Enlarged hyperechogenic substantia nigra is related to motor performance and olfaction in the elderly.
Identifieur interne : 002C89 ( Ncbi/Curation ); précédent : 002C88; suivant : 002C90Enlarged hyperechogenic substantia nigra is related to motor performance and olfaction in the elderly.
Auteurs : Daniela Berg [Allemagne] ; Klaus Seppi ; Inga Liepelt ; Katherine Schweitzer ; Frank Wollenweber ; Björn Wolf ; Ulrich Dillmann ; Heike Stockner ; Jana Godau ; Stefan Kiechl ; Alexandra Gaenslen ; Johann Willeit ; Adriana Di Santo ; Walter Maetzler ; Thomas Gasser ; Werner Poewe [Autriche] ; Stefanie BehnkeSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
Descripteurs français
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Aging (pathology), Austria, Cohort Studies, Female, Germany, Humans, Logistic Models, Male, Middle Aged, Neurologic Examination, Olfaction Disorders (pathology), Olfaction Disorders (physiopathology), Psychomotor Performance (physiology), Substantia Nigra (pathology), Substantia Nigra (ultrasonography), Ultrasonography, Doppler, Transcranial (methods).
- MESH :
- geographic : Austria, Germany.
- methods : Ultrasonography, Doppler, Transcranial.
- pathology : Aging, Olfaction Disorders, Substantia Nigra.
- physiology : Psychomotor Performance.
- physiopathology : Olfaction Disorders.
- ultrasonography : Substantia Nigra.
- Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Logistic Models, Male, Middle Aged, Neurologic Examination.
Abstract
Enlarged substantia nigra hyperechogenicity (SN+) assessed by transcranial sonography (TCS) may be associated with Parkinson's disease (PD) risk markers such as impaired motor performance and hyposmia. The aim of this multicenter cross-sectional study was to define the association between SN+ and these risk markers in a large population older than 50 years without the diagnosis of PD. In three centers (Tuebingen, Homburg, and Innsbruck), 1,839 individuals were examined. The echostatus of the SN was assessed by TCS, motor performance by the Unified Parkinson's Disease Rating Scale (UPDRS) motor score, and olfactory function with Sniffin' Sticks. From the 1,603 subjects included in the analysis, 16.2% were SN+, 23.0% scored above zero in the UPDRS motor section, and 28.0% were hyposmic as defined by less than 75% correctly classified Sniffin' Sticks. SN+ was associated with a UPDRS motor score above zero (OR 1.45, 95% CI 1.08-1.96) and with a lower odor identification capability (OR 1.48, 95% CI 1.12-1.96). The combination of these two features (OR 1.98, 95% CI 1.25-3.15) and UPDRS motor scores >or=3 lead to higher OR. It is concluded that SN+, impaired motor performance, and hyposmia are frequently observed in the elderly and in isolation are unspecific and of limited use to predict a subject's risk for PD. Whether the association of SN+ with both impaired motor performance and hyposmia as seen in this study predicts an increased risk for the development of PD needs to be evaluated in the follow-up investigations.
DOI: 10.1002/mds.23114
PubMed: 20629151
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sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name></author><author><name sortKey="Liepelt, Inga" sort="Liepelt, Inga" uniqKey="Liepelt I" first="Inga" last="Liepelt">Inga Liepelt</name></author><author><name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name></author><author><name sortKey="Wollenweber, Frank" sort="Wollenweber, Frank" uniqKey="Wollenweber F" first="Frank" last="Wollenweber">Frank Wollenweber</name></author><author><name sortKey="Wolf, Bjorn" sort="Wolf, Bjorn" uniqKey="Wolf B" first="Björn" last="Wolf">Björn Wolf</name></author><author><name sortKey="Dillmann, Ulrich" sort="Dillmann, Ulrich" uniqKey="Dillmann U" first="Ulrich" last="Dillmann">Ulrich Dillmann</name></author><author><name sortKey="Stockner, Heike" sort="Stockner, Heike" uniqKey="Stockner H" first="Heike" last="Stockner">Heike 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last="Gasser">Thomas Gasser</name></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation><country>Autriche</country><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author><author><name sortKey="Behnke, Stefanie" sort="Behnke, Stefanie" uniqKey="Behnke S" first="Stefanie" last="Behnke">Stefanie Behnke</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Aging (pathology)</term><term>Austria</term><term>Cohort Studies</term><term>Female</term><term>Germany</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Olfaction Disorders (pathology)</term><term>Olfaction Disorders (physiopathology)</term><term>Psychomotor Performance (physiology)</term><term>Substantia Nigra (pathology)</term><term>Substantia Nigra (ultrasonography)</term><term>Ultrasonography, Doppler, Transcranial (methods)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Austria</term><term>Germany</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Ultrasonography, Doppler, Transcranial</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Aging</term><term>Olfaction Disorders</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Olfaction Disorders</term></keywords><keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Autriche</term><term>Allemagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Enlarged substantia nigra hyperechogenicity (SN+) assessed by transcranial sonography (TCS) may be associated with Parkinson's disease (PD) risk markers such as impaired motor performance and hyposmia. The aim of this multicenter cross-sectional study was to define the association between SN+ and these risk markers in a large population older than 50 years without the diagnosis of PD. In three centers (Tuebingen, Homburg, and Innsbruck), 1,839 individuals were examined. The echostatus of the SN was assessed by TCS, motor performance by the Unified Parkinson's Disease Rating Scale (UPDRS) motor score, and olfactory function with Sniffin' Sticks. From the 1,603 subjects included in the analysis, 16.2% were SN+, 23.0% scored above zero in the UPDRS motor section, and 28.0% were hyposmic as defined by less than 75% correctly classified Sniffin' Sticks. SN+ was associated with a UPDRS motor score above zero (OR 1.45, 95% CI 1.08-1.96) and with a lower odor identification capability (OR 1.48, 95% CI 1.12-1.96). The combination of these two features (OR 1.98, 95% CI 1.25-3.15) and UPDRS motor scores >or=3 lead to higher OR. It is concluded that SN+, impaired motor performance, and hyposmia are frequently observed in the elderly and in isolation are unspecific and of limited use to predict a subject's risk for PD. Whether the association of SN+ with both impaired motor performance and hyposmia as seen in this study predicts an increased risk for the development of PD needs to be evaluated in the follow-up investigations.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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