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Decision making in de novo Parkinson's disease.

Identifieur interne : 002C77 ( Ncbi/Curation ); précédent : 002C76; suivant : 002C78

Decision making in de novo Parkinson's disease.

Auteurs : Michele Poletti [Italie] ; Daniela Frosini ; Claudio Lucetti ; Paolo Del Dotto ; Roberto Ceravolo ; Ubaldo Bonuccelli

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.

RBID : pubmed:20629139

English descriptors

KwdEn :
- Aged, Case-Control Studies, Cognition Disorders (etiology), Decision Making (physiology), Female, Humans, Male, Middle Aged, Parkinson Disease (complications).
MESH :
- complications : Parkinson Disease.
- etiology : Cognition Disorders.
- physiology : Decision Making.
- Aged, Case-Control Studies, Female, Humans, Male, Middle Aged.

Abstract

The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age-matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala-damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age-matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age-matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits.

DOI: 10.1002/mds.23098
PubMed: 20629139

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Le document en format XML

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<author><name sortKey="Poletti, Michele" sort="Poletti, Michele" uniqKey="Poletti M" first="Michele" last="Poletti">Michele Poletti</name>
<affiliation wicri:level="1"><nlm:affiliation>Neurology Unit, USL of Viareggio, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Neurology Unit, USL of Viareggio</wicri:regionArea>
<wicri:noRegion>USL of Viareggio</wicri:noRegion>
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<author><name sortKey="Frosini, Daniela" sort="Frosini, Daniela" uniqKey="Frosini D" first="Daniela" last="Frosini">Daniela Frosini</name>
</author>
<author><name sortKey="Lucetti, Claudio" sort="Lucetti, Claudio" uniqKey="Lucetti C" first="Claudio" last="Lucetti">Claudio Lucetti</name>
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<author><name sortKey="Del Dotto, Paolo" sort="Del Dotto, Paolo" uniqKey="Del Dotto P" first="Paolo" last="Del Dotto">Paolo Del Dotto</name>
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<author><name sortKey="Ceravolo, Roberto" sort="Ceravolo, Roberto" uniqKey="Ceravolo R" first="Roberto" last="Ceravolo">Roberto Ceravolo</name>
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<author><name sortKey="Bonuccelli, Ubaldo" sort="Bonuccelli, Ubaldo" uniqKey="Bonuccelli U" first="Ubaldo" last="Bonuccelli">Ubaldo Bonuccelli</name>
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<author><name sortKey="Lucetti, Claudio" sort="Lucetti, Claudio" uniqKey="Lucetti C" first="Claudio" last="Lucetti">Claudio Lucetti</name>
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<author><name sortKey="Del Dotto, Paolo" sort="Del Dotto, Paolo" uniqKey="Del Dotto P" first="Paolo" last="Del Dotto">Paolo Del Dotto</name>
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<author><name sortKey="Ceravolo, Roberto" sort="Ceravolo, Roberto" uniqKey="Ceravolo R" first="Roberto" last="Ceravolo">Roberto Ceravolo</name>
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<term>Decision Making (physiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (complications)</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Decision Making</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
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<term>Male</term>
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<front><div type="abstract" xml:lang="en">The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age-matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala-damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age-matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age-matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Decision making in de novo Parkinson's disease.

Decision making in de novo Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki