Topography of putaminal degeneration in multiple system atrophy: a diffusion magnetic resonance study.
Identifieur interne : 001600 ( Ncbi/Merge ); précédent : 001599; suivant : 001601Topography of putaminal degeneration in multiple system atrophy: a diffusion magnetic resonance study.
Auteurs : Klaus Seppi [Autriche] ; Michael F H. Schocke ; Kathrin Prennschuetz-Schuetzenau ; Katherina J. Mair ; Regina Esterhammer ; Christian Kremser ; Armin Muigg ; Christoph Scherfler ; Werner Jaschke ; Gregor K. Wenning ; Werner Poewe [Autriche]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- MESH :
- anatomy & histology : Putamen.
- pathology : Multiple System Atrophy, Nerve Degeneration, Putamen.
- Humans, Magnetic Resonance Imaging, Reference Values.
Abstract
There is neuropathologic evidence that, in early stages of the Parkinson variant of multiple system atrophy (MSA-P), the putamen shows a distinct topographical pathology affecting predominantly the dorsolateral and caudal regions while leaving the rostral to midparts almost intact. We investigated the topographic profile of putaminal degeneration in MSA-P patients in vivo by means of diffusion-weighted imaging (DWI), which has been shown to reveal abnormalities in the basal ganglia of patients with MSA-P compared to patients with PD and healthy controls. For this purpose, regional trace of the diffusion tensor (rTrace(D)) values were determined in the entire, anterior, and posterior putamen in 15 patients with probable MSA-P, in 20 patients with PD, and in 11 healthy volunteers matched for age and disease duration. MSA-P patients had significantly higher rTrace(D) values in entire, anterior, and posterior putamen compared to both controls and PD patients. Trace(D) values were significantly higher in the posterior compared to the anterior putamen in the MSA-P group. There were no significant differences between posterior and anterior putamen in both the control and PD group. Our study demonstrates prominent involvement of the posterior putamen in early disease stages of MSA-P in vivo by assessing putaminal diffusivity with the help of DWI.
DOI: 10.1002/mds.20843
PubMed: 16538620
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Schocke</name></author><author><name sortKey="Prennschuetz Schuetzenau, Kathrin" sort="Prennschuetz Schuetzenau, Kathrin" uniqKey="Prennschuetz Schuetzenau K" first="Kathrin" last="Prennschuetz-Schuetzenau">Kathrin Prennschuetz-Schuetzenau</name></author><author><name sortKey="Mair, Katherina J" sort="Mair, Katherina J" uniqKey="Mair K" first="Katherina J" last="Mair">Katherina J. Mair</name></author><author><name sortKey="Esterhammer, Regina" sort="Esterhammer, Regina" uniqKey="Esterhammer R" first="Regina" last="Esterhammer">Regina Esterhammer</name></author><author><name sortKey="Kremser, Christian" sort="Kremser, Christian" uniqKey="Kremser C" first="Christian" last="Kremser">Christian Kremser</name></author><author><name sortKey="Muigg, Armin" sort="Muigg, Armin" uniqKey="Muigg A" first="Armin" last="Muigg">Armin Muigg</name></author><author><name sortKey="Scherfler, Christoph" sort="Scherfler, Christoph" uniqKey="Scherfler C" first="Christoph" last="Scherfler">Christoph Scherfler</name></author><author><name sortKey="Jaschke, Werner" sort="Jaschke, Werner" uniqKey="Jaschke W" first="Werner" last="Jaschke">Werner Jaschke</name></author><author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K" last="Wenning">Gregor K. Wenning</name></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation><country>Autriche</country><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20843</idno><idno type="RBID">pubmed:16538620</idno><idno type="pmid">16538620</idno><idno type="wicri:Area/PubMed/Corpus">002D31</idno><idno type="wicri:Area/PubMed/Curation">002D31</idno><idno type="wicri:Area/PubMed/Checkpoint">002A52</idno><idno type="wicri:Area/Ncbi/Merge">001600</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Topography of putaminal degeneration in multiple system atrophy: a diffusion magnetic resonance study.