Positron emission tomography demonstrates dopamine D2 receptor supersensitivity in the striatum of patients with early Parkinson's disease.
Identifieur interne : 002F94 ( Ncbi/Curation ); précédent : 002F93; suivant : 002F95Positron emission tomography demonstrates dopamine D2 receptor supersensitivity in the striatum of patients with early Parkinson's disease.
Auteurs : U K Rinne [Finlande] ; A. Laihinen ; J O Rinne ; K. N Gren ; J. Bergman ; U. RuotsalainenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1990.
English descriptors
- KwdEn :
- Adult, Aged, Corpus Striatum (metabolism), Corpus Striatum (radionuclide imaging), Female, Humans, Male, Middle Aged, Parkinson Disease, Secondary (metabolism), Parkinson Disease, Secondary (radionuclide imaging), Raclopride, Receptors, Dopamine (metabolism), Receptors, Dopamine D2, Salicylamides (metabolism), Tomography, Emission-Computed.
- MESH :
- chemical , metabolism : Receptors, Dopamine, Salicylamides.
- chemical : Raclopride, Receptors, Dopamine D2.
- metabolism : Corpus Striatum, Parkinson Disease, Secondary.
- radionuclide imaging : Corpus Striatum, Parkinson Disease, Secondary.
- Adult, Aged, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed.
Abstract
Striatal dopamine D2 receptor binding was studied in vivo with positron emission tomography in seven patients with early Parkinson's disease using [11C]-raclopride. The patients had unilateral symptoms and none of them had received levodopa treatment. The accumulation of [11C]-raclopride in the striatum was rapid and reached a steady state at approximately 40 min after injection. The binding of [11C]-raclopride was measured in the striatum and cerebellum: The total striatal radioactivity in both hemispheres was counted and the respective striatum/cerebellum ratios were calculated. The striatum/cerebellum ratio of [11C]-raclopride binding was significantly (p less than 0.01) increased in the hemisphere contralateral to the parkinsonian symptoms as compared with the opposite hemisphere. Thus, this study demonstrates that there is denervation supersensitivity in dopamine D2 receptor binding in early Parkinson's disease.
DOI: 10.1002/mds.870050114
PubMed: 2136932
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Laihinen</name></author><author><name sortKey="Rinne, J O" sort="Rinne, J O" uniqKey="Rinne J" first="J O" last="Rinne">J O Rinne</name></author><author><name sortKey="N Gren, K" sort="N Gren, K" uniqKey="N Gren K" first="K" last="N Gren">K. N Gren</name></author><author><name sortKey="Bergman, J" sort="Bergman, J" uniqKey="Bergman J" first="J" last="Bergman">J. Bergman</name></author><author><name sortKey="Ruotsalainen, U" sort="Ruotsalainen, U" uniqKey="Ruotsalainen U" first="U" last="Ruotsalainen">U. 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Laihinen</name></author><author><name sortKey="Rinne, J O" sort="Rinne, J O" uniqKey="Rinne J" first="J O" last="Rinne">J O Rinne</name></author><author><name sortKey="N Gren, K" sort="N Gren, K" uniqKey="N Gren K" first="K" last="N Gren">K. N Gren</name></author><author><name sortKey="Bergman, J" sort="Bergman, J" uniqKey="Bergman J" first="J" last="Bergman">J. Bergman</name></author><author><name sortKey="Ruotsalainen, U" sort="Ruotsalainen, U" uniqKey="Ruotsalainen U" first="U" last="Ruotsalainen">U. Ruotsalainen</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (radionuclide imaging)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease, Secondary (metabolism)</term><term>Parkinson Disease, Secondary (radionuclide imaging)</term><term>Raclopride</term><term>Receptors, Dopamine (metabolism)</term><term>Receptors, Dopamine D2</term><term>Salicylamides (metabolism)</term><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Dopamine</term><term>Salicylamides</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Raclopride</term><term>Receptors, Dopamine D2</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Tomography, Emission-Computed</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Striatal dopamine D2 receptor binding was studied in vivo with positron emission tomography in seven patients with early Parkinson's disease using [11C]-raclopride. The patients had unilateral symptoms and none of them had received levodopa treatment. The accumulation of [11C]-raclopride in the striatum was rapid and reached a steady state at approximately 40 min after injection. The binding of [11C]-raclopride was measured in the striatum and cerebellum: The total striatal radioactivity in both hemispheres was counted and the respective striatum/cerebellum ratios were calculated. The striatum/cerebellum ratio of [11C]-raclopride binding was significantly (p less than 0.01) increased in the hemisphere contralateral to the parkinsonian symptoms as compared with the opposite hemisphere. Thus, this study demonstrates that there is denervation supersensitivity in dopamine D2 receptor binding in early Parkinson's disease.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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