Akinetic-rigid syndrome in a 13-year-old girl with HIV-related progressive multifocal leukoencephalopathy.
Identifieur interne : 004986 ( Ncbi/Curation ); précédent : 004985; suivant : 004987Akinetic-rigid syndrome in a 13-year-old girl with HIV-related progressive multifocal leukoencephalopathy.
Auteurs : C. Singer [États-Unis] ; J R Berger ; B C Bowen ; J H Bruce ; W J WeinerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1993.
English descriptors
- KwdEn :
- AIDS-Related Opportunistic Infections (diagnosis), AIDS-Related Opportunistic Infections (pathology), Adolescent, Biopsy, Brain (pathology), Female, Humans, Leukoencephalopathy, Progressive Multifocal (diagnosis), Leukoencephalopathy, Progressive Multifocal (pathology), Magnetic Resonance Imaging, Movement Disorders (diagnosis), Movement Disorders (pathology), Muscle Rigidity (diagnosis), Muscle Rigidity (pathology), Myelin Sheath (pathology), Neurologic Examination.
- MESH :
- diagnosis : AIDS-Related Opportunistic Infections, Leukoencephalopathy, Progressive Multifocal, Movement Disorders, Muscle Rigidity.
- pathology : AIDS-Related Opportunistic Infections, Brain, Leukoencephalopathy, Progressive Multifocal, Movement Disorders, Muscle Rigidity, Myelin Sheath.
- Adolescent, Biopsy, Female, Humans, Magnetic Resonance Imaging, Neurologic Examination.
Abstract
A 13-year-old HIV-infected girl presented with a rapidly progressive akinetic-rigid syndrome. Cranial magnetic resonance imaging revealed bilateral centrum semiovale lesions extending into the basal ganglia. Detailed histopathological study of a biopsy specimen from the involved regions resulted in a diagnosis of progressive multifocal leukoencephalopathy (PML). This case illustrates that an akinetic-rigid syndrome may be a rare presentation of PML. HIV-related PML may have unusual radiological features. Brain biopsy may be necessary to confirm PML in cases associated with atypical clinical and radiological presentations.
DOI: 10.1002/mds.870080120
PubMed: 8419794
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Singer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Miami School of Medicine, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, University of Miami School of Medicine</wicri:cityArea></affiliation></author><author><name sortKey="Berger, J R" sort="Berger, J R" uniqKey="Berger J" first="J R" last="Berger">J R Berger</name></author><author><name sortKey="Bowen, B C" sort="Bowen, B C" uniqKey="Bowen B" first="B C" last="Bowen">B C Bowen</name></author><author><name sortKey="Bruce, J H" sort="Bruce, J H" uniqKey="Bruce J" first="J H" last="Bruce">J H Bruce</name></author><author><name sortKey="Weiner, W J" sort="Weiner, W J" uniqKey="Weiner W" first="W J" last="Weiner">W J Weiner</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1993">1993</date><idno type="RBID">pubmed:8419794</idno><idno type="pmid">8419794</idno><idno type="doi">10.1002/mds.870080120</idno><idno type="wicri:Area/PubMed/Corpus">004C85</idno><idno type="wicri:Area/PubMed/Curation">004C85</idno><idno type="wicri:Area/PubMed/Checkpoint">004C89</idno><idno type="wicri:Area/Ncbi/Merge">004986</idno><idno type="wicri:Area/Ncbi/Curation">004986</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Akinetic-rigid syndrome in a 13-year-old girl with HIV-related progressive multifocal leukoencephalopathy.</title><author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C" last="Singer">C. Singer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Miami School of Medicine, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, University of Miami School of Medicine</wicri:cityArea></affiliation></author><author><name sortKey="Berger, J R" sort="Berger, J R" uniqKey="Berger J" first="J R" last="Berger">J R Berger</name></author><author><name sortKey="Bowen, B C" sort="Bowen, B C" uniqKey="Bowen B" first="B C" last="Bowen">B C Bowen</name></author><author><name sortKey="Bruce, J H" sort="Bruce, J H" uniqKey="Bruce J" first="J H" last="Bruce">J H Bruce</name></author><author><name sortKey="Weiner, W J" sort="Weiner, W J" uniqKey="Weiner W" first="W J" last="Weiner">W J Weiner</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS-Related Opportunistic Infections (diagnosis)</term><term>AIDS-Related Opportunistic Infections (pathology)</term><term>Adolescent</term><term>Biopsy</term><term>Brain (pathology)</term><term>Female</term><term>Humans</term><term>Leukoencephalopathy, Progressive Multifocal (diagnosis)</term><term>Leukoencephalopathy, Progressive Multifocal (pathology)</term><term>Magnetic Resonance Imaging</term><term>Movement Disorders (diagnosis)</term><term>Movement Disorders (pathology)</term><term>Muscle Rigidity (diagnosis)</term><term>Muscle Rigidity (pathology)</term><term>Myelin Sheath (pathology)</term><term>Neurologic Examination</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>AIDS-Related Opportunistic Infections</term><term>Leukoencephalopathy, Progressive Multifocal</term><term>Movement Disorders</term><term>Muscle Rigidity</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>AIDS-Related Opportunistic Infections</term><term>Brain</term><term>Leukoencephalopathy, Progressive Multifocal</term><term>Movement Disorders</term><term>Muscle Rigidity</term><term>Myelin Sheath</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Biopsy</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Neurologic Examination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A 13-year-old HIV-infected girl presented with a rapidly progressive akinetic-rigid syndrome. Cranial magnetic resonance imaging revealed bilateral centrum semiovale lesions extending into the basal ganglia. Detailed histopathological study of a biopsy specimen from the involved regions resulted in a diagnosis of progressive multifocal leukoencephalopathy (PML). This case illustrates that an akinetic-rigid syndrome may be a rare presentation of PML. HIV-related PML may have unusual radiological features. Brain biopsy may be necessary to confirm PML in cases associated with atypical clinical and radiological presentations.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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