Relative risk of spread of symptoms among the focal onset primary dystonias.
Identifieur interne : 001675 ( Ncbi/Merge ); précédent : 001674; suivant : 001676Relative risk of spread of symptoms among the focal onset primary dystonias.
Auteurs : Elliott M. Weiss [États-Unis] ; Tamara Hershey ; Morvarid Karimi ; Brad Racette ; Samer D. Tabbal ; Jonathan W. Mink ; Randal C. Paniello ; Joel S. PerlmutterSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- MESH :
- mortality : Dystonia Musculorum Deformans.
- physiopathology : Dystonia Musculorum Deformans.
- Adult, Disease Progression, Female, Humans, Male, Organ Specificity, Retrospective Studies, Risk Factors, Survival Analysis, Time Factors.
Abstract
Adult-onset primary torsion dystonia (PTD) may spread to multiple body parts, but the relative risk of spread by site of onset of dystonia has not been well characterized. We retrospectively identified 602 patients with PTD out of 1,500 dystonia patients in our electronic database and extracted age at onset, site of onset, family history, and spread. Survival analyses were performed for groups based on site of onset, and hazard ratios compared relative risk of spread across groups. Patients with adult-onset blepharospasm were more likely to spread (31% past the head) than those with dystonia starting in the neck (9%), larynx (12%), or upper extremities (16%). Hazard ratios proved that the blepharospasm group had the greatest relative risk of spread. The rate of spread after onset varied significantly between the different groups. Most spread occurred in the first 1 to 2 years after onset of blepharospasm, whereas the risk of spread was relatively constant over time in cervical and laryngeal dystonia. Different sites of onset of PTD confer different risks of spread, important for clinical prognosis. Different risks of spread may provide clues about underlying pathogenesis of adult-onset primary dystonias.
DOI: 10.1002/mds.20919
PubMed: 16673404
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Relative risk of spread of symptoms among the focal onset primary dystonias.</title><author><name sortKey="Weiss, Elliott M" sort="Weiss, Elliott M" uniqKey="Weiss E" first="Elliott M" last="Weiss">Elliott M. Weiss</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Hershey, Tamara" sort="Hershey, Tamara" uniqKey="Hershey T" first="Tamara" last="Hershey">Tamara Hershey</name></author><author><name sortKey="Karimi, Morvarid" sort="Karimi, Morvarid" uniqKey="Karimi M" first="Morvarid" last="Karimi">Morvarid Karimi</name></author><author><name sortKey="Racette, Brad" sort="Racette, Brad" uniqKey="Racette B" first="Brad" last="Racette">Brad Racette</name></author><author><name sortKey="Tabbal, Samer D" sort="Tabbal, Samer D" uniqKey="Tabbal S" first="Samer D" last="Tabbal">Samer D. Tabbal</name></author><author><name sortKey="Mink, Jonathan W" sort="Mink, Jonathan W" uniqKey="Mink J" first="Jonathan W" last="Mink">Jonathan W. Mink</name></author><author><name sortKey="Paniello, Randal C" sort="Paniello, Randal C" uniqKey="Paniello R" first="Randal C" last="Paniello">Randal C. Paniello</name></author><author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20919</idno><idno type="RBID">pubmed:16673404</idno><idno type="pmid">16673404</idno><idno type="wicri:Area/PubMed/Corpus">002C59</idno><idno type="wicri:Area/PubMed/Curation">002C59</idno><idno type="wicri:Area/PubMed/Checkpoint">002B15</idno><idno type="wicri:Area/Ncbi/Merge">001675</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Relative risk of spread of symptoms among the focal onset primary dystonias.</title><author><name sortKey="Weiss, Elliott M" sort="Weiss, Elliott M" uniqKey="Weiss E" first="Elliott M" last="Weiss">Elliott M. Weiss</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Hershey, Tamara" sort="Hershey, Tamara" uniqKey="Hershey T" first="Tamara" last="Hershey">Tamara Hershey</name></author><author><name sortKey="Karimi, Morvarid" sort="Karimi, Morvarid" uniqKey="Karimi M" first="Morvarid" last="Karimi">Morvarid Karimi</name></author><author><name sortKey="Racette, Brad" sort="Racette, Brad" uniqKey="Racette B" first="Brad" last="Racette">Brad Racette</name></author><author><name sortKey="Tabbal, Samer D" sort="Tabbal, Samer D" uniqKey="Tabbal S" first="Samer D" last="Tabbal">Samer D. Tabbal</name></author><author><name sortKey="Mink, Jonathan W" sort="Mink, Jonathan W" uniqKey="Mink J" first="Jonathan W" last="Mink">Jonathan W. Mink</name></author><author><name sortKey="Paniello, Randal C" sort="Paniello, Randal