Role of dopamine transporter SPECT for the practitioner and the general neurologist.
Identifieur interne : 000B80 ( Ncbi/Merge ); précédent : 000B79; suivant : 000B81Role of dopamine transporter SPECT for the practitioner and the general neurologist.
Auteurs : Wolfgang H. Oertel [Allemagne] ; Anja Gerstner ; Helmut Höffken ; Richard C. Dodel ; Karla M. Eggert ; Jens C. MöllerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2003.
English descriptors
- KwdEn :
- Adult, Aged, Brain (radionuclide imaging), Corpus Striatum (radionuclide imaging), Diagnosis, Differential, Dopamine Plasma Membrane Transport Proteins, Family Practice, Female, Humans, Male, Membrane Glycoproteins, Membrane Transport Proteins (analysis), Middle Aged, Nerve Tissue Proteins, Neurodegenerative Diseases (radionuclide imaging), Neurology, Parkinsonian Disorders (radionuclide imaging), Patient Care Team, Sensitivity and Specificity, Substantia Nigra (radionuclide imaging), Tomography, Emission-Computed, Tomography, Emission-Computed, Single-Photon.
- MESH :
- chemical , analysis : Membrane Transport Proteins.
- chemical : Dopamine Plasma Membrane Transport Proteins, Membrane Glycoproteins, Nerve Tissue Proteins.
- radionuclide imaging : Brain, Corpus Striatum, Neurodegenerative Diseases, Parkinsonian Disorders, Substantia Nigra.
- Adult, Aged, Diagnosis, Differential, Family Practice, Female, Humans, Male, Middle Aged, Neurology, Patient Care Team, Sensitivity and Specificity, Tomography, Emission-Computed, Tomography, Emission-Computed, Single-Photon.
Abstract
The accurate clinical diagnosis of parkinsonism may be impeded by atypical presentations and confounding comorbidity. The presence of parkinsonism is misdiagnosed in up to a quarter of cases in general practice. Movement disorder specialists misdiagnose parkinsonian syndromes using histopathological findings as the "gold standard" in up to 10% of cases. Dopamine transporter SPECT represents a simple and fast method to confirm nigrostriatal degeneration in a given patient. This study provides several case reports to illustrate when dopamine transporter SPECT might be carried out and discusses whether dopamine transporter SPECT should be used in primary health care practice or by general neurologists in uncertain cases. Ideally, all possible cases of parkinsonism should be referred to a neurologist experienced in the field of movement disorders. If this could be achieved then the role of dopamine transporter SPECT in the general practitioner's or local neurologist's practice would be extremely limited. Future studies must clarify whether it is cost effective to generously perform dopamine transporter SPECTs to minimize the time until parkinsonism can be diagnosed.
DOI: 10.1002/mds.10572
PubMed: 14531040
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Oertel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Philipps-University Marburg, Germany. oertelw@staff.uni-marburg.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps-University Marburg</wicri:regionArea><wicri:noRegion>Philipps-University Marburg</wicri:noRegion><wicri:noRegion>Philipps-University Marburg</wicri:noRegion><wicri:noRegion>Philipps-University Marburg</wicri:noRegion></affiliation></author><author><name sortKey="Gerstner, Anja" sort="Gerstner, Anja" uniqKey="Gerstner A" first="Anja" last="Gerstner">Anja Gerstner</name></author><author><name sortKey="Hoffken, Helmut" sort="Hoffken, Helmut" uniqKey="Hoffken H" first="Helmut" last="Höffken">Helmut Höffken</name></author><author><name sortKey="Dodel, Richard C" sort="Dodel, Richard C" uniqKey="Dodel R" first="Richard C" last="Dodel">Richard C. Dodel</name></author><author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M" last="Eggert">Karla M. Eggert</name></author><author><name sortKey="Moller, Jens C" sort="Moller, Jens C" uniqKey="Moller J" first="Jens C" last="Möller">Jens C. 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Oertel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Philipps-University Marburg, Germany. oertelw@staff.uni-marburg.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps-University Marburg</wicri:regionArea><wicri:noRegion>Philipps-University Marburg</wicri:noRegion><wicri:noRegion>Philipps-University Marburg</wicri:noRegion><wicri:noRegion>Philipps-University Marburg</wicri:noRegion></affiliation></author><author><name sortKey="Gerstner, Anja" sort="Gerstner, Anja" uniqKey="Gerstner A" first="Anja" last="Gerstner">Anja Gerstner</name></author><author><name sortKey="Hoffken, Helmut" sort="Hoffken, Helmut" uniqKey="Hoffken H" first="Helmut" last="Höffken">Helmut Höffken</name></author><author><name sortKey="Dodel, Richard C" sort="Dodel, Richard C" uniqKey="Dodel R" first="Richard C" last="Dodel">Richard C. Dodel</name></author><author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M" last="Eggert">Karla M. Eggert</name></author><author><name sortKey="Moller, Jens C" sort="Moller, Jens C" uniqKey="Moller J" first="Jens C" last="Möller">Jens C. Möller</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain (radionuclide imaging)</term><term>Corpus Striatum (radionuclide imaging)</term><term>Diagnosis, Differential</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Family Practice</term><term>Female</term><term>Humans</term><term>Male</term><term>Membrane Glycoproteins</term><term>Membrane Transport Proteins (analysis)</term><term>Middle Aged</term><term>Nerve Tissue Proteins</term><term>Neurodegenerative Diseases (radionuclide imaging)</term><term>Neurology</term><term>Parkinsonian Disorders (radionuclide imaging)</term><term>Patient Care Team</term><term>Sensitivity and Specificity</term><term>Substantia Nigra (radionuclide imaging)</term><term>Tomography, Emission-Computed</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Membrane Transport Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term><term>Membrane Glycoproteins</term><term>Nerve Tissue Proteins</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term><term>Corpus Striatum</term><term>Neurodegenerative Diseases</term><term>Parkinsonian Disorders</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Diagnosis, Differential</term><term>Family Practice</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurology</term><term>Patient