Impact of genetic analysis on Parkinson's disease research.
Identifieur interne : 000B58 ( Ncbi/Merge ); précédent : 000B57; suivant : 000B59Impact of genetic analysis on Parkinson's disease research.
Auteurs : John Hardy [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2003.
English descriptors
- KwdEn :
- Cysteine Endopeptidases (genetics), DNA Mutational Analysis, Genetic Predisposition to Disease (genetics), Humans, Intracellular Signaling Peptides and Proteins, Multienzyme Complexes (genetics), Nerve Tissue Proteins (genetics), Oncogene Proteins (genetics), Parkinson Disease (diagnosis), Parkinson Disease (genetics), Proteasome Endopeptidase Complex, Synucleins, Ubiquitin (genetics), Ubiquitin-Protein Ligases (genetics).
- MESH :
- chemical , genetics : Cysteine Endopeptidases, Multienzyme Complexes, Nerve Tissue Proteins, Oncogene Proteins, Ubiquitin, Ubiquitin-Protein Ligases.
- diagnosis : Parkinson Disease.
- genetics : Genetic Predisposition to Disease, Parkinson Disease.
- DNA Mutational Analysis, Humans, Intracellular Signaling Peptides and Proteins, Proteasome Endopeptidase Complex, Synucleins.
Abstract
Genetic analysis is changing our view of Parkinson's disease: not only is it challenging the long-cherished views about the diagnosis of the disease, it is also starting to suggest a biochemical pathway to disease pathogenesis. These developments are reviewed in the context of three known (synuclein, parkin, and DJ-1) and one suspected (ubiquitin hydrolase) genes for the disease.
DOI: 10.1002/mds.10569
PubMed: 14502662
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pubmed:14502662Le document en format XML
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These developments are reviewed in the context of three known (synuclein, parkin, and DJ-1) and one suspected (ubiquitin hydrolase) genes for the disease.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">14502662</PMID><DateCreated><Year>2003</Year><Month>09</Month><Day>22</Day></DateCreated><DateCompleted><Year>2004</Year><Month>02</Month><Day>24</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>18 Suppl 6</Volume><PubDate><Year>2003</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. 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These developments are reviewed in the context of three known (synuclein, parkin, and DJ-1) and one suspected (ubiquitin hydrolase) genes for the disease.</AbstractText><CopyrightInformation>Copyright 2003 Movement Disorder Society</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hardy</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. hardyj@mail.nih.gov</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov 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