The pallidosubthalamic projection: an anatomical substrate for nonmotor functions of the subthalamic nucleus in primates.
Identifieur interne : 000F55 ( Ncbi/Merge ); précédent : 000F54; suivant : 000F56The pallidosubthalamic projection: an anatomical substrate for nonmotor functions of the subthalamic nucleus in primates.
Auteurs : Carine Karachi [France] ; Jérôme Yelnik ; Dominique Tandé ; Léon Tremblay ; Etienne C. Hirsch ; Chantal FrançoisSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Animals, Biotin (analogs & derivatives), Biotin (metabolism), Calbindins, Dextrans (metabolism), Globus Pallidus (anatomy & histology), Globus Pallidus (metabolism), Immunohistochemistry (methods), Male, Neural Pathways (anatomy & histology), Neural Pathways (metabolism), Primates, S100 Calcium Binding Protein G (metabolism), Subthalamic Nucleus (anatomy & histology), Subthalamic Nucleus (metabolism), Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate (metabolism).
- MESH :
- chemical , analogs & derivatives : Biotin.
- chemical , metabolism : Biotin, Dextrans, S100 Calcium Binding Protein G, Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate.
- anatomy & histology : Globus Pallidus, Neural Pathways, Subthalamic Nucleus.
- metabolism : Globus Pallidus, Neural Pathways, Subthalamic Nucleus.
- methods : Immunohistochemistry.
- Animals, Calbindins, Male, Primates.
Abstract
The subthalamic nucleus (STN) is the best target for correcting motor disability in parkinsonian patients with high-frequency stimulation. However, STN stimulation has also been reported to modify cognitive, emotional, and motivational functions. The aim of this study was to analyze the topographic organization of the STN according to its inputs coming from the sensorimotor, associative, and limbic territories of the external globus pallidus (GPe) in monkeys, with special reference to the limbic projection. Axonal tracers were injected into the different functional territories of the GPe. Injection performed in the limbic GPe resulted in labeling of cell bodies in the dorsal nucleus accumbens and in a dense labeling of axons in the anterior and medioventral portion of the STN. In comparison, injections in the associative and sensorimotor GPe led to labeling in the central and dorsolateral parts of the STN, respectively. Individual pallidosubthalamic axons ramified into numerous varicose branches, which were restricted to a given territory in the STN. These data provide a functional cartography of this structure in primates and suggest that behavioral disorders observed in stimulated parkinsonian patients could result from a dysfunction of the limbic part of the STN.
DOI: 10.1002/mds.20302
PubMed: 15382210
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pubmed:15382210Le document en format XML
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Karachi@ccr.jussieu.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Yelnik, Jerome" sort="Yelnik, Jerome" uniqKey="Yelnik J" first="Jérôme" last="Yelnik">Jérôme Yelnik</name></author><author><name sortKey="Tande, Dominique" sort="Tande, Dominique" uniqKey="Tande D" first="Dominique" last="Tandé">Dominique Tandé</name></author><author><name sortKey="Tremblay, Leon" sort="Tremblay, Leon" uniqKey="Tremblay L" first="Léon" last="Tremblay">Léon Tremblay</name></author><author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C" last="Hirsch">Etienne C. 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Hirsch</name></author><author><name sortKey="Francois, Chantal" sort="Francois, Chantal" uniqKey="Francois C" first="Chantal" last="François">Chantal François</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biotin (analogs & derivatives)</term><term>Biotin (metabolism)</term><term>Calbindins</term><term>Dextrans (metabolism)</term><term>Globus Pallidus (anatomy & histology)</term><term>Globus Pallidus (metabolism)</term><term>Immunohistochemistry (methods)</term><term>Male</term><term>Neural Pathways (anatomy & histology)</term><term>Neural Pathways (metabolism)</term><term>Primates</term><term>S100 Calcium Binding Protein G (metabolism)</term><term>Subthalamic Nucleus (anatomy & histology)</term><term>Subthalamic Nucleus (metabolism)</term><term>Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Biotin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biotin</term><term>Dextrans</term><term>S100 Calcium Binding Protein G</term><term>Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Globus Pallidus</term><term>Neural Pathways</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Globus Pallidus</term><term>Neural Pathways</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunohistochemistry</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Calbindins</term><term>Male</term><term>Primates</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The subthalamic nucleus (STN) is the best target for correcting motor disability in parkinsonian patients with high-frequency stimulation. However, STN stimulation