MovDisordV3, Ncbi, Curation, bibRecord, 002B43

Association Between Cognition and Function in Patients With Parkinson Disease With and Without Dementia

Identifieur interne : 002B43 ( Ncbi/Curation ); précédent : 002B42; suivant : 002B44

Association Between Cognition and Function in Patients With Parkinson Disease With and Without Dementia

Auteurs : Emily Rosenthal [États-Unis] ; Laura Brennan [États-Unis] ; Sharon Xie [États-Unis] ; Howard Hurtig [États-Unis] ; Joshua Milber [États-Unis] ; Daniel Weintraub [États-Unis] ; Jason Karlawish [États-Unis] ; Andrew Siderowf [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.

RBID : PMC:2963089

English descriptors

KwdEn :
- Activities of Daily Living (psychology), Aged, Aged, 80 and over, Cognition Disorders (classification), Cognition Disorders (etiology), Dementia (complications), Dementia (psychology), Discriminant Analysis, Female, Humans, Male, Mental Status Schedule, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (psychology), ROC Curve, Sensitivity and Specificity.
MESH :
- classification : Cognition Disorders.
- complications : Dementia, Parkinson Disease.
- etiology : Cognition Disorders.
- psychology : Activities of Daily Living, Dementia, Parkinson Disease.
- Aged, Aged, 80 and over, Discriminant Analysis, Female, Humans, Male, Mental Status Schedule, Neuropsychological Tests, ROC Curve, Sensitivity and Specificity.

Abstract

Patients with Parkinson's disease (PD) often have cognitive deficits from the time of diagnosis. Except in patients with dementia, the impact of cognitive symptoms on daily function is not well documented. This study had two objectives: (1) to determine the functional significance of cognitive deficits in nondemented patients with PD and (2) to assess the sensitivity of two measures of global cognitive abilities to identify individuals with impaired ADL function. One hundred eleven subjects with PD and a range of cognitive abilities were included. Of these, 20 were diagnosed with PDD. All subjects were assessed with the Mattis Dementia Rating Scale to two (DRS-2) and the Mini-Mental State Examination (MMSE). ADL function was reported by an informant using the Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory (ADCS-ADL). The ability of the DRS-2 and MMSE to capture the impact of cognitive impairment on ADL function was assessed in the entire cohort and in subsets of nondemented individuals. After adjustment for covariates, cognition as measured by the DRS-2 was strongly related to ADL function in the entire cohort (partial correlation coefficient = 0.55, P < 0.001). The association remained strong when only nondemented subjects were included (r = 0.42, P < 0.001). The DRS-2 was significantly more accurate than the MMSE, particularly for detecting milder degrees of ADL impairment (ROC area = 0.87 vs. 0.75, P = 0.0008). Cognition is associated with impairment in ADL function, even in nondemented patients with PD. However, sensitive cognitive assessment measures may be needed to identify these functionally relevant impairments.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963089

DOI: 10.1002/mds.23073
PubMed: 20310053
PubMed Central: 2963089

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000088
to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000088
to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000365
to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001859
to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001859
to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001A33
to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002B43