C" uniqKey="Paniello R" first="Randal C" last="Paniello">Randal C. Paniello</name></author><author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Disease Progression</term><term>Dystonia Musculorum Deformans (mortality)</term><term>Dystonia Musculorum Deformans (physiopathology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Organ Specificity</term><term>Retrospective Studies</term><term>Risk Factors</term><term>Survival Analysis</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Dystonia Musculorum Deformans</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonia Musculorum Deformans</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Organ Specificity</term><term>Retrospective Studies</term><term>Risk Factors</term><term>Survival Analysis</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Adult-onset primary torsion dystonia (PTD) may spread to multiple body parts, but the relative risk of spread by site of onset of dystonia has not been well characterized. We retrospectively identified 602 patients with PTD out of 1,500 dystonia patients in our electronic database and extracted age at onset, site of onset, family history, and spread. Survival analyses were performed for groups based on site of onset, and hazard ratios compared relative risk of spread across groups. Patients with adult-onset blepharospasm were more likely to spread (31% past the head) than those with dystonia starting in the neck (9%), larynx (12%), or upper extremities (16%). Hazard ratios proved that the blepharospasm group had the greatest relative risk of spread. The rate of spread after onset varied significantly between the different groups. Most spread occurred in the first 1 to 2 years after onset of blepharospasm, whereas the risk of spread was relatively constant over time in cervical and laryngeal dystonia. Different sites of onset of PTD confer different risks of spread, important for clinical prognosis. Different risks of spread may provide clues about underlying pathogenesis of adult-onset primary dystonias.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16673404</PMID><DateCreated><Year>2006</Year><Month>08</Month><Day>30</Day></DateCreated><DateCompleted><Year>2007</Year><Month>01</Month><Day>04</Day></DateCompleted><DateRevised><Year>2007</Year><Month>12</Month><Day>03</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>21</Volume><Issue>8</Issue><PubDate><Year>2006</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Relative risk of spread of symptoms among the focal onset primary dystonias.</ArticleTitle><Pagination><MedlinePgn>1175-81</MedlinePgn></Pagination><Abstract><AbstractText>Adult-onset primary torsion dystonia (PTD) may spread to multiple body parts, but the relative risk of spread by site of onset of dystonia has not been well characterized. We retrospectively identified 602 patients with PTD out of 1,500 dystonia patients in our electronic database and extracted age at onset, site of onset, family history, and spread. Survival analyses were performed for groups based on site of onset, and hazard ratios compared relative risk of spread across groups. Patients with adult-onset blepharospasm were more likely to spread (31% past the head) than those with dystonia starting in the neck (9%), larynx (12%), or upper extremities (16%). Hazard ratios proved that the blepharospasm group had the greatest relative risk of spread. The rate of spread after onset varied significantly between the different groups. Most spread occurred in the first 1 to 2 years after onset of blepharospasm, whereas the risk of spread was relatively constant over time in cervical and laryngeal dystonia. Different sites of onset of PTD confer different risks of spread, important for clinical prognosis. 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Mink</name><name sortKey="Paniello, Randal C" sort="Paniello, Randal C" uniqKey="Paniello R" first="Randal C" last="Paniello">Randal C. Paniello</name><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name><name sortKey="Racette, Brad" sort="Racette, Brad" uniqKey="Racette B" first="Brad" last="Racette">Brad Racette</name><name sortKey="Tabbal, Samer D" sort="Tabbal, Samer D" uniqKey="Tabbal S" first="Samer D" last="Tabbal">Samer D. Tabbal</name></noCountry><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Weiss, Elliott M" sort="Weiss, Elliott M" uniqKey="Weiss E" first="Elliott M" last="Weiss">Elliott M. Weiss</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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