MovDisordV3, Ncbi, Merge, bibRecord, 001496

Anticholinesterase Effect on Motor Kinematic Measures and Brain Activation in Parkinson’s Disease

Identifieur interne : 001496 ( Ncbi/Merge ); précédent : 001495; suivant : 001497

Anticholinesterase Effect on Motor Kinematic Measures and Brain Activation in Parkinson’s Disease

Auteurs : Marc J. Mentis [États-Unis] ; Dominique Delalot [États-Unis] ; Hassan Naqvi [États-Unis] ; Mark F. Gordon [États-Unis] ; Mark Gudesblatt [États-Unis] ; Christine Edwards [États-Unis] ; Luke Donatelli [États-Unis] ; Vijay Dhawan [États-Unis] ; David Eidelberg [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.

RBID : PMC:4457276

English descriptors

KwdEn :
- Analysis of Variance, Biomechanical Phenomena, Brain (drug effects), Brain (pathology), Brain (radionuclide imaging), Cholinesterase Inhibitors (therapeutic use), Double-Blind Method, Female, Humans, Indans (therapeutic use), Male, Movement (drug effects), Parkinson Disease (drug therapy), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Piperidines (therapeutic use), Positron-Emission Tomography (methods).
MESH :
- chemical , therapeutic use : Cholinesterase Inhibitors, Indans, Piperidines.
- drug effects : Brain, Movement.
- drug therapy : Parkinson Disease.
- methods : Positron-Emission Tomography.
- pathology : Brain, Parkinson Disease.
- physiopathology : Parkinson Disease.
- radionuclide imaging : Brain.
- Analysis of Variance, Biomechanical Phenomena, Double-Blind Method, Female, Humans, Male.

Abstract

Anticholinesterase (AChE) drugs are being prescribed off label for nonmotor symptoms in Parkinson’s disease (PD). Theoretically, these drugs can impair motor function. A small literature suggests AChE therapy has little effect on clinical motor evaluation; however, no study has made objective motor kinematic measures or evaluated brain function. We hypothesized that even if clinical examination was normal in PD patients on dopamine therapy, (1) sensitive kinematic measures would be abnormal during AChE therapy or (2) normal kinematic measures would be maintained by compensatory brain activation. We carried out a randomized, double-blind, placebo-controlled trial of 8 weeks donepezil (10 mg/day) in 17 PD subjects. Subjects carried out a computerized motor task during a positron emission tomography (PET) scan before starting the drug and again after 8 weeks of donepezil or placebo. Kinematic measures of motor function and PET scans were analyzed to compare the effects of donepezil and placebo. Neither placebo nor donepezil altered motor kinematic measures. Furthermore, movement integrity while on donepezil was maintained without compensatory brain activity. Donepezil 10 mg/day can be given for nonmotor symptoms in PD without adverse motor effects or compensatory brain activity.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457276

