Erythropoietin deficiency and anaemia in multiple system atrophy.
Identifieur interne : 000465 ( Ncbi/Merge ); précédent : 000464; suivant : 000466Erythropoietin deficiency and anaemia in multiple system atrophy.
Auteurs : A S Winkler [Royaume-Uni] ; J. Marsden ; M. Parton ; P J Watkins ; K R ChaudhuriSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2001.
English descriptors
- KwdEn :
- Anemia (diagnosis), Anemia (metabolism), Autonomic Nervous System Diseases (diagnosis), Autonomic Nervous System Diseases (physiopathology), Cardiovascular System (physiopathology), Creatinine (blood), Enzyme-Linked Immunosorbent Assay, Erythropoietin (blood), Erythropoietin (deficiency), Female, Heart Rate (physiology), Hemoglobins (analysis), Humans, Hypotension, Orthostatic (diagnosis), Hypotension, Orthostatic (epidemiology), Male, Middle Aged, Multiple System Atrophy (blood), Multiple System Atrophy (physiopathology), Severity of Illness Index.
- MESH :
- chemical , analysis : Hemoglobins.
- chemical , blood : Creatinine, Erythropoietin.
- chemical , deficiency : Erythropoietin.
- blood : Multiple System Atrophy.
- diagnosis : Anemia, Autonomic Nervous System Diseases, Hypotension, Orthostatic.
- epidemiology : Hypotension, Orthostatic.
- metabolism : Anemia.
- physiology : Heart Rate.
- physiopathology : Autonomic Nervous System Diseases, Cardiovascular System, Multiple System Atrophy.
- Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Serum erythropoietin (EPO) levels are partially controlled by the sympathetic outflow to the kidney. We have studied whether patients with multiple system atrophy (MSA), known to be associated with dysautonomia, are EPO-deficient. Eighteen MSA patients were studied along with 32 idiopathic Parkinson's disease (PD) patients, 23 controls with iron-deficiency anaemia, and 18 healthy individuals. Serum creatinine was normal in all groups. Mean haemoglobin (Hb) concentration in MSA patients was 13.7 +/- 1.7 g/dL. Four MSA patients had unexplained anaemia (minimum Hb: 10.5 g/dL) and abnormal autonomic function tests including significant postural hypotension, whereas none of the PD patients was anaemic. Serum EPO levels were suppressed in relation to anaemia in MSA patients compared to elevated EPO levels in iron-deficiency anaemia patients (difference of regression lines P < 0.001), indicating EPO deficiency in the anaemic MSA patients. Serum EPO levels in PD patients were within normal range. A subset of MSA patients has anaemia and postural hypotension, which may be associated with EPO deficiency. This may have therapeutic implications.
PubMed: 11295775
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Erythropoietin deficiency and anaemia in multiple system atrophy.</title><author><name sortKey="Winkler, A S" sort="Winkler, A S" uniqKey="Winkler A" first="A S" last="Winkler">A S Winkler</name><affiliation wicri:level="3"><nlm:affiliation>Regional Movement Disorders, and Dystonia Unit, University Department of Clinical Neurosciences, King's College Hospital, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Regional Movement Disorders, and Dystonia Unit, University Department of Clinical Neurosciences, King's College Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Marsden, J" sort="Marsden, J" uniqKey="Marsden J" first="J" last="Marsden">J. Marsden</name></author><author><name sortKey="Parton, M" sort="Parton, M" uniqKey="Parton M" first="M" last="Parton">M. Parton</name></author><author><name sortKey="Watkins, P J" sort="Watkins, P J" uniqKey="Watkins P" first="P J" last="Watkins">P J Watkins</name></author><author><name sortKey="Chaudhuri, K R" sort="Chaudhuri, K R" uniqKey="Chaudhuri K" first="K R" last="Chaudhuri">K R Chaudhuri</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11295775</idno><idno type="pmid">11295775</idno><idno type="wicri:Area/PubMed/Corpus">003D86</idno><idno type="wicri:Area/PubMed/Curation">003D86</idno><idno type="wicri:Area/PubMed/Checkpoint">003D55</idno><idno type="wicri:Area/Ncbi/Merge">000465</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Erythropoietin deficiency and anaemia in multiple system atrophy.</title><author><name sortKey="Winkler, A S" sort="Winkler, A S" uniqKey="Winkler A" first="A S" last="Winkler">A S Winkler</name><affiliation wicri:level="3"><nlm:affiliation>Regional Movement Disorders, and Dystonia Unit, University Department of Clinical Neurosciences, King's College Hospital, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Regional Movement Disorders, and Dystonia Unit, University Department of Clinical Neurosciences, King's College Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Marsden, J" sort="Marsden, J" uniqKey="Marsden J" first="J" last="Marsden">J. Marsden</name></author><author><name sortKey="Parton, M" sort="Parton, M" uniqKey="Parton M" first="M" last="Parton">M. Parton</name></author><author><name sortKey="Watkins, P J" sort="Watkins, P J" uniqKey="Watkins P" first="P J" last="Watkins">P J Watkins</name></author><author><name sortKey="Chaudhuri, K R" sort="Chaudhuri, K R" uniqKey="Chaudhuri K" first="K R" last="Chaudhuri">K R Chaudhuri</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anemia (diagnosis)</term><term>Anemia (metabolism)</term><term>Autonomic Nervous System Diseases (diagnosis)</term><term>Autonomic Nervous System Diseases (physiopathology)</term><term>Cardiovascular System (physiopathology)</term><term>Creatinine (blood)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Erythropoietin (blood)</term><term>Erythropoietin (deficiency)</term><term>Female</term><term>Heart Rate (physiology)</term><term>Hemoglobins (analysis)</term><term>Humans</term><term>Hypotension, Orthostatic (diagnosis)</term><term>Hypotension, Orthostatic (epidemiology)</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (blood)</term><term>Multiple System Atrophy (physiopathology)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Hemoglobins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Creatinine</term><term>Erythropoietin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Erythropoietin</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Anemia</term><term>Autonomic Nervous System Diseases</term><term>Hypotension, Orthostatic</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Hypotension, Orthostatic</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Anemia</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Heart Rate</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Autonomic Nervous System Diseases</term><term>Cardiovascular System</term><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Serum erythropoietin (EPO) levels are partially controlled by the sympathetic outflow to the kidney. We have studied whether patients with multiple system atrophy (MSA), known to be associated with dysautonomia, are EPO-deficient. Eighteen MSA patients were studied along with 32 idiopathic Parkinson's disease (PD) patients, 23 controls with iron-deficiency anaemia, and 18 healthy individuals. Serum creatinine was normal in all groups. Mean haemoglobin (Hb) concentration in MSA patients was 13.7 +/- 1.7 g/dL. Four MSA patients had unexplained anaemia (minimum Hb: 10.5 g/dL) and abnormal autonomic function tests including significant postural hypotension, whereas none of the PD patients was anaemic. Serum EPO levels were suppressed in relation to anaemia in MSA patients compared to elevated EPO levels in iron-deficiency anaemia patients (difference of regression lines P < 0.001), indicating EPO deficiency in the anaemic MSA patients. Serum EPO levels in PD patients were within normal range. A subset of MSA patients has anaemia and postural hypotension, which may be associated with EPO deficiency. This may have therapeutic implications.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">11295775</PMID><DateCreated><Year>2001</Year><Month>04</Month><Day>11</Day></DateCreated><DateCompleted><Year>2001</Year><Month>08</Month><Day>30</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>16</Volume><Issue>2</Issue><PubDate><Year>2001</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Erythropoietin deficiency and anaemia in multiple system atrophy.</ArticleTitle><Pagination><MedlinePgn>233-9</MedlinePgn></Pagination><Abstract><AbstractText>Serum erythropoietin (EPO) levels are partially controlled by the sympathetic outflow to the kidney. We have studied whether patients with multiple system atrophy (MSA), known to be associated with dysautonomia, are EPO-deficient. Eighteen MSA patients were studied along with 32 idiopathic Parkinson's disease (PD) patients, 23 controls with iron-deficiency anaemia, and 18 healthy individuals. Serum creatinine was normal in all groups. Mean haemoglobin (Hb) concentration in MSA patients was 13.7 +/- 1.7 g/dL. Four MSA patients had unexplained anaemia (minimum Hb: 10.5 g/dL) and abnormal autonomic function tests including significant postural hypotension, whereas none of the PD patients was anaemic. Serum EPO levels were suppressed in relation to anaemia in MSA patients compared to elevated EPO levels in iron-deficiency anaemia patients (difference of regression lines P < 0.001), indicating EPO deficiency in the anaemic MSA patients. Serum EPO levels in PD patients were within normal range. A subset of MSA patients has anaemia and postural hypotension, which may be associated with EPO deficiency. This may have therapeutic implications.</AbstractText><CopyrightInformation>Copyright 2001 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Winkler</LastName><ForeName>A S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Regional Movement Disorders, and Dystonia Unit, University Department of Clinical Neurosciences, King's College Hospital, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marsden</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Parton</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Watkins</LastName><ForeName>P J</ForeName><Initials>PJ</Initials></Author><Author ValidYN="Y"><LastName>Chaudhuri</LastName><ForeName>K R</ForeName><Initials>KR</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal 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UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001342">Autonomic Nervous System Diseases</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002319">Cardiovascular System</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003404">Creatinine</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004797">Enzyme-Linked Immunosorbent Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004921">Erythropoietin</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000172">deficiency</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006339">Heart Rate</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006454">Hemoglobins</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000032">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007024">Hypotension, Orthostatic</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019578">Multiple System Atrophy</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>4</Month><Day>11</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>8</Month><Day>31</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>4</Month><Day>11</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11295775</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><noCountry><name sortKey="Chaudhuri, K R" sort="Chaudhuri, K R" uniqKey="Chaudhuri K" first="K R" last="Chaudhuri">K R Chaudhuri</name><name sortKey="Marsden, J" sort="Marsden, J" uniqKey="Marsden J" first="J" last="Marsden">J. Marsden</name><name sortKey="Parton, M" sort="Parton, M" uniqKey="Parton M" first="M" last="Parton">M. Parton</name><name sortKey="Watkins, P J" sort="Watkins, P J" uniqKey="Watkins P" first="P J" last="Watkins">P J Watkins</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Winkler, A S" sort="Winkler, A S" uniqKey="Winkler A" first="A S" last="Winkler">A S Winkler</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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