Swallowing abnormalities and dyskinesia in Parkinson's disease.
Identifieur interne : 001128 ( Ncbi/Merge ); précédent : 001127; suivant : 001129Swallowing abnormalities and dyskinesia in Parkinson's disease.
Auteurs : Francisca Sueli Monte [Brésil] ; Francisco Pereira Da Silva-Júnior ; Pedro Braga-Neto ; Miguel Angelo Nobre E Souza ; Veralice Meireles Sales De BruinSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Body Mass Index, Deglutition Disorders (chemically induced), Deglutition Disorders (diagnosis), Deglutition Disorders (physiopathology), Dyskinesia, Drug-Induced (etiology), Female, Fluoroscopy (instrumentation), Humans, Levodopa (adverse effects), Male, Middle Aged, Oropharynx (physiopathology), Parkinson Disease (drug therapy), Severity of Illness Index, Videotape Recording.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemically induced : Deglutition Disorders.
- diagnosis : Deglutition Disorders.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- instrumentation : Fluoroscopy.
- physiopathology : Deglutition Disorders, Oropharynx.
- Aged, Body Mass Index, Female, Humans, Male, Middle Aged, Severity of Illness Index, Videotape Recording.
Abstract
Gastrointestinal abnormalities in Parkinson's disease (PD) have been known for almost two centuries, but many aspects concerning their pathophysiology have not been completely clarified. The aim of this study was to characterize the oropharyngeal dynamics in PD patients with and without levodopa-induced dyskinesia. Fifteen dyskinetic, 12 nondyskinetic patients, and a control group were included. Patients were asked about dysphagia and evaluated with the Unified Parkinson's Disease Rating Scale Parts II and III and the Hoehn and Yahr scale. Deglutition was assessed using modified barium swallow with videofluoroscopy. Nondyskinetic patients, but not the dyskinetic ones, showed less oropharyngeal swallowing efficiency (OPSE) for liquid food than controls (Dunnett, P = 0.02). Dyskinetic patients tended to have a greater OPSE than nondyskinetic (Dunnett, P = 0.06). Patients who were using a higher dose of levodopa had a greater OPSE and a trend toward a smaller oral transit time (Pearson's correlation, P = 0.01 and 0.08, respectively). Neither the report of dysphagia nor any of the PD severity parameters correlated to the videofluoroscopic variables. In the current study, dyskinetic patients performed better in swallowing function, which could be explained on the basis of a greater levodopa dose. Our results suggest a role for levodopa in the oral phase of deglutition and confirm that dysphagia is not a good predictor of deglutition alterations in PD.
DOI: 10.1002/mds.20342
PubMed: 15625689
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Swallowing abnormalities and dyskinesia in Parkinson's disease.</title><author><name sortKey="Monte, Francisca Sueli" sort="Monte, Francisca Sueli" uniqKey="Monte F" first="Francisca Sueli" last="Monte">Francisca Sueli Monte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy, Federal University of Ceará, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Pharmacy, Federal University of Ceará</wicri:regionArea><wicri:noRegion>Federal University of Ceará</wicri:noRegion></affiliation></author><author><name sortKey="Da Silva Junior, Francisco Pereira" sort="Da Silva Junior, Francisco Pereira" uniqKey="Da Silva Junior F" first="Francisco Pereira" last="Da Silva-Júnior">Francisco Pereira Da Silva-Júnior</name></author><author><name sortKey="Braga Neto, Pedro" sort="Braga Neto, Pedro" uniqKey="Braga Neto P" first="Pedro" last="Braga-Neto">Pedro Braga-Neto</name></author><author><name sortKey="Nobre E Souza, Miguel Angelo" sort="Nobre E Souza, Miguel Angelo" uniqKey="Nobre E Souza M" first="Miguel Angelo" last="Nobre E Souza">Miguel Angelo Nobre E Souza</name></author><author><name sortKey="De Bruin, Veralice Meireles Sales" sort="De Bruin, Veralice Meireles Sales" uniqKey="De Bruin V" first="Veralice Meireles Sales" last="De Bruin">Veralice Meireles Sales De Bruin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1002/mds.20342</idno><idno type="RBID">pubmed:15625689</idno><idno type="pmid">15625689</idno><idno type="wicri:Area/PubMed/Corpus">003173</idno><idno type="wicri:Area/PubMed/Curation">003173</idno><idno type="wicri:Area/PubMed/Checkpoint">002F48</idno><idno type="wicri:Area/Ncbi/Merge">001128</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Swallowing abnormalities and dyskinesia in Parkinson's disease.</title><author><name sortKey="Monte, Francisca Sueli" sort="Monte, Francisca Sueli" uniqKey="Monte F" first="Francisca Sueli" last="Monte">Francisca Sueli Monte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy, Federal University of Ceará, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Pharmacy, Federal University of Ceará</wicri:regionArea><wicri:noRegion>Federal University of Ceará</wicri:noRegion></affiliation></author><author><name sortKey="Da Silva Junior, Francisco Pereira" sort="Da Silva Junior, Francisco Pereira" uniqKey="Da Silva Junior F" first="Francisco Pereira" last="Da Silva-Júnior">Francisco Pereira Da Silva-Júnior</name></author><author><name sortKey="Braga Neto, Pedro" sort="Braga Neto, Pedro" uniqKey="Braga Neto P" first="Pedro" last="Braga-Neto">Pedro Braga-Neto</name></author><author><name sortKey="Nobre E Souza, Miguel Angelo" sort="Nobre E Souza, Miguel Angelo" uniqKey="Nobre E Souza M" first="Miguel Angelo" last="Nobre E Souza">Miguel Angelo Nobre E Souza</name></author><author><name sortKey="De Bruin, Veralice Meireles Sales" sort="De Bruin, Veralice Meireles Sales" uniqKey="De Bruin V" first="Veralice Meireles Sales" last="De Bruin">Veralice Meireles Sales De Bruin</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (adverse effects)</term><term>Body Mass Index</term><term>Deglutition Disorders (chemically induced)</term><term>Deglutition Disorders (diagnosis)</term><term>Deglutition Disorders (physiopathology)</term><term>Dyskinesia, Drug-Induced (etiology)</term><term>Female</term><term>Fluoroscopy (instrumentation)</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Oropharynx (physiopathology)</term><term>Parkinson Disease (drug therapy)</term><term>Severity of Illness Index</term><term>Videotape Recording</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Deglutition Disorders</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Deglutition Disorders</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Fluoroscopy</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Deglutition Disorders</term><term>Oropharynx</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Body Mass Index</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Videotape Recording</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gastrointestinal abnormalities in Parkinson's disease (PD) have been known for almost two centuries, but many aspects concerning their pathophysiology have not been completely clarified. The aim of this study was to characterize the oropharyngeal dynamics in PD patients with and without levodopa-induced dyskinesia. Fifteen dyskinetic, 12 nondyskinetic patients, and a control group were included. Patients were asked about dysphagia and evaluated with the Unified Parkinson's Disease Rating Scale Parts II and III and the Hoehn and Yahr scale. Deglutition was assessed using modified barium swallow with videofluoroscopy. Nondyskinetic patients, but not the dyskinetic ones, showed less oropharyngeal swallowing efficiency (OPSE) for liquid food than controls (Dunnett, P = 0.02). Dyskinetic patients tended to have a greater OPSE than nondyskinetic (Dunnett, P = 0.06). Patients who were using a higher dose of levodopa had a greater OPSE and a trend toward a smaller oral transit time (Pearson's correlation, P = 0.01 and 0.08, respectively). Neither the report of dysphagia nor any of the PD severity parameters correlated to the videofluoroscopic variables. In the current study, dyskinetic patients performed better in swallowing function, which could be explained on the basis of a greater levodopa dose. Our results suggest a role for levodopa in the oral phase of deglutition and confirm that dysphagia is not a good predictor of deglutition alterations in PD.