has also been reported to modify cognitive, emotional, and motivational functions. The aim of this study was to analyze the topographic organization of the STN according to its inputs coming from the sensorimotor, associative, and limbic territories of the external globus pallidus (GPe) in monkeys, with special reference to the limbic projection. Axonal tracers were injected into the different functional territories of the GPe. Injection performed in the limbic GPe resulted in labeling of cell bodies in the dorsal nucleus accumbens and in a dense labeling of axons in the anterior and medioventral portion of the STN. In comparison, injections in the associative and sensorimotor GPe led to labeling in the central and dorsolateral parts of the STN, respectively. Individual pallidosubthalamic axons ramified into numerous varicose branches, which were restricted to a given territory in the STN. These data provide a functional cartography of this structure in primates and suggest that behavioral disorders observed in stimulated parkinsonian patients could result from a dysfunction of the limbic part of the STN.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">15382210</PMID><DateCreated><Year>2005</Year><Month>02</Month><Day>22</Day></DateCreated><DateCompleted><Year>2005</Year><Month>04</Month><Day>25</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>20</Volume><Issue>2</Issue><PubDate><Year>2005</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>The pallidosubthalamic projection: an anatomical substrate for nonmotor functions of the subthalamic nucleus in primates.</ArticleTitle><Pagination><MedlinePgn>172-80</MedlinePgn></Pagination><Abstract><AbstractText>The subthalamic nucleus (STN) is the best target for correcting motor disability in parkinsonian patients with high-frequency stimulation. However, STN stimulation has also been reported to modify cognitive, emotional, and motivational functions. The aim of this study was to analyze the topographic organization of the STN according to its inputs coming from the sensorimotor, associative, and limbic territories of the external globus pallidus (GPe) in monkeys, with special reference to the limbic projection. Axonal tracers were injected into the different functional territories of the GPe. Injection performed in the limbic GPe resulted in labeling of cell bodies in the dorsal nucleus accumbens and in a dense labeling of axons in the anterior and medioventral portion of the STN. In comparison, injections in the associative and sensorimotor GPe led to labeling in the central and dorsolateral parts of the STN, respectively. Individual pallidosubthalamic axons ramified into numerous varicose branches, which were restricted to a given territory in the STN. These data provide a functional cartography of this structure in primates and suggest that behavioral disorders observed in stimulated parkinsonian patients could result from a dysfunction of the limbic part of the STN.</AbstractText><CopyrightInformation>Copyright 2004 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Karachi</LastName><ForeName>Carine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, Paris, France. 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UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009434">Neural Pathways</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000033">anatomy & histology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011323">Primates</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D064030">S100 Calcium Binding Protein G</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020531">Subthalamic Nucleus</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000033">anatomy & histology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018998">Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>9</Month><Day>24</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>4</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>9</Month><Day>24</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15382210</ArticleId><ArticleId IdType="doi">10.1002/mds.20302</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Francois, Chantal" sort="Francois, Chantal" uniqKey="Francois C" first="Chantal" last="François">Chantal François</name><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C" last="Hirsch">Etienne C. Hirsch</name><name sortKey="Tande, Dominique" sort="Tande, Dominique" uniqKey="Tande D" first="Dominique" last="Tandé">Dominique Tandé</name><name sortKey="Tremblay, Leon" sort="Tremblay, Leon" uniqKey="Tremblay L" first="Léon" last="Tremblay">Léon Tremblay</name><name sortKey="Yelnik, Jerome" sort="Yelnik, Jerome" uniqKey="Yelnik J" first="Jérôme" last="Yelnik">Jérôme Yelnik</name></noCountry><country name="France"><noRegion><name sortKey="Karachi, Carine" sort="Karachi, Carine" uniqKey="Karachi C" first="Carine" last="Karachi">Carine Karachi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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