MovDisordV3, Ncbi, Merge, bibRecord, 000B63

Different effects of unilateral versus bilateral subthalamic nucleus stimulation on walking and reaching in Parkinson's disease.

Identifieur interne : 000B63 ( Ncbi/Merge ); précédent : 000B62; suivant : 000B64

Different effects of unilateral versus bilateral subthalamic nucleus stimulation on walking and reaching in Parkinson's disease.

Auteurs : Amy J. Bastian [États-Unis] ; Valerie E. Kelly ; Fredy J. Revilla ; Joel S. Perlmutter ; Jonathan W. Mink

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2003.

RBID : pubmed:14502667

English descriptors

KwdEn :
- Adult, Aged, Biomechanical Phenomena, Electric Stimulation Therapy, Electrodes, Implanted, Female, Gait, Humans, Male, Middle Aged, Movement, Parkinson Disease (physiopathology), Parkinson Disease (surgery), Subthalamic Nucleus (surgery), Treatment Outcome, Walking.
MESH :
- physiopathology : Parkinson Disease.
- surgery : Parkinson Disease, Subthalamic Nucleus.
- Adult, Aged, Biomechanical Phenomena, Electric Stimulation Therapy, Electrodes, Implanted, Female, Gait, Humans, Male, Middle Aged, Movement, Treatment Outcome, Walking.

Abstract

The purpose of this study was to determine the effects of unilateral versus bilateral subthalamic nucleus (STN) stimulation on quantitative measures of walking and reaching in Parkinson's disease (PD). We used kinematic measures and the Unified Parkinson's Disease Rating Scale (UPDRS) motor subscale (subscale III) to evaluate the movement of 6 people with PD who had bilateral STN stimulators implanted for at least 6 months and withheld their anti-parkinson medication for at least 8 hours. Subjects were studied with both stimulators off, one on, and both on. Kinematic data were collected as subjects walked, reached to a target, and were rated using the UPDRS motor subscale. STN stimulation improved walking speed and stride length, with the greatest benefit from bilateral stimulation. Reaching speed was improved by unilateral STN stimulation alone, with no additive effect of bilateral stimulation. UPDRS motor subscale ratings paralleled the kinematic findings. STN stimulation did not restore PD subjects' movements to the level of age-matched controls. Overall, these results provide further evidence that the basal ganglia pathways involved in control of walking and reaching may be distinct. We speculate that basal ganglia may influence walking through bilateral pedunculopontine projections and reaching through ipsilateral thalamocortical projections. Our findings also suggest that maximal improvement of walking requires bilateral rather than unilateral STN stimulation.

