Treatment of Sydenham chorea with corticosteroids.
Identifieur interne : 000C39 ( Ncbi/Merge ); précédent : 000C38; suivant : 000C40Treatment of Sydenham chorea with corticosteroids.
Auteurs : Francisco Cardoso [Brésil] ; Débora Maia ; Mauro César Q S. Cunningham ; Guilherme ValençaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2003.
English descriptors
- KwdEn :
- Adolescent, Adult, Anti-Inflammatory Agents (administration & dosage), Anti-Inflammatory Agents (therapeutic use), Child, Chorea (drug therapy), Drug Administration Schedule, Female, Follow-Up Studies, Humans, Injections, Intravenous, Male, Methylprednisolone (administration & dosage), Methylprednisolone (therapeutic use), Middle Aged, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Anti-Inflammatory Agents, Methylprednisolone.
- chemical , therapeutic use : Anti-Inflammatory Agents, Methylprednisolone.
- drug therapy : Chorea.
- Adolescent, Adult, Child, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Injections, Intravenous, Male, Middle Aged, Treatment Outcome.
Abstract
Despite treatment with valproic acid and neuroleptics, a significant proportion of patients with Sydenham chorea (SC) remain with chorea. We evaluated the effect of intravenous methyl-prednisolone followed by oral prednisone in patients with SC refractory to conventional treatment. Patients were enrolled in the study if they failed to improve with conventional treatment, despite the development of side effects. Chorea was rated on a 0 to 4 score. Five patients, 3 of them women, were included in the study. The median pretreatment rating score of the chorea was 3 (range, 3-4) and dropped to 1 (range, 0-2) after a median follow-up of 7 months (range, 3-7 months). Two patients developed Cushing syndrome. Our data suggest that intravenous methyl-prednisolone followed by oral prednisone is an effective and well-tolerated treatment of refractory SC.
DOI: 10.1002/mds.10521
PubMed: 14639684
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Cunningham</name></author><author><name sortKey="Valenca, Guilherme" sort="Valenca, Guilherme" uniqKey="Valenca G" first="Guilherme" last="Valença">Guilherme Valença</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Anti-Inflammatory Agents (administration & dosage)</term><term>Anti-Inflammatory Agents (therapeutic use)</term><term>Child</term><term>Chorea (drug therapy)</term><term>Drug Administration Schedule</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Injections, Intravenous</term><term>Male</term><term>Methylprednisolone (administration & dosage)</term><term>Methylprednisolone (therapeutic use)</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Methylprednisolone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Methylprednisolone</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Chorea</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Drug Administration Schedule</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Injections, Intravenous</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite treatment with valproic acid and neuroleptics, a significant proportion of patients with Sydenham chorea (SC) remain with chorea. We evaluated the effect of intravenous methyl-prednisolone followed by oral prednisone in patients with SC refractory to conventional treatment. Patients were enrolled in the study if they failed to improve with conventional treatment, despite the development of side effects. Chorea was rated on a 0 to 4 score. Five patients, 3 of them women, were included in the study. The median pretreatment rating score of the chorea was 3 (range, 3-4) and dropped to 1 (range, 0-2) after a median follow-up of 7 months (range, 3-7 months). Two patients developed Cushing syndrome. Our data suggest that intravenous methyl-prednisolone followed by oral prednisone is an effective and well-tolerated treatment of refractory SC.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">14639684</PMID><DateCreated><Year>2003</Year><Month>11</Month><Day>25</Day></DateCreated><DateCompleted><Year>2004</Year><Month>03</Month><Day>25</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>18</Volume><Issue>11</Issue><PubDate><Year>2003</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Treatment of Sydenham chorea with corticosteroids.</ArticleTitle><Pagination><MedlinePgn>1374-7</MedlinePgn></Pagination><Abstract><AbstractText>Despite treatment with valproic acid and neuroleptics, a significant proportion of patients with Sydenham chorea (SC) remain with chorea. We evaluated the effect of intravenous methyl-prednisolone followed by oral prednisone in patients with SC refractory to conventional treatment. Patients were enrolled in the study if they failed to improve with conventional treatment, despite the development of side effects. Chorea was rated on a 0 to 4 score. Five patients, 3 of them women, were included in the study. The median pretreatment rating score of the chorea was 3 (range, 3-4) and dropped to 1 (range, 0-2) after a median follow-up of 7 months (range, 3-7 months). Two patients developed Cushing syndrome. 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Cunningham</name><name sortKey="Maia, Debora" sort="Maia, Debora" uniqKey="Maia D" first="Débora" last="Maia">Débora Maia</name><name sortKey="Valenca, Guilherme" sort="Valenca, Guilherme" uniqKey="Valenca G" first="Guilherme" last="Valença">Guilherme Valença</name></noCountry><country name="Brésil"><region name="Minas Gerais"><name sortKey="Cardoso, Francisco" sort="Cardoso, Francisco" uniqKey="Cardoso F" first="Francisco" last="Cardoso">Francisco Cardoso</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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