Memory and executive function impairment predict dementia in Parkinson's disease.
Identifieur interne : 000932 ( Ncbi/Merge ); précédent : 000931; suivant : 000933Memory and executive function impairment predict dementia in Parkinson's disease.
Auteurs : Gilberto Levy [États-Unis] ; Diane M. Jacobs ; Ming-Xin Tang ; Lucien J. Côté ; Elan D. Louis ; Brenda Alfaro ; Helen Mejia ; Yaakov Stern ; Karen MarderSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2002.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Amnesia (diagnosis), Amnesia (psychology), Cognition Disorders (diagnosis), Cognition Disorders (psychology), Cohort Studies, Dementia (diagnosis), Dementia (psychology), Female, Follow-Up Studies, Humans, Male, Middle Aged, Neurologic Examination (statistics & numerical data), Neuropsychological Tests (statistics & numerical data), New York City, Parkinson Disease (diagnosis), Parkinson Disease (psychology), Prognosis, Psychometrics.
- MESH :
- geographic : New York City.
- diagnosis : Amnesia, Cognition Disorders, Dementia, Parkinson Disease.
- psychology : Amnesia, Cognition Disorders, Dementia, Parkinson Disease.
- statistics & numerical data : Neurologic Examination, Neuropsychological Tests.
- Aged, Aged, 80 and over, Cohort Studies, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Psychometrics.
Abstract
We analyzed the association of neuropsychological test impairment at baseline with the development of dementia in idiopathic Parkinson's disease (PD) patients. A cohort of nondemented PD patients from northern Manhattan, NY was followed annually with neurological and neuropsychological evaluations. The neuropsychological battery included tests of verbal and nonverbal memory, orientation, visuospatial ability, language, and abstract reasoning. The association of baseline neuropsychological tests scores with incident dementia was analyzed using Cox proportional hazards models. The analysis controlled for age, gender, education, duration of PD, and the total Unified Parkinson's Disease Rating Scale motor score at baseline. Forty-five out of 164 patients (27%) became demented during a mean follow-up of 3.7 +/- 2.3 years. Four neuropsychological test scores were significantly associated with incident dementia in the Cox model: total immediate recall (RR: 0.92, 95% CI: 0.87-0.97, P = 0.001) and delayed recall (RR: 0.73, 95% CI: 0.59-0.91, P = 0.005) of the Selective Reminding Test (SRT), letter fluency (RR: 0.87, 95% CI: 0.77-0.99, P = 0.03), and Identities and Oddities of the Mattis Dementia Rating Scale (RR: 0.85, 95% CI: 0.73-0.98, P = 0.03). When the analysis was performed excluding patients with a clinical dementia rating of 0.5 (questionable dementia) at baseline evaluation, total immediate recall and delayed recall were still predictive of dementia in PD. Our results indicate that impairment in verbal memory and executive function are associated with the development of dementia in patients with PD.
DOI: 10.1002/mds.10280
PubMed: 12465060
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 003919
- to stream PubMed, to step Curation: 003919
- to stream PubMed, to step Checkpoint: 003A24
Links to Exploration step
pubmed:12465060Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Memory and executive function impairment predict dementia in Parkinson's disease.</title><author><name sortKey="Levy, Gilberto" sort="Levy, Gilberto" uniqKey="Levy G" first="Gilberto" last="Levy">Gilberto Levy</name><affiliation wicri:level="4"><nlm:affiliation>Gertrude H. Sergievsky Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Jacobs, Diane M" sort="Jacobs, Diane M" uniqKey="Jacobs D" first="Diane M" last="Jacobs">Diane M. Jacobs</name></author><author><name sortKey="Tang, Ming Xin" sort="Tang, Ming Xin" uniqKey="Tang M" first="Ming-Xin" last="Tang">Ming-Xin Tang</name></author><author><name sortKey="Cote, Lucien J" sort="Cote, Lucien J" uniqKey="Cote L" first="Lucien J" last="Côté">Lucien J. Côté</name></author><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D" last="Louis">Elan D. Louis</name></author><author><name sortKey="Alfaro, Brenda" sort="Alfaro, Brenda" uniqKey="Alfaro B" first="Brenda" last="Alfaro">Brenda Alfaro</name></author><author><name sortKey="Mejia, Helen" sort="Mejia, Helen" uniqKey="Mejia H" first="Helen" last="Mejia">Helen Mejia</name></author><author><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name></author><author><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:12465060</idno><idno type="pmid">12465060</idno><idno type="doi">10.1002/mds.10280</idno><idno type="wicri:Area/PubMed/Corpus">003919</idno><idno type="wicri:Area/PubMed/Curation">003919</idno><idno type="wicri:Area/PubMed/Checkpoint">003A24</idno><idno type="wicri:Area/Ncbi/Merge">000932</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Memory and executive function impairment predict dementia in Parkinson's disease.