Abnormal visual activation in Parkinson's disease patients.
Identifieur interne : 002C51 ( Ncbi/Curation ); précédent : 002C50; suivant : 002C52Abnormal visual activation in Parkinson's disease patients.
Auteurs : Ellison Fernando Cardoso [Brésil] ; Felipe Fregni ; Fernanda Martins Maia ; Luciano M. Melo ; João R. Sato ; Antonio Cesário Cruz ; Edno Tales Bianchi ; Danilo Botelho Fernandes ; Mário Luiz Ribeiro Monteiro ; Egberto Reis Barbosa ; Edson AmaroSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Face, Female, Humans, Image Processing, Computer-Assisted (methods), Magnetic Resonance Imaging (methods), Male, Middle Aged, Neurologic Examination (methods), Neuropsychological Tests, Oxygen (blood), Parkinson Disease (complications), Parkinson Disease (pathology), Pattern Recognition, Visual (physiology), Perceptual Disorders (etiology), Photic Stimulation (methods), Statistics as Topic, Visual Cortex (blood supply), Visual Cortex (physiopathology), Visual Pathways (blood supply), Visual Pathways (physiopathology).
- MESH :
- chemical , blood : Oxygen.
- blood supply : Visual Cortex, Visual Pathways.
- complications : Parkinson Disease.
- etiology : Perceptual Disorders.
- methods : Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Neurologic Examination, Photic Stimulation.
- pathology : Parkinson Disease.
- physiology : Pattern Recognition, Visual.
- physiopathology : Visual Cortex, Visual Pathways.
- Aged, Analysis of Variance, Face, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Statistics as Topic.
Abstract
Among nonmotor symptoms observed in Parkinson's disease (PD) dysfunction in the visual system, including hallucinations, has a significant impact in their quality of life. To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD.
DOI: 10.1002/mds.23101
PubMed: 20623771
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Melo</name></author><author><name sortKey="Sato, Joao R" sort="Sato, Joao R" uniqKey="Sato J" first="João R" last="Sato">João R. 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To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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