Magnetic resonance imaging of the substantia nigra in Parkinson's disease.
Identifieur interne : 003685 ( Ncbi/Curation ); précédent : 003684; suivant : 003686Magnetic resonance imaging of the substantia nigra in Parkinson's disease.
Auteurs : Stéphane Lehéricy [France] ; Michael A. Sharman ; Clarisse Longo Dos Santos ; Raphaël Paquin ; Cecile GalleaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
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Abstract
Until recently, conventional magnetic resonance imaging (MRI) was most often negative in Parkinson's disease or showed nonspecific findings. Recent developments in structural MRI, including relaxometry, magnetization transfer, and neuromelanin imaging, have demonstrated improved contrast and enabled more accurate visualization of deep brain nuclei, in particular, the substantia nigra. Meanwhile, diffusion imaging has provided useful biomarkers of substantia nigra degeneration, showing reduced anisotropy and anatomical connectivity with the striatum and thalamus. These advances in structural imaging are complemented by findings of magnetic resonance spectroscopy on brain metabolism and resting-state functional MRI on functional connectivity. This article presents an overview of these new structural, metabolic, and resting-state functional MRI techniques and their implications for Parkinson's disease. The techniques are reviewed in the context of their potential for better understanding the disease in terms of diagnosis and pathophysiology and as biomarkers of its progression.
DOI: 10.1002/mds.25015
PubMed: 22649063
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Sharman</name></author><author><name sortKey="Dos Santos, Clarisse Longo" sort="Dos Santos, Clarisse Longo" uniqKey="Dos Santos C" first="Clarisse Longo" last="Dos Santos">Clarisse Longo Dos Santos</name></author><author><name sortKey="Paquin, Raphael" sort="Paquin, Raphael" uniqKey="Paquin R" first="Raphaël" last="Paquin">Raphaël Paquin</name></author><author><name sortKey="Gallea, Cecile" sort="Gallea, Cecile" uniqKey="Gallea C" first="Cecile" last="Gallea">Cecile Gallea</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.25015</idno><idno type="RBID">pubmed:22649063</idno><idno type="pmid">22649063</idno><idno type="wicri:Area/PubMed/Corpus">000D61</idno><idno type="wicri:Area/PubMed/Curation">000D61</idno><idno type="wicri:Area/PubMed/Checkpoint">000D48</idno><idno type="wicri:Area/Ncbi/Merge">003685</idno><idno type="wicri:Area/Ncbi/Curation">003685</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Magnetic resonance imaging of the substantia nigra in Parkinson's disease.</title><author><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stéphane" last="Lehéricy">Stéphane Lehéricy</name><affiliation wicri:level="1"><nlm:affiliation>Centre de NeuroImagerie de Recherche-CENIR, Groupe Hospitalier Pitie-Salpetriere, Paris, France. stephane.lehericy@upmc.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de NeuroImagerie de Recherche-CENIR, Groupe Hospitalier Pitie-Salpetriere, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sharman, Michael A" sort="Sharman, Michael A" uniqKey="Sharman M" first="Michael A" last="Sharman">Michael A. Sharman</name></author><author><name sortKey="Dos Santos, Clarisse Longo" sort="Dos Santos, Clarisse Longo" uniqKey="Dos Santos C" first="Clarisse Longo" last="Dos Santos">Clarisse Longo Dos Santos</name></author><author><name sortKey="Paquin, Raphael" sort="Paquin, Raphael" uniqKey="Paquin R" first="Raphaël" last="Paquin">Raphaël Paquin</name></author><author><name sortKey="Gallea, Cecile" sort="Gallea, Cecile" uniqKey="Gallea C" first="Cecile" last="Gallea">Cecile Gallea</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Parkinson Disease (pathology)</term><term>Relaxation</term><term>Substantia Nigra (pathology)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Relaxation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Until recently, conventional magnetic resonance imaging (MRI) was most often negative in Parkinson's disease or showed nonspecific findings. Recent developments in structural MRI, including relaxometry, magnetization transfer, and neuromelanin imaging, have demonstrated improved contrast and enabled more accurate visualization of deep brain nuclei, in particular, the substantia nigra. Meanwhile, diffusion imaging has provided useful biomarkers of substantia nigra degeneration, showing reduced anisotropy and anatomical connectivity with the striatum and thalamus. These advances in structural imaging are complemented by findings of magnetic resonance spectroscopy on brain metabolism and resting-state functional MRI on functional connectivity. This article presents an overview of these new structural, metabolic, and resting-state functional MRI techniques and their implications for Parkinson's disease. The techniques are reviewed in the context of their potential for better understanding the disease in terms of diagnosis and pathophysiology and as biomarkers of its progression.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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