Care Team</term><term>Sensitivity and Specificity</term><term>Tomography, Emission-Computed</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The accurate clinical diagnosis of parkinsonism may be impeded by atypical presentations and confounding comorbidity. The presence of parkinsonism is misdiagnosed in up to a quarter of cases in general practice. Movement disorder specialists misdiagnose parkinsonian syndromes using histopathological findings as the "gold standard" in up to 10% of cases. Dopamine transporter SPECT represents a simple and fast method to confirm nigrostriatal degeneration in a given patient. This study provides several case reports to illustrate when dopamine transporter SPECT might be carried out and discusses whether dopamine transporter SPECT should be used in primary health care practice or by general neurologists in uncertain cases. Ideally, all possible cases of parkinsonism should be referred to a neurologist experienced in the field of movement disorders. If this could be achieved then the role of dopamine transporter SPECT in the general practitioner's or local neurologist's practice would be extremely limited. Future studies must clarify whether it is cost effective to generously perform dopamine transporter SPECTs to minimize the time until parkinsonism can be diagnosed.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">14531040</PMID><DateCreated><Year>2003</Year><Month>10</Month><Day>07</Day></DateCreated><DateCompleted><Year>2004</Year><Month>03</Month><Day>29</Day></DateCompleted><DateRevised><Year>2005</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>18 Suppl 7</Volume><PubDate><Year>2003</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Role of dopamine transporter SPECT for the practitioner and the general neurologist.</ArticleTitle><Pagination><MedlinePgn>S9-15</MedlinePgn></Pagination><Abstract><AbstractText>The accurate clinical diagnosis of parkinsonism may be impeded by atypical presentations and confounding comorbidity. The presence of parkinsonism is misdiagnosed in up to a quarter of cases in general practice. Movement disorder specialists misdiagnose parkinsonian syndromes using histopathological findings as the "gold standard" in up to 10% of cases. Dopamine transporter SPECT represents a simple and fast method to confirm nigrostriatal degeneration in a given patient. This study provides several case reports to illustrate when dopamine transporter SPECT might be carried out and discusses whether dopamine transporter SPECT should be used in primary health care practice or by general neurologists in uncertain cases. Ideally, all possible cases of parkinsonism should be referred to a neurologist experienced in the field of movement disorders. If this could be achieved then the role of dopamine transporter SPECT in the general practitioner's or local neurologist's practice would be extremely limited. Future studies must clarify whether it is cost effective to generously perform dopamine transporter SPECTs to minimize the time until parkinsonism can be diagnosed.</AbstractText><CopyrightInformation>Copyright 2003 Movement Disorder Society</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Oertel</LastName><ForeName>Wolfgang H</ForeName><Initials>WH</Initials><AffiliationInfo><Affiliation>Department of Neurology, Philipps-University Marburg, Germany. oertelw@staff.uni-marburg.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gerstner</LastName><ForeName>Anja</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Höffken</LastName><ForeName>Helmut</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Dodel</LastName><ForeName>Richard C</ForeName><Initials>RC</Initials></Author><Author ValidYN="Y"><LastName>Eggert</LastName><ForeName>Karla M</ForeName><Initials>KM</Initials></Author><Author ValidYN="Y"><LastName>Möller</LastName><ForeName>Jens C</ForeName><Initials>JC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D050483">Dopamine Plasma Membrane Transport Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D026901">Membrane Transport Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009419">Nerve Tissue 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Practice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D008562">Membrane Glycoproteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D026901">Membrane Transport Proteins</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000032">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D009419">Nerve Tissue Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019636">Neurodegenerative Diseases</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009462">Neurology</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020734">Parkinsonian Disorders</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010348">Patient Care Team</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012680">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013378">Substantia Nigra</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D014055">Tomography, Emission-Computed</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D015899">Tomography, Emission-Computed, Single-Photon</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>10</Month><Day>8</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>3</Month><Day>30</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>10</Month><Day>8</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">14531040</ArticleId><ArticleId IdType="doi">10.1002/mds.10572</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Dodel, Richard C" sort="Dodel, Richard C" uniqKey="Dodel R" first="Richard C" last="Dodel">Richard C. Dodel</name><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M" last="Eggert">Karla M. Eggert</name><name sortKey="Gerstner, Anja" sort="Gerstner, Anja" uniqKey="Gerstner A" first="Anja" last="Gerstner">Anja Gerstner</name><name sortKey="Hoffken, Helmut" sort="Hoffken, Helmut" uniqKey="Hoffken H" first="Helmut" last="Höffken">Helmut Höffken</name><name sortKey="Moller, Jens C" sort="Moller, Jens C" uniqKey="Moller J" first="Jens C" last="Möller">Jens C. Möller</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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