The pathogenesis of multiple system atrophy: past, present, and future.
Identifieur interne : 000326 ( Ncbi/Merge ); précédent : 000325; suivant : 000327The pathogenesis of multiple system atrophy: past, present, and future.
Auteurs : E. Jaros [Royaume-Uni] ; D J BurnSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2000.
English descriptors
- KwdEn :
- Biological Markers, Brain (metabolism), Brain (pathology), Gene Expression Regulation, Genes, Regulator, Humans, Inclusion Bodies (metabolism), Inclusion Bodies (pathology), Multiple System Atrophy (classification), Multiple System Atrophy (etiology), Multiple System Atrophy (genetics), Multiple System Atrophy (metabolism), Multiple System Atrophy (pathology), Mutation, Nerve Tissue Proteins (genetics), Nerve Tissue Proteins (metabolism), Neuregulins (genetics), Oligodendroglia (metabolism), Oligodendroglia (pathology), Polymorphism, Genetic, Synucleins, alpha-Synuclein, tau Proteins (metabolism).
- MESH :
- chemical , genetics : Nerve Tissue Proteins, Neuregulins.
- chemical , metabolism : Nerve Tissue Proteins, tau Proteins.
- chemical : Biological Markers, Synucleins, alpha-Synuclein.
- classification : Multiple System Atrophy.
- etiology : Multiple System Atrophy.
- genetics : Multiple System Atrophy.
- metabolism : Brain, Inclusion Bodies, Multiple System Atrophy, Oligodendroglia.
- pathology : Brain, Inclusion Bodies, Multiple System Atrophy, Oligodendroglia.
- Gene Expression Regulation, Genes, Regulator, Humans, Mutation, Polymorphism, Genetic.
Abstract
Multiple system atrophy is a sporadic, adult-onset neurodegenerative disease of unknown etiology. The condition may be unique among neurodegenerative diseases by the prominent, if not primary, role played by the oligodendroglial cell in the pathogenetic process. Recent developments in our understanding of multiple system atrophy have included the detection of glial cytoplasmic inclusions and alpha-synuclein accumulation in these inclusions. The latter finding links multiple system atrophy as an "alpha-synucleinopathy" to Parkinson's disease and dementia with Lewy bodies. This article reviews recent important findings of potential relevance to the pathogenesis of multiple system atrophy. We also speculate on areas in which further advances may be made to progress our understanding of this devastating condition.
PubMed: 11009180
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pubmed:11009180Le document en format XML
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<front><div type="abstract" xml:lang="en">Multiple system atrophy is a sporadic, adult-onset neurodegenerative disease of unknown etiology. The condition may be unique among neurodegenerative diseases by the prominent, if not primary, role played by the oligodendroglial cell in the pathogenetic process. Recent developments in our understanding of multiple system atrophy have included the detection of glial cytoplasmic inclusions and alpha-synuclein accumulation in these inclusions. The latter finding links multiple system atrophy as an "alpha-synucleinopathy" to Parkinson's disease and dementia with Lewy bodies. This article reviews recent important findings of potential relevance to the pathogenesis of multiple system atrophy. We also speculate on areas in which further advances may be made to progress our understanding of this devastating condition.</div>
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