Renganathan</name>
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<author><name sortKey="Connolly, Sean" sort="Connolly, Sean" uniqKey="Connolly S" first="Sean" last="Connolly">Sean Connolly</name>
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<author><name sortKey="Lynch, Tim" sort="Lynch, Tim" uniqKey="Lynch T" first="Tim" last="Lynch">Tim Lynch</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma.</title>
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<author><name sortKey="Renganathan, Radhakrishnan" sort="Renganathan, Radhakrishnan" uniqKey="Renganathan R" first="Radhakrishnan" last="Renganathan">Radhakrishnan Renganathan</name>
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<author><name sortKey="Connolly, Sean" sort="Connolly, Sean" uniqKey="Connolly S" first="Sean" last="Connolly">Sean Connolly</name>
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<author><name sortKey="Lynch, Tim" sort="Lynch, Tim" uniqKey="Lynch T" first="Tim" last="Lynch">Tim Lynch</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
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<term>Electromyography (methods)</term>
<term>Glutamate Decarboxylase (metabolism)</term>
<term>Humans</term>
<term>Kidney Neoplasms (complications)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Muscle, Skeletal (physiopathology)</term>
<term>Paraneoplastic Syndromes (etiology)</term>
<term>Paraneoplastic Syndromes (metabolism)</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glutamate Decarboxylase</term>
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<term>Kidney Neoplasms</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Paraneoplastic Syndromes</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Paraneoplastic Syndromes</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electromyography</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Muscle, Skeletal</term>
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<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti-GAD positive PSPS in a 53-year-old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS.</div>
</front>
</TEI>
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<DateCreated><Year>2007</Year>
<Month>07</Month>
<Day>30</Day>
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<DateCompleted><Year>2008</Year>
<Month>04</Month>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma.</ArticleTitle>
<Pagination><MedlinePgn>1343-6</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti-GAD positive PSPS in a 53-year-old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS.</AbstractText>
<CopyrightInformation>2007 Movement Disorder Society</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McHugh</LastName>
<ForeName>John C</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Mater Misericordiae University Hospital, Dublin, Ireland. drjohnmchugh@ireland.com</Affiliation>
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<name sortKey="Murray, Brian" sort="Murray, Brian" uniqKey="Murray B" first="Brian" last="Murray">Brian Murray</name>
<name sortKey="Renganathan, Radhakrishnan" sort="Renganathan, Radhakrishnan" uniqKey="Renganathan R" first="Radhakrishnan" last="Renganathan">Radhakrishnan Renganathan</name>
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<country name="Irlande (pays)"><noRegion><name sortKey="Mchugh, John C" sort="Mchugh, John C" uniqKey="Mchugh J" first="John C" last="Mchugh">John C. Mchugh</name>
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