L-dihydroxyphenylalanine and its decarboxylase: new ideas on their neuroregulatory roles.
Identifieur interne : 004717 ( Ncbi/Curation ); précédent : 004716; suivant : 004718L-dihydroxyphenylalanine and its decarboxylase: new ideas on their neuroregulatory roles.
Auteurs : J. Opacka-Juffry [Royaume-Uni] ; D J BrooksSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1995.
English descriptors
- KwdEn :
- Animals, Brain (physiopathology), Brain Mapping, Corpus Striatum (physiology), Dihydroxyphenylalanine (physiology), Dopa Decarboxylase (physiology), Dopamine (physiology), Humans, Neurotransmitter Agents (physiology), Parkinson Disease (physiopathology), Synaptic Transmission (physiology), Tomography, Emission-Computed.
- MESH :
- chemical , physiology : Dihydroxyphenylalanine, Dopa Decarboxylase, Dopamine, Neurotransmitter Agents.
- physiology : Corpus Striatum, Synaptic Transmission.
- physiopathology : Brain, Parkinson Disease.
- Animals, Brain Mapping, Humans, Tomography, Emission-Computed.
Abstract
Recent experimental reports concerning L-dihydroxyphenylalanine (L-DOPA) and aromatic L-amino acid decarboxylase (AADC, L-DOPA decarboxylase) are reviewed in this article. Both in vitro and in vivo data now suggest that L-DOPA is an endogenous neuroactive compound that is released from neurons and acts as a neurotransmitter or neuromodulator in the brain. Administration of exogenous L-DOPA affects dopamine receptor status, AADC activity, and mitochondrial oxidation in experimental animals. The type and severity of these effects depend on the duration of the treatment. These findings may partly explain the limited efficacy of L-DOPA therapy in Parkinson's disease (PD). AADC also plays a controlling role in the central nervous system, being a regulatory enzyme in the synthesis of a putative neuromodulator 2-phenylethylamine and other trace amines. Recent experimental findings on AADC activity and localisation are of importance because they suggest that striatal [18F]DOPA uptake used as an indicator of PD progression in positron emission tomography (PET) studies is likely to overestimate nigrostriatal integrity in advanced PD. Possible new PET tracers of presynaptic dopaminergic function are discussed in this context.
DOI: 10.1002/mds.870100302
PubMed: 7651438
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :004995
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :004995
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :004965
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :004717
Links to Exploration step
pubmed:7651438Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">L-dihydroxyphenylalanine and its decarboxylase: new ideas on their neuroregulatory roles.</title><author><name sortKey="Opacka Juffry, J" sort="Opacka Juffry, J" uniqKey="Opacka Juffry J" first="J" last="Opacka-Juffry">J. Opacka-Juffry</name><affiliation wicri:level="2"><nlm:affiliation>MRC Cyclotron Unit, Hammersmith Hospital, London, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Cyclotron Unit, Hammersmith Hospital, London</wicri:cityArea></affiliation></author><author><name sortKey="Brooks, D J" sort="Brooks, D J" uniqKey="Brooks D" first="D J" last="Brooks">D J Brooks</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1995">1995</date><idno type="RBID">pubmed:7651438</idno><idno type="pmid">7651438</idno><idno type="doi">10.1002/mds.870100302</idno><idno type="wicri:Area/PubMed/Corpus">004995</idno><idno type="wicri:Area/PubMed/Curation">004995</idno><idno type="wicri:Area/PubMed/Checkpoint">004965</idno><idno type="wicri:Area/Ncbi/Merge">004717</idno><idno type="wicri:Area/Ncbi/Curation">004717</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">L-dihydroxyphenylalanine and its decarboxylase: new ideas on their neuroregulatory roles.</title><author><name sortKey="Opacka Juffry, J" sort="Opacka Juffry, J" uniqKey="Opacka Juffry J" first="J" last="Opacka-Juffry">J. Opacka-Juffry</name><affiliation wicri:level="2"><nlm:affiliation>MRC Cyclotron Unit, Hammersmith Hospital, London, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Cyclotron Unit, Hammersmith Hospital, London</wicri:cityArea></affiliation></author><author><name sortKey="Brooks, D J" sort="Brooks, D J" uniqKey="Brooks D" first="D J" last="Brooks">D J Brooks</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1995" type="published">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brain (physiopathology)</term><term>Brain Mapping</term><term>Corpus Striatum (physiology)</term><term>Dihydroxyphenylalanine (physiology)</term><term>Dopa Decarboxylase (physiology)</term><term>Dopamine (physiology)</term><term>Humans</term><term>Neurotransmitter Agents (physiology)</term><term>Parkinson Disease (physiopathology)</term><term>Synaptic Transmission (physiology)</term><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dihydroxyphenylalanine</term><term>Dopa Decarboxylase</term><term>Dopamine</term><term>Neurotransmitter Agents</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Corpus Striatum</term><term>Synaptic Transmission</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Brain Mapping</term><term>Humans</term><term>Tomography, Emission-Computed</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent experimental reports concerning L-dihydroxyphenylalanine (L-DOPA) and aromatic L-amino acid decarboxylase (AADC, L-DOPA decarboxylase) are reviewed in this article. Both in vitro and in vivo data now suggest that L-DOPA is an endogenous neuroactive compound that is released from neurons and acts as a neurotransmitter or neuromodulator in the brain. Administration of exogenous L-DOPA affects dopamine receptor status, AADC activity, and mitochondrial oxidation in experimental animals. The type and severity of these effects depend on the duration of the treatment. These findings may partly explain the limited efficacy of L-DOPA therapy in Parkinson's disease (PD). AADC also plays a controlling role in the central nervous system, being a regulatory enzyme in the synthesis of a putative neuromodulator 2-phenylethylamine and other trace amines. Recent experimental findings on AADC activity and localisation are of importance because they suggest that striatal [18F]DOPA uptake used as an indicator of PD progression in positron emission tomography (PET) studies is likely to overestimate nigrostriatal integrity in advanced PD. Possible new PET tracers of presynaptic dopaminergic function are discussed in this context.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004717 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 004717 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:7651438
|texte= L-dihydroxyphenylalanine and its decarboxylase: new ideas on their neuroregulatory roles.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:7651438" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |