The pharmacological treatment for uremic restless legs syndrome: evidence-based review.
Identifieur interne : 002C00 ( Ncbi/Curation ); précédent : 002B99; suivant : 002C01The pharmacological treatment for uremic restless legs syndrome: evidence-based review.
Auteurs : Márcio Moysés De Oliveira [Brésil] ; Cristiane Fiquene Conti ; Juliana Spelta Valbuza ; Luciane Bizari Coin De Carvalho ; Gilmar Fernandes Do PradoSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- complications : Restless Legs Syndrome.
- drug therapy : Restless Legs Syndrome, Uremia.
- etiology : Uremia.
- statistics & numerical data : Databases, Factual.
- Cross-Over Studies, Double-Blind Method, Evidence-Based Medicine, Humans, Randomized Controlled Trials as Topic.
Abstract
Restless legs syndrome (RLS) is a common and often misdiagnosed entity among the general population and it may be more common among dialysis patients, with an estimated prevalence of 6.6 to 21.5%. The treatment for uremic RLS has been controversial and therefore a systematic synthesis of the evidence is needed in order to evaluate the effectiveness and safety of treatments for uremic RLS. This was a systematic review of randomized or quasi-randomized double-blind trials on treatments for uremic RLS. The outcomes considered were relief of RLS symptoms marked on a validated scale, subjective sleep quality, sleep quality measured using night polysomnography and actigraphy, quality of life measured subjectively, and adverse events associated with these treatments. Six eligible clinical trials were included. The results from subjective analyses in these studies were divergent, although objective analyses in one trial showed that there was a statistically significant improvement in periodic leg movement while asleep in the treatment group. No combined analysis (meta-analysis) was performed. The most common adverse event seen was gastrointestinal symptoms. Only a few therapeutic trials on patients with uremia with RLS have been published, and there is insufficient scientific evidence to favor any specific therapeutic regimen for uremic-associated RLS. Therapy using levodopa, dopaminergic agonists, anticonvulsants, and clonidine tend to be effective, but further studies are needed.
DOI: 10.1002/mds.22955
PubMed: 20544816
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scheme="KwdEn" xml:lang="en"><term>Cross-Over Studies</term><term>Databases, Factual (statistics & numerical data)</term><term>Double-Blind Method</term><term>Evidence-Based Medicine</term><term>Humans</term><term>Randomized Controlled Trials as Topic</term><term>Restless Legs Syndrome (complications)</term><term>Restless Legs Syndrome (drug therapy)</term><term>Uremia (drug therapy)</term><term>Uremia (etiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Restless Legs Syndrome</term><term>Uremia</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Uremia</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Databases, Factual</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cross-Over Studies</term><term>Double-Blind Method</term><term>Evidence-Based Medicine</term><term>Humans</term><term>Randomized Controlled Trials as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Restless legs syndrome (RLS) is a common and often misdiagnosed entity among the general population and it may be more common among dialysis patients, with an estimated prevalence of 6.6 to 21.5%. The treatment for uremic RLS has been controversial and therefore a systematic synthesis of the evidence is needed in order to evaluate the effectiveness and safety of treatments for uremic RLS. This was a systematic review of randomized or quasi-randomized double-blind trials on treatments for uremic RLS. The outcomes considered were relief of RLS symptoms marked on a validated scale, subjective sleep quality, sleep quality measured using night polysomnography and actigraphy, quality of life measured subjectively, and adverse events associated with these treatments. Six eligible clinical trials were included. The results from subjective analyses in these studies were divergent, although objective analyses in one trial showed that there was a statistically significant improvement in periodic leg movement while asleep in the treatment group. No combined analysis (meta-analysis) was performed. The most common adverse event seen was gastrointestinal symptoms. Only a few therapeutic trials on patients with uremia with RLS have been published, and there is insufficient scientific evidence to favor any specific therapeutic regimen for uremic-associated RLS. Therapy using levodopa, dopaminergic agonists, anticonvulsants, and clonidine tend to be effective, but further studies are needed.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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