DOI: 10.1002/mds.10493
PubMed: 14502667

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Le document en format XML

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<author><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J" last="Bastian">Amy J. Bastian</name>
<affiliation wicri:level="1"><nlm:affiliation>Kennedy Krieger Institute, Baltimore, Maryland 21205, USA. bastian@kennedykrieger.org</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Kennedy Krieger Institute, Baltimore, Maryland 21205</wicri:regionArea>
<wicri:noRegion>Maryland 21205</wicri:noRegion>
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<author><name sortKey="Kelly, Valerie E" sort="Kelly, Valerie E" uniqKey="Kelly V" first="Valerie E" last="Kelly">Valerie E. Kelly</name>
</author>
<author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J" last="Revilla">Fredy J. Revilla</name>
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<author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name>
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<author><name sortKey="Mink, Jonathan W" sort="Mink, Jonathan W" uniqKey="Mink J" first="Jonathan W" last="Mink">Jonathan W. Mink</name>
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<author><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J" last="Bastian">Amy J. Bastian</name>
<affiliation wicri:level="1"><nlm:affiliation>Kennedy Krieger Institute, Baltimore, Maryland 21205, USA. bastian@kennedykrieger.org</nlm:affiliation>
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<author><name sortKey="Kelly, Valerie E" sort="Kelly, Valerie E" uniqKey="Kelly V" first="Valerie E" last="Kelly">Valerie E. Kelly</name>
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<author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J" last="Revilla">Fredy J. Revilla</name>
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<term>Aged</term>
<term>Biomechanical Phenomena</term>
<term>Electric Stimulation Therapy</term>
<term>Electrodes, Implanted</term>
<term>Female</term>
<term>Gait</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Movement</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Subthalamic Nucleus (surgery)</term>
<term>Treatment Outcome</term>
<term>Walking</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Biomechanical Phenomena</term>
<term>Electric Stimulation Therapy</term>
<term>Electrodes, Implanted</term>
<term>Female</term>
<term>Gait</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">The purpose of this study was to determine the effects of unilateral versus bilateral subthalamic nucleus (STN) stimulation on quantitative measures of walking and reaching in Parkinson's disease (PD). We used kinematic measures and the Unified Parkinson's Disease Rating Scale (UPDRS) motor subscale (subscale III) to evaluate the movement of 6 people with PD who had bilateral STN stimulators implanted for at least 6 months and withheld their anti-parkinson medication for at least 8 hours. Subjects were studied with both stimulators off, one on, and both on. Kinematic data were collected as subjects walked, reached to a target, and were rated using the UPDRS motor subscale. STN stimulation improved walking speed and stride length, with the greatest benefit from bilateral stimulation. Reaching speed was improved by unilateral STN stimulation alone, with no additive effect of bilateral stimulation. UPDRS motor subscale ratings paralleled the kinematic findings. STN stimulation did not restore PD subjects' movements to the level of age-matched controls. Overall, these results provide further evidence that the basal ganglia pathways involved in control of walking and reaching may be distinct. We speculate that basal ganglia may influence walking through bilateral pedunculopontine projections and reaching through ipsilateral thalamocortical projections. Our findings also suggest that maximal improvement of walking requires bilateral rather than unilateral STN stimulation.</div>
</front>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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</Journal>
<ArticleTitle>Different effects of unilateral versus bilateral subthalamic nucleus stimulation on walking and reaching in Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>1000-7</MedlinePgn>
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<Abstract><AbstractText>The purpose of this study was to determine the effects of unilateral versus bilateral subthalamic nucleus (STN) stimulation on quantitative measures of walking and reaching in Parkinson's disease (PD). We used kinematic measures and the Unified Parkinson's Disease Rating Scale (UPDRS) motor subscale (subscale III) to evaluate the movement of 6 people with PD who had bilateral STN stimulators implanted for at least 6 months and withheld their anti-parkinson medication for at least 8 hours. Subjects were studied with both stimulators off, one on, and both on. Kinematic data were collected as subjects walked, reached to a target, and were rated using the UPDRS motor subscale. STN stimulation improved walking speed and stride length, with the greatest benefit from bilateral stimulation. Reaching speed was improved by unilateral STN stimulation alone, with no additive effect of bilateral stimulation. UPDRS motor subscale ratings paralleled the kinematic findings. STN stimulation did not restore PD subjects' movements to the level of age-matched controls. Overall, these results provide further evidence that the basal ganglia pathways involved in control of walking and reaching may be distinct. We speculate that basal ganglia may influence walking through bilateral pedunculopontine projections and reaching through ipsilateral thalamocortical projections. Our findings also suggest that maximal improvement of walking requires bilateral rather than unilateral STN stimulation.</AbstractText>
<CopyrightInformation>Copyright 2003 Movement Disorder Society</CopyrightInformation>
</Abstract>
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<Author ValidYN="Y"><LastName>Revilla</LastName>
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<name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name>
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<country name="États-Unis"><noRegion><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J" last="Bastian">Amy J. Bastian</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Different effects of unilateral versus bilateral subthalamic nucleus stimulation on walking and reaching in Parkinson's disease.

Different effects of unilateral versus bilateral subthalamic nucleus stimulation on walking and reaching in Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki