Electrophysiological evaluation of pharyngeal phase of swallowing in patients with Parkinson's disease.
Identifieur interne : 000893 ( Ncbi/Merge ); précédent : 000892; suivant : 000894Electrophysiological evaluation of pharyngeal phase of swallowing in patients with Parkinson's disease.
Auteurs : Cumhur Ertekin [Turquie] ; Sultan Tarlaci ; Ibrahim Aydogdu ; Nefati Kiylioglu ; Nur Yuceyar ; A Bulent Turman ; Yaprak Secil ; Figen EsmeliSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2002.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Cricoid Cartilage (physiopathology), Deglutition Disorders (diagnosis), Deglutition Disorders (etiology), Deglutition Disorders (physiopathology), Female, Humans, Larynx (physiopathology), Male, Middle Aged, Parkinson Disease (complications), Pharynx (physiopathology), Time Factors.
- MESH :
- complications : Parkinson Disease.
- diagnosis : Deglutition Disorders.
- etiology : Deglutition Disorders.
- physiopathology : Cricoid Cartilage, Deglutition Disorders, Larynx, Pharynx.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Time Factors.
Abstract
We studied the various physiological aspects of oropharyngeal swallowing in Parkinson's disease (PD). Fifty-eight patients with PD were investigated by clinical and electrophysiological methods that measured the oropharyngeal phase of swallowing. All patients except 1 had mild to moderate degree of disability score. Dysphagia was demonstrated in 53% of all patients in whom the test of dysphagia limit was abnormal. All PD patients with or without dysphagia displayed the following abnormalities: (1) the triggering of the swallowing reflex was prolonged probably due to inadequate bolus control in the mouth and tongue and/or a specific delay in the execution of the swallowing reflex; (2) the duration of the pharyngeal reflex time was extremely prolonged due to slowness of the sequential muscle movements, especially those of the suprahyoid-submental muscles; (3) cricopharyngeal muscle of the upper oesophageal sphincter was found to be electrophysiologically normal; and (4) the electrophysiological phenomena in PD patients could not be strongly correlated with the degree of the disability and clinical score of the PD. It was concluded that various motor disorders of PD have considerable influence on oropharyngeal swallowing: hypokinesia, reduced rate of spontaneous swallowing, and the slowness of segmented but coordinated sequential movements rather than any abnormalities in the central pattern generator of the bulbar center. Some compensatory mechanisms in the course of PD may explain the benign nature of swallowing disorder until the terminal stage of the disease. Similarly, the swallowing problems of PD are not only related with the dopamine deficiency; some other nondopaminergic mechanisms may also be involved.
DOI: 10.1002/mds.10240
PubMed: 12360543
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Electrophysiological evaluation of pharyngeal phase of swallowing in patients with Parkinson's disease.</title><author><name sortKey="Ertekin, Cumhur" sort="Ertekin, Cumhur" uniqKey="Ertekin C" first="Cumhur" last="Ertekin">Cumhur Ertekin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Ege University Medical School Hospital, Bornova, Izmir, Turkey. erteker@unimedya.net.tr</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Neurology, Ege University Medical School Hospital, Bornova, Izmir</wicri:regionArea><wicri:noRegion>Izmir</wicri:noRegion></affiliation></author><author><name sortKey="Tarlaci, Sultan" sort="Tarlaci, Sultan" uniqKey="Tarlaci S" first="Sultan" last="Tarlaci">Sultan Tarlaci</name></author><author><name sortKey="Aydogdu, Ibrahim" sort="Aydogdu, Ibrahim" uniqKey="Aydogdu I" first="Ibrahim" last="Aydogdu">Ibrahim Aydogdu</name></author><author><name sortKey="Kiylioglu, Nefati" sort="Kiylioglu, Nefati" uniqKey="Kiylioglu N" first="Nefati" last="Kiylioglu">Nefati Kiylioglu</name></author><author><name sortKey="Yuceyar, Nur" sort="Yuceyar, Nur" uniqKey="Yuceyar N" first="Nur" last="Yuceyar">Nur Yuceyar</name></author><author><name sortKey="Turman, A Bulent" sort="Turman, A Bulent" uniqKey="Turman A" first="A Bulent" last="Turman">A Bulent Turman</name></author><author><name sortKey="Secil, Yaprak" sort="Secil, Yaprak" uniqKey="Secil Y" first="Yaprak" last="Secil">Yaprak Secil</name></author><author><name sortKey="Esmeli, Figen" sort="Esmeli, Figen" uniqKey="Esmeli F" first="Figen" last="Esmeli">Figen Esmeli</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:12360543</idno><idno type="pmid">12360543</idno><idno type="doi">10.1002/mds.10240</idno><idno type="wicri:Area/PubMed/Corpus">003958</idno><idno 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Tarlaci</name></author><author><name sortKey="Aydogdu, Ibrahim" sort="Aydogdu, Ibrahim" uniqKey="Aydogdu I" first="Ibrahim" last="Aydogdu">Ibrahim Aydogdu</name></author><author><name sortKey="Kiylioglu, Nefati" sort="Kiylioglu, Nefati" uniqKey="Kiylioglu N" first="Nefati" last="Kiylioglu">Nefati Kiylioglu</name></author><author><name sortKey="Yuceyar, Nur" sort="Yuceyar, Nur" uniqKey="Yuceyar N" first="Nur" last="Yuceyar">Nur Yuceyar</name></author><author><name sortKey="Turman, A Bulent" sort="Turman, A Bulent" uniqKey="Turman A" first="A Bulent" last="Turman">A Bulent Turman</name></author><author><name sortKey="Secil, Yaprak" sort="Secil, Yaprak" uniqKey="Secil Y" first="Yaprak" last="Secil">Yaprak Secil</name></author><author><name sortKey="Esmeli, Figen" sort="Esmeli, Figen" uniqKey="Esmeli F" first="Figen" last="Esmeli">Figen Esmeli</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cricoid Cartilage (physiopathology)</term><term>Deglutition Disorders (diagnosis)</term><term>Deglutition Disorders (etiology)</term><term>Deglutition Disorders (physiopathology)</term><term>Female</term><term>Humans</term><term>Larynx (physiopathology)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Pharynx (physiopathology)</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Deglutition Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Deglutition Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cricoid Cartilage</term><term>Deglutition