</title><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Innsbruck Medical University, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Innsbruck Medical University</wicri:regionArea><wicri:noRegion>Innsbruck Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Schocke, Michael F H" sort="Schocke, Michael F H" uniqKey="Schocke M" first="Michael F H" last="Schocke">Michael F H. Schocke</name></author><author><name sortKey="Prennschuetz Schuetzenau, Kathrin" sort="Prennschuetz Schuetzenau, Kathrin" uniqKey="Prennschuetz Schuetzenau K" first="Kathrin" last="Prennschuetz-Schuetzenau">Kathrin Prennschuetz-Schuetzenau</name></author><author><name sortKey="Mair, Katherina J" sort="Mair, Katherina J" uniqKey="Mair K" first="Katherina J" last="Mair">Katherina J. Mair</name></author><author><name sortKey="Esterhammer, Regina" sort="Esterhammer, Regina" uniqKey="Esterhammer R" first="Regina" last="Esterhammer">Regina Esterhammer</name></author><author><name sortKey="Kremser, Christian" sort="Kremser, Christian" uniqKey="Kremser C" first="Christian" last="Kremser">Christian Kremser</name></author><author><name sortKey="Muigg, Armin" sort="Muigg, Armin" uniqKey="Muigg A" first="Armin" last="Muigg">Armin Muigg</name></author><author><name sortKey="Scherfler, Christoph" sort="Scherfler, Christoph" uniqKey="Scherfler C" first="Christoph" last="Scherfler">Christoph Scherfler</name></author><author><name sortKey="Jaschke, Werner" sort="Jaschke, Werner" uniqKey="Jaschke W" first="Werner" last="Jaschke">Werner Jaschke</name></author><author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K" last="Wenning">Gregor K. Wenning</name></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation><country>Autriche</country><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Multiple System Atrophy (pathology)</term><term>Nerve Degeneration (pathology)</term><term>Putamen (anatomy & histology)</term><term>Putamen (pathology)</term><term>Reference Values</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Multiple System Atrophy</term><term>Nerve Degeneration</term><term>Putamen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Reference Values</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is neuropathologic evidence that, in early stages of the Parkinson variant of multiple system atrophy (MSA-P), the putamen shows a distinct topographical pathology affecting predominantly the dorsolateral and caudal regions while leaving the rostral to midparts almost intact. We investigated the topographic profile of putaminal degeneration in MSA-P patients in vivo by means of diffusion-weighted imaging (DWI), which has been shown to reveal abnormalities in the basal ganglia of patients with MSA-P compared to patients with PD and healthy controls. For this purpose, regional trace of the diffusion tensor (rTrace(D)) values were determined in the entire, anterior, and posterior putamen in 15 patients with probable MSA-P, in 20 patients with PD, and in 11 healthy volunteers matched for age and disease duration. MSA-P patients had significantly higher rTrace(D) values in entire, anterior, and posterior putamen compared to both controls and PD patients. Trace(D) values were significantly higher in the posterior compared to the anterior putamen in the MSA-P group. There were no significant differences between posterior and anterior putamen in both the control and PD group. Our study demonstrates prominent involvement of the posterior putamen in early disease stages of MSA-P in vivo by assessing putaminal diffusivity with the help of DWI.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16538620</PMID><DateCreated><Year>2006</Year><Month>06</Month><Day>13</Day></DateCreated><DateCompleted><Year>2006</Year><Month>11</Month><Day>14</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>21</Volume><Issue>6</Issue><PubDate><Year>2006</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Topography of putaminal degeneration in multiple system atrophy: a diffusion magnetic resonance study.