Emerging therapies for gait disability and balance impairment: promises and pitfalls.
Identifieur interne : 003D80 ( Ncbi/Curation ); précédent : 003D79; suivant : 003D81Emerging therapies for gait disability and balance impairment: promises and pitfalls.
Auteurs : Walter Maetzler [Allemagne] ; Freek Nieuwhof ; Sandra E. Hasmann ; Bastiaan R. BloemSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- methods : Emergency Medical Services.
- physiology : Postural Balance.
- psychology : Gait Disorders, Neurologic, Sensation Disorders.
- therapy : Gait Disorders, Neurologic, Sensation Disorders.
- Humans, Quality of Life.
Abstract
Therapeutic management of gait and balance impairment during aging and neurodegeneration has long been a neglected topic. This has changed considerably during recent years, for several reasons: (1) an increasing recognition that gait and balance deficits are among the most relevant determinants of an impaired quality of life and increased mortality for affected individuals; (2) the arrival of new technology, which has allowed for new insights into the anatomy and functional (dis)integrity of gait and balance circuits; and (3) based in part on these improved insights, the development of new, more specific treatment strategies in the field of pharmacotherapy, deep brain surgery, and physiotherapy. The initial experience with these emerging treatments is encouraging, although much work remains to be done. The objective of this narrative review is to discuss several promising developments in the field of gait and balance treatment. We also address several pitfalls that can potentially hinder a fast and efficient continuation of this vital progress. Important issues that should be considered in future research include a clear differentiation between gait and balance as two distinctive targets for treatment and recognition of compensatory mechanisms as a separate target for therapeutic intervention.
DOI: 10.1002/mds.25682
PubMed: 24132846
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Hasmann</name></author><author><name sortKey="Bloem, Bastiaan R" sort="Bloem, Bastiaan R" uniqKey="Bloem B" first="Bastiaan R" last="Bloem">Bastiaan R. 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Hasmann</name></author><author><name sortKey="Bloem, Bastiaan R" sort="Bloem, Bastiaan R" uniqKey="Bloem B" first="Bastiaan R" last="Bloem">Bastiaan R. Bloem</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Emergency Medical Services (methods)</term><term>Gait Disorders, Neurologic (psychology)</term><term>Gait Disorders, Neurologic (therapy)</term><term>Humans</term><term>Postural Balance (physiology)</term><term>Quality of Life</term><term>Sensation Disorders (psychology)</term><term>Sensation Disorders (therapy)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Emergency Medical Services</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Postural Balance</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Gait Disorders, Neurologic</term><term>Sensation Disorders</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Gait Disorders, Neurologic</term><term>Sensation Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Quality of Life</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Therapeutic management of gait and balance impairment during aging and neurodegeneration has long been a neglected topic. This has changed considerably during recent years, for several reasons: (1) an increasing recognition that gait and balance deficits are among the most relevant determinants of an impaired quality of life and increased mortality for affected individuals; (2) the arrival of new technology, which has allowed for new insights into the anatomy and functional (dis)integrity of gait and balance circuits; and (3) based in part on these improved insights, the development of new, more specific treatment strategies in the field of pharmacotherapy, deep brain surgery, and physiotherapy. The initial experience with these emerging treatments is encouraging, although much work remains to be done. The objective of this narrative review is to discuss several promising developments in the field of gait and balance treatment. We also address several pitfalls that can potentially hinder a fast and efficient continuation of this vital progress. Important issues that should be considered in future research include a clear differentiation between gait and balance as two distinctive targets for treatment and recognition of compensatory mechanisms as a separate target for therapeutic intervention.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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