Increased prefrontal volume in PD with levodopa-induced dyskinesias: a voxel-based morphometry study.
Identifieur interne : 003021 ( Ncbi/Curation ); précédent : 003020; suivant : 003022Increased prefrontal volume in PD with levodopa-induced dyskinesias: a voxel-based morphometry study.
Auteurs : Antonio Cerasa [Italie] ; Demetrio Messina ; Pierfrancesco Pugliese ; Maurizio Morelli ; Pierluigi Lanza ; Maria Salsone ; Fabiana Novellino ; Giuseppe Nicoletti ; Gennarina Arabia ; Aldo QuattroneSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Brain Mapping, Dyskinesia, Drug-Induced (etiology), Dyskinesia, Drug-Induced (pathology), Female, Humans, Imaging, Three-Dimensional, Levodopa (adverse effects), Magnetic Resonance Imaging (methods), Male, Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (pathology), Prefrontal Cortex (drug effects), Prefrontal Cortex (pathology), Statistics, Nonparametric.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- drug effects : Prefrontal Cortex.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- methods : Magnetic Resonance Imaging.
- pathology : Dyskinesia, Drug-Induced, Parkinson Disease, Prefrontal Cortex.
- Aged, Brain Mapping, Female, Humans, Imaging, Three-Dimensional, Male, Middle Aged, Statistics, Nonparametric.
Abstract
Levodopa-induced dyskinesias represent disabling complications from long-term therapy with dopaminergic drugs for treating Parkinson's disease (PD). Although several neuroimaging studies have reported altered striatofrontal function that contributes to the emergence of these motor complications, the neuroanatomical correlates of this disorder are still unknown. Optimized voxel-based morphometry (VBM) was applied to the MRI brain images of 36 PD patients with levodopa-induced dyskinesias, 36 PD patients without levodopa-induced dyskinesias, and 32 age- and sex-matched controls. The VBM analysis comparing dyskinetic and nondyskinetic groups provided evidence of increased gray matter volume of the bilateral inferior frontal gyrus in dyskinetic patients, a finding that was more evident in patients with early-onset PD. No significant differences were detected in the dyskinetic and nondyskinetic groups when compared with the controls. Our findings suggest that the presence of dyskinesias in patients with PD is characterized by an aberrant neural plasticity that could play a role in the pathophysiology of these motor complications.
DOI: 10.1002/mds.23660
PubMed: 21384430
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of Neurological Sciences, National Research Council, Germaneto (CZ), Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Neuroimaging Research Unit, Institute of Neurological Sciences, National Research Council, Germaneto (CZ)</wicri:regionArea><wicri:noRegion>Germaneto (CZ)</wicri:noRegion></affiliation></author><author><name sortKey="Messina, Demetrio" sort="Messina, Demetrio" uniqKey="Messina D" first="Demetrio" last="Messina">Demetrio Messina</name></author><author><name sortKey="Pugliese, Pierfrancesco" sort="Pugliese, Pierfrancesco" uniqKey="Pugliese P" first="Pierfrancesco" last="Pugliese">Pierfrancesco Pugliese</name></author><author><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name></author><author><name sortKey="Lanza, Pierluigi" sort="Lanza, Pierluigi" uniqKey="Lanza P" first="Pierluigi" last="Lanza">Pierluigi Lanza</name></author><author><name sortKey="Salsone, Maria" sort="Salsone, Maria" uniqKey="Salsone M" first="Maria" last="Salsone">Maria Salsone</name></author><author><name sortKey="Novellino, Fabiana" sort="Novellino, Fabiana" uniqKey="Novellino F" first="Fabiana" last="Novellino">Fabiana Novellino</name></author><author><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name></author><author><name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (adverse effects)</term><term>Brain Mapping</term><term>Dyskinesia, Drug-Induced (etiology)</term><term>Dyskinesia, Drug-Induced (pathology)</term><term>Female</term><term>Humans</term><term>Imaging, Three-Dimensional</term><term>Levodopa (adverse effects)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (pathology)</term><term>Prefrontal Cortex (drug effects)</term><term>Prefrontal Cortex (pathology)</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Parkinson Disease</term><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Imaging, Three-Dimensional</term><term>Male</term><term>Middle Aged</term><term>Statistics, Nonparametric</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa-induced dyskinesias represent disabling complications from long-term therapy with dopaminergic drugs for treating Parkinson's disease (PD). Although several neuroimaging studies have reported altered striatofrontal function that contributes to the emergence of these motor complications, the neuroanatomical correlates of this disorder are still unknown. Optimized voxel-based morphometry (VBM) was applied to the MRI brain images of 36 PD patients with levodopa-induced dyskinesias, 36 PD patients without levodopa-induced dyskinesias, and 32 age- and sex-matched controls. The VBM analysis comparing dyskinetic and nondyskinetic groups provided evidence of increased gray matter volume of the bilateral inferior frontal gyrus in dyskinetic patients, a finding that was more evident in patients with early-onset PD. No significant differences were detected in the dyskinetic and nondyskinetic groups when compared with the controls. Our findings suggest that the presence of dyskinesias in patients with PD is characterized by an aberrant neural plasticity that could play a role in the pathophysiology of these motor complications.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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