A double-blind, placebo-controlled study of intranasal apomorphine spray as a rescue agent for off-states in Parkinson's disease.
Identifieur interne : 005027 ( Ncbi/Curation ); précédent : 005026; suivant : 005028A double-blind, placebo-controlled study of intranasal apomorphine spray as a rescue agent for off-states in Parkinson's disease.
Auteurs : R B Dewey [États-Unis] ; D M Maraganore ; J E Ahlskog ; J Y MatsumotoSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1998.
English descriptors
- KwdEn :
- Administration, Intranasal, Aerosols, Aged, Antiemetics (administration & dosage), Antiemetics (adverse effects), Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Apomorphine (administration & dosage), Apomorphine (adverse effects), Benzamides (administration & dosage), Benzamides (adverse effects), Cross-Over Studies, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Levodopa (administration & dosage), Levodopa (adverse effects), Male, Middle Aged, Neurologic Examination (drug effects), Parkinson Disease (drug therapy), Pilot Projects, Premedication, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Antiemetics, Antiparkinson Agents, Apomorphine, Benzamides, Levodopa.
- chemical , adverse effects : Antiemetics, Antiparkinson Agents, Apomorphine, Benzamides, Levodopa.
- chemical : Aerosols.
- drug effects : Neurologic Examination.
- drug therapy : Parkinson Disease.
- Administration, Intranasal, Aged, Cross-Over Studies, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Pilot Projects, Premedication, Treatment Outcome.
Abstract
Nine patients with advanced levodopa-responsive Parkinson's disease were enrolled in a double-blind, placebo-controlled crossover trial of intranasal apomorphine as rescue therapy for parkinsonian off-states. Patients were assigned in random order to each of four possible combinations of apomorphine, trimethobenzamide antiemetic, and their matched placebos and received detailed in-office motor scoring during each of the four study periods. Patients also completed diaries describing the effectiveness of the nasal spray for reversing off-states. A statistically significant reduction in the Unified Parkinson's Disease Rating Scale (UPDRS) motor score was seen following active apomorphine during in-office evaluation visits but not following placebo nasal spray. Patient diaries revealed that active apomorphine had a latency to onset of 11 minutes and a duration of 50 minutes. Significant nausea from apomorphine spray was seen in only one patient whereas nasal irritation was disabling in three and mild in two. We conclude that intranasal apomorphine is an effective rescue agent for parkinsonian off-states although nasal irritation is a limiting factor.
DOI: 10.1002/mds.870130505
PubMed: 9756146
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pubmed:9756146Le document en format XML
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wicri:level="1"><nlm:affiliation>Department of Neurology, University of Texas Southwestern Medical School, Dallas 75235-8897, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Texas Southwestern Medical School, Dallas 75235-8897</wicri:regionArea><wicri:noRegion>Dallas 75235-8897</wicri:noRegion></affiliation></author><author><name sortKey="Maraganore, D M" sort="Maraganore, D M" uniqKey="Maraganore D" first="D M" last="Maraganore">D M Maraganore</name></author><author><name sortKey="Ahlskog, J E" sort="Ahlskog, J E" uniqKey="Ahlskog J" first="J E" last="Ahlskog">J E Ahlskog</name></author><author><name sortKey="Matsumoto, J Y" sort="Matsumoto, J Y" uniqKey="Matsumoto J" first="J Y" last="Matsumoto">J Y Matsumoto</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1998" 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Patients were assigned in random order to each of four possible combinations of apomorphine, trimethobenzamide antiemetic, and their matched placebos and received detailed in-office motor scoring during each of the four study periods. Patients also completed diaries describing the effectiveness of the nasal spray for reversing off-states. A statistically significant reduction in the Unified Parkinson's Disease Rating Scale (UPDRS) motor score was seen following active apomorphine during in-office evaluation visits but not following placebo nasal spray. Patient diaries revealed that active apomorphine had a latency to onset of 11 minutes and a duration of 50 minutes. Significant nausea from apomorphine spray was seen in only one patient whereas nasal irritation was disabling in three and mild in two. We conclude that intranasal apomorphine is an effective rescue agent for parkinsonian off-states although nasal irritation is a limiting factor.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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