</title><author><name sortKey="Levy, Gilberto" sort="Levy, Gilberto" uniqKey="Levy G" first="Gilberto" last="Levy">Gilberto Levy</name><affiliation wicri:level="4"><nlm:affiliation>Gertrude H. Sergievsky Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Jacobs, Diane M" sort="Jacobs, Diane M" uniqKey="Jacobs D" first="Diane M" last="Jacobs">Diane M. Jacobs</name></author><author><name sortKey="Tang, Ming Xin" sort="Tang, Ming Xin" uniqKey="Tang M" first="Ming-Xin" last="Tang">Ming-Xin Tang</name></author><author><name sortKey="Cote, Lucien J" sort="Cote, Lucien J" uniqKey="Cote L" first="Lucien J" last="Côté">Lucien J. Côté</name></author><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D" last="Louis">Elan D. Louis</name></author><author><name sortKey="Alfaro, Brenda" sort="Alfaro, Brenda" uniqKey="Alfaro B" first="Brenda" last="Alfaro">Brenda Alfaro</name></author><author><name sortKey="Mejia, Helen" sort="Mejia, Helen" uniqKey="Mejia H" first="Helen" last="Mejia">Helen Mejia</name></author><author><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name></author><author><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Amnesia (diagnosis)</term><term>Amnesia (psychology)</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (psychology)</term><term>Cohort Studies</term><term>Dementia (diagnosis)</term><term>Dementia (psychology)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination (statistics & numerical data)</term><term>Neuropsychological Tests (statistics & numerical data)</term><term>New York City</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (psychology)</term><term>Prognosis</term><term>Psychometrics</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>New York City</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Amnesia</term><term>Cognition Disorders</term><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Amnesia</term><term>Cognition Disorders</term><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Neurologic Examination</term><term>Neuropsychological Tests</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Psychometrics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We analyzed the association of neuropsychological test impairment at baseline with the development of dementia in idiopathic Parkinson's disease (PD) patients. A cohort of nondemented PD patients from northern Manhattan, NY was followed annually with neurological and neuropsychological evaluations. The neuropsychological battery included tests of verbal and nonverbal memory, orientation, visuospatial ability, language, and abstract reasoning. The association of baseline neuropsychological tests scores with incident dementia was analyzed using Cox proportional hazards models. The analysis controlled for age, gender, education, duration of PD, and the total Unified Parkinson's Disease Rating Scale motor score at baseline. Forty-five out of 164 patients (27%) became demented during a mean follow-up of 3.7 +/- 2.3 years. Four neuropsychological test scores were significantly associated with incident dementia in the Cox model: total immediate recall (RR: 0.92, 95% CI: 0.87-0.97, P = 0.001) and delayed recall (RR: 0.73, 95% CI: 0.59-0.91, P = 0.005) of the Selective Reminding Test (SRT), letter fluency (RR: 0.87, 95% CI: 0.77-0.99, P = 0.03), and Identities and Oddities of the Mattis Dementia Rating Scale (RR: 0.85, 95% CI: 0.73-0.98, P = 0.03). When the analysis was performed excluding patients with a clinical dementia rating of 0.5 (questionable dementia) at baseline evaluation, total immediate recall and delayed recall were still predictive of dementia in PD. Our results indicate that impairment in verbal memory and executive function are associated with the development of dementia in patients with PD.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">12465060</PMID><DateCreated><Year>2002</Year><Month>12</Month><Day>04</Day></DateCreated><DateCompleted><Year>2003</Year><Month>03</Month><Day>24</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>17</Volume><Issue>6</Issue><PubDate><Year>2002</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Memory and executive function impairment predict dementia in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1221-6</MedlinePgn></Pagination><Abstract><AbstractText>We analyzed the association of neuropsychological test impairment at baseline with the development of dementia in idiopathic Parkinson's disease (PD) patients. A cohort of nondemented PD patients from northern Manhattan, NY was followed annually with neurological and neuropsychological evaluations. The neuropsychological battery included tests of verbal and nonverbal memory, orientation, visuospatial ability, language, and abstract reasoning. The association of baseline neuropsychological tests scores with incident dementia was analyzed using Cox proportional