Symptoms and duration of the prodromal phase in Parkinson's disease.
Identifieur interne : 004E13 ( Ncbi/Curation ); précédent : 004E12; suivant : 004E14Symptoms and duration of the prodromal phase in Parkinson's disease.
Auteurs : E G Gonera [Pays-Bas] ; M. Van'T Hof ; H J Berger ; C. Van Weel ; M W HorstinkSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1997.
English descriptors
- KwdEn :
- MESH :
Abstract
To investigate the duration of a prodromal phase before the onset of the classic symptoms of idiopathic Parkinson's disease, the authors conducted a retrospective case-control study of 60 patients with Parkinson's disease and 58 age- and sex-matched control subjects, covering the decade preceding the onset of classic Parkinson's disease. The symptoms were derived from files of the patients' general practitioners. Compared with control subjects, patients pre-Parkinson's disease had more central nervous system, psychologic, musculoskeletal, and cardiovascular (i.e., autonomic) symptoms. Patients pre-Parkinson's disease also made more visits to general practitioners and medical specialists. The results indicate that the onset of classic parkinsonism is frequently preceded by a prodromal phase lasting from 4-6 years.
DOI: 10.1002/mds.870120607
PubMed: 9399209
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pubmed:9399209Le document en format XML
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<author><name sortKey="Van Weel, C" sort="Van Weel, C" uniqKey="Van Weel C" first="C" last="Van Weel">C. Van Weel</name>
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<author><name sortKey="Horstink, M W" sort="Horstink, M W" uniqKey="Horstink M" first="M W" last="Horstink">M W Horstink</name>
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<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mood Disorders (complications)</term>
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<term>Parkinson Disease (complications)</term>
<term>Respiratory Tract Diseases (complications)</term>
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<front><div type="abstract" xml:lang="en">To investigate the duration of a prodromal phase before the onset of the classic symptoms of idiopathic Parkinson's disease, the authors conducted a retrospective case-control study of 60 patients with Parkinson's disease and 58 age- and sex-matched control subjects, covering the decade preceding the onset of classic Parkinson's disease. The symptoms were derived from files of the patients' general practitioners. Compared with control subjects, patients pre-Parkinson's disease had more central nervous system, psychologic, musculoskeletal, and cardiovascular (i.e., autonomic) symptoms. Patients pre-Parkinson's disease also made more visits to general practitioners and medical specialists. The results indicate that the onset of classic parkinsonism is frequently preceded by a prodromal phase lasting from 4-6 years.</div>
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