Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial.
Identifieur interne : 003A19 ( Ncbi/Curation ); précédent : 003A18; suivant : 003A20Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial.
Auteurs : Asako Yoritaka [Japon] ; Masashi Takanashi ; Masaaki Hirayama ; Toshiki Nakahara ; Shigeo Ohta ; Nobutaka HattoriSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
Descripteurs français
- Wicri :
- geographic : Japon.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (therapeutic use), Double-Blind Method, Female, Humans, Hydrogen (therapeutic use), Japan, Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (drug therapy), Pilot Projects, Severity of Illness Index, Statistics, Nonparametric, Water (administration & dosage).
- MESH :
- chemical , administration & dosage : Water.
- chemical , therapeutic use : Antiparkinson Agents, Hydrogen, Levodopa.
- geographic : Japan.
- drug therapy : Parkinson Disease.
- Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Pilot Projects, Severity of Illness Index, Statistics, Nonparametric.
Abstract
Oxidative stress is involved in the progression of Parkinson's disease (PD). Recent studies have confirmed that molecular hydrogen (H₂) functions as a highly effective antioxidant in cultured cells and animal models. Drinking H₂-dissolved water (H₂-water) reduced oxidative stress and improved Parkinson's features in model animals.
DOI: 10.1002/mds.25375
PubMed: 23400965
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pubmed:23400965Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial.</title>
<author><name sortKey="Yoritaka, Asako" sort="Yoritaka, Asako" uniqKey="Yoritaka A" first="Asako" last="Yoritaka">Asako Yoritaka</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, Juntendo University School of Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
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<author><name sortKey="Takanashi, Masashi" sort="Takanashi, Masashi" uniqKey="Takanashi M" first="Masashi" last="Takanashi">Masashi Takanashi</name>
</author>
<author><name sortKey="Hirayama, Masaaki" sort="Hirayama, Masaaki" uniqKey="Hirayama M" first="Masaaki" last="Hirayama">Masaaki Hirayama</name>
</author>
<author><name sortKey="Nakahara, Toshiki" sort="Nakahara, Toshiki" uniqKey="Nakahara T" first="Toshiki" last="Nakahara">Toshiki Nakahara</name>
</author>
<author><name sortKey="Ohta, Shigeo" sort="Ohta, Shigeo" uniqKey="Ohta S" first="Shigeo" last="Ohta">Shigeo Ohta</name>
</author>
<author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial.</title>
<author><name sortKey="Yoritaka, Asako" sort="Yoritaka, Asako" uniqKey="Yoritaka A" first="Asako" last="Yoritaka">Asako Yoritaka</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, Juntendo University School of Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
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<author><name sortKey="Takanashi, Masashi" sort="Takanashi, Masashi" uniqKey="Takanashi M" first="Masashi" last="Takanashi">Masashi Takanashi</name>
</author>
<author><name sortKey="Hirayama, Masaaki" sort="Hirayama, Masaaki" uniqKey="Hirayama M" first="Masaaki" last="Hirayama">Masaaki Hirayama</name>
</author>
<author><name sortKey="Nakahara, Toshiki" sort="Nakahara, Toshiki" uniqKey="Nakahara T" first="Toshiki" last="Nakahara">Toshiki Nakahara</name>
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<author><name sortKey="Ohta, Shigeo" sort="Ohta, Shigeo" uniqKey="Ohta S" first="Shigeo" last="Ohta">Shigeo Ohta</name>
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<author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2013" type="published">2013</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Hydrogen (therapeutic use)</term>
<term>Japan</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Pilot Projects</term>
<term>Severity of Illness Index</term>
<term>Statistics, Nonparametric</term>
<term>Water (administration & dosage)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Water</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Hydrogen</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Japan</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pilot Projects</term>
<term>Severity of Illness Index</term>
<term>Statistics, Nonparametric</term>
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<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Japon</term>
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<front><div type="abstract" xml:lang="en">Oxidative stress is involved in the progression of Parkinson's disease (PD). Recent studies have confirmed that molecular hydrogen (H₂) functions as a highly effective antioxidant in cultured cells and animal models. Drinking H₂-dissolved water (H₂-water) reduced oxidative stress and improved Parkinson's features in model animals.</div>
</front>
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</record>
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