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Subthalamic Nucleus Neuronal Firing Rate Increases with Parkinson’s Disease Progression

Identifieur interne : 003207 ( Ncbi/Curation ); précédent : 003206; suivant : 003208

Subthalamic Nucleus Neuronal Firing Rate Increases with Parkinson’s Disease Progression

Auteurs : Michael S. Remple ; Courtney H. Bradenham ; C. Chris Kao ; P. David Charles ; Joseph S. Neimat ; Peter E. Konrad

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2011.

RBID : PMC:3151310

English descriptors

KwdEn :
- Action Potentials (physiology), Aged, Deep Brain Stimulation (methods), Disease Progression, Female, Humans, Male, Microelectrodes, Middle Aged, Neurons (physiology), Parkinson Disease (pathology), Parkinson Disease (therapy), Subthalamic Nucleus (pathology).
MESH :
- methods : Deep Brain Stimulation.
- pathology : Parkinson Disease, Subthalamic Nucleus.
- physiology : Action Potentials, Neurons.
- therapy : Parkinson Disease.
- Aged, Disease Progression, Female, Humans, Male, Microelectrodes, Middle Aged.

Abstract

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic cells in the central nervous system, in particular the substantia nigra, resulting in an unrelenting loss of motor and non-motor function. Animal models of PD reveal hyperactive neurons in the subthalamic nucleus (STN) that have increased firing rates and bursting activity compared to controls. Although STN activity has been characterized in advanced stage PD patients, it has not been described in early stage PD patients. Here we present the results of STN neuronal recordings from early stage PD patients (Hoehn and Yahr stage II) enrolled in an ongoing clinical trial compared to recordings from age and sex matched advanced PD patients. STN neurons had a significantly lower firing rate in early versus advanced PD (28.7Hz vs. 36.3Hz; p<0.01). The overall activity of the STN was also significantly lower in early versus late PD, as measured by background neuronal noise (12.4mV vs. 14.0mV; p <0.05). No significant difference was identified between groups in the bursting or variability of neuronal firing in the STN, as measured by a burst index or the interspike interval coefficient of variability. The results suggest that neuronal firing in STN increases with PD progression.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151310

DOI: 10.1002/mds.23708
PubMed: 21542021
PubMed Central: 3151310

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Michael S. Remple

<affiliation><nlm:aff id="A1"> Dept of Neurosurgery, Vanderbilt University Medical Center, Nashville TN</nlm:aff>
<wicri:noCountry code="subfield">Nashville TN</wicri:noCountry>
</affiliation>

Courtney H. Bradenham

<affiliation><nlm:aff id="A2"> Dept of Neurology, Vanderbilt University Medical Center, Nashville TN</nlm:aff>
<wicri:noCountry code="subfield">Nashville TN</wicri:noCountry>
</affiliation>

C. Chris Kao

<affiliation><nlm:aff id="A1"> Dept of Neurosurgery, Vanderbilt University Medical Center, Nashville TN</nlm:aff>
<wicri:noCountry code="subfield">Nashville TN</wicri:noCountry>
</affiliation>

P. David Charles

<affiliation><nlm:aff id="A2"> Dept of Neurology, Vanderbilt University Medical Center, Nashville TN</nlm:aff>
<wicri:noCountry code="subfield">Nashville TN</wicri:noCountry>
</affiliation>

Joseph S. Neimat

<affiliation><nlm:aff id="A1"> Dept of Neurosurgery, Vanderbilt University Medical Center, Nashville TN</nlm:aff>
<wicri:noCountry code="subfield">Nashville TN</wicri:noCountry>
</affiliation>

Peter E. Konrad

<affiliation><nlm:aff id="A1"> Dept of Neurosurgery, Vanderbilt University Medical Center, Nashville TN</nlm:aff>
<wicri:noCountry code="subfield">Nashville TN</wicri:noCountry>
</affiliation>

Le document en format XML

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<author><name sortKey="Konrad, Peter E" sort="Konrad, Peter E" uniqKey="Konrad P" first="Peter E." last="Konrad">Peter E. Konrad</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Microelectrodes</term>
<term>Middle Aged</term>
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<term>Disease Progression</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic cells in the central nervous system, in particular the substantia nigra, resulting in an unrelenting loss of motor and non-motor function. Animal models of PD reveal hyperactive neurons in the subthalamic nucleus (STN) that have increased firing rates and bursting activity compared to controls. Although STN activity has been characterized in advanced stage PD patients, it has not been described in early stage PD patients. Here we present the results of STN neuronal recordings from early stage PD patients (Hoehn and Yahr stage II) enrolled in an ongoing clinical trial compared to recordings from age and sex matched advanced PD patients. STN neurons had a significantly lower firing rate in early versus advanced PD (28.7Hz vs. 36.3Hz; p<0.01). The overall activity of the STN was also significantly lower in early versus late PD, as measured by background neuronal noise (12.4mV vs. 14.0mV; p <0.05). No significant difference was identified between groups in the bursting or variability of neuronal firing in the STN, as measured by a burst index or the interspike interval coefficient of variability. The results suggest that neuronal firing in STN increases with PD progression.</p>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Subthalamic Nucleus Neuronal Firing Rate Increases with Parkinson’s Disease Progression

Subthalamic Nucleus Neuronal Firing Rate Increases with Parkinson’s Disease Progression

Source :

English descriptors

Abstract

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