hazards models. The analysis controlled for age, gender, education, duration of PD, and the total Unified Parkinson's Disease Rating Scale motor score at baseline. Forty-five out of 164 patients (27%) became demented during a mean follow-up of 3.7 +/- 2.3 years. Four neuropsychological test scores were significantly associated with incident dementia in the Cox model: total immediate recall (RR: 0.92, 95% CI: 0.87-0.97, P = 0.001) and delayed recall (RR: 0.73, 95% CI: 0.59-0.91, P = 0.005) of the Selective Reminding Test (SRT), letter fluency (RR: 0.87, 95% CI: 0.77-0.99, P = 0.03), and Identities and Oddities of the Mattis Dementia Rating Scale (RR: 0.85, 95% CI: 0.73-0.98, P = 0.03). When the analysis was performed excluding patients with a clinical dementia rating of 0.5 (questionable dementia) at baseline evaluation, total immediate recall and delayed recall were still predictive of dementia in PD. Our results indicate that impairment in verbal memory and executive function are associated with the development of dementia in patients with PD.</AbstractText><CopyrightInformation>Copyright 2002 Movement Disorder Society</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Levy</LastName><ForeName>Gilberto</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Gertrude H. Sergievsky Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacobs</LastName><ForeName>Diane M</ForeName><Initials>DM</Initials></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Ming-Xin</ForeName><Initials>MX</Initials></Author><Author ValidYN="Y"><LastName>Côté</LastName><ForeName>Lucien J</ForeName><Initials>LJ</Initials></Author><Author ValidYN="Y"><LastName>Louis</LastName><ForeName>Elan D</ForeName><Initials>ED</Initials></Author><Author ValidYN="Y"><LastName>Alfaro</LastName><ForeName>Brenda</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Mejia</LastName><ForeName>Helen</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Stern</LastName><ForeName>Yaakov</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Marder</LastName><ForeName>Karen</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>AG07232</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AG10963</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>NS36630</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RR00645</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000647">Amnesia</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003072">Cognition Disorders</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015331">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003704">Dementia</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005500">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009460">Neurologic Examination</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000706">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D009483">Neuropsychological Tests</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000706">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic" UI="D009519">New York City</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011379">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011594">Psychometrics</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>12</Month><Day>5</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>3</Month><Day>26</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>12</Month><Day>5</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12465060</ArticleId><ArticleId IdType="doi">10.1002/mds.10280</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><noCountry><name sortKey="Alfaro, Brenda" sort="Alfaro, Brenda" uniqKey="Alfaro B" first="Brenda" last="Alfaro">Brenda Alfaro</name><name sortKey="Cote, Lucien J" sort="Cote, Lucien J" uniqKey="Cote L" first="Lucien J" last="Côté">Lucien J. Côté</name><name sortKey="Jacobs, Diane M" sort="Jacobs, Diane M" uniqKey="Jacobs D" first="Diane M" last="Jacobs">Diane M. Jacobs</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D" last="Louis">Elan D. Louis</name><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><name sortKey="Mejia, Helen" sort="Mejia, Helen" uniqKey="Mejia H" first="Helen" last="Mejia">Helen Mejia</name><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name><name sortKey="Tang, Ming Xin" sort="Tang, Ming Xin" uniqKey="Tang M" first="Ming-Xin" last="Tang">Ming-Xin Tang</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Levy, Gilberto" sort="Levy, Gilberto" uniqKey="Levy G" first="Gilberto" last="Levy">Gilberto Levy</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000932 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000932 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= pubmed:12465060
|texte= Memory and executive function impairment predict dementia in Parkinson's disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:12465060" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |