Adult-onset generalized dystonia due to a mutation in the neuroferritinopathy gene.
Identifieur interne : 001007 ( Ncbi/Merge ); précédent : 001006; suivant : 001008Adult-onset generalized dystonia due to a mutation in the neuroferritinopathy gene.
Auteurs : Pablo Mir [Royaume-Uni] ; Mark J. Edwards ; Andrew R J. Curtis ; Kailash P. Bhatia ; Niall P. QuinnSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Adult, Basal Ganglia (pathology), Chromosome Disorders (genetics), DNA Mutational Analysis (methods), Dystonic Disorders (blood), Dystonic Disorders (genetics), Dystonic Disorders (pathology), Ferritins (genetics), Humans, Magnetic Resonance Imaging (methods), Male, Mutation, Protein Subunits (genetics).
- MESH :
- chemical , genetics : Ferritins, Protein Subunits.
- blood : Dystonic Disorders.
- genetics : Chromosome Disorders, Dystonic Disorders.
- methods : DNA Mutational Analysis, Magnetic Resonance Imaging.
- pathology : Basal Ganglia, Dystonic Disorders.
- Adult, Humans, Male, Mutation.
Abstract
Neuroferritinopathy is a recently recognized autosomal dominant disorder that results in abnormal aggregates of iron and ferritin in the brain due to a mutation in the ferritin light chain gene on chromosome 19q13.3. We present the clinical details of a patient with adult-onset generalized dystonia associated with this mutation. Neuroferritinopathy appears to be a rare disorder; hence, there is a need to report new cases to further our understanding of the clinical phenotype, diagnostic challenges, the course of the condition and imaging characteristics.
DOI: 10.1002/mds.20280
PubMed: 15390032
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pubmed:15390032Le document en format XML
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<front><div type="abstract" xml:lang="en">Neuroferritinopathy is a recently recognized autosomal dominant disorder that results in abnormal aggregates of iron and ferritin in the brain due to a mutation in the ferritin light chain gene on chromosome 19q13.3. We present the clinical details of a patient with adult-onset generalized dystonia associated with this mutation. Neuroferritinopathy appears to be a rare disorder; hence, there is a need to report new cases to further our understanding of the clinical phenotype, diagnostic challenges, the course of the condition and imaging characteristics.</div>
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<Abstract><AbstractText>Neuroferritinopathy is a recently recognized autosomal dominant disorder that results in abnormal aggregates of iron and ferritin in the brain due to a mutation in the ferritin light chain gene on chromosome 19q13.3. We present the clinical details of a patient with adult-onset generalized dystonia associated with this mutation. Neuroferritinopathy appears to be a rare disorder; hence, there is a need to report new cases to further our understanding of the clinical phenotype, diagnostic challenges, the course of the condition and imaging characteristics.</AbstractText>
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