Botulinum toxin and neuromotor rehabilitation: An integrated approach to idiopathic cervical dystonia.
Identifieur interne : 001889 ( Ncbi/Merge ); précédent : 001888; suivant : 001890Botulinum toxin and neuromotor rehabilitation: An integrated approach to idiopathic cervical dystonia.
Auteurs : Cristina Tassorelli [Italie] ; Francesca Mancini ; Laura Balloni ; Claudio Pacchetti ; Giorgio Sandrini ; Giuseppe Nappi ; Emilia MartignoniSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Activities of Daily Living, Aged, Analysis of Variance, Botulinum Toxins, Type A (therapeutic use), Cross-Over Studies, Double-Blind Method, Electromyography (methods), Female, Humans, Injections, Intramuscular, Male, Middle Aged, Neuromuscular Agents (therapeutic use), Pain Measurement, Physical Therapy Specialty (methods), Time Factors, Torticollis (drug therapy), Torticollis (rehabilitation), Treatment Outcome.
- MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- drug therapy : Torticollis.
- methods : Electromyography, Physical Therapy Specialty.
- rehabilitation : Torticollis.
- Activities of Daily Living, Aged, Analysis of Variance, Cross-Over Studies, Double-Blind Method, Female, Humans, Injections, Intramuscular, Male, Middle Aged, Pain Measurement, Time Factors, Treatment Outcome.
Abstract
Currently, the best treatment option for idiopathic cervical dystonia (ICD) is injection of botulinum toxin (BTX) into the affected muscles, whereas rehabilitative approaches have given disappointing results. We evaluated whether the association of an ad hoc rehabilitative program may improve the clinical efficacy of BTX treatment in a single-center, cross-over, controlled study. Forty patients with ICD were randomly assigned to two different treatment groups: (1) BTX type A (BTX-A) plus a specific program of physical therapy (BTX-PT) or (2) BTX-A alone (BTX-0). Patients in the BTX-PT group showed a longer duration of the clinical benefit (118.8 vs. 99.1 days) and needed a lower dose of BTX at reinjection (284.5 vs. 325.5 units). In addition, they showed more marked reductions in their disability in activities of daily living (-9.7 vs. -4.85 points) and subjective pain (-13.35 vs. 6.95 points) scores. Association of BTX-A therapy with a specific program of physical therapy may improve ICD treatment outcome.
DOI: 10.1002/mds.21145
PubMed: 17029278
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pubmed:17029278Le document en format XML
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<author><name sortKey="Tassorelli, Cristina" sort="Tassorelli, Cristina" uniqKey="Tassorelli C" first="Cristina" last="Tassorelli">Cristina Tassorelli</name>
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<term>Aged</term>
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<term>Botulinum Toxins, Type A (therapeutic use)</term>
<term>Cross-Over Studies</term>
<term>Double-Blind Method</term>
<term>Electromyography (methods)</term>
<term>Female</term>
<term>Humans</term>
<term>Injections, Intramuscular</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuromuscular Agents (therapeutic use)</term>
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<term>Time Factors</term>
<term>Torticollis (drug therapy)</term>
<term>Torticollis (rehabilitation)</term>
<term>Treatment Outcome</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins, Type A</term>
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<term>Analysis of Variance</term>
<term>Cross-Over Studies</term>
<term>Double-Blind Method</term>
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<term>Humans</term>
<term>Injections, Intramuscular</term>
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<front><div type="abstract" xml:lang="en">Currently, the best treatment option for idiopathic cervical dystonia (ICD) is injection of botulinum toxin (BTX) into the affected muscles, whereas rehabilitative approaches have given disappointing results. We evaluated whether the association of an ad hoc rehabilitative program may improve the clinical efficacy of BTX treatment in a single-center, cross-over, controlled study. Forty patients with ICD were randomly assigned to two different treatment groups: (1) BTX type A (BTX-A) plus a specific program of physical therapy (BTX-PT) or (2) BTX-A alone (BTX-0). Patients in the BTX-PT group showed a longer duration of the clinical benefit (118.8 vs. 99.1 days) and needed a lower dose of BTX at reinjection (284.5 vs. 325.5 units). In addition, they showed more marked reductions in their disability in activities of daily living (-9.7 vs. -4.85 points) and subjective pain (-13.35 vs. 6.95 points) scores. Association of BTX-A therapy with a specific program of physical therapy may improve ICD treatment outcome.</div>
</front>
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<Abstract><AbstractText>Currently, the best treatment option for idiopathic cervical dystonia (ICD) is injection of botulinum toxin (BTX) into the affected muscles, whereas rehabilitative approaches have given disappointing results. We evaluated whether the association of an ad hoc rehabilitative program may improve the clinical efficacy of BTX treatment in a single-center, cross-over, controlled study. Forty patients with ICD were randomly assigned to two different treatment groups: (1) BTX type A (BTX-A) plus a specific program of physical therapy (BTX-PT) or (2) BTX-A alone (BTX-0). Patients in the BTX-PT group showed a longer duration of the clinical benefit (118.8 vs. 99.1 days) and needed a lower dose of BTX at reinjection (284.5 vs. 325.5 units). In addition, they showed more marked reductions in their disability in activities of daily living (-9.7 vs. -4.85 points) and subjective pain (-13.35 vs. 6.95 points) scores. Association of BTX-A therapy with a specific program of physical therapy may improve ICD treatment outcome.</AbstractText>
<CopyrightInformation>Copyright 2006 Movement Disorder Society.</CopyrightInformation>
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<country name="Italie"><noRegion><name sortKey="Tassorelli, Cristina" sort="Tassorelli, Cristina" uniqKey="Tassorelli C" first="Cristina" last="Tassorelli">Cristina Tassorelli</name>
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