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">15625689</PMID><DateCreated><Year>2005</Year><Month>04</Month><Day>13</Day></DateCreated><DateCompleted><Year>2005</Year><Month>08</Month><Day>25</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>20</Volume><Issue>4</Issue><PubDate><Year>2005</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Swallowing abnormalities and dyskinesia in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>457-62</MedlinePgn></Pagination><Abstract><AbstractText>Gastrointestinal abnormalities in Parkinson's disease (PD) have been known for almost two centuries, but many aspects concerning their pathophysiology have not been completely clarified. The aim of this study was to characterize the oropharyngeal dynamics in PD patients with and without levodopa-induced dyskinesia. Fifteen dyskinetic, 12 nondyskinetic patients, and a control group were included. Patients were asked about dysphagia and evaluated with the Unified Parkinson's Disease Rating Scale Parts II and III and the Hoehn and Yahr scale. Deglutition was assessed using modified barium swallow with videofluoroscopy. Nondyskinetic patients, but not the dyskinetic ones, showed less oropharyngeal swallowing efficiency (OPSE) for liquid food than controls (Dunnett, P = 0.02). Dyskinetic patients tended to have a greater OPSE than nondyskinetic (Dunnett, P = 0.06). Patients who were using a higher dose of levodopa had a greater OPSE and a trend toward a smaller oral transit time (Pearson's correlation, P = 0.01 and 0.08, respectively). Neither the report of dysphagia nor any of the PD severity parameters correlated to the videofluoroscopic variables. In the current study, dyskinetic patients performed better in swallowing function, which could be explained on the basis of a greater levodopa dose. Our results suggest a role for levodopa in the oral phase of deglutition and confirm that dysphagia is not a good predictor of deglutition alterations in PD.</AbstractText><CopyrightInformation>Copyright 2004 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Monte</LastName><ForeName>Francisca Sueli</ForeName><Initials>FS</Initials><AffiliationInfo><Affiliation>Department of Pharmacy, Federal University of Ceará, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>da Silva-Júnior</LastName><ForeName>Francisco Pereira</ForeName><Initials>FP</Initials></Author><Author ValidYN="Y"><LastName>Braga-Neto</LastName><ForeName>Pedro</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Nobre e Souza</LastName><ForeName>Miguel Angelo</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>de Bruin</LastName><ForeName>Veralice Meireles 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UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007980">Levodopa</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009960">Oropharynx</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014743">Videotape Recording</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>12</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>8</Month><Day>27</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>12</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.20342</ArticleId><ArticleId IdType="pubmed">15625689</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Brésil</li></country></list><tree><noCountry><name sortKey="Braga Neto, Pedro" sort="Braga Neto, Pedro" uniqKey="Braga Neto P" first="Pedro" last="Braga-Neto">Pedro Braga-Neto</name><name sortKey="Da Silva Junior, Francisco Pereira" sort="Da Silva Junior, Francisco Pereira" uniqKey="Da Silva Junior F" first="Francisco Pereira" last="Da Silva-Júnior">Francisco Pereira Da Silva-Júnior</name><name sortKey="De Bruin, Veralice Meireles Sales" sort="De Bruin, Veralice Meireles Sales" uniqKey="De Bruin V" first="Veralice Meireles Sales" last="De Bruin">Veralice Meireles Sales De Bruin</name><name sortKey="Nobre E Souza, Miguel Angelo" sort="Nobre E Souza, Miguel Angelo" uniqKey="Nobre E Souza M" first="Miguel Angelo" last="Nobre E Souza">Miguel Angelo Nobre E Souza</name></noCountry><country name="Brésil"><noRegion><name sortKey="Monte, Francisca Sueli" sort="Monte, Francisca Sueli" uniqKey="Monte F" first="Francisca Sueli" last="Monte">Francisca Sueli Monte</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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