</ArticleTitle><Pagination><MedlinePgn>847-52</MedlinePgn></Pagination><Abstract><AbstractText>There is neuropathologic evidence that, in early stages of the Parkinson variant of multiple system atrophy (MSA-P), the putamen shows a distinct topographical pathology affecting predominantly the dorsolateral and caudal regions while leaving the rostral to midparts almost intact. We investigated the topographic profile of putaminal degeneration in MSA-P patients in vivo by means of diffusion-weighted imaging (DWI), which has been shown to reveal abnormalities in the basal ganglia of patients with MSA-P compared to patients with PD and healthy controls. For this purpose, regional trace of the diffusion tensor (rTrace(D)) values were determined in the entire, anterior, and posterior putamen in 15 patients with probable MSA-P, in 20 patients with PD, and in 11 healthy volunteers matched for age and disease duration. MSA-P patients had significantly higher rTrace(D) values in entire, anterior, and posterior putamen compared to both controls and PD patients. Trace(D) values were significantly higher in the posterior compared to the anterior putamen in the MSA-P group. There were no significant differences between posterior and anterior putamen in both the control and PD group. Our study demonstrates prominent involvement of the posterior putamen in early disease stages of MSA-P in vivo by assessing putaminal diffusivity with the help of DWI.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Seppi</LastName><ForeName>Klaus</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Neurology, Innsbruck Medical University, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schocke</LastName><ForeName>Michael F H</ForeName><Initials>MF</Initials></Author><Author ValidYN="Y"><LastName>Prennschuetz-Schuetzenau</LastName><ForeName>Kathrin</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Mair</LastName><ForeName>Katherina J</ForeName><Initials>KJ</Initials></Author><Author ValidYN="Y"><LastName>Esterhammer</LastName><ForeName>Regina</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Kremser</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Muigg</LastName><ForeName>Armin</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Scherfler</LastName><ForeName>Christoph</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Jaschke</LastName><ForeName>Werner</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Wenning</LastName><ForeName>Gregor K</ForeName><Initials>GK</Initials></Author><Author ValidYN="Y"><LastName>Poewe</LastName><ForeName>Werner</ForeName><Initials>W</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D008279">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019578">Multiple System Atrophy</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009410">Nerve Degeneration</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011699">Putamen</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000033">anatomy & histology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012016">Reference Values</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>3</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>11</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>3</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.20843</ArticleId><ArticleId IdType="pubmed">16538620</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Autriche</li></country><region><li>Tyrol (Land)</li></region><settlement><li>Innsbruck</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><noCountry><name sortKey="Esterhammer, Regina" sort="Esterhammer, Regina" uniqKey="Esterhammer R" first="Regina" last="Esterhammer">Regina Esterhammer</name><name sortKey="Jaschke, Werner" sort="Jaschke, Werner" uniqKey="Jaschke W" first="Werner" last="Jaschke">Werner Jaschke</name><name sortKey="Kremser, Christian" sort="Kremser, Christian" uniqKey="Kremser C" first="Christian" last="Kremser">Christian Kremser</name><name sortKey="Mair, Katherina J" sort="Mair, Katherina J" uniqKey="Mair K" first="Katherina J" last="Mair">Katherina J. Mair</name><name sortKey="Muigg, Armin" sort="Muigg, Armin" uniqKey="Muigg A" first="Armin" last="Muigg">Armin Muigg</name><name sortKey="Prennschuetz Schuetzenau, Kathrin" sort="Prennschuetz Schuetzenau, Kathrin" uniqKey="Prennschuetz Schuetzenau K" first="Kathrin" last="Prennschuetz-Schuetzenau">Kathrin Prennschuetz-Schuetzenau</name><name sortKey="Scherfler, Christoph" sort="Scherfler, Christoph" uniqKey="Scherfler C" first="Christoph" last="Scherfler">Christoph Scherfler</name><name sortKey="Schocke, Michael F H" sort="Schocke, Michael F H" uniqKey="Schocke M" first="Michael F H" last="Schocke">Michael F H. Schocke</name><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K" last="Wenning">Gregor K. Wenning</name></noCountry><country name="Autriche"><noRegion><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name></noRegion><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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