Links to Exploration step

PMC:2963089

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association Between Cognition and Function in Patients With Parkinson Disease With and Without Dementia</title>
<author><name sortKey="Rosenthal, Emily" sort="Rosenthal, Emily" uniqKey="Rosenthal E" first="Emily" last="Rosenthal">Emily Rosenthal</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brennan, Laura" sort="Brennan, Laura" uniqKey="Brennan L" first="Laura" last="Brennan">Laura Brennan</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xie, Sharon" sort="Xie, Sharon" uniqKey="Xie S" first="Sharon" last="Xie">Sharon Xie</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Biostatistics, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hurtig, Howard" sort="Hurtig, Howard" uniqKey="Hurtig H" first="Howard" last="Hurtig">Howard Hurtig</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Milber, Joshua" sort="Milber, Joshua" uniqKey="Milber J" first="Joshua" last="Milber">Joshua Milber</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weintraub, Daniel" sort="Weintraub, Daniel" uniqKey="Weintraub D" first="Daniel" last="Weintraub">Daniel Weintraub</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Psychiatry, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Karlawish, Jason" sort="Karlawish, Jason" uniqKey="Karlawish J" first="Jason" last="Karlawish">Jason Karlawish</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Medicine and Medical Ethics, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine and Medical Ethics, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Siderowf, Andrew" sort="Siderowf, Andrew" uniqKey="Siderowf A" first="Andrew" last="Siderowf">Andrew Siderowf</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20310053</idno>
<idno type="pmc">2963089</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963089</idno>
<idno type="RBID">PMC:2963089</idno>
<idno type="doi">10.1002/mds.23073</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">000088</idno>
<idno type="wicri:Area/Pmc/Curation">000088</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000365</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001859</idno>
<idno type="wicri:Area/PubMed/Curation">001859</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001A33</idno>
<idno type="wicri:Area/Ncbi/Merge">002B43</idno>
<idno type="wicri:Area/Ncbi/Curation">002B43</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association Between Cognition and Function in Patients With Parkinson Disease With and Without Dementia</title>
<author><name sortKey="Rosenthal, Emily" sort="Rosenthal, Emily" uniqKey="Rosenthal E" first="Emily" last="Rosenthal">Emily Rosenthal</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brennan, Laura" sort="Brennan, Laura" uniqKey="Brennan L" first="Laura" last="Brennan">Laura Brennan</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xie, Sharon" sort="Xie, Sharon" uniqKey="Xie S" first="Sharon" last="Xie">Sharon Xie</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Biostatistics, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hurtig, Howard" sort="Hurtig, Howard" uniqKey="Hurtig H" first="Howard" last="Hurtig">Howard Hurtig</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Milber, Joshua" sort="Milber, Joshua" uniqKey="Milber J" first="Joshua" last="Milber">Joshua Milber</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weintraub, Daniel" sort="Weintraub, Daniel" uniqKey="Weintraub D" first="Daniel" last="Weintraub">Daniel Weintraub</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Psychiatry, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Karlawish, Jason" sort="Karlawish, Jason" uniqKey="Karlawish J" first="Jason" last="Karlawish">Jason Karlawish</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Medicine and Medical Ethics, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine and Medical Ethics, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Siderowf, Andrew" sort="Siderowf, Andrew" uniqKey="Siderowf A" first="Andrew" last="Siderowf">Andrew Siderowf</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living (psychology)</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cognition Disorders (classification)</term>
<term>Cognition Disorders (etiology)</term>
<term>Dementia (complications)</term>
<term>Dementia (psychology)</term>
<term>Discriminant Analysis</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mental Status Schedule</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (psychology)</term>
<term>ROC Curve</term>
<term>Sensitivity and Specificity</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Cognition Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dementia</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Activities of Daily Living</term>
<term>Dementia</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Discriminant Analysis</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mental Status Schedule</term>
<term>Neuropsychological Tests</term>
<term>ROC Curve</term>
<term>Sensitivity and Specificity</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Patients with Parkinson's disease (PD) often have cognitive deficits from the time of diagnosis. Except in patients with dementia, the impact of cognitive symptoms on daily function is not well documented. This study had two objectives: (1) to determine the functional significance of cognitive deficits in nondemented patients with PD and (2) to assess the sensitivity of two measures of global cognitive abilities to identify individuals with impaired ADL function. One hundred eleven subjects with PD and a range of cognitive abilities were included. Of these, 20 were diagnosed with PDD. All subjects were assessed with the Mattis Dementia Rating Scale to two (DRS-2) and the Mini-Mental State Examination (MMSE). ADL function was reported by an informant using the Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory (ADCS-ADL). The ability of the DRS-2 and MMSE to capture the impact of cognitive impairment on ADL function was assessed in the entire cohort and in subsets of nondemented individuals. After adjustment for covariates, cognition as measured by the DRS-2 was strongly related to ADL function in the entire cohort (partial correlation coefficient = 0.55, <italic>P</italic>
 < 0.001). The association remained strong when only nondemented subjects were included (<italic>r</italic>
 = 0.42, <italic>P</italic>
 < 0.001). The DRS-2 was significantly more accurate than the MMSE, particularly for detecting milder degrees of ADL impairment (ROC area = 0.87 vs. 0.75, <italic>P</italic>
 = 0.0008). Cognition is associated with impairment in ADL function, even in nondemented patients with PD. However, sensitive cognitive assessment measures may be needed to identify these functionally relevant impairments.</p>
</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002B43 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 002B43 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Ncbi
   |étape=   Curation
   |type=    RBID
   |clé=     PMC:2963089
   |texte=   Association Between Cognition and Function in Patients With Parkinson Disease With and Without Dementia
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i   -Sk "pubmed:20310053" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a MovDisordV3

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Association Between Cognition and Function in Patients With Parkinson Disease With and Without Dementia

Association Between Cognition and Function in Patients With Parkinson Disease With and Without Dementia

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki