Movement Disorders (revue)

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Symptoms and duration of the prodromal phase in Parkinson's disease.

Identifieur interne : 004E13 ( Ncbi/Curation ); précédent : 004E12; suivant : 004E14

Symptoms and duration of the prodromal phase in Parkinson's disease.

Auteurs : E G Gonera [Pays-Bas] ; M. Van'T Hof ; H J Berger ; C. Van Weel ; M W Horstink

Source :

RBID : pubmed:9399209

English descriptors

Abstract

To investigate the duration of a prodromal phase before the onset of the classic symptoms of idiopathic Parkinson's disease, the authors conducted a retrospective case-control study of 60 patients with Parkinson's disease and 58 age- and sex-matched control subjects, covering the decade preceding the onset of classic Parkinson's disease. The symptoms were derived from files of the patients' general practitioners. Compared with control subjects, patients pre-Parkinson's disease had more central nervous system, psychologic, musculoskeletal, and cardiovascular (i.e., autonomic) symptoms. Patients pre-Parkinson's disease also made more visits to general practitioners and medical specialists. The results indicate that the onset of classic parkinsonism is frequently preceded by a prodromal phase lasting from 4-6 years.

DOI: 10.1002/mds.870120607
PubMed: 9399209

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pubmed:9399209

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<nlm:affiliation>Department of Neurology, University Hospital Nijmegen, The Netherlands.</nlm:affiliation>
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<term>Cardiovascular Diseases</term>
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<term>Aged</term>
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<div type="abstract" xml:lang="en">To investigate the duration of a prodromal phase before the onset of the classic symptoms of idiopathic Parkinson's disease, the authors conducted a retrospective case-control study of 60 patients with Parkinson's disease and 58 age- and sex-matched control subjects, covering the decade preceding the onset of classic Parkinson's disease. The symptoms were derived from files of the patients' general practitioners. Compared with control subjects, patients pre-Parkinson's disease had more central nervous system, psychologic, musculoskeletal, and cardiovascular (i.e., autonomic) symptoms. Patients pre-Parkinson's disease also made more visits to general practitioners and medical specialists. The results indicate that the onset of classic parkinsonism is frequently preceded by a prodromal phase lasting from 4-6 years.</div>
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