Disorders</term><term>Larynx</term><term>Pharynx</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the various physiological aspects of oropharyngeal swallowing in Parkinson's disease (PD). Fifty-eight patients with PD were investigated by clinical and electrophysiological methods that measured the oropharyngeal phase of swallowing. All patients except 1 had mild to moderate degree of disability score. Dysphagia was demonstrated in 53% of all patients in whom the test of dysphagia limit was abnormal. All PD patients with or without dysphagia displayed the following abnormalities: (1) the triggering of the swallowing reflex was prolonged probably due to inadequate bolus control in the mouth and tongue and/or a specific delay in the execution of the swallowing reflex; (2) the duration of the pharyngeal reflex time was extremely prolonged due to slowness of the sequential muscle movements, especially those of the suprahyoid-submental muscles; (3) cricopharyngeal muscle of the upper oesophageal sphincter was found to be electrophysiologically normal; and (4) the electrophysiological phenomena in PD patients could not be strongly correlated with the degree of the disability and clinical score of the PD. It was concluded that various motor disorders of PD have considerable influence on oropharyngeal swallowing: hypokinesia, reduced rate of spontaneous swallowing, and the slowness of segmented but coordinated sequential movements rather than any abnormalities in the central pattern generator of the bulbar center. Some compensatory mechanisms in the course of PD may explain the benign nature of swallowing disorder until the terminal stage of the disease. Similarly, the swallowing problems of PD are not only related with the dopamine deficiency; some other nondopaminergic mechanisms may also be involved.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">12360543</PMID><DateCreated><Year>2002</Year><Month>10</Month><Day>02</Day></DateCreated><DateCompleted><Year>2003</Year><Month>01</Month><Day>08</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>17</Volume><Issue>5</Issue><PubDate><Year>2002</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Electrophysiological evaluation of pharyngeal phase of swallowing in patients with Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>942-9</MedlinePgn></Pagination><Abstract><AbstractText>We studied the various physiological aspects of oropharyngeal swallowing in Parkinson's disease (PD). Fifty-eight patients with PD were investigated by clinical and electrophysiological methods that measured the oropharyngeal phase of swallowing. All patients except 1 had mild to moderate degree of disability score. Dysphagia was demonstrated in 53% of all patients in whom the test of dysphagia limit was abnormal. All PD patients with or without dysphagia displayed the following abnormalities: (1) the triggering of the swallowing reflex was prolonged probably due to inadequate bolus control in the mouth and tongue and/or a specific delay in the execution of the swallowing reflex; (2) the duration of the pharyngeal reflex time was extremely prolonged due to slowness of the sequential muscle movements, especially those of the suprahyoid-submental muscles; (3) cricopharyngeal muscle of the upper oesophageal sphincter was found to be electrophysiologically normal; and (4) the electrophysiological phenomena in PD patients could not be strongly correlated with the degree of the disability and clinical score of the PD. It was concluded that various motor disorders of PD have considerable influence on oropharyngeal swallowing: hypokinesia, reduced rate of spontaneous swallowing, and the slowness of segmented but coordinated sequential movements rather than any abnormalities in the central pattern generator of the bulbar center. Some compensatory mechanisms in the course of PD may explain the benign nature of swallowing disorder until the terminal stage of the disease. Similarly, the swallowing problems of PD are not only related with the dopamine deficiency; some other nondopaminergic mechanisms may also be involved.</AbstractText><CopyrightInformation>Copyright 2002 Movement Disorder Society</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ertekin</LastName><ForeName>Cumhur</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurology, Ege University Medical School Hospital, Bornova, Izmir, Turkey. erteker@unimedya.net.tr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tarlaci</LastName><ForeName>Sultan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Aydogdu</LastName><ForeName>Ibrahim</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Kiylioglu</LastName><ForeName>Nefati</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Yuceyar</LastName><ForeName>Nur</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Turman</LastName><ForeName>A Bulent</ForeName><Initials>AB</Initials></Author><Author ValidYN="Y"><LastName>Secil</LastName><ForeName>Yaprak</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Esmeli</LastName><ForeName>Figen</ForeName><Initials>F</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003413">Cricoid Cartilage</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003680">Deglutition Disorders</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007830">Larynx</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010614">Pharynx</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013997">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>10</Month><Day>3</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>1</Month><Day>9</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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last="Tarlaci">Sultan Tarlaci</name><name sortKey="Turman, A Bulent" sort="Turman, A Bulent" uniqKey="Turman A" first="A Bulent" last="Turman">A Bulent Turman</name><name sortKey="Yuceyar, Nur" sort="Yuceyar, Nur" uniqKey="Yuceyar N" first="Nur" last="Yuceyar">Nur Yuceyar</name></noCountry><country name="Turquie"><noRegion><name sortKey="Ertekin, Cumhur" sort="Ertekin, Cumhur" uniqKey="Ertekin C" first="Cumhur" last="Ertekin">Cumhur Ertekin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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