DOI: 10.1002/mds.20706
PubMed: 16228997
PubMed Central: 4457276

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PMC:4457276

Le document en format XML

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<term>Brain (radionuclide imaging)</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">Anticholinesterase (AChE) drugs are being prescribed off label for nonmotor symptoms in Parkinson’s disease (PD). Theoretically, these drugs can impair motor function. A small literature suggests AChE therapy has little effect on clinical motor evaluation; however, no study has made objective motor kinematic measures or evaluated brain function. We hypothesized that even if clinical examination was normal in PD patients on dopamine therapy, (1) sensitive kinematic measures would be abnormal during AChE therapy or (2) normal kinematic measures would be maintained by compensatory brain activation. We carried out a randomized, double-blind, placebo-controlled trial of 8 weeks donepezil (10 mg/day) in 17 PD subjects. Subjects carried out a computerized motor task during a positron emission tomography (PET) scan before starting the drug and again after 8 weeks of donepezil or placebo. Kinematic measures of motor function and PET scans were analyzed to compare the effects of donepezil and placebo. Neither placebo nor donepezil altered motor kinematic measures. Furthermore, movement integrity while on donepezil was maintained without compensatory brain activity. Donepezil 10 mg/day can be given for nonmotor symptoms in PD without adverse motor effects or compensatory brain activity.</p>
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<wicri:regionArea>Center for Neurosciences, North Shore–LIJ Health System, New Hyde Park, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Naqvi, Hassan" sort="Naqvi, Hassan" uniqKey="Naqvi H" first="Hassan" last="Naqvi">Hassan Naqvi</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Movement Disorders Center, North Shore–LIJ Health System, New Hyde Park, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Movement Disorders Center, North Shore–LIJ Health System, New Hyde Park, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gordon, Mark F" sort="Gordon, Mark F" uniqKey="Gordon M" first="Mark F." last="Gordon">Mark F. Gordon</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Movement Disorders Center, North Shore–LIJ Health System, New Hyde Park, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Movement Disorders Center, North Shore–LIJ Health System, New Hyde Park, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gudesblatt, Mark" sort="Gudesblatt, Mark" uniqKey="Gudesblatt M" first="Mark" last="Gudesblatt">Mark Gudesblatt</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Neurology, South Shore Associates, Bay Shore, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Neurology, South Shore Associates, Bay Shore, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Edwards, Christine" sort="Edwards, Christine" uniqKey="Edwards C" first="Christine" last="Edwards">Christine Edwards</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Center for Neurosciences, North Shore–LIJ Health System, New Hyde Park, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neurosciences, North Shore–LIJ Health System, New Hyde Park, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Donatelli, Luke" sort="Donatelli, Luke" uniqKey="Donatelli L" first="Luke" last="Donatelli">Luke Donatelli</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Center for Neurosciences, North Shore–LIJ Health System, New Hyde Park, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neurosciences, North Shore–LIJ Health System, New Hyde Park, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Center for Neurosciences, North Shore–LIJ Health System, New Hyde Park, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neurosciences, North Shore–LIJ Health System, New Hyde Park, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Center for Neurosciences, North Shore–LIJ Health System, New Hyde Park, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neurosciences, North Shore–LIJ Health System, New Hyde Park, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2006">2006</date>
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<front><div type="abstract" xml:lang="en"><p id="P1">Anticholinesterase (AChE) drugs are being prescribed off label for nonmotor symptoms in Parkinson’s disease (PD). Theoretically, these drugs can impair motor function. A small literature suggests AChE therapy has little effect on clinical motor evaluation; however, no study has made objective motor kinematic measures or evaluated brain function. We hypothesized that even if clinical examination was normal in PD patients on dopamine therapy, (1) sensitive kinematic measures would be abnormal during AChE therapy or (2) normal kinematic measures would be maintained by compensatory brain activation. We carried out a randomized, double-blind, placebo-controlled trial of 8 weeks donepezil (10 mg/day) in 17 PD subjects. Subjects carried out a computerized motor task during a positron emission tomography (PET) scan before starting the drug and again after 8 weeks of donepezil or placebo. Kinematic measures of motor function and PET scans were analyzed to compare the effects of donepezil and placebo. Neither placebo nor donepezil altered motor kinematic measures. Furthermore, movement integrity while on donepezil was maintained without compensatory brain activity. Donepezil 10 mg/day can be given for nonmotor symptoms in PD without adverse motor effects or compensatory brain activity.</p>
</div>
</front>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anticholinesterase effect on motor kinematic measures and brain activation in Parkinson's disease.</title>
<author><name sortKey="Mentis, Marc J" sort="Mentis, Marc J" uniqKey="Mentis M" first="Marc J" last="Mentis">Marc J. Mentis</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Neurosciences, North Shore-LIJ Health System, New Hyde Park, NY 11030, USA. mentis@nshs.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neurosciences, North Shore-LIJ Health System, New Hyde Park, NY 11030</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delalot, Dominique" sort="Delalot, Dominique" uniqKey="Delalot D" first="Dominique" last="Delalot">Dominique Delalot</name>
</author>
<author><name sortKey="Naqvi, Hassan" sort="Naqvi, Hassan" uniqKey="Naqvi H" first="Hassan" last="Naqvi">Hassan Naqvi</name>
</author>
<author><name sortKey="Gordon, Mark F" sort="Gordon, Mark F" uniqKey="Gordon M" first="Mark F" last="Gordon">Mark F. Gordon</name>
</author>
<author><name sortKey="Gudesblatt, Mark" sort="Gudesblatt, Mark" uniqKey="Gudesblatt M" first="Mark" last="Gudesblatt">Mark Gudesblatt</name>
</author>
<author><name sortKey="Edwards, Christine" sort="Edwards, Christine" uniqKey="Edwards C" first="Christine" last="Edwards">Christine Edwards</name>
</author>
<author><name sortKey="Donatelli, Luke" sort="Donatelli, Luke" uniqKey="Donatelli L" first="Luke" last="Donatelli">Luke Donatelli</name>
</author>
<author><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name>
</author>
<author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2006">2006</date>
<idno type="doi">10.1002/mds.20706</idno>
<idno type="RBID">pubmed:16228997</idno>
<idno type="pmid">16228997</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Anticholinesterase effect on motor kinematic measures and brain activation in Parkinson's disease.</title>
<author><name sortKey="Mentis, Marc J" sort="Mentis, Marc J" uniqKey="Mentis M" first="Marc J" last="Mentis">Marc J. Mentis</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Neurosciences, North Shore-LIJ Health System, New Hyde Park, NY 11030, USA. mentis@nshs.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neurosciences, North Shore-LIJ Health System, New Hyde Park, NY 11030</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delalot, Dominique" sort="Delalot, Dominique" uniqKey="Delalot D" first="Dominique" last="Delalot">Dominique Delalot</name>
</author>
<author><name sortKey="Naqvi, Hassan" sort="Naqvi, Hassan" uniqKey="Naqvi H" first="Hassan" last="Naqvi">Hassan Naqvi</name>
</author>
<author><name sortKey="Gordon, Mark F" sort="Gordon, Mark F" uniqKey="Gordon M" first="Mark F" last="Gordon">Mark F. Gordon</name>
</author>
<author><name sortKey="Gudesblatt, Mark" sort="Gudesblatt, Mark" uniqKey="Gudesblatt M" first="Mark" last="Gudesblatt">Mark Gudesblatt</name>
</author>
<author><name sortKey="Edwards, Christine" sort="Edwards, Christine" uniqKey="Edwards C" first="Christine" last="Edwards">Christine Edwards</name>
</author>
<author><name sortKey="Donatelli, Luke" sort="Donatelli, Luke" uniqKey="Donatelli L" first="Luke" last="Donatelli">Luke Donatelli</name>
</author>
<author><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name>
</author>
<author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2006" type="published">2006</date>
</imprint>
</series>
</biblStruct>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term>
<term>Biomechanical Phenomena</term>
<term>Brain (drug effects)</term>
<term>Brain (pathology)</term>
<term>Brain (radionuclide imaging)</term>
<term>Cholinesterase Inhibitors (therapeutic use)</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Indans (therapeutic use)</term>
<term>Male</term>
<term>Movement (drug effects)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Piperidines (therapeutic use)</term>
<term>Positron-Emission Tomography (methods)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Cholinesterase Inhibitors</term>
<term>Indans</term>
<term>Piperidines</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brain</term>
<term>Movement</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Positron-Emission Tomography</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term>
<term>Biomechanical Phenomena</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Anticholinesterase (AChE) drugs are being prescribed off label for nonmotor symptoms in Parkinson's disease (PD). Theoretically, these drugs can impair motor function. A small literature suggests AChE therapy has little effect on clinical motor evaluation; however, no study has made objective motor kinematic measures or evaluated brain function. We hypothesized that even if clinical examination was normal in PD patients on dopamine therapy, (1) sensitive kinematic measures would be abnormal during AChE therapy or (2) normal kinematic measures would be maintained by compensatory brain activation. We carried out a randomized, double-blind, placebo-controlled trial of 8 weeks donepezil (10 mg/day) in 17 PD subjects. Subjects carried out a computerized motor task during a positron emission tomography (PET) scan before starting the drug and again after 8 weeks of donepezil or placebo. Kinematic measures of motor function and PET scans were analyzed to compare the effects of donepezil and placebo. Neither placebo nor donepezil altered motor kinematic measures. Furthermore, movement integrity while on donepezil was maintained without compensatory brain activity. Donepezil 10 mg/day can be given for nonmotor symptoms in PD without adverse motor effects or compensatory brain activity.</div>
</front>
</TEI>
</pubmed>
</double>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Anticholinesterase Effect on Motor Kinematic Measures and Brain Activation in Parkinson’s Disease

Anticholinesterase Effect on Motor Kinematic Measures and Brain Activation in Parkinson’s Disease

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